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    CASP8 caspase 8, apoptosis-related cysteine peptidase [ Homo sapiens ]

    Gene ID: 841, updated on 19-May-2012
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    Summary

    Official Symbol
    CASP8provided by HGNC
    Official Full Name
    caspase 8, apoptosis-related cysteine peptidaseprovided by HGNC
    Primary source
    HGNC:1509
    See related
    Ensembl:ENSG00000064012; HPRD:03459; MIM:601763; Vega:OTTHUMG00000132821
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; FLJ17672; MGC78473
    Summary
    This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    2q33-q34
    Sequence :
    Chromosome: 2; NC_000002.11 (202098166..202152434)
    See CASP8 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene ribosomal protein L38 pseudogene Neighboring gene caspase 10, apoptosis-related cysteine peptidase Neighboring gene amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 Neighboring gene trafficking protein, kinesin binding 2 Neighboring gene SCY1-like 2 (S. cerevisiae) pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome. Gringhuis SI, et al. Nat Immunol, 2012 Jan 22. PMID 22267217.
    2. De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF. Mahul-Mellier AL, et al. Cell Death Differ, 2012 May. PMID 22179575.
    3. Fine-mapping CASP8 risk variants in breast cancer. Camp NJ, et al. Cancer Epidemiol Biomarkers Prev, 2012 Jan. PMID 22056502.
    4. Caspase 8 inhibits programmed necrosis by processing CYLD. O'Donnell MA, et al. Nat Cell Biol, 2011 Oct 30. PMID 22037414.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (523) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. This review discusses the latest insights in caspase-8 homo- versus heterodimerization and the implication this has for cellular death or survival.
      Title: Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate.
    2. Authrors identified a three-SNP haplotype across rs3834129, rs6723097, and rs3817578 in CASP8 that was significantly associated with breast cancer.
      Title: Fine-mapping CASP8 risk variants in breast cancer.
    3. DJ-1 protects against TRAIL-induced apoptosis through the regulation of death-inducing signaling complex (DISC) formation.
      Title: DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD.
    4. dectin-1 acted as an extracellular sensor for pathogens that induced both IL-1beta production and maturation through a noncanonical caspase-8-dependent inflammasome for protective immunity
      Title: Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome.
    5. Apigenin increases CASP3 and CASP8 mRNA expression but decreases mTOR and CCND1 mRNA expression in HT29 cells.
      Title: Evaluation of the effects of the flavonoid apigenin on apoptotic pathway gene expression on the colon cancer cell line (HT29).
    6. Mechanistic studies showed that MLN2238-triggered apoptosis is associated with activation of caspase-3, caspase-8, and caspase-9.
      Title: In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells.
    7. Data indicate that NGA could increase the expression of the apoptosis-related proteins FasL, caspase-3, caspase-8, caspase-9, and Bax and decrease the expression of anti-apoptotic protein Bcl-2 accompanied by the mitochondrial transmembrane damage.
      Title: The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells.
    8. Following tumor necrosis factor stimulation, caspase 8 cleaves CYLD to generate a survival signal.
      Title: Caspase 8 inhibits programmed necrosis by processing CYLD.
    9. Results demonstrated that CIDEC-induced apoptosis was independent of FADD, suggesting that CIDEC-induced apoptosis might be in a death-receptor-independent, caspase-8-dependent manner.
      Title: Human cell-death-inducing DFF45-like effector C induces apoptosis via caspase-8.
    10. YC-1 may enhance the apoptotic effect of TRAIL on ovarian carcinoma cell lines by increasing the activation of the caspase-8- and Bid-dependent pathways.
      Title: Guanylate cyclase activator YC-1 enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells via activation of apoptosis-related proteins.
    Submit: New GeneRIF Correction See all (316)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Breast cancer, protection against

    Hepatocellular carcinoma, somatic

    Immunodeficiency due to CASP8 deficiency

    Lung cancer, protection against

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Nef nef Stable expression of HIV-1 Nef in Jurkat T cells confers resistance to Fas-mediated apoptosis through inactivation of caspase-3 and caspase-8 PubMed
    Tat tat HIV-1 Tat induces apoptosis and increases sensitivity to apoptotic signals by upregulating FLICE/Caspase-8 PubMed
    Vpr vpr HIV-1 Vpr induces apoptosis through caspase activation and caspase 8 has been specifically demonstrated in one study to be activated during this process, however in other studies it was not activated PubMed
    retropepsin gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells, which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_203519.1 NP_000035.2 AR    BIND  PubMed Androgen Receptor interacts with caspase 8. 
    NP_203519.1 NP_001931.1 ATN1    BIND  PubMed Atrophin-1 interacts with caspase 8. 
    NP_203519.1 NP_002102.2 HTT    BIND  PubMed Htt interacts with caspase 8. 
    Q14790 O14727 APAF1    HPRD  PubMed  
    Q14790 P05067 APP    HPRD  PubMed  
    Q14790 P10275 AR    HPRD  PubMed  
    Q14790 P51572 BCAP31    HPRD  PubMed  
    Q14790 P10415 BCL2    HPRD  PubMed  
    Q14790 Q07817 BCL2L1    HPRD  PubMed  
    Q14790 Q9NZS9 BFAR    HPRD  PubMed  
    Q14790 P55957 BID    HPRD  PubMed  
    Q14790 Q92851 CASP10    HPRD  PubMed  
    Q14790 P31944 CASP14    HPRD  PubMed  
    Q14790 P42574 CASP3    HPRD  PubMed  
    Q14790 P55212 CASP6    HPRD  PubMed  
    Q14790 Q14790 CASP8    HPRD  PubMed  
    Q14790 Q9UKL3 CASP8AP2    HPRD  PubMed  
    Q14790 P12830 CDH1    HPRD  PubMed  
    Q14790 Q9UQ88 CDK11A    HPRD  PubMed  
    Q14790 P21127 CDK11B    HPRD  PubMed  
    Q14790 P46527 CDKN1B    HPRD  PubMed  
    Q14790 O15519 CFLAR    HPRD  PubMed  
    Q14790 Q12873 CHD3    HPRD  PubMed  
    Q14790 O15111 CHUK    HPRD  PubMed  
    Q14790 P78560 CRADD    HPRD  PubMed  
    Q14790 P35222 CTNNB1    HPRD  PubMed  
    Q14790 O75618 DEDD    HPRD  PubMed  
    Q14790 Q8WXF8 DEDD2    HPRD  PubMed  
    Q14790 Q9HAV5 EDA2R    HPRD  PubMed  
    Q14790 P19525 EIF2AK2    HPRD  PubMed  
    Q14790 NP_003815.1 FADD    BIND  PubMed CASP8 (caspase-8) interacts with FADD. 
    Q14790 Q13158 FADD    HPRD  PubMed  
    Q14790 Q9UNN5 FAF1    HPRD  PubMed  
    Q14790 P25445 FAS    HPRD  PubMed  
    Q14790 P06241 FYN    HPRD  PubMed  
    Q14790 Q9Y692 GMEB1    HPRD  PubMed  
    Q14790 P42261 GRIA1    HPRD  PubMed  
    Q14790 O00291 HIP1    HPRD  PubMed  
    Q14790 O14920 IKBKB    HPRD  PubMed  
    Q14790 Q9Y6K9 IKBKG    HPRD  PubMed  
    Q14790 Q13418 ILK    HPRD  PubMed  
    Q14790 P05783 KRT18    HPRD  PubMed  
    Q14790 Q99558 MAP3K14    HPRD  PubMed  
    Q14790 P28482 MAPK1    HPRD  PubMed  
    Q14790 P27361 MAPK3    HPRD  PubMed  
    Q14790 P10636 MAPT    HPRD  PubMed  
    Q14790 Q9Y239 NOD1    HPRD  PubMed  
    Q14790 O60936 NOL3    HPRD  PubMed  
    Q14790 Q96RI1 NR1H4    HPRD  PubMed  
    Q14790 O60260 PARK2    HPRD  PubMed  
    Q14790 Q9UGN5 PARP2    HPRD  PubMed  
    Q14790 P49585 PCYT1A    HPRD  PubMed  
    Q14790 Q15121 PEA15    HPRD  PubMed  
    Q14790 NP_057250.1 PIAS1    BIND  PubMed CASP8 (caspase-8) interacts with PIAS-1. 
    Q14790 O75925 PIAS1    HPRD  PubMed  
    Q14790 Q13492 PICALM    HPRD  PubMed  
    Q14790 Q15149 PLEC    HPRD  PubMed  
    Q14790 Q05513 PRKCZ    HPRD  PubMed  
    Q14790 P49768 PSEN1    HPRD  PubMed  
    Q14790 P49810 PSEN2    HPRD  PubMed  
    Q14790 Q15311 RALBP1    HPRD  PubMed  
    Q14790 NP_000312.1 RB1    BIND  PubMed CASP8 (caspase-8) cleaves RB-1 (hRB) into the p68 form and to a lesser extent the p61 form. 
    Q14790 P06400 RB1    HPRD  PubMed  
    Q14790 Q13546 RIPK1    HPRD  PubMed  
    Q14790 O43353 RIPK2    HPRD  PubMed  
    Q14790 Q8N488 RYBP    HPRD  PubMed  
    Q14790 P11831 SRF    HPRD  PubMed  
    Q14790 Q9Y6E0 STK24    HPRD  PubMed  
    Q14790 NP_003343.1 SUMO1    BIND  PubMed CASP8 (caspase-8) interacts with SUMO1. 
    Q14790 P63165 SUMO1    HPRD  PubMed  
    Q14790 Q12800 TFCP2    HPRD  PubMed  
    Q14790 O00220 TNFRSF10A    HPRD  PubMed  
    Q14790 O14763 TNFRSF10B    HPRD  PubMed  
    Q14790 Q9NS56 TOPORS    HPRD  PubMed  
    Q14790 Q13077 TRAF1    HPRD  PubMed  
    Q14790 Q12933 TRAF2    HPRD  PubMed  
    Q14790 O60763 USO1    HPRD  PubMed  
    Q14790 P08670 VIM    HPRD  PubMed  
    BioGRID:107291 BioGRID:35900 AIF1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:107291 BioGRID:106814 APAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:106889 ARHGDIA    BioGRID  PubMed Co-purification 
    BioGRID:107291 BioGRID:115437 BCAP31    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107291 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression 
    BioGRID:107291 BioGRID:107070 BCL2L1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:107291 BioGRID:107106 BID    BioGRID  PubMed Biochemical Activity; Co-purification 
    BioGRID:107291 BioGRID:106826 BIRC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:107284 CASP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107291 BioGRID:107293 CASP10    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-purification 
    BioGRID:107291 BioGRID:117116 CASP14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:107285 CASP2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107291 BioGRID:107286 CASP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:107291 BioGRID:107287 CASP4    BioGRID  PubMed Biochemical Activity 
    BioGRID:107291 BioGRID:107289 CASP6    BioGRID  PubMed Biochemical Activity 
    BioGRID:107291 BioGRID:107290 CASP7    BioGRID  PubMed Biochemical Activity 
    BioGRID:107291 BioGRID:107291 CASP8    BioGRID  PubMed Biochemical Activity; Co-crystal Structure; Two-hybrid 
    BioGRID:107291 BioGRID:115315 CASP8AP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:107292 CASP9    BioGRID  PubMed Biochemical Activity; Phenotypic Suppression 
    AAC51623.1 CFLAR    BIND  PubMed MRIT-beta-1 interacts with FLICE. This interaction was modelled on a demonstrated interaction between human MRIT-beta-1 and FLICE from an unspecified species. 
    NP_003870.3 CFLAR    BIND  PubMed MRIT-alpha-1 interacts with FLICE. This interaction was modelled on a demonstrated interaction between human MRIT-alpha-1 and FLICE from an unspecified species. 
    BioGRID:107291 BioGRID:114364 CFLAR    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:107291 BioGRID:107532 CHD3    BioGRID  PubMed Two-hybrid 
    BioGRID:107291 BioGRID:107569 CHUK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:114627 DEDD    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107291 BioGRID:127838 DEDD2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107291 BioGRID:113271 EZR    BioGRID  PubMed Co-purification 
    NP_003815.1 FADD    BIND  PubMed caspase-8 interacts with FADD. 
    BioGRID:107291 BioGRID:114302 FADD    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:107291 BioGRID:116298 FAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:106851 FAS    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107291 BioGRID:106852 FASLG    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107291 BioGRID:119613 HDAC7    BioGRID  PubMed Biochemical Activity 
    BioGRID:107291 BioGRID:109339 HIP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:120396 IFT57    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:109767 IKBKB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:115900 KHDRBS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:124137 MAP1LC3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:123565 MAP1LC3B    BioGRID  PubMed Two-hybrid 
    BioGRID:107291 BioGRID:114487 MAP3K14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:111585 MAPK8    BioGRID  PubMed Co-purification 
    BioGRID:107291 BioGRID:34595 MCA1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:107291 BioGRID:110584 MSN    BioGRID  PubMed Co-purification 
    BioGRID:107291 BioGRID:121814 NLRC4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:115664 NOD1    BioGRID  PubMed Affinity Capture-Western 
    NP_003937.1 NOL3    BIND  PubMed ARC interacts with procaspase-8. 
    BioGRID:107291 BioGRID:114477 NOL3    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression 
    BioGRID:107291 BioGRID:115296 NR1H4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107291 BioGRID:114230 PEA15    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107291 BioGRID:111700 PTEN    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107291 BioGRID:116131 RALBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:111836 RALGDS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:106880 RHOA    BioGRID  PubMed Co-purification 
    BioGRID:107291 BioGRID:114274 RIPK1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107291 BioGRID:114397 SQSTM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:112882 TFCP2    BioGRID  PubMed Two-hybrid 
    BioGRID:107291 BioGRID:112983 TNFAIP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:114325 TNFRSF10A    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107291 BioGRID:114323 TNFRSF10B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-purification 
    BioGRID:107291 BioGRID:112986 TNFRSF1A    BioGRID  PubMed Co-purification 
    BioGRID:107291 BioGRID:114257 TRADD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:113037 TRAF1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107291 BioGRID:113038 TRAF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:108165 TSC22D3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107291 BioGRID:114553 USP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107291 BioGRID:113272 VIM    BioGRID  PubMed Two-hybrid 
    BioGRID:107291 BioGRID:106828 XIAP    BioGRID  PubMed Phenotypic Suppression 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of Pro-Caspase 8, organism-specific biosystem (from REACTOME)
      Activation of Pro-Caspase 8, organism-specific biosystemPro-caspase-8 is known to be activated by various factors in response to a variety of external and internal stimuli. These include FAS, TRAIL, and TNF.
    • Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystem (from REACTOME)
      Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystemBID may promote cell death by activating BAX and BAK while inactivating anti-apoptotic proteins. The engagement of cell surface receptors activates the caspase-8, a heterodimer, that cleaves BID in i...
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
      Apoptosis Modulation by HSP70, organism-specific biosystem
      Apoptosis Modulation by HSP70
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Caspase-8 is formed from procaspase-8, organism-specific biosystem (from REACTOME)
      Caspase-8 is formed from procaspase-8, organism-specific biosystemCaspase-8 is formed from the precursor protein pro-Caspase-8 as a cleavage product.
    • Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem (from REACTOME)
      Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystemCaspase-mediated cleavage of a number of proteins in the cortical actin network ( ) microfilament system and others involved in maintenance of the cytoskeletal architecture (vimentin, or Gas2 and ...
    • Ceramide signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Ceramide signaling pathway, organism-specific biosystem
      Ceramide signaling pathway
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
      Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
    • Extrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Extrinsic Pathway for Apoptosis, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
    • FAS (CD95) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FAS (CD95) signaling pathway, organism-specific biosystem
      FAS (CD95) signaling pathway
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • FasL/ CD95L signaling, organism-specific biosystem (from REACTOME)
      FasL/ CD95L signaling, organism-specific biosystemThe Fas family of cell surface receptors initiate the apototic pathway through interaction with the external ligand, FasL. The cytoplasmic domain of Fas interacts with a number of molecules in the t...
    • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
      HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
      HIV-1 Nef: Negative effector of Fas and TNF-alpha
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
      Integrins in angiogenesis, organism-specific biosystem
      Integrins in angiogenesis
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystem (from REACTOME)
      NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystemFas-associateddeathdomain (FADD) and receptor interacting protein 1 (RIP1) are death domain containing molecules that interact with the C-terminal portion of IPS-1 and induce NF-kB through interactio...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD1/2 Signaling Pathway, organism-specific biosystem (from REACTOME)
      NOD1/2 Signaling Pathway, organism-specific biosystemNOD1 is ubiquitously expressed, while NOD2 expression is restricted to monocytes, macrophages, dendritic cells, and intestinal Paneth cells (Inohara et al. 2005). NOD1 and NOD2 activation induces tra...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TNF receptor signaling pathway, organism-specific biosystem
      TNF receptor signaling pathway
    • TNF signaling, organism-specific biosystem (from REACTOME)
      TNF signaling, organism-specific biosystemThe Tumor Necrosis Factor alpha (TNF-alpha) mediated apoptosis pathway has been implicated in the pathogenesis of a number of diseases including sepsis, diabetes, cancer, osteoporosis, multiple scler...
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • TRAIL signaling, organism-specific biosystem (from REACTOME)
      TRAIL signaling, organism-specific biosystemTumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a member of the tumor necrosis factor (TNF) family. This group of apoptosis induction pathways all work throug...
    • TRAIL signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TRAIL signaling pathway, organism-specific biosystem
      TRAIL signaling pathway
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cysteine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
    		  
    cysteine-type peptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    activation of pro-apoptotic gene products TAS
    Traceable Author Statement
    more info
    		  
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cellular component disassembly involved in apoptosis TAS
    Traceable Author Statement
    more info
    		  
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		  
    heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis by extracellular signals IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    induction of apoptosis by extracellular signals TAS
    Traceable Author Statement
    more info
    		  
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    macrophage differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    neural tube formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    nucleotide-binding oligomerization domain containing signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of I-kappaB kinase/NF-kappaB cascade IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    protein heterooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    proteolysis involved in cellular protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to cobalt ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to cold IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to tumor necrosis factor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    CD95 death-inducing signaling complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Noc1p-Noc2p complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    caspase-8
    Names
    caspase-8
    FADD-like ICE
    MACH-alpha-1/2/3 protein
    apoptotic protease Mch-5
    MACH-beta-1/2/3/4 protein
    apoptotic cysteine protease
    ICE-like apoptotic protease 5
    MORT1-associated ced-3 homolog
    FADD-homologous ICE/CED-3-like protease
    caspase 8, apoptosis-related cysteine protease
    NP_001073593.1
    NP_001073594.1
    NP_001219.2
    NP_203519.1
    NP_203520.1
    NP_203522.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007497.1 RefSeqGene

      Range
      4986..59254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_34

    mRNA and Protein(s)

    1. NM_001080124.1 → NP_001073593.1  caspase-8 isoform C precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (F) includes different segments in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant G. Variants C and F both encode isoform C, which is shorter than isoform G. Isoform C has also been labelled as Alpha-2 or MCH5-beta.
      Source sequence(s)
      AC007256, AF422927, AI351872, DA420056
      Consensus CDS
      CCDS2343.1
      UniProtKB/Swiss-Prot
      Q14790
      Related
      ENSP00000376091, OTTHUMP00000165063, ENST00000392263, OTTHUMT00000257909
      Conserved Domains (3) summary
      cd00032
      Location:210 – 462
      Blast Score: 791
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:3 – 84
      Blast Score: 336
      DED_Caspase_8_repeat1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98 – 180
      Blast Score: 344
      DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

    2. NM_001080125.1 → NP_001073594.1  caspase-8 isoform G precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (G), also known as procaspase-8L or 8L, encodes the longest protein (isoform G).
      Source sequence(s)
      AC007256, AF422927, AI351872, X98172
      Consensus CDS
      CCDS42798.1
      UniProtKB/Swiss-Prot
      Q14790
      Related
      ENSP00000351273, OTTHUMP00000163717, ENST00000358485, OTTHUMT00000256278
      Conserved Domains (3) summary
      cd00032
      Location:284 – 536
      Blast Score: 799
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:62 – 143
      Blast Score: 340
      DED_Caspase_8_repeat1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:157 – 239
      Blast Score: 349
      DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

    3. NM_001228.4 → NP_001219.2  caspase-8 isoform A precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A), also known as Alpha-4, has multiple differences in the 5' UTR and coding region, compared to variant G. It encodes isoform A which is shorter than isoform G.
      Source sequence(s)
      AC007256, AI351872, BC028223, DA420056, U60520
      Consensus CDS
      CCDS42799.1
      UniProtKB/Swiss-Prot
      Q14790
      Related
      ENSP00000264275, OTTHUMP00000165062, ENST00000264275, OTTHUMT00000257907
      Conserved Domains (3) summary
      cd00032
      Location:242 – 494
      Blast Score: 792
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:3 – 84
      Blast Score: 339
      DED_Caspase_8_repeat1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:134 – 212
      Blast Score: 333
      DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

    4. NM_033355.3 → NP_203519.1  caspase-8 isoform B precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) includes different segments in its 5' UTR and lacks a 5' coding region segment, compared to variant G. This results in translation at a downstream start codon, and the encoded protein (isoform B) has a shorter N-terminus when it is compared to isoform G.
      Source sequence(s)
      AC007256, AF422928, AI351872, DA420056
      Consensus CDS
      CCDS2342.1
      UniProtKB/Swiss-Prot
      Q14790
      Related
      ENSP00000412523, OTTHUMP00000206552, ENST00000432109, OTTHUMT00000336853
      Conserved Domains (3) summary
      cd00032
      Location:225 – 477
      Blast Score: 791
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:3 – 84
      Blast Score: 336
      DED_Caspase_8_repeat1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98 – 180
      Blast Score: 344
      DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

    5. NM_033356.3 → NP_203520.1  caspase-8 isoform C precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) includes a different segment in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant G. Variants C and F both encode isoform C, which is shorter than isoform G. Isoform C has also been labelled as Alpha-2 or MCH5-beta.
      Source sequence(s)
      AC007256, AI351872, AL601594, BC028223, X98173
      Consensus CDS
      CCDS2343.1
      UniProtKB/Swiss-Prot
      Q14790
      Related
      ENSP00000325722, OTTHUMP00000165064, ENST00000323492, OTTHUMT00000257912
      Conserved Domains (3) summary
      cd00032
      Location:210 – 462
      Blast Score: 791
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:3 – 84
      Blast Score: 336
      DED_Caspase_8_repeat1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98 – 180
      Blast Score: 344
      DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

    6. NM_033358.3 → NP_203522.1  caspase-8 isoform E

      Status: REVIEWED

      Description
      Transcript Variant: This variant (E), also known as Beta-1, has multiple differences, one of which causes a frameshift, compared to variant G. It encodes isoform E, which is shorter than isoform G.
      Source sequence(s)
      DA420056, DB157537, X98176
      Consensus CDS
      CCDS2345.1
      UniProtKB/Swiss-Prot
      Q14790
      Related
      ENSP00000376087, OTTHUMP00000163720, ENST00000392258, OTTHUMT00000256281
      Conserved Domains (2) summary
      cd08333
      Location:3 – 84
      Blast Score: 301
      DED_Caspase_8_repeat1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98 – 180
      Blast Score: 322
      DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      202098166..202152434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      193949530..194000819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033357.2: Suppressed sequence

      Description
      NM_033357.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB038985.2 BAB32555.1
    genomic AC007256.5 AAY24225.1
    genomic AC007283.3 (200..3062) None
    genomic AF102139.1 AAD24962.1
    genomic AF102140.1 AAD24962.1
    genomic AF102141.1 AAD24962.1
    genomic AF102142.1 AAD24962.1
    genomic AF102143.1 AAD24962.1
    genomic AF102144.1 AAD24962.1
    genomic AF102145.1 AAD24962.1
    genomic AF102146.1 AAD24962.1
    genomic AF207672.1 AAG10682.1
    genomic CH471063.1 EAW70253.1
      EAW70254.1
      EAW70258.1
      EAW70262.1
    genomic DQ355026.1 ABC67468.1
    genomic HA637638.1 CAZ39541.1
    genomic HI179126.1 CBX53871.1
    genomic HI179128.1 CBX53872.1
    genomic HI179130.1 CBX53873.1
    genomic HI179132.1 CBX53874.1
    mRNA AA312258.1 None
    mRNA AB451282.1 BAG70096.1
    mRNA AB451414.1 BAG70228.1
    mRNA AF009620.1 AAB70913.1
    mRNA AF380342.1 AAK57437.1
    mRNA AF422926.1 AAL87629.1
    mRNA AF422927.1 AAL87630.1
    mRNA AF422928.1 AAL87631.1
    mRNA AF422929.1 AAL87632.1
    mRNA AI351872.1 None
    mRNA AK310630.1 None
    mRNA AL600571.1 None
    mRNA AL601594.1 None
    mRNA AL702116.1 None
    mRNA BC010390.1 None
    mRNA BC017031.1 None
    mRNA BC028223.2 None
    mRNA BC068050.1 AAH68050.1
    mRNA BG498355.1 None
    mRNA BX395849.2 None
    mRNA CB990598.1 None
    mRNA DA420056.1 None
    mRNA DB157537.1 None
    mRNA EU168332.1 ABX09989.1
    mRNA EU670044.1 ACF93415.1
    mRNA U58143.1 AAC50602.1
    mRNA U60520.1 AAC50645.1
    mRNA X98172.1 CAA66853.1
    mRNA X98173.1 CAA66854.1
    mRNA X98174.1 CAA66855.1
    mRNA X98175.1 CAA66856.1
    mRNA X98176.1 CAA66857.1
    mRNA X98177.1 CAA66858.1
    mRNA X98178.1 CAA66859.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14790.1 GenPept UniProtKB/Swiss-Prot:Q14790
    Q6NVI2 GenPept UniProtKB/TrEMBL:Q6NVI2
    Q9HBU4 GenPept UniProtKB/TrEMBL:Q9HBU4
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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    Tools
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      Supplemental Content

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