IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [Homo sapiens (human)] - Gene

Summary

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Official Symbol: IL12Bprovided by HGNC
Official Full Name: interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)provided by HGNC
Primary source: HGNC:5970
See related: Ensembl:ENSG00000113302; HPRD:01194; MIM:161561; Vega:OTTHUMG00000130307
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CLMF; NKSF; CLMF2; NKSF2; IL-12B
Summary: This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 5q31.1-q33.1

Sequence :: Chromosome: 5; NC_000005.9 (158741791..158757481, complement)

See IL12B in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The IL-8 -251T/A and IL-12B 1188A/C polymorphisms may be relevant host susceptibility factors for the development of gout.
Title: IL-8 -251T/A and IL-12B 1188A/C polymorphisms are associated with gout in a Chinese male population.
The dual commitment of IRF3 and IRF5 in the regulation of the Il12b enhancer and promoter is unique and may have implications for understanding the evolution of this gene.
Title: Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5.
Silencing the SOCS1 and IL12 genes enhances dendritic cell-mediated anti-laryngocarcinoma immunity.
Title: [Silencing of SOCS1 and IL-12 gene cotransferred by adenoviral enhances DC-mediated anti-laryngocarcinoma immunity in vitro].
IL12B SNPs and copy number variation in IL23R gene associated with susceptibility to leprosy.
Title: IL12B SNPs and copy number variation in IL23R gene associated with susceptibility to leprosy.
The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.
Title: The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.
Autoimmune diseases appear to cluster in two groups that either show strong associations with the Th1/Th17 pathway (IL12B and IL23R) or the Th1/IL-35 pathway ( polymorphisms in the IL12A gene region). Review
Title: Genetic variations in interleukin-12 related genes in immune-mediated diseases.
IL-12p40 deficiency has high but incomplete penetrance, with 33.3% of genetically affected relatives of index cases showing no symptoms of mendelian susceptibility to mycobacterial disease. However, prognosis is poor, with mortality rates of up to 28.6%.
Title: Inherited IL-12p40 deficiency: genetic, immunologic, and clinical features of 49 patients from 30 kindreds.
Genotyped IL12A and IL12B polymorphisms in four hundred-five patients with cervical cancer and four hundred fifty unrelated Showed that the IL12B polymorphism may be a genetic risk factor for cervical cancer.
Title: Contribution of IL12A and IL12B polymorphisms to the risk of cervical cancer.
This is the first study to provide an evidence for the association of IL-12beta (1188A/C) gene polymorphism with the risk of cervical cancer.
Title: Interleukin-12 gene polymorphism and cervical cancer risk.
There is a strong association between rs6887595 (IL12B) and psoriatic arthritis.
Title: Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritis.

Submit: New GeneRIF Correction See all (207)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Disseminated atypical mycobacterial infection

MIM: 209950

Genetic Testing Registry

NHGRI GWAS Catalog

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Env, gp160, envelope glycoprotein	env	Chimeric HIV-1 gp140 - CD40L trimers can target and activate dendritic cells to release IL-6, IL-10 and IL-12	PubMed
	env	IL-7 and IL-12 significantly augment proliferative responses to HIV-1 gp160	PubMed
Envelope surface glycoprotein gp120	env	HIV-1 gp120 inhibits early and late production of interleukin (IL)-12 by peripheral blood mononuclear cells (PBMC)	PubMed
	env	Secretion of IL-12 is found in macrophages primed with gamma interferon (IFN-gamma) and subsequently treated with gp120	PubMed
	env	Apoptosis of CD4+ lymphocytes induced by HIV-1 gp120 cross-linking to CD4 is inhibited by IL-12	PubMed
	env	HIV-gp120 induces a significant IL-10 synthesis, which in turn inhibits IL-12 subunits mRNA accumulation and protein secretion after Staphylococcus aureus strain cowan I (SAC)-activation	PubMed
Nef, p27	nef	IL-12 and GM-CSF increase the magnitude of the specific immune response with higher breadth by targeting HIV-1 Nef peptides (amino acids 9-23, 11-26, 140-155, 179-193, and 181-195)	PubMed
	nef	HIV-1 Nef upregulates IL-12 release in immature human and macaque dendritic cells	PubMed
	nef	IL-1beta, IL-12, and IL-15 are factors involved in the upregulation of IFN-gamma expression in coculture between Nef-pulsed iDCs and NK cells	PubMed
Tat, p14	tat	Wild-type Tat but not Cys-22 and oxidized Tat induces CD1A-expressing monocyte-derived dendritic cells (MDDC) maturation and increases the production of cytokines TNF-alpha, IL-12, MIP-1alpha, and MIP-1beta	PubMed
	tat	HIV-1 Tat upregulates IL-12 expression in Jurkat T-cells, Raji B-cells, and monocyte-derived dendritic cells	PubMed
	tat	HIV-1 Tat downregulates IL-12 production by human dendritic cells by blocking extracellular calcium influx	PubMed
	tat	HIV-1 Tat downregulates IL-12 production by human peripheral blood mononuclear cells (PBMCs)	PubMed
matrix	gag	HIV-1 Matrix upregulates levels of IL-2, IL-12 and IL-15 in natural killer cells and induces natural killer cell proliferation	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_002178.2	NP_002178.2	IL12B	BIND	PubMed	p40 interacts with p40 and forms a homodimer.
NP_002178.2			BIND	PubMed	p40 interacts with IL12R.
P29460	P29459	IL12A	HPRD	PubMed
P29460	P29460	IL12B	HPRD	PubMed
P29460	P42701	IL12RB1	HPRD	PubMed
P29460	Q99665	IL12RB2	HPRD	PubMed
BioGRID:109807	BioGRID:109806	IL12A	BioGRID	PubMed	Co-crystal Structure
BioGRID:109807	BioGRID:119611	IL23A	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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African trypanosomiasis, organism-specific biosystem (from KEGG)
African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
African trypanosomiasis, conserved biosystem (from KEGG)
African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
Allograft rejection, organism-specific biosystem (from KEGG)
Allograft rejection, organism-specific biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
Allograft rejection, conserved biosystem (from KEGG)
Allograft rejection, conserved biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
Amoebiasis, organism-specific biosystem (from KEGG)
Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Amoebiasis, conserved biosystem (from KEGG)
Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokines and Inflammatory Response, organism-specific biosystem (from WikiPathways)
Cytokines and Inflammatory Response, organism-specific biosystemInflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an imp...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL12-mediated signaling events, organism-specific biosystem
IL12-mediated signaling events
IL23-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL23-mediated signaling events, organism-specific biosystem
IL23-mediated signaling events
IL27-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL27-mediated signaling events, organism-specific biosystem
IL27-mediated signaling events
Influenza A, organism-specific biosystem (from KEGG)
Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Influenza A, conserved biosystem (from KEGG)
Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Legionellosis, organism-specific biosystem (from KEGG)
Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
Legionellosis, conserved biosystem (from KEGG)
Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
Leishmaniasis, organism-specific biosystem (from KEGG)
Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
Leishmaniasis, conserved biosystem (from KEGG)
Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
Measles, organism-specific biosystem (from KEGG)
Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Measles, conserved biosystem (from KEGG)
Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Pertussis, organism-specific biosystem (from KEGG)
Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Pertussis, conserved biosystem (from KEGG)
Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toxoplasmosis, organism-specific biosystem (from KEGG)
Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Toxoplasmosis, conserved biosystem (from KEGG)
Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Type I diabetes mellitus, organism-specific biosystem (from KEGG)
Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
Type I diabetes mellitus, conserved biosystem (from KEGG)
Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...

General gene information

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Markers

G10637 (e-PCR)
- UniSTS:60436

SGC35786 (e-PCR)
- UniSTS:51991

NoName (e-PCR)
- UniSTS:480804

RH17728 (e-PCR)
- UniSTS:24645

NoName (e-PCR)
- UniSTS:481890

IL12B_146 (e-PCR)
- UniSTS:277362

D5S1480 (e-PCR), detects polymorphism
- UniSTS:80294

PMC321570P1 (e-PCR)
- UniSTS:273112

Homology

Homologs of the IL12B gene: The IL12B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to cytokine activity	IDA Inferred from Direct Assay more info	PubMed
cytokine receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to growth factor activity	IDA Inferred from Direct Assay more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
interleukin-12 alpha subunit binding	IEA Inferred from Electronic Annotation more info
interleukin-12 receptor binding	TAS Traceable Author Statement more info	PubMed
contributes_to interleukin-12 receptor binding	TAS Traceable Author Statement more info	PubMed
contributes_to interleukin-23 receptor binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
T-helper 1 type immune response	TAS Traceable Author Statement more info	PubMed
T-helper cell differentiation	IDA Inferred from Direct Assay more info	PubMed
cell cycle arrest	IDA Inferred from Direct Assay more info	PubMed
cell migration	IDA Inferred from Direct Assay more info	PubMed
cellular response to interferon-gamma	IEA Inferred from Electronic Annotation more info
cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
defense response to protozoan	IEA Inferred from Electronic Annotation more info
defense response to virus	IEA Inferred from Electronic Annotation more info
interferon-gamma biosynthetic process	TAS Traceable Author Statement more info	PubMed
natural killer cell activation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of growth of symbiont in host	IEA Inferred from Electronic Annotation more info
negative regulation of inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of interleukin-17 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of NF-kappaB import into nucleus	TAS Traceable Author Statement more info
positive regulation of NK T cell activation	IC Inferred by Curator more info
positive regulation of NK T cell activation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of NK T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T-helper 1 type immune response	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T-helper 1 type immune response	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T-helper 17 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T-helper 17 type immune response	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of activation of JAK2 kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
positive regulation of defense response to virus by host	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of granulocyte macrophage colony-stimulating factor production	IDA Inferred from Direct Assay more info
positive regulation of inflammatory response	IC Inferred by Curator more info	PubMed
positive regulation of interferon-gamma biosynthetic process	TAS Traceable Author Statement more info	PubMed
positive regulation of interferon-gamma production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-10 production	TAS Traceable Author Statement more info	PubMed
positive regulation of interleukin-12 production	IDA Inferred from Direct Assay more info
positive regulation of interleukin-17 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of lymphocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of memory T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of natural killer cell activation	IC Inferred by Curator more info
positive regulation of natural killer cell activation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA Inferred from Direct Assay more info	PubMed
positive regulation of natural killer cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of smooth muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of tissue remodeling	IC Inferred by Curator more info	PubMed
positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of tyrosine phosphorylation of Stat3 protein	IDA Inferred from Direct Assay more info	PubMed
positive regulation of tyrosine phosphorylation of Stat4 protein	IDA Inferred from Direct Assay more info	PubMed
positive regulation of tyrosine phosphorylation of Stat5 protein	IDA Inferred from Direct Assay more info	PubMed
regulation of cytokine biosynthetic process	TAS Traceable Author Statement more info	PubMed
regulation of tyrosine phosphorylation of Stat1 protein	IDA Inferred from Direct Assay more info	PubMed
response to UV-B	IDA Inferred from Direct Assay more info	PubMed
sexual reproduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
extracellular space	TAS Traceable Author Statement more info	PubMed
interleukin-12 complex	IDA Inferred from Direct Assay more info	PubMed
interleukin-23 complex	IDA Inferred from Direct Assay more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-12 subunit beta

Names: interleukin-12 subunit beta; CLMF p40; IL-12 subunit p40; IL12, subunit p40; interleukin 12, p40; interleukin-12 beta chain; NK cell stimulatory factor chain 2; cytotoxic lymphocyte maturation factor 40 kDa subunit; natural killer cell stimulatory factor, 40 kD subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009618.1 RefSeqGene

Range

5001..20691

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_71

mRNA and Protein(s)

NM_002187.2 → NP_002178.2 interleukin-12 subunit beta precursor

Status: REVIEWED

Source sequence(s)

AC011418, M65272, M65290

Consensus CDS

CCDS4346.1

UniProtKB/Swiss-Prot

P29460

Related

ENSP00000231228, OTTHUMP00000160820, ENST00000231228, OTTHUMT00000252652

Conserved Domains (2) summary

pfam10420
Location:125 – 217
Blast Score: 287

IL12p40_C; Cytokine interleukin-12p40 C-terminus

smart00408
Location:42 – 90
Blast Score: 106

IGc2; Immunoglobulin C-2 Type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p10 Primary Assembly

Range

158741791..158757481, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

153836180..153851870, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018916.1 Alternate CHM1_1.0

Range

158969635..158985325, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01044239.1 (2916..18606)	None
genomic	AC011418.5 (13146..28836)	None
genomic	AF512686.1	AAM34792.1
genomic	AMYH01015756.1 (262951..278641)	None
genomic	AY008847.1	AAG32620.1
genomic	AY064126.1	None
genomic	CH471062.2	EAW61576.1
genomic	JA104591.1	CCA63965.1
genomic	U89323.1	None
mRNA	AF180563.1	AAD56386.1
mRNA	AY046592.1	AAL05890.1
mRNA	AY046593.1	AAL05891.1
mRNA	BC067498.1	AAH67498.1
mRNA	BC067499.1	AAH67499.1
mRNA	BC067500.1	AAH67500.1
mRNA	BC067501.1	AAH67501.1
mRNA	BC067502.1	AAH67502.1
mRNA	BC074723.2	AAH74723.1
mRNA	EF173865.1	ABM53138.1
mRNA	M65272.1	AAA35695.1
mRNA	M65290.1	AAA59938.1
other-genetic	HQ447568.1	ADQ32054.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P29460.1	GenPept	UniProtKB/Swiss-Prot:P29460

Additional links

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Additional Links

Epigenomics
MIM 161561
IL12Bbase: Mutation registry for Interleukin-12 (IL-12) p40 deficiency IL12Bbase/
IL12B homepage - Mendelian genes IL12B
Resource of Asian Primary Immunodeficiency Diseases (RAPID) AGID_79
UCSC UCSC
Asthma Gene Database Asthma Gene Database
UniGene Hs.674