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    RXRB retinoid X receptor, beta [ Homo sapiens (human) ]

    Gene ID: 6257, updated on 11-May-2013
    Official Symbol
    RXRBprovided by HGNC
    Official Full Name
    retinoid X receptor, betaprovided by HGNC
    Primary source
    HGNC:10478
    Locus tag
    DADB-100D22.1
    See related
    Ensembl:ENSG00000204231; HPRD:01578; MIM:180246; Vega:OTTHUMG00000031298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NR2B2; DAUDI6; RCoR-1; H-2RIIBP
    Summary
    This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (33161362..33168473, complement)
    See RXRB in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex, class II, DP alpha 3 (pseudogene) Neighboring gene collagen, type XI, alpha 2 Neighboring gene RNA, Ro-associated Y4 pseudogene 10 Neighboring gene solute carrier family 39 (zinc transporter), member 7 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 8

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    2. A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. Liu RZ, et al. J Pathol, 2012 Nov. PMID 22322885.
    3. Human CCAAT/enhancer-binding protein β interacts with chromatin remodeling complexes of the imitation switch subfamily. Steinberg XP, et al. Biochemistry, 2012 Feb 7. PMID 22242598.
    4. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832.
    5. LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes. Ishaq M, et al. BMC Mol Biol, 2011 Sep 16. PMID 21923909.

    See all (79) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. A fatty acid-binding protein 7/RXRbeta pathway enhances survival and proliferation in triple-negative breast cancer.
      Title: A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    3. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Genetic variability of RXRB, PPARA, and PPARG in Wegener's granulomatosis.
    4. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
    6. In healthy elderly men reduction of RXRbeta expression in peripheral blood mononuclear cells might be a common feature of physiological senescence.
      Title: Age-related change in the retinoid X receptor beta gene expression in peripheral blood mononuclear cells of healthy volunteers: effect of 13-cis retinoic acid supplementation.
    7. PPARgamma/retinoid X receptor complex released from activated platelets in microparticles was internalized by a monocytic cell line.
      Title: Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles.
    8. Family studies revealed significant linkage disequilibrium between the RXRB alleles and a number of HLA-DPB1 alleles.
      Title: Linkage disequilibrium between HLA-DPB1 alleles and retinoid X receptor beta haplotypes.
    9. partial dissociation of TR/retinoid X receptor heterodimer complex from the TRE is involved in the suppression of transcription induced by polychlorinated biphenyls
      Title: Polychlorinated biphenyls suppress thyroid hormone receptor-mediated transcription through a novel mechanism.
    10. polymorphism is unrelated to schizophrenia or alcoholism.
      Title: Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence.
    Submit: New GeneRIF Correction See all (14)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Nef, p27 nef HIV-1 Nef induces loss of F-actin assembly and inhibits retinoid receptor-mediated transcription PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_068811.1 NP_858045.1 NCOA3    BIND  PubMed TRAM-1 interacts with RXR-beta. This interaction was modelled on a demonstrated interaction between human TRAM-1 and mouse RXR-beta. 
    NP_068811.1 NP_000452.2 THRB    BIND  PubMed THR-beta interacts with RXR-beta. This interaction was modelled on a demonstrated interaction between rat TR-beta and mouse RXR-beta. 
    NP_068811.1     BIND  PubMed RXRB interacts with the THRA-PCSK2 promoter complex. 
    P28702 Q12802 AKAP13    HPRD  PubMed  
    P28702 P27816 MAP4    HPRD  PubMed  
    P28702 Q15788 NCOA1    HPRD  PubMed  
    P28702 Q9Y6Q9 NCOA3    HPRD  PubMed  
    P28702 Q15466 NR0B2    HPRD  PubMed  
    P28702 P55055 NR1H2    HPRD  PubMed  
    P28702 Q13133 NR1H3    HPRD  PubMed  
    P28702 O75469 NR1I2    HPRD  PubMed  
    P28702 P49116 NR2C2    HPRD  PubMed  
    P28702 Q9Y5X4 NR2E3    HPRD  PubMed  
    P28702 P43354 NR4A2    HPRD  PubMed  
    P28702 P48552 NRIP1    HPRD  PubMed  
    P28702 Q03181 PPARD    HPRD  PubMed  
    P28702 P37231 PPARG    HPRD  PubMed  
    P28702 P10276 RARA    HPRD  PubMed  
    P28702 P10826 RARB    HPRD  PubMed  
    P28702 P13631 RARG    HPRD  PubMed  
    P28702 P28702 RXRB    HPRD  PubMed  
    P28702 O43791 SPOP    HPRD  PubMed  
    P28702 O95359 TACC2    HPRD  PubMed  
    P28702 Q15544 TAF11    HPRD  PubMed  
    P28702 P10827 THRA    HPRD  PubMed  
    P28702 P37243 THRB    HPRD  PubMed  
    P28702 P11473 VDR    HPRD  PubMed  
    BioGRID:112169 BioGRID:116383 AKAP13    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112169 BioGRID:107228 CACNA1B    BioGRID  PubMed Affinity Capture-RNA; Affinity Capture-Western 
    BioGRID:112169 BioGRID:246438 Cebpb    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112169 BioGRID:116995 GRIP1    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:109220 GTF2H1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112169 BioGRID:110306 MAP4    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:111465 MED1    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:113222 NR1H2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112169 BioGRID:115373 NR1H3    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:114380 NR1I2    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:113034 NR2C2    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:109165 NR3C1    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:110983 NR4A2    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:113843 NRIP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112169 BioGRID:111463 PPARD    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:111464 PPARG    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:111849 RARA    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:111850 RARB    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:111851 RARG    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:113993 SPOP    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:115329 SRA1    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:112592 SRC    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112169 BioGRID:112924 THRB    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112169 BioGRID:113264 VDR    BioGRID  PubMed Two-hybrid 
    BioGRID:112169 BioGRID:124326 ZDHHC12    BioGRID  PubMed Two-hybrid 
    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
      Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Non-small cell lung cancer, conserved biosystem (from KEGG)
      Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
      Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...
    • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
      Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
    • PPAR signaling pathway, organism-specific biosystem (from KEGG)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, conserved biosystem (from KEGG)
      PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Thyroid cancer, organism-specific biosystem (from KEGG)
      Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Thyroid cancer, conserved biosystem (from KEGG)
      Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Vitamin A and carotenoid metabolism, organism-specific biosystem (from WikiPathways)
      Vitamin A and carotenoid metabolism, organism-specific biosystemThis pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some ...

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC1831

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    9-cis retinoic acid receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    intracellular receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    retinoic acid receptor RXR-beta
    Names
    retinoic acid receptor RXR-beta
    MHC class I promoter binding protein
    nuclear receptor subfamily 2 group B member 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023374.1 RefSeqGene

      Range
      4960..12071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270401.1 → NP_001257330.1  retinoic acid receptor RXR-beta isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK225842, AL645940, AW473828, DC425042
      Consensus CDS
      CCDS59007.1
      UniProtKB/Swiss-Prot
      P28702
      Related
      ENSP00000363817, OTTHUMP00000029438, ENST00000374685, OTTHUMT00000076644
      Conserved Domains (2) summary
      cd06943
      Location:299 – 515
      Blast Score: 1027
      NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily.
      cd06956
      Location:204 – 279
      Blast Score: 313
      NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers

    2. NM_021976.4 → NP_068811.1  retinoic acid receptor RXR-beta isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL645940, AW473828, BC001167, BE704198, DC425042
      Consensus CDS
      CCDS4768.1
      UniProtKB/Swiss-Prot
      P28702
      UniProtKB/TrEMBL
      Q5STP9
      Related
      ENSP00000363812, OTTHUMP00000029436, ENST00000374680, OTTHUMT00000076642
      Conserved Domains (2) summary
      cd06943
      Location:299 – 511
      Blast Score: 1043
      NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily.
      cd06956
      Location:204 – 279
      Blast Score: 313
      NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p10 ALT_REF_LOCI_2

      Range
      4605198..4612307, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p10 ALT_REF_LOCI_3

      Range
      4442669..4449780, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p10 ALT_REF_LOCI_4

      Range
      4618677..4625789, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p10 ALT_REF_LOCI_5

      Range
      4635126..4642234, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p10 ALT_REF_LOCI_6

      Range
      4393584..4400696, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p10 Primary Assembly

      Range
      33161362..33168473, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      32903933..32910518, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018917.1 Alternate CHM1_1.0

      Range
      33077126..33084235, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01038138.1 None
    genomic AF065396.1 AAC18599.1
    genomic AF120161.1 AAD13794.1
    genomic AL031228.1 CAA20239.1
      CAI95622.1
    genomic AL645940.4 (78624..85691) None
    genomic AL662824.9 (175208..182273) None
    genomic AL844527.6 (22040..29152) None
    genomic AMYH01016242.1 (1086..8195) None
    genomic CH471081.1 EAX03679.1
    genomic CR354565.6 (51572..58684) None
    genomic CR759733.4 (65874..72985) None
    genomic CR936877.4 (40872..47980) None
    mRNA AB209244.1 BAD92481.1
    mRNA AK225842.1 None
    mRNA AK295759.1 BAH12180.1
    mRNA AK300402.1 BAH13278.1
    mRNA AK301096.1 BAH13409.1
    mRNA AK302125.1 BAH13631.1
    mRNA AW473828.1 None
    mRNA BC001167.1 AAH01167.1
    mRNA BE704198.1 None
    mRNA BM982876.1 None
    mRNA BT007280.1 AAP35944.1
    mRNA DC425042.1 None
    mRNA HQ692844.1 ADZ17355.1
    mRNA HQ709179.1 ADZ17386.1
    mRNA M84820.1 AAA60293.1
    mRNA X63522.1 CAA45087.1
    mRNA X63523.1 None
    mRNA X65463.1 CAA46456.1
    mRNA X66424.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28702.2 GenPept UniProtKB/Swiss-Prot:P28702

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
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        3D structure of a gene
      • BioAssay
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        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
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        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
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        SNPs linked from GeneView
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        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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