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    HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) [ Homo sapiens ]

    Gene ID: 3187, updated on 11-May-2012
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    Summary

    Official Symbol
    HNRNPH1provided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein H1 (H)provided by HGNC
    Primary source
    HGNC:5041
    See related
    Ensembl:ENSG00000169045; HPRD:03021; MIM:601035; Vega:OTTHUMG00000130908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPH; HNRPH1; hnRNPH; DKFZp686A15170
    Summary
    This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]
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    Genomic context

    Location :
    5q35.3
    Sequence :
    Chromosome: 5; NC_000005.9 (179041179..179050722, complement)
    See HNRNPH1 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 60 pseudogene Neighboring gene RUN and FYVE domain containing 1 Neighboring gene peroxiredoxin 2 pseudogene Neighboring gene chromosome 5 open reading frame 60 pseudogene Neighboring gene chromosome 5 open reading frame 60

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. Identification of ubiquitinated proteins from human multiple myeloma U266 cells by proteomics. Jia H, et al. Biomed Environ Sci, 2011 Aug. PMID 22108332.
    3. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    4. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    5. Proteomic dissection of the von Hippel-Lindau (VHL) interactome. Lai Y, et al. J Proteome Res, 2011 Nov 4. PMID 21942715.

    See all (70) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. hnRNPH activity appears to be involved in the pathogenesis and progression of malignant gliomas as the centre of a splicing oncogenic switch
      Title: Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas.
    2. spatial interactions of hnRNPH1, NF45, and C14orf166 with HCVc174 likely modulate HCV or cellular functions during acute and chronic HCV infection
      Title: Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein.
    3. Insight on the crucial role of hnRNP H1 in the regulation of the alternative splicing of the rpL3 gene.
      Title: Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP.
    4. Nuclear heterogeneous nuclear ribonucleo-protein H expression was related to survival in colorectal cancer.
      Title: The expression profile of RNA-binding proteins in primary and metastatic colorectal cancer: relationship of heterogeneous nuclear ribonucleoproteins with prognosis.
    5. altered function of hnRNP H1/H2 in tumor cells is a novel determinant of aberrant thymidine phosphorylase splicing thereby resulting in acquired chemoresistance to TP-activated fluoropyrimidine anticancer drugs.
      Title: Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance.
    6. the G-stretches within exon 9B regulate RAGE alternative splicing via interaction with hnRNP H
      Title: Regulation of alternative splicing of the receptor for advanced glycation endproducts (RAGE) through G-rich cis-elements and heterogenous nuclear ribonucleoprotein H.
    7. working model in which rpL3 recruits hnRNP H1 and, through cooperation with other splicing factors, promotes selection of the alternative splice site
      Title: hnRNP H1 and intronic G runs in the splicing control of the human rpL3 gene.
    8. Results suggest that hnRNP H and F are nuclear shuttling proteins whose posttranslational modifications may alter interaction with transportin 1, nuclear localization, and hence function.
      Title: A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1.
    9. A-Raf prevents cancer cell apoptosis contingent on the expression of the heterogeneous nuclear ribonucleoprotein H (hnRNP H) splice factor, which is required for the correct transcription and expression of a-raf.
      Title: Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription.
    10. Interactions between different hnRNP proteins bound to distinct locations on a pre-mRNA can change its conformation to affect splicing decisions.
      Title: hnRNP A1 and hnRNP H can collaborate to modulate 5' splice site selection.
    Submit: New GeneRIF Correction See all (12)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P31943 Q14194 CRMP1    HPRD  PubMed  
    P31943 P52597 HNRNPF    HPRD  PubMed  
    P31943 Q09161 NCBP1    HPRD  PubMed  
    P31943 P52298 NCBP2    HPRD  PubMed  
    P31943 Q92597 NDRG1    HPRD  PubMed  
    P31943 Q8WXA9 SREK1    HPRD  PubMed  
    P31943 Q6EEV6 SUMO4    HPRD  PubMed  
    P31943 O14776 TCERG1    HPRD  PubMed  
    P31943 O75674 TOM1L1    HPRD  PubMed  
    P31943 P61981 YWHAG    HPRD  PubMed  
    BioGRID:109428 BioGRID:106819 APBB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:115826 CCT4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:116603 CCT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:114418 CPNE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:107790 CRMP1    BioGRID  PubMed Two-hybrid 
    BioGRID:109428 BioGRID:198534 Cbx1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:115776 DDX17    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:108021 DDX5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:119986 DGCR8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:116452 GPN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:109420 HNRNPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:109425 HNRNPD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:109426 HNRNPF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109428 BioGRID:109429 HNRNPH2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:109431 HNRNPK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:110751 HNRNPM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:109433 HNRNPU    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:109561 HSPD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:208484 Hnrnph1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:128436 KHDRBS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:114139 KHSRP    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109428 BioGRID:110036 KPNA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:125363 MYSM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:110766 NCBP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109428 BioGRID:116578 NCBP2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109428 BioGRID:115669 NDRG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:114573 RQCD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:115755 SYNCRIP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:116120 TCERG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:115895 YKT6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:119543 YTHDF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:116303 ZWINT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109428 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    poly(U) RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    RNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    RNA splicing TAS
    Traceable Author Statement
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    nuclear mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    nuclear mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		  
    regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    heterogeneous nuclear ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein H
    Names
    heterogeneous nuclear ribonucleoprotein H
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257293.1 → NP_001244222.1  heterogeneous nuclear ribonucleoprotein H

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC001348, BQ028714, DA204744
      UniProtKB/Swiss-Prot
      P31943
      Conserved Domains (2) summary
      cd00590
      Location:113 – 185
      Blast Score: 146
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam08080
      Location:255 – 290
      Blast Score: 195
      zf-RNPHF; RNPHF zinc finger

    2. NM_005520.2 → NP_005511.1  heterogeneous nuclear ribonucleoprotein H

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK124530, BC001348, DA603645
      Consensus CDS
      CCDS4446.1
      UniProtKB/Swiss-Prot
      P31943
      Related
      ENSP00000397797, OTTHUMP00000223418, ENST00000442819, OTTHUMT00000372279
      Conserved Domains (2) summary
      cd00590
      Location:113 – 185
      Blast Score: 146
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam08080
      Location:255 – 290
      Blast Score: 195
      zf-RNPHF; RNPHF zinc finger

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      179041179..179050722, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      173768106..173777652, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC136604.2 (58688..68178) None
    genomic CH471165.2 EAW53807.1
      EAW53808.1
      EAW53809.1
    mRNA AK092273.1 None
    mRNA AK124530.1 BAG54048.1
    mRNA AK298193.1 BAG60463.1
    mRNA AK307693.1 None
    mRNA AK311021.1 None
    mRNA BC001348.2 AAH01348.1
    mRNA BQ028714.1 None
    mRNA BX647205.1 None
    mRNA CR456778.1 CAG33059.1
    mRNA CR749414.1 CAH18256.1
    mRNA DA204744.1 None
    mRNA DA603645.1 None
    mRNA L22009.1 AAA91346.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31943.4 GenPept UniProtKB/Swiss-Prot:P31943
    Q68DG4 GenPept UniProtKB/TrEMBL:Q68DG4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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