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    PRKCE protein kinase C, epsilon [ Homo sapiens ]

    Gene ID: 5581, updated on 19-May-2012
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    Summary

    Official Symbol
    PRKCEprovided by HGNC
    Official Full Name
    protein kinase C, epsilonprovided by HGNC
    Primary source
    HGNC:9401
    See related
    Ensembl:ENSG00000171132; HPRD:01500; MIM:176975; Vega:OTTHUMG00000128817
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKCE; nPKC-epsilon; MGC125656; MGC125657
    Summary
    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    2p21
    Sequence :
    Chromosome: 2; NC_000002.11 (45879043..46415129)
    See PRKCE in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein UNQ6975/PRO21958 Neighboring gene S1 RNA binding domain 1 Neighboring gene transfer RNA glutamine 39 (anticodon UUG) pseudogene Neighboring gene ribosomal protein L26 pseudogene 15 Neighboring gene ribosomal protein L36a pseudogene 14 Neighboring gene uncharacterized LOC100652809 Neighboring gene endothelial PAS domain protein 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Lau E, et al. Cell, 2012 Feb 3. PMID 22304920.
    2. Protein kinase Cε regulates proliferation and cell sensitivity to TGF-1β of CD4+ T lymphocytes: implications for Hashimoto thyroiditis. Mirandola P, et al. J Immunol, 2011 Nov 1. PMID 21964026.
    3. The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma. Huang B, et al. J Exp Clin Cancer Res, 2011 Sep 28. PMID 21955404.
    4. Urokinase plasminogen activator inhibits HIV virion release from macrophage-differentiated chronically infected cells via activation of RhoA and PKCε. Graziano F, et al. PLoS One, 2011. PMID 21858203.
    5. Protein kinase C epsilon affects mitochondrial function through estrogen-related receptor alpha. Lu N, et al. Cell Signal, 2011 Sep. PMID 21596133.

    See all (228) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The ability of ATF2 to reach the mitochondria is determined by PKCepsilon, which directs ATF2 nuclear localization. Genotoxic stress attenuates PKCepsilon effect on ATF2; enables ATF2 nuclear export and localization at the mitochondria.
      Title: PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.
    2. Data indicate that RhoA, PKCdelta and PKCepsilon modulated uPA-induced cell adhesion and polarization, whereas only RhoA and PKCepsilon were also responsible for the redirection of virions in intracellular vesicles.
      Title: Urokinase plasminogen activator inhibits HIV virion release from macrophage-differentiated chronically infected cells via activation of RhoA and PKCε.
    3. These data demonstrate that TRAIL and PKCepsilon must be reciprocally regulated to ensure physiological colon epithelial cell differentiation starting from the stem cell pool.
      Title: TRAIL up-regulation must be accompanied by a reciprocal PKCε down-regulation during differentiation of colonic epithelial cell: implications for colorectal cancer cell differentiation.
    4. PKCepsilon controls cell proliferation but not cell activation of CD4-positive T lymphocytes; for the first time, increased expression of PKCepsilon is found in CD4-positive T cells of Hashimoto thyroiditis patients.
      Title: Protein kinase Cε regulates proliferation and cell sensitivity to TGF-1β of CD4+ T lymphocytes: implications for Hashimoto thyroiditis.
    5. Overexpression of protein kinase C epsilon is associated with clear cell renal cell carcinoma.
      Title: The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma.
    6. Enhanced PKCepsilon mediated phosphorylation of connexin43 at serine 368 by a carboxyl-terminal mimetic peptide is dependent on injury.
      Title: Enhanced PKCε mediated phosphorylation of connexin43 at serine 368 by a carboxyl-terminal mimetic peptide is dependent on injury.
    7. Suppression of protein kinase C epsilon activity alters mitochondrial homeostasis.
      Title: Protein kinase C epsilon affects mitochondrial function through estrogen-related receptor alpha.
    8. study identified PKCepsilon as the isoform involved in VIP-dependent F508del-CFTR membrane insertion
      Title: VIP-dependent increase in F508del-CFTR membrane localization is mediated by PKCε.
    9. partial blockade of PKC potentiates aggregation and dense granule secretion by ADP in association with increased Ca(2+)
      Title: Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+.
    10. the tumor suppression in SMMC-7721 by C/EBPbeta 3'UTR RNA is due to the inhibition of protein kinase Cepsilon activity through direct physical interaction between C/EBPbeta 3'UTR RNA and protein kinase Cepsilon.
      Title: Tumor suppression by RNA from C/EBPβ 3'UTR through the inhibition of protein kinase Cε activity.
    Submit: New GeneRIF Correction See all (126)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association study of hematological and biochemical traits in a Japanese population.

    Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
    env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    env HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels PubMed
    env Downmodulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection PubMed
    env A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C PubMed
    env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate PubMed
    env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
    Nef nef HIV-1 Nef downregulates the expression of PKC epsilon in human astrocytoma cells PubMed
    Tat tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed
    tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
    tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
    retropepsin gag-pol Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease PubMed
    reverse transcriptase gag-pol HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005391.1 PDPK1    BIND  PubMed An unspecified isoform of PDPK1 (PDK1) phosphorylates PRKCE (PKC-epsilon). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCE from an unspecified species. 
    NP_005391.1 NP_005391.1 PRKCE    BIND  PubMed PRKCE (PKC-epsilon) autophosphorylates. This interaction was modeled on a demonstrated interaction using PRKCE from an unspecified species. 
    NP_005391.1 NP_002733.1 PRKD1    BIND  PubMed PRKCE (PKC-epsilon) phosphorylates PRKD1 (PKC-mu). This interaction was modeled on a demonstrated interaction between PRKCE from an unspecified species and human PRKD1. 
    Q02156 P68133 ACTA1    HPRD  PubMed  
    Q02156 P68032 ACTC1    HPRD  PubMed  
    Q02156 O75689 ADAP1    HPRD  PubMed  
    Q02156 Actin filament associated protein AFAP1    HPRD  PubMed  
    Q02156 Q99996 AKAP9    HPRD  PubMed  
    Q02156 P15056 BRAF    HPRD  PubMed  
    Q02156 Q06187 BTK    HPRD  PubMed  
    Q02156 P13569 CFTR    HPRD  PubMed  
    Q02156 P28329 CHAT    HPRD  PubMed  
    Q02156 P51911 CNN1    HPRD  PubMed  
    Q02156 P53618 COPB1    HPRD  PubMed  
    Q02156 P35606 COPB2    HPRD  PubMed  
    Q02156 P06241 FYN    HPRD  PubMed  
    Q02156 Q99259 GAD1    HPRD  PubMed  
    Q02156 Q05329 GAD2    HPRD  PubMed  
    Q02156 P17302 GJA1    HPRD  PubMed  
    Q02156 Q14344 GNA13    HPRD  PubMed  
    Q02156 P63244 GNB2L1    HPRD  PubMed  
    Q02156 Q05586 GRIN1    HPRD  PubMed  
    Q02156 O15399 GRIN2D    HPRD  PubMed  
    Q02156 P41594 GRM5    HPRD  PubMed  
    Q02156 P52789 HK2    HPRD  PubMed  
    Q02156 P05556 ITGB1    HPRD  PubMed  
    Q02156 P04264 KRT1    HPRD  PubMed  
    Q02156 P05783 KRT18    HPRD  PubMed  
    Q02156 P28482 MAPK1    HPRD  PubMed  
    Q02156 P27361 MAPK3    HPRD  PubMed  
    Q02156 Q9UKX2 MYH2    HPRD  PubMed  
    Q02156 P49757 NUMB    HPRD  PubMed  
    Q02156 P41143 OPRD1    HPRD  PubMed  
    Q02156 Q96HC4 PDLIM5    HPRD  PubMed  
    Q02156 O15530 PDPK1    HPRD  PubMed  
    Q02156 P16284 PECAM1    HPRD  PubMed  
    Q02156 P42338 PIK3CB    HPRD  PubMed  
    Q02156 Q96A00 PPP1R14A    HPRD  PubMed  
    Q02156 Q02156 PRKCE    HPRD  PubMed  
    Q02156 Q15139 PRKD1    HPRD  PubMed  
    Q02156 P04049 RAF1    HPRD  PubMed  
    Q02156 Q9UBS0 RPS6KB2    HPRD  PubMed  
    Q02156 P12235 SLC25A4    HPRD  PubMed  
    Q02156 P48751 SLC4A3    HPRD  PubMed  
    Q02156 P37840 SNCA    HPRD  PubMed  
    Q02156 P12931 SRC    HPRD  PubMed  
    Q02156 Q13009 TIAM1    HPRD  PubMed  
    Q02156 Q8NER1 TRPV1    HPRD  PubMed  
    Q02156 P21796 VDAC1    HPRD  PubMed  
    BioGRID:111567 BioGRID:106573 ACTA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111567 BioGRID:116222 ADAP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111567 BioGRID:121895 AFAP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111567 BioGRID:107506 CFTR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111567 BioGRID:114693 COPB2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111567 BioGRID:108166 DSP    BioGRID  PubMed Two-hybrid 
    BioGRID:111567 BioGRID:108845 GAD1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111567 BioGRID:108846 GAD2    BioGRID  PubMed Biochemical Activity 
    BioGRID:111567 BioGRID:108964 GJA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111567 BioGRID:109030 GNA12    BioGRID  PubMed Biochemical Activity 
    BioGRID:111567 BioGRID:115914 GNA13    BioGRID  PubMed Biochemical Activity 
    BioGRID:111567 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:111567 BioGRID:109346 HK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111567 BioGRID:109558 HSP90AB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111567 BioGRID:110046 KRT1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111567 BioGRID:110073 KRT18    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111567 BioGRID:110054 KRT8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111567 BioGRID:114838 MAP4K4    BioGRID  PubMed Two-hybrid 
    BioGRID:111567 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111567 BioGRID:110712 MYH9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111567 BioGRID:115857 PDLIM5    BioGRID  PubMed Two-hybrid 
    BioGRID:111567 BioGRID:111309 PIK3CB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111567 BioGRID:111567 PRKCE    BioGRID  PubMed Biochemical Activity 
    BioGRID:111567 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111567 BioGRID:117315 RASGRP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:111567 BioGRID:106788 SLC25A4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111567 BioGRID:112649 STAT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111567 BioGRID:112930 TIAM1    BioGRID  PubMed Biochemical Activity 
    BioGRID:111567 BioGRID:113259 VDAC1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:111567 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CDC42 signaling events, organism-specific biosystem
      CDC42 signaling events
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • DAG and IP3 signaling, organism-specific biosystem (from REACTOME)
      DAG and IP3 signaling, organism-specific biosystemThis pathway describes the generation of DAG and IP3 by the PLCgamma-mediated hydrolysis of PIP2 and the subsequent downstream signaling events.
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      Downstream signaling in naive CD8+ T cells, organism-specific biosystem
      Downstream signaling in naive CD8+ T cells
    • Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • EGFR interacts with phospholipase C-gamma, organism-specific biosystem (from REACTOME)
      EGFR interacts with phospholipase C-gamma, organism-specific biosystemActivated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosp...
    • Effects of PIP2 hydrolysis, organism-specific biosystem (from REACTOME)
      Effects of PIP2 hydrolysis, organism-specific biosystemHydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into th...
    • Endothelins, organism-specific biosystem (from Pathway Interaction Database)
      Endothelins, organism-specific biosystem
      Endothelins
    • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
      Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
      Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
      G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • G alpha (z) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (z) signalling events, organism-specific biosystemThe heterotrimeric G protein Gz, is a member of the Gi family. Unlike other Gi family members it lacks an ADP ribosylation site cysteine four residues from the carboxyl terminus and is thus pertussis...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hypothetical Network for Drug Addiction, organism-specific biosystem (from WikiPathways)
      Hypothetical Network for Drug Addiction, organism-specific biosystemAdapted from figure 2 in [http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0040002 Li et al.].
    • IL2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL2-mediated signaling events, organism-specific biosystem
      IL2-mediated signaling events
    • LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
      LPA receptor mediated events, organism-specific biosystem
      LPA receptor mediated events
    • LPA4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      LPA4-mediated signaling events, organism-specific biosystem
      LPA4-mediated signaling events
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • PLC-gamma1 signalling, organism-specific biosystem (from REACTOME)
      PLC-gamma1 signalling, organism-specific biosystemThe activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosph...
    • PLCG1 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      PLCG1 events in ERBB2 signaling, organism-specific biosystemActivation of PLCG1 signaling is observed only in the presence of ERBB2:EGFR heterodimers, with PLCG1 binding to phosphorylated tyrosine Y992 and Y1173 in the C-tail of EGFR (Chattopadhyay et al. 199...
    • Phospholipase C-mediated cascade, organism-specific biosystem (from REACTOME)
      Phospholipase C-mediated cascade, organism-specific biosystemPhospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 dom...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
      Role of Calcineurin-dependent NFAT signaling in lymphocytes
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells
    • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Thromboxane A2 receptor signaling, organism-specific biosystem
      Thromboxane A2 receptor signaling
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, conserved biosystem (from KEGG)
      Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    actin monomer binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    calcium-independent protein kinase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enzyme activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ethanol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase C activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transducer activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    TRAM-dependent toll-like receptor 4 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    activation of phospholipase C activity TAS
    Traceable Author Statement
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    induction of apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    lipopolysaccharide-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    locomotory exploration behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    macrophage activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    platelet activation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of I-kappaB kinase/NF-kappaB cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of cell cycle cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of fibroblast migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of mucus secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to morphine IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell periphery ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    protein kinase C epsilon type
    Names
    protein kinase C epsilon type
    NP_005391.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005400.2 → NP_005391.1  protein kinase C epsilon type

      Status: REVIEWED

      Source sequence(s)
      AL832345, BC054052, CA424727, X65293
      Consensus CDS
      CCDS1824.1
      UniProtKB/Swiss-Prot
      Q02156
      Related
      ENSP00000306124, OTTHUMP00000159032, ENST00000306156, OTTHUMT00000250751
      Conserved Domains (4) summary
      cd00029
      Location:243 – 292
      Blast Score: 166
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05591
      Location:412 – 732
      Blast Score: 1719
      STKc_nPKC_epsilon; Catalytic domain of the Protein Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      cd04014
      Location:3 – 135
      Blast Score: 628
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      smart00220
      Location:408 – 668
      Blast Score: 778
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      45879043..46415129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      45617217..46153158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC017006.4 AAX93253.1
    genomic AC017078.8 AAY14773.1
    genomic AC079892.4 AAX93119.1
    genomic AC092600.2 None
    genomic AC115109.2 None
    genomic CH471053.2 EAX00257.1
      EAX00258.1
      EAX00259.1
    genomic EU332867.1 ABY87556.1
    genomic U51244.1 AAD08855.1
    mRNA AK128749.1 None
    mRNA AK313842.1 BAG36574.1
    mRNA AL832345.1 None
    mRNA BC051195.1 None
    mRNA BC054052.1 None
    mRNA BC109033.2 AAI09034.1
    mRNA BC109034.2 AAI09035.1
    mRNA CA424727.1 None
    mRNA X65293.1 CAA46388.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02156.1 GenPept UniProtKB/Swiss-Prot:Q02156
    Q53RT0 GenPept UniProtKB/TrEMBL:Q53RT0
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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