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    BCL2L1 BCL2-like 1 [ Homo sapiens ]

    Gene ID: 598, updated on 13-May-2012
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    Summary

    Official Symbol
    BCL2L1provided by HGNC
    Official Full Name
    BCL2-like 1provided by HGNC
    Primary source
    HGNC:992
    Locus tag
    RP5-857M17.3
    See related
    Ensembl:ENSG00000171552; HPRD:02497; MIM:600039; Vega:OTTHUMG00000032192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; PPP1R52; BCL-XL/S; DKFZp781P2092
    Summary
    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    20q11.21
    Sequence :
    Chromosome: 20; NC_000020.10 (30252261..30310656, complement)
    See BCL2L1 in Epigenomics, MapViewer

    Chromosome 20 - NC_000020.10Genomic Context describing neighboring genes Neighboring gene microRNA 3193 Neighboring gene cytochrome c oxidase subunit IV isoform 2 (lung) Neighboring gene TPX2, microtubule-associated, homolog (Xenopus laevis) Neighboring gene myosin light chain kinase 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Developing and activated T cell survival depends on differential signaling pathways to regulate anti-apoptotic Bcl-x(L). Wang R, et al. Clin Dev Immunol, 2012. PMID 22235227.
    2. Directed evolution of mammalian anti-apoptosis proteins by somatic hypermutation. Majors BS, et al. Protein Eng Des Sel, 2012 Jan. PMID 22160868.
    3. TCERG1 regulates alternative splicing of the Bcl-x gene by modulating the rate of RNA polymerase II transcription. Montes M, et al. Mol Cell Biol, 2012 Feb. PMID 22158966.
    4. Extracellular recombinant annexin II confers UVC-radiation resistance and increases the Bcl-xL to Bax protein ratios in human UVC-radiation-sensitive cells. Kita K, et al. Radiat Res, 2011 Dec. PMID 22141411.
    5. Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: in vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737. Ishitsuka K, et al. Cancer Lett, 2012 Apr 28. PMID 22138435.

    See all (427) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data show that the engineered B cells expressing Bcl-x(L) exhibited progressively lower increases in apoptosis activation.
      Title: Directed evolution of mammalian anti-apoptosis proteins by somatic hypermutation.
    2. Studies indicate that Bcl-x(L) ensures the survival of both developing and peripheral T cells, which is essential for a functional immune system.
      Title: Developing and activated T cell survival depends on differential signaling pathways to regulate anti-apoptotic Bcl-x(L).
    3. Nuclear clusterin sequesters Bcl-XL via a putative motif in the C-terminal coiled coil (CC2) domain, releasing Bax and promoting apoptosis.
      Title: Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain.
    4. Bcl-xL expression was confirmed as an independent prognostic factor for persistent disease in differentiated thyroid carcinomas.
      Title: Clinicopathological correlations of Bcl-xL and Bax expression in differentiated thyroid carcinoma.
    5. BclXL stimulates neurogenesis; BclXL enhances dopaminergic neuron survival, augments expression of key developmental/maintenance genes, lengthens cell cycle early during differentiation, and regulates cell proliferation. [REVIEW]
      Title: Modulation of the generation of dopaminergic neurons from human neural stem cells by Bcl-X(L): mechanisms of action.
    6. Data show that ABT-737, a small molecule inhibitor of Bcl-2, Bcl-X(L), and Bcl-w, significantly induced apoptosis in HTLV-1 infected T-cell lines as well as in fresh adult T-cell leukemia/lymphoma (ATLL) cells
      Title: Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: in vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737.
    7. We propose that TCERG1 modulates the elongation rate of RNAPII to relieve pausing, thereby activating the proapoptotic Bcl-x(S) 5' splice site.
      Title: TCERG1 regulates alternative splicing of the Bcl-x gene by modulating the rate of RNA polymerase II transcription.
    8. correlation between mitochondrial transcription factor A expression and BCL2L1 expression in ovarian cancer cell lines & clinical specimens; results suggest mtTFA is prognostic factor for poor ovarian cancer outcome and may regulate genes like BCL2L1
      Title: Mitochondrial transcription factor A regulates BCL2L1 gene expression and is a prognostic factor in serous ovarian cancer.
    9. These data support a model in which Bcl-xL promotes cell survival and increases cloning efficiency of dissociated human embryonic stem cells.
      Title: Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal.
    10. The authors report here the in vitro formation of various types of aggregates by Bcl-xL, a protein of the Bcl-2 family involved in the regulation of apoptosis.
      Title: Amyloid fibrils formed by the programmed cell death regulator Bcl-xL.
    Submit: New GeneRIF Correction See all (285)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Treatment of CD4+ cells with HIV-1 gp160 causes intracellular calcium increase followed by the release of cytochrome c from mitochondria; association of BAD with Bcl-xL is observed, and a portion of BAD is dephosphorylated after gp160 induction PubMed
    Nef nef HIV-1 Nef enhances apoptosis in CD4+ human lymphoblastoid cell lines through mechanisms that include the downregulation of the anti-apoptotic proteins Bcl-2 and Bcl-XL PubMed
    nef HIV-1 Nef suppresses apoptosis of TF-1 macrophages by upregulating mitochondrial anti-apoptosis protein Bcl-XL expression; cell survival and Bcl-XL induction by Nef are dependent on the Erk/MAPK pathway, but independent of PI3K and Akt activation PubMed
    Tat tat HIV-1 Tat upregulates several anti-apoptotic genes, including AKT-1, AKT-2, BCL2, BCL-XL, and insulin-like growth factor I in vincristine-treated Kaposi's sarcoma cells PubMed
    Vpr vpr Expression of HIV-1 Vpr causes redistribution of Bcl-X protein into an organized, network-like manner to form filamentous structures PubMed
    vpr HIV-1 Vpr downregulated Bcl-X expression in transgenic mice suggesting a role in Vpr mediated apoptosis of T lymphocytes PubMed
    Vpu vpu Levels of Bcl-xL are reduced in T cells as a result of HIV-1 Vpu-mediated inhibition of NF-kappa B activation PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001182.1 NP_000385.1 CRYAA    BIND  PubMed HalphaA-crystallin interacts with Bcl-Xs. 
    NP_001182.1 NP_001876.1 CRYAB    BIND  PubMed HalphaB-crystallin interacts with Bcl-Xs. 
    NP_612815.1 NP_004313.1 BAD    BIND  PubMed Bad interacts with Bcl-XL. 
    NP_612815.1 NP_004313.1 BAD    BIND  PubMed Bad interacts with Bcl-xL. 
    NP_612815.1 BAD    BIND  PubMed Bcl-XL interacts with Bad. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bad. 
    NP_612815.1 NP_620116.1 BAX    BIND  PubMed Bax interacts with Bcl-XL via its BH3 domain. This interaction was modeled on a demonstrated interaction between mouse Bax and human Bcl-XL. 
    NP_612815.1 NP_620116.1 BAX    BIND  PubMed Bax interacts with Bcl-xL. 
    NP_612815.1 BAX    BIND  PubMed Bax interacts with Bcl-XL. 
    NP_612815.1 NP_055232.1 BBC3    BIND  PubMed Puma interacts with Bcl-XL. 
    NP_612815.1 NP_055232.1 BBC3    BIND  PubMed PUMA interacts with Bcl-xL. 
    NP_612815.1 NP_055232.1 BBC3    BIND  PubMed Bcl-XL interacts with Puma. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Puma. 
    NP_612815.1 NP_006529.1 BCL2L11    BIND  PubMed Bim interacts with Bcl-XL. 
    NP_612815.1 BCL2L11    BIND  PubMed Bcl-XL interacts with Bim. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bim. 
    NP_612815.1 NP_001187.1 BID    BIND  PubMed BCL-XL interacts with the alpha-helical region of the BID BH3 death domain. 
    NP_612815.1 NP_001187.1 BID    BIND  PubMed Bid interacts with Bcl-XL. 
    NP_612815.1 NP_001187.1 BID    BIND  PubMed Bid interacts with Bcl-xL. 
    NP_612815.1 NP_932070.1 BID    BIND  PubMed BCL-XL interacts with the alpha-helical region of the BID-EL BH3 death domain. 
    NP_612815.1 BID    BIND  PubMed Bcl-XL interacts with Bid. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bid. 
    NP_612815.1 NP_001188.1 BIK    BIND  PubMed Bik interacts with Bcl-XL. 
    NP_612815.1 NP_001188.1 BIK    BIND  PubMed Bcl-XL interacts with Bik. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bik. 
    NP_612815.1 NP_001003940.1 BMF    BIND  PubMed Bmf interacts with Bcl-XL. This interaction was modelled on a demonstrated interaction between mouse Bmf and human Bcl-XL. 
    NP_612815.1 NP_001003940.1 BMF    BIND  PubMed Bcl-XL interacts with Bmf. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bmf. 
    NP_612815.1 NP_003797.1 HRK    BIND  PubMed Hrk interacts with Bcl-XL. 
    NP_612815.1 NP_003797.1 HRK    BIND  PubMed Bcl-XL interacts with Hrk. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Hrk. 
    NP_612815.1 NP_003797.1 HRK    BIND  PubMed Hrk interacts with Bcl-XL. 
    NP_612815.1 NP_071434.2 MOAP1    BIND  PubMed MAP-1 interacts with Bcl-XL via its amino and carboxy terminal regions. 
    NP_612815.1 NP_996734.1 RTN1    BIND  PubMed NSP-C interacts with Bcl-XL. 
    NP_612815.1 NP_722550.1 RTN4    BIND  PubMed RTN-XS interacts with Bcl-XL. 
    NP_612815.1 NP_000537.2 TP53    BIND  PubMed Bcl-xl interacts with p53. 
    NP_612815.1 NP_003286.1 TPT1    BIND  PubMed Bcl-xL interacts with TCTP. 
    Q07817 Q9H6X2 ANTXR1    HPRD  PubMed  
    Q07817 O14727 APAF1    HPRD  PubMed  
    Q07817 Q9NQS1 AVEN    HPRD  PubMed  
    Q07817 Q92934 BAD    HPRD  PubMed  
    Q07817 Q99933 BAG1    HPRD  PubMed  
    Q07817 Q16611 BAK1    HPRD  PubMed  
    Q07817 Q07814 BAX    HPRD  PubMed  
    Q07817 Q9BXH1 BBC3    HPRD  PubMed  
    Q07817 P51572 BCAP31    HPRD  PubMed  
    Q07817 P10415 BCL2    HPRD  PubMed  
    Q07817 Q07817 BCL2L1    HPRD  PubMed  
    Q07817 Q9HD36 BCL2L10    HPRD  PubMed  
    Q07817 O43521 BCL2L11    HPRD  PubMed  
    Q07817 Q9HB09 BCL2L12    HPRD  PubMed  
    Q07817 Q9BZR8 BCL2L14    HPRD  PubMed  
    Q07817 Q9NYF8 BCLAF1    HPRD  PubMed  
    Q07817 Q14457 BECN1    HPRD  PubMed  
    Q07817 P55957 BID    HPRD  PubMed  
    Q07817 Q13323 BIK    HPRD  PubMed  
    Q07817 Q96LC9 BMF    HPRD  PubMed  
    Q07817 Q12981 BNIP1    HPRD  PubMed  
    Q07817 Q12983 BNIP3    HPRD  PubMed  
    Q07817 O60238 BNIP3L    HPRD  PubMed  
    Q07817 P07384 CAPN1    HPRD  PubMed  
    Q07817 P29466 CASP1    HPRD  PubMed  
    Q07817 Q14790 CASP8    HPRD  PubMed  
    Q07817 P55211 CASP9    HPRD  PubMed  
    Q07817 O15519 CFLAR    HPRD  PubMed  
    Q07817 P02489 CRYAA    HPRD  PubMed  
    Q07817 P02511 CRYAB    HPRD  PubMed  
    Q07817 P99999 CYCS    HPRD  PubMed  
    Q07817 Q14318 FKBP8    HPRD  PubMed  
    Q07817 O00198 HRK    HPRD  PubMed  
    Q07817 Q9UKT9 IKZF3    HPRD  PubMed  
    Q07817 P35568 IRS1    HPRD  PubMed  
    Q07817 Q9Y4H2 IRS2    HPRD  PubMed  
    Q07817 P45983 MAPK8    HPRD  PubMed  
    Q07817 Q07820 MCL1    HPRD  PubMed  
    Q07817 Q96BY2 MOAP1    HPRD  PubMed  
    Q07817 Q9C000 NLRP1    HPRD  PubMed  
    Q07817 Q13794 PMAIP1    HPRD  PubMed  
    Q07817 P62136 PPP1CA    HPRD  PubMed  
    Q07817 P49768 PSEN1    HPRD  PubMed  
    Q07817 P49810 PSEN2    HPRD  PubMed  
    Q07817 Q99638 RAD9A    HPRD  PubMed  
    Q07817 Q16799 RTN1    HPRD  PubMed  
    Q07817 Q9NQC3 RTN4    HPRD  PubMed  
    Q07817 O15304 SIVA1    HPRD  PubMed  
    Q07817 P37840 SNCA    HPRD  PubMed  
    Q07817 SPINL SPNS1    HPRD  PubMed  
    Q07817 P55061 TMBIM6    HPRD  PubMed  
    Q07817 P04637 TP53    HPRD  PubMed  
    Q07817 P21796 VDAC1    HPRD  PubMed  
    BioGRID:107070 BioGRID:106575 ACTB    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:106814 APAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:121366 AVEN    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107070 BioGRID:107048 BAD    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:107070 BioGRID:107054 BAK1    BioGRID  PubMed Affinity Capture-Western; FRET; Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:107070 BioGRID:107057 BAX    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:107070 BioGRID:118009 BBC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:115437 BCAP31    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107070 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western; Protein-peptide 
    BioGRID:107070 BioGRID:115335 BCL2L11    BioGRID  PubMed Affinity Capture-Western; FRET; Two-hybrid 
    BioGRID:107070 BioGRID:122658 BCL2L14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:114226 BECN1    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:107106 BID    BioGRID  PubMed Protein-peptide 
    BioGRID:107070 BioGRID:107107 BIK    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Two-hybrid 
    BioGRID:107070 BioGRID:136097 BLID    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107070 BioGRID:107109 BLK    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107070 BioGRID:107130 BNIP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107070 BioGRID:107132 BNIP3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107070 BioGRID:127211 BNIPL    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107070 BioGRID:198352 Bcl2l11    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Two-hybrid 
    BioGRID:107070 BioGRID:117548 C10orf137    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:107285 CASP2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:107070 BioGRID:107291 CASP8    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:107070 BioGRID:107292 CASP9    BioGRID  PubMed Affinity Capture-Western 
    NP_003870.3 CFLAR    BIND  PubMed MRIT-alpha-1 interacts with BclXL. This interaction was modelled on a demonstrated interaction between human MRIT-alpha-1 and BclXL from an unspecified species. 
    BioGRID:107070 BioGRID:114364 CFLAR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:119922 CYCS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:124527 DOCK7    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:114206 DYNLL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:108497 FBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:117270 FKBP8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:119237 GLOD4    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:114276 HRK    BioGRID  PubMed Affinity Capture-Western; FRET; Two-hybrid 
    BioGRID:107070 BioGRID:116484 IKZF3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107070 BioGRID:109874 IRS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:115156 KEAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:116947 LARP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:110338 MCL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:125870 METTL23    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:122069 MOAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:116446 PARK7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107070 BioGRID:114966 PDIA4    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:128154 PGAM5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:117173 PLD3    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:111379 PMAIP1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide 
    BioGRID:107070 BioGRID:119596 PPHLN1    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:111493 PPP1CA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107070 BioGRID:111642 PSEN1    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:111643 PSEN2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107070 BioGRID:111731 PTN    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:111820 RAD9A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107070 BioGRID:111831 RAF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107070 BioGRID:115480 RBM5    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:112165 RTN1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107070 BioGRID:121400 RTN4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107070 BioGRID:123836 SPNS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107070 BioGRID:112943 TLE1    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:113010 TP53    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:113012 TP53BP2    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107070 BioGRID:128238 UBR1    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:125434 UHRF2    BioGRID  PubMed Far Western 
    BioGRID:107070 BioGRID:113259 VDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107070 BioGRID:119749 ZFYVE1    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:116406 ZHX1    BioGRID  PubMed Two-hybrid 
    BioGRID:107070 BioGRID:119387 ZNF219    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • EPO signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      EPO signaling pathway, organism-specific biosystem
      EPO signaling pathway
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-4 signaling Pathway, organism-specific biosystemInterleukin-4 belongs to the IL-2 family of cytokines, which includes IL-2, IL-7, IL-9, IL-15 and IL-21. It signals through 2 different receptor complexes; Receptor complex 1 comprises of IL-4 recept...
    • IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by PI3K, organism-specific biosystem
      IL2 signaling events mediated by PI3K
    • IL2 signaling events mediated by STAT5, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by STAT5, organism-specific biosystem
      IL2 signaling events mediated by STAT5
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammasomes, organism-specific biosystem (from REACTOME)
      Inflammasomes, organism-specific biosystemIn contrast to NOD1/2 some NLRPs function as large macromolecular complexes called 'Inflammasomes'. These multiprotein platforms control activation of the cysteinyl aspartate protease caspase-1 and t...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • The NLRP1 inflammasome, organism-specific biosystem (from REACTOME)
      The NLRP1 inflammasome, organism-specific biosystemNLRP1 is activated by MDP (Faustin et al. 2007). The NLRP1 inflammasome was the first to be characterized. It was described as a complex containing NALP1, ASC, caspase-1 and caspase-5 (Martinon et al...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    BH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    anti-apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptotic mitochondrial changes TAS
    Traceable Author Statement
    more info
    		 PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cellular process regulating host cell cycle in response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to alkaloid IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    germ cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle G2/M transition checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		  
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of establishment of protein localization in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    negative regulation of intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		  
    negative regulation of neuron apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of release of cytochrome c from mitochondria IC
    Inferred by Curator
    more info
    		  
    negative regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of survival gene product expression TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of anti-apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of mitochondrial membrane permeability IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of mitochondrial membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to cycloheximide IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Bcl-2 family protein complex IDA
    Inferred from Direct Assay
    more info
    		  
    centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial outer membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    mitochondrial part IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    bcl-2-like protein 1
    Names
    bcl-2-like protein 1
    apoptosis regulator Bcl-X
    protein phosphatase 1, regulatory subunit 52
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029002.1 RefSeqGene

      Range
      5001..63396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001191.2 → NP_001182.1  bcl-2-like protein 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is also known as bcl-xS or bcl-x beta. It lacks an exon within the coding region when compared to variant 1. The translation remains in-frame, and results in a shorter isoform (2) that lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      Z23116
      Consensus CDS
      CCDS13188.1
      UniProtKB/Swiss-Prot
      Q07817
      UniProtKB/TrEMBL
      Q5TE63
      Related
      ENSP00000365223, OTTHUMP00000030551, ENST00000376055, OTTHUMT00000078573
      Conserved Domains (3) summary
      cl02540
      Location:1 – 27
      Blast Score: 132
      BH4; Bcl-2 homology region 4
      TIGR00865
      Location:126 – 170
      Blast Score: 135
      bcl-2; apoptosis regulator
      cl02575
      Location:81 – 125
      Blast Score: 133
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

    2. NM_138578.1 → NP_612815.1  bcl-2-like protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is also known as bcl-xL. It encodes a longer isoform (1).
      Source sequence(s)
      BC019307
      Consensus CDS
      CCDS13189.1
      UniProtKB/Swiss-Prot
      Q07817
      Related
      ENSP00000302564, OTTHUMP00000030553, ENST00000307677, OTTHUMT00000078575
      Conserved Domains (3) summary
      cd06845
      Location:81 – 194
      Blast Score: 409
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      cl02540
      Location:1 – 27
      Blast Score: 130
      BH4; Bcl-2 homology region 4
      TIGR00865
      Location:1 – 233
      Blast Score: 833
      bcl-2; apoptosis regulator

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000020.10 Reference GRCh37.p5 Primary Assembly

      Range
      30252261..30310656, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000152.1 Alternate HuRef

      Range
      27040965..27099720, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL117381.32 CAI23025.1
      CAI23026.1
      CAI23027.1
    genomic AL160175.5 CAC10003.1
      CAI12811.1
      CAI12812.1
      CAI12813.1
      CAI12814.1
      CAI12815.1
    genomic CH471077.2 EAW76424.1
      EAW76425.1
      EAW76426.1
      EAW76427.1
      EAW76428.1
      EAW76429.1
    genomic FB721215.1 CAT03369.1
    genomic FB725892.1 CAT03400.1
    genomic HI574024.1 CBX47501.1
    genomic HI574026.1 CBX47502.1
    genomic U72398.1 AAB17354.1
    mRNA AK290968.1 BAF83657.1
    mRNA AY263335.1 AAP22027.1
    mRNA AY263336.1 AAP22028.1
    mRNA AY263337.1 AAP22029.1
    mRNA BC019307.1 AAH19307.1
    mRNA BT007208.1 AAP35872.1
    mRNA BX647525.1 None
    mRNA CR936637.1 CAI56777.1
    mRNA Z23115.1 CAA80661.1
    mRNA Z23116.1 CAA80662.1
    other-genetic DQ893461.2 ABM84387.1
    other-genetic DQ896311.2 ABM87310.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07817.1 GenPept UniProtKB/Swiss-Prot:Q07817
    Q5QP56 GenPept UniProtKB/TrEMBL:Q5QP56
    Q5QP59 GenPept UniProtKB/TrEMBL:Q5QP59
    Q5TE63 GenPept UniProtKB/TrEMBL:Q5TE63
    Q5TE64 GenPept UniProtKB/TrEMBL:Q5TE64
    Q9H1R6 GenPept UniProtKB/TrEMBL:Q9H1R6
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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