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nef p27 [ Human immunodeficiency virus 1 ]

Gene ID: 156110, updated on 12-Apr-2014
Gene symbol
nef
Gene description
p27
Locus tag
HIV1gp9
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Human immunodeficiency virus 1 (gb-acronym: HIV-1)
Lineage
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
Sequence :
NC_001802.1 (8343..8963)

NC_001802.1Genomic Context describing neighboring genes Neighboring gene p23 Neighboring gene p15 Neighboring gene p14 Neighboring gene p19 Neighboring gene p16 Neighboring gene gp160; envelope glycoprotein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
ATP-binding cassette sub-family A member 1 ABCA1 inhibited by PubMed
ABCA1 interacts with PubMed
ABCA1 downregulates PubMed
acetylcholinesterase isoform E4-E6 precursor ACHE upregulates PubMed
ACHE co-localizes with PubMed
acyl-coenzyme A thioesterase 8 ACOT8 interacts with PubMed
ACOT8 binds PubMed
ACOT8 binds PubMed
actin, alpha skeletal muscle ACTA1 inhibits PubMed
ACTA1 interacts with PubMed
ACTA1 inhibits PubMed
ACTA1 disrupts PubMed
actin, aortic smooth muscle ACTA2 inhibits PubMed
ACTA2 inhibits PubMed
actin, cytoplasmic 1 ACTB inhibits PubMed
ACTB inhibits PubMed
ACTB interacts with PubMed
ACTB interacts with PubMed
ACTB induces rearrangement of PubMed
ACTB associates with PubMed
actin, alpha cardiac muscle 1 proprotein ACTC1 inhibits PubMed
ACTC1 inhibits PubMed
actin, cytoplasmic 2 ACTG1 inhibits PubMed
ACTG1 inhibits PubMed
ACTG1 induces rearrangement of PubMed
ACTG1 associates with PubMed
actin, gamma-enteric smooth muscle isoform 1 precursor ACTG2 inhibits PubMed
ACTG2 inhibits PubMed
double-stranded RNA-specific adenosine deaminase isoform a ADAR upregulates PubMed
adenylate cyclase type 1 isoform 1 ADCY1 activates PubMed
adenylate cyclase type 2 ADCY2 activates PubMed
adenylate cyclase type 3 ADCY3 activates PubMed
adenylate cyclase type 4 ADCY4 activates PubMed
adenylate cyclase type 5 isoform 1 ADCY5 activates PubMed
adenylate cyclase type 6 isoform a ADCY6 activates PubMed
adenylate cyclase type 7 isoform 1 ADCY7 activates PubMed
adenylate cyclase type 8 ADCY8 activates PubMed
adenylate cyclase type 9 ADCY9 activates PubMed
RAC-alpha serine/threonine-protein kinase AKT1 induces phosphorylation of PubMed
AKT1 decreases phosphorylation of PubMed
RAC-beta serine/threonine-protein kinase isoform 1 AKT2 induces phosphorylation of PubMed
AKT2 decreases phosphorylation of PubMed
RAC-gamma serine/threonine-protein kinase isoform 1 AKT3 induces phosphorylation of PubMed
AKT3 decreases phosphorylation of PubMed
ALK tyrosine kinase receptor precursor ALK interacts with PubMed
ALK interacts with PubMed
ALK interacts with PubMed
ALK upregulates PubMed
annexin A2 isoform 2 ANXA2 co-localizes with PubMed
AP-1 complex subunit beta-1 isoform a AP1B1 activates PubMed
AP1B1 stabilizes PubMed
AP1B1 binds PubMed
AP1B1 interacts with PubMed
AP-1 complex subunit gamma-1 isoform b AP1G1 interacts with PubMed
AP1G1 activates PubMed
AP1G1 interacts with PubMed
AP1G1 interacts with PubMed
AP1G1 binds PubMed
AP1G1 stabilizes PubMed
AP-1 complex subunit gamma-like 2 isoform 1 AP1G2 activates PubMed
AP1G2 stabilizes PubMed
AP1G2 binds PubMed
AP1G2 interacts with PubMed
AP-1 complex subunit mu-1 isoform 2 AP1M1 complexes with PubMed
AP1M1 interacts with PubMed
AP1M1 complexes with PubMed
AP1M1 activates PubMed
AP1M1 interacts with PubMed
AP1M1 interacts with PubMed
AP1M1 interacts with PubMed
AP1M1 interacts with PubMed
AP1M1 binds PubMed
AP1M1 Interacts with PubMed
AP1M1 binds PubMed
AP1M1 interacts with PubMed
AP1M1 Interacts with PubMed
AP1M1 stabilizes PubMed
AP-1 complex subunit sigma-1A AP1S1 activates PubMed
AP1S1 stabilizes PubMed
AP1S1 binds PubMed
AP1S1 interacts with PubMed
AP-1 complex subunit sigma-2 isoform 2 AP1S2 activates PubMed
AP1S2 binds PubMed
AP1S2 stabilizes PubMed
AP1S2 interacts with PubMed
AP-1 complex subunit sigma-3 AP1S3 stabilizes PubMed
AP1S3 binds PubMed
AP1S3 interacts with PubMed
AP-2 complex subunit alpha-1 isoform 1 AP2A1 inhibited by PubMed
AP2A1 binds PubMed
AP2A1 binds PubMed
AP-2 complex subunit alpha-2 isoform 2 AP2A2 inhibited by PubMed
AP2A2 binds PubMed
AP2A2 binds PubMed
AP-2 complex subunit beta isoform b AP2B1 binds PubMed
AP2B1 interacts with PubMed
AP2B1 co-localizes with PubMed
AP2B1 co-localizes with PubMed
AP-2 complex subunit mu isoform a AP2M1 interacts with PubMed
AP2M1 requires PubMed
AP2M1 Requires PubMed
AP-3 complex subunit delta-1 isoform 2 AP3D1 binds PubMed
AP3D1 co-localizes with PubMed
AP-3 complex subunit mu-1 AP3M1 interacts with PubMed
apolipoprotein A-I preproprotein APOA1 inhibits PubMed
ADP-ribosylation factor 1 ARF1 complexes with PubMed
ARF1 requires PubMed
ARF1 binds PubMed
ADP-ribosylation factor 6 ARF6 inhibited by PubMed
ARF6 activates PubMed
ARF6 regulated by PubMed
rho guanine nucleotide exchange factor 6 ARHGEF6 induces phosphorylation of PubMed
rho guanine nucleotide exchange factor 7 isoform a ARHGEF7 induces complex with PubMed
cyclic AMP-dependent transcription factor ATF-2 isoform 1 ATF2 inhibits PubMed
cyclic AMP-dependent transcription factor ATF-3 isoform 1 ATF3 upregulates PubMed
V-type proton ATPase subunit H isoform 2 ATP6V1H cooperates with PubMed
ATP6V1H binds PubMed
bcl2 antagonist of cell death BAD induces phosphorylation of PubMed
apoptosis regulator Bcl-2 alpha isoform BCL2 downregulates PubMed
bcl-2-like protein 1 isoform 1 BCL2L1 downregulates PubMed
BCL2L1 upregulates PubMed
beclin-1 BECN1 interacts with PubMed
bone marrow stromal antigen 2 precursor BST2 upregulates PubMed
BST2 upregulates PubMed
complement C3 precursor C3 upregulates PubMed
C5a anaphylatoxin chemotactic receptor 1 C5AR1 upregulates PubMed
calmodulin CALM1 interacts with PubMed
CALM1 requires PubMed
CALM1 binds PubMed
CALM1 interacts with PubMed
CALM2 interacts with PubMed
CALM2 requires PubMed
CALM2 interacts with PubMed
CALM3 interacts with PubMed
CALM3 requires PubMed
CALM3 interacts with PubMed
caspase-3 preproprotein CASP3 activates PubMed
CASP3 inactivates PubMed
CASP3 requires PubMed
caspase-8 isoform A precursor CASP8 inactivates PubMed
caspase-9 isoform alpha precursor CASP9 upregulates PubMed
E3 ubiquitin-protein ligase CBL CBL induces complex with PubMed
CBL induces phosphorylation of PubMed
C-C motif chemokine 19 precursor CCL19 inhibits PubMed
C-C motif chemokine 2 precursor CCL2 upregulates PubMed
C-C motif chemokine 20 isoform 1 precursor CCL20 upregulates PubMed
C-C motif chemokine 24 precursor CCL24 upregulates PubMed
C-C motif chemokine 3 precursor CCL3 inhibits PubMed
CCL3 upregulates PubMed
CCL3 upregulates PubMed
C-C motif chemokine 4 precursor CCL4 downregulates PubMed
CCL4 upregulates PubMed
CCL4 interacts with PubMed
CCL4 upregulates PubMed
CCL4 upregulates PubMed
C-C motif chemokine 5 isoform 1 precursor CCL5 downregulates PubMed
CCL5 upregulates PubMed
G1/S-specific cyclin-D1 CCND1 upregulates PubMed
G1/S-specific cyclin-E1 CCNE1 downregulates PubMed
cyclin-K CCNK interacts with PubMed
CCNK interacts with PubMed
C-C chemokine receptor type 5 CCR5 downregulates PubMed
CCR5 downregulates PubMed
CCR5 downregulates PubMed
C-C chemokine receptor type 7 precursor CCR7 upregulates PubMed
monocyte differentiation antigen CD14 precursor CD14 downregulates PubMed
CD14 upregulates PubMed
scavenger receptor cysteine-rich type 1 protein M130 isoform a precursor CD163 downregulates PubMed
T-cell surface glycoprotein CD1a precursor CD1A interacts with PubMed
CD1A downregulates PubMed
antigen-presenting glycoprotein CD1d precursor CD1D downregulates PubMed
CD1D downregulates PubMed
CD1D inhibits PubMed
CD1D downregulates PubMed
CD209 antigen isoform 1 CD209 upregulates PubMed
CD209 upregulates PubMed
CD209 upregulates PubMed
B-cell receptor CD22 isoform 1 precursor CD22 upregulates PubMed
CD226 antigen precursor CD226 interacts with PubMed
T-cell surface glycoprotein CD3 zeta chain isoform 1 precursor CD247 colocalizes with PubMed
CD247 interacts with PubMed
CD247 Interacts with PubMed
CD247 Upregulates PubMed
T-cell-specific surface glycoprotein CD28 isoform 1 precursor CD28 downregulates PubMed
CD28 downregulates PubMed
CD28 downregulates PubMed
CD28 downregulates PubMed
CD28 downregulates PubMed
CD28 upregulates PubMed
CD28 co-localizes with PubMed
T-cell surface glycoprotein CD3 delta chain isoform A precursor CD3D interacts with PubMed
CD3D downregulates PubMed
T-cell surface glycoprotein CD3 epsilon chain precursor CD3E interacts with PubMed
CD3E interacts with PubMed
CD3E downregulates PubMed
T-cell surface glycoprotein CD3 gamma chain precursor CD3G interacts with PubMed
CD3G downregulates PubMed
CD3G downregulates PubMed
T-cell surface glycoprotein CD4 isoform 1 precursor CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 interacts with PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 enhances PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 degrades PubMed
CD4 complexes with PubMed
CD4 downregulates PubMed
CD4 interacts with PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 binds PubMed
CD4 binds PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 degrades PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 binds PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 interacts with PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 modulates PubMed
CD4 downregulates PubMed
CD40 ligand CD40LG inhibits PubMed
CD40LG upregulates PubMed
T-cell surface glycoprotein CD5 precursor CD5 interacts with PubMed
lymphocyte function-associated antigen 3 isoform 1 CD58 upregulates PubMed
CD63 antigen isoform A CD63 co-localizes with PubMed
CD63 co-localizes with PubMed
CD63 co-localizes with PubMed
early activation antigen CD69 CD69 upregulates PubMed
CD69 downregulates PubMed
CD69 downregulates PubMed
HLA class II histocompatibility antigen gamma chain isoform b CD74 upregulates PubMed
CD74 upregulates PubMed
CD74 upregulates PubMed
CD74 upregulates PubMed
CD74 upregulates PubMed
CD74 upregulates PubMed
CD74 upregulates PubMed
T-lymphocyte activation antigen CD80 precursor CD80 binds PubMed
CD80 downregulates PubMed
CD80 downregulates PubMed
CD80 binds PubMed
CD80 downregulates PubMed
CD80 interacts with PubMed
CD81 antigen CD81 co-localizes with PubMed
T-lymphocyte activation antigen CD86 isoform 1 precursor CD86 binds PubMed
CD86 downregulates PubMed
CD86 downregulates PubMed
CD86 binds PubMed
CD86 downregulates PubMed
T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor CD8A downregulates PubMed
CD8A colocalizes with PubMed
CD8A downregulates PubMed
T-cell surface glycoprotein CD8 beta chain isoform 2 precursor CD8B downregulates PubMed
CD8B downregulates PubMed
CD8B co-localizes with PubMed
CD8B downregulates PubMed
cell division control protein 42 homolog isoform 1 precursor CDC42 interacts with PubMed
CDC42 inhibits PubMed
CDC42 upregulates PubMed
cyclin-dependent kinase 9 CDK9 interacts with PubMed
CDK9 upregulates PubMed
CDK9 interacts with PubMed
cyclin-dependent kinase inhibitor 2A isoform p16INK4a CDKN2A interacts with PubMed
cofilin-1 CFL1 induces phosphorylation of PubMed
CFL1 induces phosphorylation of PubMed
CFL1 induces phosphorylation of PubMed
cofilin-2 isoform 1 CFL2 induces phosphorylation of PubMed
inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK induces phosphorylation of PubMed
CHUK induces phosphorylation of PubMed
clathrin light chain A isoform a CLTA complexes with PubMed
CLTA complexes with PubMed
CLTA interacts with PubMed
clathrin light chain B isoform a CLTB complexes with PubMed
CLTB complexes with PubMed
CLTB interacts with PubMed
clathrin heavy chain 1 isoform 1 CLTC complexes with PubMed
CLTC interacts with PubMed
CLTC interacts with PubMed
coatomer subunit beta COPB1 cooperates with PubMed
COPB1 cooperates with PubMed
COPB1 interacts with PubMed
COPB1 binds PubMed
COPB1 co-localizes with PubMed
cytochrome c oxidase subunit II (mitochondrion) COX2 downregulates PubMed
macrophage colony-stimulating factor 1 receptor precursor CSF1R downregulates PubMed
CSF1R deglycosylates PubMed
CSF1R disrupts PubMed
CSF1R inhibits PubMed
granulocyte-macrophage colony-stimulating factor precursor CSF2 interacts with PubMed
cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM precursor CTLA4 upregulates PubMed
cathepsin D preproprotein CTSD induces release of PubMed
C-X-C motif chemokine 10 precursor CXCL10 upregulates PubMed
stromal cell-derived factor 1 isoform beta precursor CXCL12 modulates PubMed
CXCL12 inhibits PubMed
interleukin-8 precursor CXCL8 upregulates PubMed
C-X-C chemokine receptor type 3 isoform 1 CXCR3 interacts with PubMed
C-X-C chemokine receptor type 4 isoform b CXCR4 downregulates PubMed
CXCR4 upregulates PubMed
CXCR4 downregulates PubMed
CXCR4 modulates PubMed
CXCR4 downregulates PubMed
CXCR4 inhibits PubMed
CXCR4 interacts with PubMed
CXCR4 interacts with PubMed
CXCR4 Interacts with PubMed
cytochrome b-245 light chain CYBA associates with PubMed
lanosterol 14-alpha demethylase isoform 1 precursor CYP51A1 upregulates PubMed
dnaJ homolog subfamily B member 1 DNAJB1 interacts with PubMed
DNAJB1 Upregulates PubMed
DNAJB1 Interacts with PubMed
dynamin-2 isoform 3 DNM2 requires PubMed
DNM2 binds PubMed
DNM2 regulated by PubMed
dedicator of cytokinesis protein 2 DOCK2 Interacts with PubMed
dermatopontin precursor DPT upregulates PubMed
endothelin-1 isoform 1 preproprotein EDN1 inhibits PubMed
polycomb protein EED isoform a EED inhibits PubMed
EED binds PubMed
EED relocalizes PubMed
interferon-induced, double-stranded RNA-activated protein kinase isoform a EIF2AK2 interacts with PubMed
ETS domain-containing protein Elk-1 isoform a ELK1 induces phosphorylation of PubMed
engulfment and cell motility protein 1 isoform 1 ELMO1 Interacts with PubMed
endothelial PAS domain-containing protein 1 EPAS1 upregulates PubMed
ephrin type-B receptor 2 isoform 2 precursor EPHB2 inactivates PubMed
endoplasmic reticulum-Golgi intermediate compartment protein 1 ERGIC1 interacts with PubMed
exocyst complex component 1 isoform 1 EXOC1 binds PubMed
exocyst complex component 2 EXOC2 regulated by PubMed
EXOC2 binds PubMed
exocyst complex component 3 EXOC3 binds PubMed
exocyst complex component 4 isoform a EXOC4 interacts with PubMed
EXOC4 binds PubMed
exocyst complex component 6 isoform a EXOC6 binds PubMed
tumor necrosis factor receptor superfamily member 6 isoform 1 precursor FAS inhibits PubMed
FAS inhibits PubMed
FAS upregulates PubMed
FAS upregulates PubMed
tumor necrosis factor ligand superfamily member 6 FASLG upregulates PubMed
FASLG upregulates PubMed
FASLG upregulates PubMed
FASLG upregulates PubMed
FASLG upregulates PubMed
FASLG upregulates PubMed
low affinity immunoglobulin epsilon Fc receptor isoform a FCER2 Induces release of PubMed
high affinity immunoglobulin gamma Fc receptor I precursor FCGR1A downregulates PubMed
high affinity immunoglobulin gamma Fc receptor IB isoform 1 precursor FCGR1B downregulates PubMed
low affinity immunoglobulin gamma Fc region receptor II-a isoform 2 precursor FCGR2A downregulates PubMed
low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor FCGR2B downregulates PubMed
vascular endothelial growth factor receptor 1 isoform 1 precursor FLT1 upregulates PubMed
fibronectin isoform 1 preproprotein FN1 upregulates PubMed
proto-oncogene c-Fos FOS downregulates PubMed
FOS activates PubMed
ferritin heavy chain FTH1 induces release of PubMed
ferritin light chain FTL induces release of PubMed
tyrosine-protein kinase Fyn isoform a FYN binds PubMed
FYN binds PubMed
FYN binds PubMed
erythroid transcription factor GATA1 binds PubMed
trans-acting T-cell-specific transcription factor GATA-3 isoform 2 GATA3 binds PubMed
glial fibrillary acidic protein isoform 1 GFAP downregulates PubMed
GFAP co-localizes with PubMed
GFAP upregulates PubMed
guanine nucleotide-binding protein G(o) subunit alpha isoform a GNAO1 binds PubMed
guanine nucleotide-binding protein subunit beta-2-like 1 GNB2L1 binds PubMed
Golgin subfamily A member 2 GOLGA2 relocalizes PubMed
Golgi reassembly-stacking protein 1 isoform 1 GORASP1 activates PubMed
growth factor receptor-bound protein 2 isoform 1 GRB2 upregulates PubMed
glycogen synthase kinase-3 alpha GSK3A induces phosphorylation of PubMed
glycogen synthase kinase-3 beta isoform 1 GSK3B induces phosphorylation of PubMed
granzyme A precursor GZMA upregulates PubMed
tyrosine-protein kinase HCK isoform a HCK binds PubMed
HCK binds PubMed
HCK binds PubMed
HCK binds PubMed
HCK activates PubMed
HCK activates PubMed
HCK complexes with PubMed
HCK complexes with PubMed
HCK binds PubMed
HCK binds PubMed
HCK binds PubMed
HCK binds PubMed
HCK activates PubMed
HCK activates PubMed
HCK binds PubMed
HCK binds PubMed
HCK activates PubMed
HCK activates PubMed
HCK Inhibits PubMed
HCK activates PubMed
HCK activates PubMed
HCK activates PubMed
HCK requires PubMed
HCK binds PubMed
HCK binds PubMed
HCK interacts with PubMed
HCK interacts with PubMed
HCK binds PubMed
hereditary hemochromatosis protein isoform 1 precursor HFE downregulates PubMed
HFE downregulates PubMed
HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA-A complexes with PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A complexes with PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A interacts with PubMed
HLA-A downregulates PubMed
HLA-A interacts with PubMed
HLA-A targeted by PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A degrades PubMed
HLA-A relocalizes PubMed
HLA-A downregulates PubMed
HLA-A inhibits PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A binds PubMed
HLA-A downregulates PubMed
HLA-A modulates PubMed
HLA-A inhibits PubMed
HLA-A binds PubMed
HLA-A inhibits PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A modulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A binds PubMed
HLA-A co-localizes with PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
HLA-A downregulates PubMed
major histocompatibility complex, class I, B precursor HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B complexes with PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B binds PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B interacts with PubMed
HLA-B targeted by PubMed
HLA-B degrades PubMed
HLA-B downregulates PubMed
HLA-B modulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B co-localizes with PubMed
HLA-B downregulates PubMed
HLA-B modulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA-B downregulates PubMed
HLA class I histocompatibility antigen, Cw-1 alpha chain precursor HLA-C downregulates PubMed
HLA-C downregulates PubMed
HLA-C complexes with PubMed
HLA-C downregulates PubMed
HLA-C downregulates PubMed
HLA-C downregulates PubMed
HLA-C downregulates PubMed
HLA-C downregulates PubMed
HLA-C downregulates PubMed
HLA-C downregulates PubMed
HLA-C binds PubMed
HLA-C downregulates PubMed
HLA-C interacts with PubMed
HLA-C downregulates PubMed
HLA-C downregulates PubMed
HLA-C targeted by PubMed
HLA-C degrades PubMed
HLA-C downregulates PubMed
HLA class II histocompatibility antigen, DM alpha chain precursor HLA-DMA downregulates PubMed
HLA-DMA downregulates PubMed
HLA-DMA inhibits PubMed
HLA-DMA downregulates PubMed
HLA class II histocompatibility antigen, DM beta chain precursor HLA-DMB downregulates PubMed
HLA-DMB downregulates PubMed
HLA-DMB inhibits PubMed
HLA-DMB downregulates PubMed
HLA class II histocompatibility antigen, DO alpha chain precursor HLA-DOA downregulates PubMed
HLA-DOA downregulates PubMed
HLA-DOA inhibits PubMed
HLA-DOA downregulates PubMed
HLA class II histocompatibility antigen, DO beta chain precursor HLA-DOB downregulates PubMed
HLA-DOB downregulates PubMed
HLA-DOB inhibits PubMed
HLA-DOB downregulates PubMed
HLA class II histocompatibility antigen, DP alpha 1 chain precursor HLA-DPA1 downregulates PubMed
HLA-DPA1 downregulates PubMed
HLA-DPA1 inhibits PubMed
HLA-DPA1 downregulates PubMed
HLA class II histocompatibility antigen, DP beta 1 chain precursor HLA-DPB1 downregulates PubMed
HLA-DPB1 downregulates PubMed
HLA-DPB1 inhibits PubMed
HLA-DPB1 downregulates PubMed
HLA class II histocompatibility antigen, DQ alpha 1 chain precursor HLA-DQA1 downregulates PubMed
HLA-DQA1 downregulates PubMed
HLA-DQA1 inhibits PubMed
HLA-DQA1 downregulates PubMed
HLA class II histocompatibility antigen, DQ alpha 2 chain precursor HLA-DQA2 downregulates PubMed
HLA-DQA2 downregulates PubMed
HLA-DQA2 inhibits PubMed
HLA-DQA2 downregulates PubMed
HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor HLA-DQB1 downregulates PubMed
HLA-DQB1 downregulates PubMed
HLA-DQB1 inhibits PubMed
HLA-DQB1 downregulates PubMed
HLA class II histocompatibility antigen, DQ beta 2 chain precursor HLA-DQB2 downregulates PubMed
HLA-DQB2 downregulates PubMed
HLA-DQB2 inhibits PubMed
HLA-DQB2 downregulates PubMed
HLA class II histocompatibility antigen, DR alpha chain precursor HLA-DRA inhibits PubMed
HLA-DRA downregulates PubMed
HLA-DRA downregulates PubMed
HLA-DRA downregulates PubMed
HLA-DRA inhibits PubMed
HLA-DRA downregulates PubMed
HLA-DRA binds PubMed
major histocompatibility complex, class II, DR beta 1 precursor HLA-DRB1 inhibits PubMed
HLA-DRB1 binds PubMed
HLA-DRB1 downregulates PubMed
HLA-DRB1 downregulates PubMed
HLA-DRB1 interacts with PubMed
major histocompatibility complex, class II, DR beta 3 precursor HLA-DRB3 inhibits PubMed
HLA-DRB3 binds PubMed
HLA-DRB3 downregulates PubMed
HLA-DRB3 downregulates PubMed
major histocompatibility complex, class II, DR beta 4 precursor HLA-DRB4 inhibits PubMed
HLA-DRB4 binds PubMed
HLA-DRB4 downregulates PubMed
HLA-DRB4 downregulates PubMed
major histocompatibility complex, class II, DR beta 5 precursor HLA-DRB5 inhibits PubMed
HLA-DRB5 downregulates PubMed
HLA-DRB5 downregulates PubMed
HLA-DRB5 binds PubMed
HLA class I histocompatibility antigen, alpha chain E precursor HLA-E downregulates PubMed
HLA-E downregulates PubMed
HLA-E downregulates PubMed
HLA-E binds PubMed
HLA-E downregulates PubMed
HLA-E downregulates PubMed
HLA-E downregulates PubMed
HLA-E interacts with PubMed
HLA-E downregulates PubMed
HLA-E degrades PubMed
HLA-E downregulates PubMed
HLA class I histocompatibility antigen, alpha chain F isoform 2 precursor HLA-F downregulates PubMed
HLA-F downregulates PubMed
HLA-F downregulates PubMed
HLA-F downregulates PubMed
HLA-F downregulates PubMed
HLA-F downregulates PubMed
HLA-F downregulates PubMed
HLA-F binds PubMed
HLA-F downregulates PubMed
HLA-F interacts with PubMed
HLA-F degrades PubMed
HLA class I histocompatibility antigen, alpha chain G precursor HLA-G downregulates PubMed
HLA-G downregulates PubMed
HLA-G downregulates PubMed
HLA-G downregulates PubMed
HLA-G downregulates PubMed
HLA-G downregulates PubMed
HLA-G binds PubMed
HLA-G downregulates PubMed
HLA-G interacts with PubMed
HLA-G degrades PubMed
HLA-G downregulates PubMed
HLA-G downregulates PubMed
helicase-like transcription factor HLTF upregulates PubMed
3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1 HMGCR Modulates PubMed
heterogeneous nuclear ribonucleoprotein K isoform a HNRNPK interacts with PubMed
GTPase HRas isoform 1 HRAS activates PubMed
HRAS synergizes with PubMed
heat shock factor protein 1 HSF1 interacts with PubMed
heat shock 70 kDa protein 1A/1B HSPA1A interacts with PubMed
HSPA1A inhibits PubMed
HSPA1B interacts with PubMed
HSPA1B inhibits PubMed
heat shock-related 70 kDa protein 2 HSPA2 interacts with PubMed
heat shock 70 kDa protein 4 HSPA4 interacts with PubMed
78 kDa glucose-regulated protein precursor HSPA5 interacts with PubMed
heat shock 70 kDa protein 6 HSPA6 interacts with PubMed
heat shock cognate 71 kDa protein isoform 1 HSPA8 interacts with PubMed
HSPA8 co-localizes with PubMed
stress-70 protein, mitochondrial precursor HSPA9 interacts with PubMed
HSPA9 binds PubMed
HIV Tat-specific factor 1 HTATSF1 upregulates PubMed
intercellular adhesion molecule 1 precursor ICAM1 co-localizes with PubMed
ICAM1 upregulates PubMed
ICAM1 interacts with PubMed
ICAM1 Induces release of PubMed
interferon beta precursor IFNB1 upregulates PubMed
IFNB1 upregulates PubMed
interferon gamma precursor IFNG interacts with PubMed
IFNG inhibits PubMed
IFNG inhibits PubMed
IFNG upregulates PubMed
IFNG upregulates PubMed
IFNG downregulates PubMed
inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1 IKBKB induces phosphorylation of PubMed
interleukin-10 precursor IL10 downregulates PubMed
IL10 upregulates PubMed
IL10 upregulates PubMed
IL10 inhibits PubMed
IL10 upregulates PubMed
interleukin-12 subunit alpha precursor IL12A interacts with PubMed
IL12A interacts with PubMed
IL12A upregulates PubMed
interleukin-12 subunit beta precursor IL12B interacts with PubMed
IL12B upregulates PubMed
IL12B interacts with PubMed
interleukin-15 isoform 1 preproprotein IL15 interacts with PubMed
IL15 upregulates PubMed
interleukin-1 beta proprotein IL1B interacts with PubMed
IL1B upregulates PubMed
IL1B upregulates PubMed
IL1B upregulates PubMed
interleukin-2 precursor IL2 interacts with PubMed
IL2 upregulates PubMed
IL2 upregulates PubMed
IL2 inhibits PubMed
IL2 Inhibits PubMed
IL2 downregulates PubMed
IL2 inhibits PubMed
interleukin-2 receptor subunit alpha precursor IL2RA upregulates PubMed
IL2RA downregulates PubMed
interleukin-4 isoform 1 precursor IL4 inhibits PubMed
interleukin-6 precursor IL6 upregulates PubMed
IL6 upregulates PubMed
IL6 upregulates PubMed
IL6 upregulates PubMed
IL6 upregulates PubMed
IL6 upregulates PubMed
interferon regulatory factor 1 IRF1 upregulates PubMed
interferon regulatory factor 2 IRF2 upregulates PubMed
interferon regulatory factor 3 isoform 1 IRF3 activates PubMed
IRF3 activates PubMed
immunity-related GTPase family M protein IRGM interacts with PubMed
IRGM interacts with PubMed
integrin alpha-L isoform a precursor ITGAL downregulates PubMed
ITGAL interacts with PubMed
integrin alpha-M isoform 2 precursor ITGAM interacts with PubMed
integrin alpha-X isoform 2 precursor ITGAX inhibits PubMed
ITGAX downregulates PubMed
inositol 1,4,5-trisphosphate receptor type 1 isoform 2 ITPR1 Interacts with PubMed
transcription factor AP-1 JUN downregulates PubMed
JUN activates PubMed
vascular endothelial growth factor receptor 2 precursor KDR upregulates PubMed
KH domain-containing, RNA-binding, signal transduction-associated protein 1 isoform 1 KHDRBS1 inhibited by PubMed
killer cell immunoglobulin-like receptor 2DL2 precursor KIR2DL2 inhibits PubMed
mast/stem cell growth factor receptor Kit isoform 1 precursor KIT upregulates PubMed
NKG2-D type II integral membrane protein KLRK1 downregulates PubMed
lysosome-associated membrane glycoprotein 1 precursor LAMP1 co-localizes with PubMed
lysosome-associated membrane glycoprotein 2 isoform A precursor LAMP2 co-localizes with PubMed
linker for activation of T-cells family member 1 isoform a LAT inhibits PubMed
LAT induces accumulation of PubMed
tyrosine-protein kinase Lck LCK relocalizes PubMed
LCK inhibits PubMed
LCK relocalizes PubMed
LCK relocalizes PubMed
LCK relocalizes PubMed
LCK induces accumulation of PubMed
LCK interacts with PubMed
LCK activates PubMed
LCK complexes with PubMed
LCK complexes with PubMed
LCK complexes with PubMed
LCK activates PubMed
LCK modulated by PubMed
LCK co-localizes with PubMed
LCK interacts with PubMed
LCK inactivates PubMed
LCK binds PubMed
LCK Interacts with PubMed
LCK interacts with PubMed
LCK upregulates PubMed
LCK binds PubMed
LCK binds PubMed
LCK requires PubMed
lymphocyte cytosolic protein 2 LCP2 associates with PubMed
LCP2 inhibits PubMed
LCP2 inhibits PubMed
low-density lipoprotein receptor isoform 1 precursor LDLR upregulates PubMed
LIM domain kinase 1 isoform 1 LIMK1 activates PubMed
tyrosine-protein kinase Lyn isoform A LYN activates PubMed
LYN activates PubMed
LYN interacts with PubMed
lysosomal-trafficking regulator LYST regulated by PubMed
dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 activates PubMed
MAP2K1 upregulates PubMed
dual specificity mitogen-activated protein kinase kinase 2 MAP2K2 upregulates PubMed
mitogen-activated protein kinase kinase kinase 5 MAP3K5 inhibits PubMed
MAP3K5 inhibits PubMed
MAP3K5 inhibits PubMed
MAP3K5 binds PubMed
mitogen-activated protein kinase 1 MAPK1 induces phosphorylation of PubMed
MAPK1 activates PubMed
MAPK1 induces phosphorylation of PubMed
MAPK1 activates PubMed
MAPK1 activates PubMed
MAPK1 induces phosphorylation of PubMed
MAPK1 activates PubMed
MAPK1 binds PubMed
MAPK1 activates PubMed
MAPK1 activates PubMed
MAPK1 activates PubMed
MAPK1 regulated by PubMed
MAPK1 upregulates PubMed
MAPK1 Inhibits PubMed
MAPK1 activates PubMed
MAPK1 activates PubMed
MAPK1 inhibits PubMed
mitogen-activated protein kinase 14 isoform 1 MAPK14 induces phosphorylation of PubMed
MAPK14 regulated by PubMed
MAPK14 inhibits PubMed
MAPK14 activates PubMed
mitogen-activated protein kinase 3 isoform 1 MAPK3 induces phosphorylation of PubMed
MAPK3 induces phosphorylation of PubMed
MAPK3 activates PubMed
MAPK3 induces phosphorylation of PubMed
MAPK3 activates PubMed
MAPK3 activates PubMed
mitogen-activated protein kinase 8 isoform alpha2 MAPK8 activates PubMed
MAPK8 activates PubMed
MAPK8 activates PubMed
microfibrillar-associated protein 2 isoform a precursor MFAP2 binds PubMed
MHC class I polypeptide-related sequence A isoform 1 (MICA*001) precursor MICA downregulates PubMed
antigen KI-67 isoform 1 MKI67 upregulates PubMed
72 kDa type IV collagenase isoform a preproprotein MMP2 activates PubMed
matrix metalloproteinase-9 preproprotein MMP9 activates PubMed
MMP9 activates PubMed
macrophage mannose receptor 1 precursor MRC1 downregulates PubMed
mitochondrial carrier homolog 1 PSAP-LS MTCH1 interacts with PubMed
bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor MTHFD2 interacts with PubMed
cytoplasmic protein NCK1 isoform 1 NCK1 associates with PubMed
merlin isoform 1 NF2 induces phosphorylation of PubMed
nuclear factor of activated T-cells, cytoplasmic 1 isoform A NFATC1 inhibits PubMed
NFATC1 upregulates PubMed
NFATC1 activates PubMed
nuclear factor of activated T-cells, cytoplasmic 2 isoform B NFATC2 inhibits PubMed
NFATC2 activates PubMed
nuclear factor NF-kappa-B p105 subunit isoform 1 NFKB1 activates PubMed
NFKB1 activates PubMed
NFKB1 binds PubMed
NFKB1 activates PubMed
NFKB1 inhibits PubMed
NFKB1 inhibits PubMed
NFKB1 inhibits PubMed
NFKB1 inhibits PubMed
NFKB1 downregulates PubMed
NFKB1 activates PubMed
NF-kappa-B inhibitor alpha NFKBIA upregulates PubMed
NFKBIA degrades PubMed
glycylpeptide N-tetradecanoyltransferase 1 NMT1 interacts with PubMed
NMT1 myristoylated by PubMed
NMT1 interacts with PubMed
glycylpeptide N-tetradecanoyltransferase 2 NMT2 myristoylated by PubMed
nitric oxide synthase, endothelial isoform 1 NOS3 downregulates PubMed
NADPH oxidase 1 isoform 1 NOX1 phosphorylates PubMed
NOX1 activates PubMed
NOX1 inhibits PubMed
GTPase NRas NRAS activates PubMed
neuropilin-1 isoform a precursor NRP1 upregulates PubMed
occludin isoform a OCLN downregulates PubMed
phosphofurin acidic cluster sorting protein 1 PACS1 binds PubMed
PACS1 binds PubMed
PACS1 interacts with PubMed
PACS1 binds PubMed
phosphofurin acidic cluster sorting protein 2 isoform 2 PACS2 binds PubMed
PACS2 binds PubMed
serine/threonine-protein kinase PAK 1 isoform 2 PAK1 interacts with PubMed
PAK1 activates PubMed
PAK1 activates PubMed
PAK1 activates PubMed
PAK1 activates PubMed
PAK1 activates PubMed
PAK1 associates with PubMed
PAK1 associates with PubMed
serine/threonine-protein kinase PAK 2 PAK2 associates with PubMed
PAK2 associates with PubMed
PAK2 associates with PubMed
PAK2 complexes with PubMed
PAK2 activates PubMed
PAK2 associates with PubMed
PAK2 regulates PubMed
PAK2 associates with PubMed
PAK2 associates with PubMed
PAK2 associates with PubMed
PAK2 activates PubMed
PAK2 activates PubMed
PAK2 binds PubMed
PAK2 co-localizes with PubMed
PAK2 interacts with PubMed
PAK2 binds PubMed
poly [ADP-ribose] polymerase 1 PARP1 induces cleavage of PubMed
PARP1 induces cleavage of PubMed
programmed cell death protein 1 precursor PDCD1 upregulates PubMed
programmed cell death 6-interacting protein isoform 1 PDCD6IP co-localizes with PubMed
PDCD6IP binds PubMed
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha PIK3C2A complexes with PubMed
PIK3C2A upregulates PubMed
PIK3C2A interacts with PubMed
PIK3C2A downregulates PubMed
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta PIK3C2B complexes with PubMed
PIK3C2B upregulates PubMed
PIK3C2B interacts with PubMed
PIK3C2B downregulates PubMed
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 3 PIK3C2G complexes with PubMed
PIK3C2G upregulates PubMed
PIK3C2G interacts with PubMed
PIK3C2G downregulates PubMed
phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 complexes with PubMed
PIK3C3 upregulates PubMed
PIK3C3 interacts with PubMed
PIK3C3 downregulates PubMed
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PIK3CA complexes with PubMed
PIK3CA interacts with PubMed
PIK3CA upregulates PubMed
PIK3CA downregulates PubMed
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1 PIK3CB complexes with PubMed
PIK3CB upregulates PubMed
PIK3CB interacts with PubMed
PIK3CB downregulates PubMed
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform PIK3CD complexes with PubMed
PIK3CD upregulates PubMed
PIK3CD interacts with PubMed
PIK3CD downregulates PubMed
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG downregulates PubMed
PIK3CG interacts with PubMed
PIK3CG complexes with PubMed
PIK3CG upregulates PubMed
phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 PIK3R1 complexes with PubMed
PIK3R1 upregulates PubMed
PIK3R1 interacts with PubMed
PIK3R1 downregulates PubMed
PIK3R1 binds PubMed
phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 complexes with PubMed
PIK3R2 upregulates PubMed
PIK3R2 interacts with PubMed
PIK3R2 downregulates PubMed
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform a PLCG1 inhibits PubMed
peroxisome proliferator-activated receptor gamma isoform 1 PPARG downregulates PubMed
peptidyl-prolyl cis-trans isomerase A PPIA binds PubMed
perforin-1 precursor PRF1 upregulates PubMed
cAMP-dependent protein kinase catalytic subunit alpha isoform 1 PRKACA phosphorylated by PubMed
cAMP-dependent protein kinase catalytic subunit beta isoform 2 PRKACB phosphorylated by PubMed
cAMP-dependent protein kinase catalytic subunit gamma PRKACG phosphorylated by PubMed
cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a PRKAR1A phosphorylated by PubMed
cAMP-dependent protein kinase type I-beta regulatory subunit PRKAR1B phosphorylated by PubMed
cAMP-dependent protein kinase type II-alpha regulatory subunit PRKAR2A phosphorylated by PubMed
cAMP-dependent protein kinase type II-beta regulatory subunit PRKAR2B phosphorylated by PubMed
protein kinase C alpha type PRKCA requires PubMed
PRKCA phosphorylated by PubMed
PRKCA phosphorylated by PubMed
protein kinase C beta type isoform 2 PRKCB downregulates PubMed
protein kinase C delta type PRKCD complexes with PubMed
protein kinase C epsilon type PRKCE downregulates PubMed
protein kinase C eta type PRKCH associates with PubMed
protein kinase C theta type isoform 1 PRKCQ complexes with PubMed
PRKCQ complexes with PubMed
PRKCQ interacts with PubMed
proteasome subunit beta type-4 PSMB4 downregulates PubMed
PSMB4 binds PubMed
protein-tyrosine kinase 2-beta isoform a PTK2B upregulates PubMed
receptor-type tyrosine-protein phosphatase C isoform 1 precursor PTPRC upregulates PubMed
poliovirus receptor isoform alpha precursor PVR downregulates PubMed
PVR interacts with PubMed
ras-related protein Rab-11A isoform 1 RAB11A inhibited by PubMed
RAB11A Co-localizes with PubMed
ras-related protein Rab-11B RAB11B inhibited by PubMed
RAB11B co-localizes with PubMed
ras-related protein Rab-5A RAB5A regulated by PubMed
ras-related protein Rab-7a RAB7A interacts with PubMed
ras-related C3 botulinum toxin substrate 1 isoform Rac1 RAC1 inhibited by PubMed
RAC1 interacts with PubMed
RAC1 activates PubMed
RAC1 Interacts with PubMed
ras-related C3 botulinum toxin substrate 2 RAC2 Interacts with PubMed
RAF proto-oncogene serine/threonine-protein kinase RAF1 binds PubMed
retinoic acid receptor alpha isoform 1 RARA inhibits PubMed
retinoic acid receptor beta isoform 1 RARB inhibits PubMed
retinoic acid receptor gamma isoform 1 RARG inhibits PubMed
retinoblastoma-associated protein RB1 upregulates PubMed
40S ribosomal protein S10 RPS10 interacts with PubMed
40S ribosomal protein S20 isoform 2 RPS20 binds PubMed
retinoic acid receptor RXR-alpha RXRA inhibits PubMed
retinoic acid receptor RXR-beta isoform 2 RXRB inhibits PubMed
retinoic acid receptor RXR-gamma isoform a RXRG inhibits PubMed
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA interacts with PubMed
semaphorin-3A precursor SEMA3A downregulates PubMed
solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 inhibits PubMed
sphingomyelin phosphodiesterase isoform 1 precursor SMPD1 modulates PubMed
U1 small nuclear ribonucleoprotein A SNRPA upregulates PubMed
suppressor of cytokine signaling 1 SOCS1 upregulates PubMed
proto-oncogene tyrosine-protein kinase Src SRC activates PubMed
SRC binds PubMed
SRC interacts with PubMed
SRC interacts with PubMed
SRC binds PubMed
sterol regulatory element-binding protein 2 SREBF2 upregulates PubMed
signal transducer and activator of transcription 1-alpha/beta isoform alpha STAT1 induces phosphorylation of PubMed
STAT1 induces phosphorylation of PubMed
STAT1 activates PubMed
signal transducer and activator of transcription 2 isoform 1 STAT2 induces phosphorylation of PubMed
signal transducer and activator of transcription 3 isoform 1 STAT3 induces phosphorylation of PubMed
STAT3 induces phosphorylation of PubMed
STAT3 interacts with PubMed
STAT3 activates PubMed
STAT3 activates PubMed
STAT3 upregulates PubMed
STAT3 activates PubMed
STAT3 activates PubMed
tyrosine-protein kinase SYK isoform 1 SYK recruits PubMed
synaptopodin isoform A SYNPO downregulates PubMed
TBC1 domain family member 4 isoform 1 TBC1D4 decreases phosphorylation of PubMed
transcription elongation factor B polypeptide 3 TCEB3 upregulates PubMed
transferrin receptor protein 1 TFRC downregulates PubMed
TFRC modulates PubMed
tight junction protein ZO-1 isoform a TJP1 downregulates PubMed
toll-like receptor 2 precursor TLR2 upregulates PubMed
TLR2 upregulates PubMed
tumor necrosis factor TNF upregulates PubMed
TNF upregulates PubMed
TNF upregulates PubMed
TNF upregulates PubMed
TNF upregulates PubMed
TNF inhibits PubMed
TNF activates PubMed
TNF upregulates PubMed
TNF disrupts PubMed
TNF upregulates PubMed
TNF upregulates PubMed
TNF upregulates PubMed
TNF upregulates PubMed
TNF upregulates PubMed
TNF upregulates PubMed
TNF inhibits PubMed
tumor necrosis factor ligand superfamily member 14 isoform 1 precursor TNFSF14 upregulates PubMed
TNFAIP3-interacting protein 1 isoform 3 TNIP1 binds PubMed
cellular tumor antigen p53 isoform a TP53 binds PubMed
TP53 interacts with PubMed
TNF receptor-associated factor 2 TRAF2 binds PubMed
TRAF2 requires PubMed
TNF receptor-associated factor 6 TRAF6 requires PubMed
TRAF6 binds PubMed
thioredoxin isoform 1 TXN stabilizes PubMed
ubiquitin-conjugating enzyme E2 L3 isoform 1 UBE2L3 relocalizes PubMed
UBE2L3 relocalizes PubMed
NKG2D ligand 1 precursor ULBP1 downregulates PubMed
NKG2D ligand 2 precursor ULBP2 downregulates PubMed
protein unc-119 homolog A isoform a UNC119 regulated by PubMed
vesicle-associated membrane protein 3 VAMP3 inhibits PubMed
proto-oncogene vav isoform 1 VAV1 associates with PubMed
VAV1 recruits PubMed
VAV1 binds PubMed
VAV1 binds PubMed
vinculin isoform VCL VCL polarizes PubMed
vascular endothelial growth factor A isoform b VEGFA upregulates PubMed
vacuolar protein sorting-associated protein 4A VPS4A requires PubMed
vacuolar protein sorting-associated protein 4B VPS4B requires PubMed
neural Wiskott-Aldrich syndrome protein WASL inhibits PubMed
Wilms tumor protein isoform A WT1 downregulates PubMed
tyrosine-protein kinase ZAP-70 isoform 1 ZAP70 inhibits PubMed
ZAP70 induces phosphorylation of PubMed
zinc finger E-box-binding homeobox 1 isoform b ZEB1 upregulates PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Assembly Of The HIV Virion, organism-specific biosystem (from REACTOME)
    Assembly Of The HIV Virion, organism-specific biosystemVirion assembly packages all the components required for infectivity. These steps include two copies of the positive sense genomic viral RNA, cellular tRNALys, the viral envelope (Env) protein, the G...
  • Binding and entry of HIV virion, organism-specific biosystem (from REACTOME)
    Binding and entry of HIV virion, organism-specific biosystemHIV enters cells by fusion at the cell surface, that results in a productive infection. The envelope (Env) protein of HIV mediates entry. Env is composed of a surface subunit, gp120, and a transmemb...
  • Budding and maturation of HIV virion, organism-specific biosystem (from REACTOME)
    Budding and maturation of HIV virion, organism-specific biosystemWith the virus components precariously assembled on the inner leaflet of the plasma membrane, the host cell machinery is required for viral budding. The virus takes advantage of the host ESCRT pathwa...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Early Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
    Early Phase of HIV Life Cycle, organism-specific biosystemIn the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core...
  • HIV Infection, organism-specific biosystem (from REACTOME)
    HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
  • HIV Life Cycle, organism-specific biosystem (from REACTOME)
    HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
  • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
    HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
    HIV-1 Nef: Negative effector of Fas and TNF-alpha
  • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
    Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
  • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
    Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
  • Nef Mediated CD4 Down-regulation, organism-specific biosystem (from REACTOME)
    Nef Mediated CD4 Down-regulation, organism-specific biosystemThe presence of Nef accelerates endocytosis and lysosomal degradation of the transmembrane glycoprotein CD4. CD4 has its own internalization motif, though this motif is normally concealed by CD4 inte...
  • Nef Mediated CD8 Down-regulation, organism-specific biosystem (from REACTOME)
    Nef Mediated CD8 Down-regulation, organism-specific biosystemHuman immunodeficiency virus (HIV) Nef is a membrane-associated protein decreasing surface expression of CD4, CD28, and major histocompatibility complex class I on infected cells. Nef also strongly d...
  • Nef and signal transduction, organism-specific biosystem (from REACTOME)
    Nef and signal transduction, organism-specific biosystemNef interferes with cellular signal transduction pathways in a number of ways. Nef is associated with lipid rafts through its amino-terminal myristoylation and a proline-rich SH3-binding domain. Thes...
  • Nef mediated downregulation of CD28 cell surface expression, organism-specific biosystem (from REACTOME)
    Nef mediated downregulation of CD28 cell surface expression, organism-specific biosystemDown-regulation of CD28 receptors involves a dileucine-based motif in the second disordered loop of Nef, which connects Nef to adaptor protein (AP) complex, which is a part of cellular endocytosis ma...
  • Nef mediated downregulation of MHC class I complex cell surface expression, organism-specific biosystem (from REACTOME)
    Nef mediated downregulation of MHC class I complex cell surface expression, organism-specific biosystemDown-regulation of MHC class I involves Nef-mediated connection in the endosomes between MHC-I's cytoplasmic tail and the phosphofurin acidic cluster sorting protein-1 (PACS-1)-dependent protein-sort...
  • Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystem (from REACTOME)
    Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystemThe maximal virulence of HIV-1 requires Nef, a virally encoded peripheral membrane protein. Nef binds to the adaptor protein (AP) complexes of coated vesicles, inducing an expansion of the endosomal ...
  • The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystem (from REACTOME)
    The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystemThe HIV-1 Nef protein is a 27-kDa myristoylated protein that is abundantly produced during the early phase of viral replication cycle. It is highly conserved in all primate lentiviruses, suggesting t...
  • Uncoating of the HIV Virion, organism-specific biosystem (from REACTOME)
    Uncoating of the HIV Virion, organism-specific biosystemHIV-1 uncoating is a poorly understood process. It likely involves a progressive and partial dissembly of matrix and capsid layers. While viral proteins like MA and Nef are thought to be involved, t...
Products Interactant Other Gene Complex Source Pubs Description
Preferred Names
p27
Names
Nef
NP_057857.2
  • This particular nucleotide sequence has a premature stop codon in place of a well-conserved tryptophan codon at position 8712-8714 that truncates the HIV1 Nef protein sequence to a 123 amino acids-long N-terminal portion (not shown).

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001802.1

    Range
    8343..8963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_057857.2 Nef [Human immunodeficiency virus 1]

    See proteins identical to NP_057857.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P04601
    Conserved Domains (1) summary
    pfam00469
    Location:2205
    Blast Score: 885
    F-protein; Negative factor, (F-Protein) or Nef

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