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ULK1 unc-51 like autophagy activating kinase 1 [ Homo sapiens (human) ]

Gene ID: 8408, updated on 15-May-2016
Official Symbol
ULK1provided by HGNC
Official Full Name
unc-51 like autophagy activating kinase 1provided by HGNC
Primary source
HGNC:HGNC:12558
See related
Ensembl:ENSG00000177169 HPRD:11933; MIM:603168; Vega:OTTHUMG00000168052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATG1; ATG1A; UNC51; hATG1; Unc51.1
Orthologs
Location:
12q24.3
Exon count:
28
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (131894734..131923162)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (132379279..132407707)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370089 Neighboring gene uncharacterized LOC105370088 Neighboring gene matrix metallopeptidase 17 Neighboring gene pseudouridylate synthase 1 Neighboring gene E1A binding protein p400 Neighboring gene small nucleolar RNA, H/ACA box 49

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef downregulates the mRNA expression of ULK1 in human mesenchymal stem cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ38455, FLJ46475

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
axon extension IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
macroautophagy TAS
Traceable Author Statement
more info
 
negative regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection regeneration IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ATG1/ULK1 kinase complex IPI
Inferred from Physical Interaction
more info
PubMed 
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extrinsic component of autophagosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of omegasome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of pre-autophagosomal structure membrane IDA
Inferred from Direct Assay
more info
PubMed 
pre-autophagosomal structure membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase ULK1
Names
ATG1 autophagy related 1 homolog
autophagy-related protein 1 homolog
NP_003556.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003565.2NP_003556.1  serine/threonine-protein kinase ULK1

    See identical proteins and their annotated locations for NP_003556.1

    Status: VALIDATED

    Source sequence(s)
    AB018265, AF045458, BI822269, BU729635, CF131673
    Consensus CDS
    CCDS9274.1
    UniProtKB/Swiss-Prot
    O75385
    Related
    ENSP00000324560, OTTHUMP00000237722, ENST00000321867, OTTHUMT00000397769
    Conserved Domains (3) summary
    smart00220
    Location:16278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12063
    Location:8331049
    DUF3543; Domain of unknown function (DUF3543)
    cd14202
    Location:13279
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    131894734..131923162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538798.1XP_011537100.1  

    Conserved Domains (3) summary
    smart00220
    Location:16278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12063
    Location:8561072
    DUF3543; Domain of unknown function (DUF3543)
    cd14202
    Location:13279
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1
  2. XM_011538799.1XP_011537101.1  

    Conserved Domains (3) summary
    smart00220
    Location:16278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12063
    Location:8271043
    DUF3543; Domain of unknown function (DUF3543)
    cd14202
    Location:13279
    STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1

RNA

  1. XR_944753.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    132200212..132228619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)