Pathways from BioSystems

• Assembly of HIV virion, organism-specific biosystem (from REACTOME)
  Assembly of HIV virion, organism-specific biosystemThis pathway module includes annotations of events leading to synthesis and organization of GAG, GAGPOL and ENV proteins. This section will annotated in future.
• Disease, organism-specific biosystem (from REACTOME)
  Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
• HIV Infection, organism-specific biosystem (from REACTOME)
  HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
• HIV Life Cycle, organism-specific biosystem (from REACTOME)
  HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
• HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
  HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
  HIV-1 Nef: Negative effector of Fas and TNF-alpha
• Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
  Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
• Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
  Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
• Nef Mediated CD4 Down-regulation, organism-specific biosystem (from REACTOME)
  Nef Mediated CD4 Down-regulation, organism-specific biosystemThe presence of Nef accelerates endocytosis and lysosomal degradation of the transmembrane glycoprotein CD4. CD4 has its own internalization motif, though this motif is normally concealed by CD4 inte...
• Nef Mediated CD8 Down-regulation, organism-specific biosystem (from REACTOME)
  Nef Mediated CD8 Down-regulation, organism-specific biosystemHuman immunodeficiency virus (HIV) Nef is a membrane-associated protein decreasing surface expression of CD4, CD28, and major histocompatibility complex class I on infected cells. Nef also strongly d...
• Nef and signal transduction, organism-specific biosystem (from REACTOME)
  Nef and signal transduction, organism-specific biosystemNef interferes with cellular signal transduction pathways in a number of ways. Nef is associated with lipid rafts through its amino-terminal myristoylation and a proline-rich SH3-binding domain. Thes...
• Nef mediated downregulation of CD28 cell surface expression, organism-specific biosystem (from REACTOME)
  Nef mediated downregulation of CD28 cell surface expression, organism-specific biosystemDown-regulation of CD28 receptors involves a dileucine-based motif in the second disordered loop of Nef, which connects Nef to adaptor protein (AP) complex, which is a part of cellular endocytosis ma...
• Nef mediated downregulation of MHC class I complex cell surface expression, organism-specific biosystem (from REACTOME)
  Nef mediated downregulation of MHC class I complex cell surface expression, organism-specific biosystemDown-regulation of MHC class I involves Nef-mediated connection in the endosomes between MHC-I's cytoplasmic tail and the phosphofurin acidic cluster sorting protein-1 (PACS-1)-dependent protein-sort...
• Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystem (from REACTOME)
  Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystemThe maximal virulence of HIV-1 requires Nef, a virally encoded peripheral membrane protein. Nef binds to the adaptor protein (AP) complexes of coated vesicles, inducing an expansion of the endosomal ...
• Synthesis and processing of accessory proteins, organism-specific biosystem (from REACTOME)
  Synthesis and processing of accessory proteins, organism-specific biosystem
  Synthesis and processing of accessory proteins
• The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystem (from REACTOME)
  The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystemThe HIV-1 Nef protein is a 27-kDa myristoylated protein that is abundantly produced during the early phase of viral replication cycle. It is highly conserved in all primate lentiviruses, suggesting t...