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    E3 ubiquitin-protein ligase NEDD4 isoform 1 [Homo sapiens]

    NCBI Reference Sequence: NP_006145.2

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      • Run BLAST
        Find regions of similarity between this sequence and other sequences using BLAST.
      • Identify Conserved Domains
        View conserved domains detected in this protein sequence using CD-search.
      • Highlight Sequence Features
        Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...
      • Find in this Sequence
        Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...

      Articles about the NEDD4 gene

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      Pathways for the NEDD4 gene

      • Epstein-Barr virus infection
        Epstein-Barr virus infectionEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxic ... [bsid585562]
      • Endocytosis
        EndocytosisEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins ent ... [bsid102279]
      • Ubiquitin mediated proteolysis
        Ubiquitin mediated proteolysisProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins ... [bsid83056]
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      Reference sequence information

      • RefSeq mRNA
        See reference mRNA sequence for the NEDD4 gene (NM_006154.2).
      • RefSeq protein isoforms
        See the other reference sequence protein isoform for the NEDD4 gene (NP_940682.2).

      More about the NEDD4 gene

      • NEDD4 gene
        Also Known As: PIG53, KIAA0093, MGC176...

      LinkOut to external resources

      Related information

      • BLink
        BLAST Link. Pre-computed sequence similarity results (BLAST) including alignments for the current protein against the NCBI nr protein database. Organism specific, RefSeq and other database subsets are available as well as access to a pre-computed multiple alignment.
      • Related Sequences
        Protein sequences related by sequence similarity (BLAST) score to the current records.
      • BioProject
        Proteins related to BioProjects
      • BioSystems
        Pathways and other biosystems containing the current proteins.
      • CCDS
        Link to Consensus CDS
      • CDD Search Results
        Graphical display of conserved domains identified in the protein using RPS-BLAST. The concise results (top-scoring hits) are shown by default, with an option to view the full results, if desired. Click on any domain footprint in the graphical display to see more details and to view the query protein sequence embedded in the domain model’s multiple sequence alignment.
      • Conserved Domains (Concise)
        Concise (top-scoring) list of conserved domains present in the current proteins as determined by a Conserved Domain Database search using RPS-BLAST. For each region on a protein query sequence, this set includes: (a) a specific hit, if one is available, (b) the conserved domain superfamily, and (c) the best-scoring hit that is classified as a multi-domain model, if the alignment is near-complete with respect to that multidomain model footprint.
      • Conserved Domains (Full)
        Full list of Conserved domains present in the current proteins as determined by a Conserved Domain Database search using RPS-BLAST. This set includes all domain models that meet or exceed the RPS-BLAST threshold for statistical significance, as well as the conserved domain superfamilies to which they belong.
      • Domain Relatives
        Conserved Domain Architecture Retrieval Tool (cDART) results for proteins in the current set. cDART identifies proteins that have similar kinds of conserved domains with similar organization.
      • Encoding mRNA
        Link from protein to encoding mRNA
      • Full text in PMC
        Free full-text articles in PubMed central that cite protein records in the current set.
      • Gene
        Gene records referencing the current protein sequence records. Sequences included in Gene records are added manually by NCBI.
      • GeneView in dbSNP
        Geneview in dbSNP showing single nucleotide polymorphisms (SNPs) mapped to the genes associated with the current records.
      • Genome
        Genome records that have the current protein records as annotated features.
      • Map Viewer
        Graphical Map Viewer display of the current proteins mapped to assembled genomes. Protein sequences are aligned through the corresponding mRNA sequence.
      • Nucleotide
        Nucleotide records that are the source of protein records in the current set. The protein sequences are generated through translation of coding region features on the nucleotide records.
      • OMIM
        Online Mendelian Inheritance in Man (OMIM) records that refer to protein records in the current set.
      • Protein (UniProtKB)
        Corresponding UniProt records for Reference Sequence (RefSeq) protein records in the current set.
      • PubMed
        PubMed articles that cite the protein records in the current set. These are articles that report the International Nucleotide Database Collaboration (DDBJ, EMBL, GenBank) records. These articles are also linked to Reference Sequences derived from the GenBank records.
      • PubMed (RefSeq)
        Link to RefSeq PubMed articles
      • PubMed (Weighted)
        PubMed articles associated with the current protein record through related Gene database records. These articles include Reference into Function, citations in related OMIM, and those associated with sequences in the Gene record.
      • Related Structures (List)
        List of three dimensional structure records that contain one or more protein molecules similar in sequence to the current protein(s). Each 3D structure and its corresponding sequence data can be viewed interactively in the free Cn3D tool.
      • Related Structures (Summary)
        Graphical summary of three dimensional structures that contain one or more protein molecules similar in sequence to your query protein. Alignment footprints indicate regions of similarity between the query protein and the structure-based protein, with an option to view the 3D structure and corresponding sequence alignment interactively in the free Cn3D tool.
      • SNP
        Single nucleotide polymorphisms (SNPs) mapped to the current records.
      • Taxonomy
        NCBI Taxonomy entries and classification information for the source organisms of the current set of records.
      • UniGene
        UniGene clusters of expressed sequences that contain Reference Sequnce protein records in the current set. Protein records are included in UniGene through sequence similarity to the translations of expressed sequences in the UniGene cluster.

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