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    CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) [ Homo sapiens ]

    Gene ID: 1026, updated on 20-May-2012
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    Summary

    Official Symbol
    CDKN1Aprovided by HGNC
    Official Full Name
    cyclin-dependent kinase inhibitor 1A (p21, Cip1)provided by HGNC
    Primary source
    HGNC:1784
    See related
    Ensembl:ENSG00000124762; HPRD:00298; MIM:116899; Vega:OTTHUMG00000014603
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1
    Summary
    This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]
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    Genomic context

    Location :
    6p21.2
    Sequence :
    Chromosome: 6; NC_000006.11 (36644237..36655116)
    See CDKN1A in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene microRNA 3925 Neighboring gene leucine aminopeptidase 3 pseudogene 2 Neighboring gene RAB44, member RAS oncogene family Neighboring gene RAB44, member RAS oncogene family

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. Masgras I, et al. J Biol Chem, 2012 Mar 23. PMID 22311974.
    2. Activation of p53-p21 is closely associated with the acquisition of resistance to apoptosis caused by β1-integrin silencing in head and neck cancer cells. Kim MR, et al. Biochem Biophys Res Commun, 2012 Feb 10. PMID 22266309.
    3. Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin II induced premature senescence. Jiao S, et al. Can J Physiol Pharmacol, 2012 Jan. PMID 22217266.
    4. Radiation sensitivity of esophageal adenocarcinoma: the contribution of the RNA-binding protein RNPC1 and p21-mediated cell cycle arrest to radioresistance. Hötte GJ, et al. Radiat Res, 2012 Mar. PMID 22214381.
    5. Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells. Douville JM, et al. PLoS One, 2011. PMID 22206000.

    See all (945) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the balance between cancer cell death and arrest after p21 up-regulation depends on the specific effects of p21-induced ROS on the mitochondria.
      Title: Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21.
    2. results indicate that STAT1 is implicated in the mediation of Ang II-induced HMC senescence through p53/ p21Cip1 pathway.
      Title: Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin II induced premature senescence.
    3. Our results suggest a role for variant p21 alt-a in hypoxia and for variant p21B in acute myocardial ischemia
      Title: Stress-specific responses of p21 expression: implication of transcript variant p21 alt-a in long-term hypoxia.
    4. Retinoid X receptor antagonist HX531 exerts anti-obesity/anti-diabetes properties by up-regulating the p53-p21 pathway, resulting in G0/G1 cell cycle arrest and the inhibition of cellular hypertrophy of adipocytes.
      Title: RXR antagonism induces G0 /G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21(Cip1) pathway in adipocytes.
    5. RNPC1 contributes to tumor resistance to radiotherapy, which likely occurs through a p21-mediated G/G accumulation mechanism
      Title: Radiation sensitivity of esophageal adenocarcinoma: the contribution of the RNA-binding protein RNPC1 and p21-mediated cell cycle arrest to radioresistance.
    6. MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA binding independent manner.
      Title: Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.
    7. Tension force activates Ras-p38 MAPK pathways in periodontal ligament fibroblasts, which up-regulate p21 and arrest cell cycle progression at the G1 phase.
      Title: Tensile force inhibits the proliferation of human periodontal ligament fibroblasts through Ras-p38 MAPK up-regulation.
    8. Data suggest that this novel role of caspase-2 as a translational regulator of p21 expression occurs not only independently of its enzymatic activity but also does not require known caspase-2-activating platforms.
      Title: Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1).
    9. these data collectively indicate that beta1-integrin-related cell death is closely associated with EMT phenotypes and activation of the p53-p21 pathway is partly involved in the acquisition of resistance to apoptosis induced by beta1-integrin silencing.
      Title: Activation of p53-p21 is closely associated with the acquisition of resistance to apoptosis caused by β1-integrin silencing in head and neck cancer cells.
    10. Although p21 expression was not correlated with survival incorporating p21 into a multivariable Cox model did contribute to improved model quality for predicting cancer-specific survival.
      Title: Expression of p53, p21 and cyclin D1 in penile cancer: p53 predicts poor prognosis.
    Submit: New GeneRIF Correction See all (729)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.

    Several common variants modulate heart rate, PR interval and QRS duration.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces NF-kappaB activation and increases p21(cip1/waf1) and p27(kip1) protein levels in human mesangial cells PubMed
    Tat tat A p53 fusion protein with the HIV-1 Tat basic domain at its N terminus activates the expression of p21and downregulates the levels of caspase-3 and Bcl-2 PubMed
    Vpr vpr Activation of p21/Waf1/Cip1 by HIV-1 Vpr appears to be dependent upon p53 PubMed
    vpr HIV-1 Vpr activates the expression and transcription of the cyclin-dependent kinase inhibitor p21/Waf1/Cip1, an inhibitor of the G1 and G2/M phase transitions in T lymphoid and myeloid cells PubMed
    vpr Results from GST pull-down assays show the association of Vpr with p53 in extracts containing Sp1, suggesting the physical interaction of Vpr with Sp1 and p53 could modulate transcriptional activity of p21 PubMed
    vpr HIV-1 Vpr activates promoter activity of p21/Cip1/Waf1 through the GC-rich region located between nucleotides -84 and -74 in a manner that requires cooperativity of Sp1, which binds to the DNA sequence spanning -84 to -74 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AF497972.1     BIND  PubMed p53 tetramer interacts with p21 promoter. 
    NC_000006.9 NP_001632.2 APEX1    BIND  PubMed Ref1 interacts weakly with p21 promoter. 
    NC_000006.9 NP_004387.1 DDX5    BIND  PubMed p68 interacts with the p21 promoter. 
    NC_000006.9 NP_004955.2 HDAC1    BIND  PubMed HDAC1 interacts with the CDKN1A (p21) promoter. 
    NC_000006.9 NP_004765.2 MED1    BIND  PubMed MED1 interacts with p21 promoter. 
    NC_000006.9 NP_004255.2 MED21    BIND  PubMed MED21 interacts with p21 promoter. 
    NC_000006.9 MITF    BIND  PubMed An unspecified isoform of Mitf interacts with the p21 promoter. 
    NC_000006.9 NP_002458.1 MYC    BIND  PubMed c-Myc interacts with p21WAF1 promoter. 
    NC_000006.9 NP_000312.1 RB1    BIND  PubMed Rb interacts with the p21 promoter. 
    NC_000006.9 NP_003063.2 SMARCA4    BIND  PubMed BRG1 interacts with p21 promoter. 
    NC_000006.9 NP_612482.2 SP1    BIND  PubMed SP1 interacts with the CDKN1A (p21) promoter. 
    NC_000006.9 NP_000537.2 TP53    BIND  PubMed p53 interacts with p21 promoter. 
    NC_000006.9 NP_000537.2 TP53    BIND  PubMed p53 interacts with p21 promoter. 
    NC_000006.9 NP_000537.2 TP53    BIND  PubMed p53 interacts with the p21 promoter. 
    NC_000006.9 NP_000537.2 TP53    BIND  PubMed TP53 (p53) interacts with the CDKN1A (p21) promoter. 
    NC_000006.9 CAA72219.1 TP73    BIND  PubMed p73-beta interacts with p21 promoter. This interaction was modeled on a demonstrated interaction between p73-beta from an unspecified species and human p21 promoter. 
    NC_000006.9 NP_005418.1 TP73    BIND  PubMed p73-alpha interacts with p21 promoter. 
    NC_000006.9 NP_003434.1 ZBTB17    BIND  PubMed Miz1 interacts with p21WAF1 promoter. 
    NC_000006.9     BIND  PubMed Miz-1-Myc-Dnmt3a complex interacts with p21Cip1 promoter. 
    NC_000006.9     BIND  PubMed RNA polymerase II interacts with the CDKN1A (p21) promoter. 
    NC_000006.9     BIND  PubMed p53 tetramer interacts with p21 promoter. 
    NC_000006.9     BIND  PubMed p53 dimer interacts with p21 promoter. 
    NP_000380.1 NP_003905.1 CCNA1    BIND  PubMed cyclin A1 interacts with p21. 
    NP_000380.1 NP_001228.1 CCNA2    BIND  PubMed cyclin A interacts with p21. This interaction was modeled on a demonstrated interaction between monkey cyclin A and monkey p21. 
    NP_000380.1 NP_001228.1 CCNA2    BIND  PubMed p21 interacts with cyclin A. 
    NP_000380.1 NP_001228.1 CCNA2    BIND  PubMed CDKN1A (p21) interacts with CCNA2 (cyclin A). 
    NP_000380.1 NP_114172.1 CCNB1    BIND  PubMed CDKN1A (p21) interacts with CCNB1 (cyclin B1). 
    NP_000380.1 NP_444284.1 CCND1    BIND  PubMed Cyclin D1 interacts with p21. 
    NP_000380.1 NP_444284.1 CCND1    BIND  PubMed p21 interacts with cyclin D. 
    NP_000380.1 NP_444284.1 CCND1    BIND  PubMed CDKN1A (p21) interacts with CCND1 (cyclin D1). 
    NP_000380.1 CCNE1    BIND  PubMed p21 interacts with cyclin E. 
    NP_000380.1 CCNE1    BIND  PubMed CDKN1A (p21) interacts with CCNE1 (cyclin E). 
    NP_000380.1 NP_001777.1 CDK1    BIND  PubMed p21 interacts with CDC2. This interaction was modeled on a demonstrated interaction between human p21 and hamster CDC2. 
    NP_000380.1 CDK2    BIND  PubMed p21 interacts with an unspecified isoform of Cdk2. 
    NP_000380.1 CDK2    BIND  PubMed p21WAF1 interacts with an unspecified isoform of Cdk2. This interaction was modelled on a demonstrated interaction between human p21WAF1 and Cdk2 from an unspecified species. 
    NP_000380.1 CDK2    BIND  PubMed p21 interacts with Cdk2. 
    NP_000380.1 CDK2    BIND  PubMed p21 interacts with CDK2. This interaction was modeled on a demonstrated interaction between human p21 and hamster CDK2. 
    NP_000380.1 NP_000066.1 CDK4    BIND  PubMed Cdk4 interacts with p21. 
    NP_000380.1 NP_004371.1 CREBBP    BIND  PubMed CBP interacts with p21. 
    NP_000380.1 NP_002583.1 PCNA    BIND  PubMed p21 interacts with PCNA. 
    NP_000380.1 NP_002583.1 PCNA    BIND  PubMed p21WAF1 interacts with PCNA. 
    NP_000380.1 NP_002583.1 PCNA    BIND  PubMed PCNA interacts with p21. 
    NP_000380.1 NP_002583.1 PCNA    BIND  PubMed p21WAF1 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21WAF1 and Pisum sativum v. Onward PCNA. 
    NP_000380.1 NP_002583.1 PCNA    BIND  PubMed p21 interacts with PCNA. 
    NP_000380.1 NP_002583.1 PCNA    BIND  PubMed CDKN1A (p21) interacts with PCNA. 
    NP_000380.1 NP_002583.1 PCNA    BIND  PubMed p21 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21 and PCNA from an unspecified species. 
    NP_000380.1 NP_002583.1 PCNA    BIND  PubMed PCNA interacts with p21. 
    NP_000380.1 NP_002583.1 PCNA    BIND  PubMed p21 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21 and hamster PCNA. 
    NP_000380.1 BAC54273.1     BIND  PubMed Hepatitis C virus core protein interacts with human p21. 
    NP_000380.1     BIND  PubMed PCNA trimer interacts with p21. 
    NP_000380.1     BIND  PubMed The cyclin E / cdk2 complex interacts with p21. 
    NP_000380.1     BIND  PubMed The CDC2/cyclin B1 complex interacts with CDKN1A (p21). 
    NP_000380.1     BIND  PubMed p21 interacts with CycA/Cdk2 complex. This interaction was modeled on a demonstrated interaction between human p21, bovine CycA and human Cdk2. 
    NP_000380.1     BIND  PubMed CDKN1A (CIP1) interacts with the cyclin E-CDK2 complex. 
    NP_510867.1 NP_006221.1 POLD2    BIND  PubMed Waf1 interacts with p50 subunit of DNA polymerase delta. 
    NT_007592.14 NP_002006.2 FOXO1    BIND  PubMed FoxO1 binds the distal region of the p21Cip1 promoter. This interaction was modelled on a demonstrated interaction between FoxO1 from an unspecified species and p21Cip1 promoter from an unspecified species. 
    NT_007592.14 NP_001446.1 FOXO3    BIND  PubMed FoxO3 binds the distal region of the p21Cip1 promoter. 
    NT_007592.14 NP_005929.1 FOXO4    BIND  PubMed FoxO4 binds the distal region of the p21Cip1 promoter. This interaction was modelled on a demonstrated interaction between FoxO4 from an unspecified species and p21Cip1 promoter from an unspecified species. 
    NT_007592.14 NP_002458.1 MYC    BIND  PubMed c-Myc binds the proximal region of the p21Cip1 promoter. 
    NT_007592.14 PIAS2    BIND  PubMed Miz1 interacts with p-P21CIP1. 
    NT_007592.14 NP_005350.1 SMAD4    BIND  PubMed Smad4 binds the distal region of the p21Cip1 promoter. 
    P38936 P31749 AKT1    HPRD  PubMed  
    P38936 Q9P287 BCCIP    HPRD  PubMed  
    P38936 Q9NWV4 C1orf123    HPRD  PubMed  
    P38936 P42574 CASP3    HPRD  PubMed  
    P38936 Q15834 CCDC85B    HPRD  PubMed  
    P38936 P78396 CCNA1    HPRD  PubMed  
    P38936 P20248 CCNA2    HPRD  PubMed  
    P38936 P14635 CCNB1    HPRD  PubMed  
    P38936 O95067 CCNB2    HPRD  PubMed  
    P38936 P24385 CCND1    HPRD  PubMed  
    P38936 P30279 CCND2    HPRD  PubMed  
    P38936 P30281 CCND3    HPRD  PubMed  
    P38936 P24864 CCNE1    HPRD  PubMed  
    P38936 O96020 CCNE2    HPRD  PubMed  
    P38936 O75419 CDC45    HPRD  PubMed  
    P38936 Q99459 CDC5L    HPRD  PubMed  
    P38936 Q99741 CDC6    HPRD  PubMed  
    P38936 O00311 CDC7    HPRD  PubMed  
    P38936 P06493 CDK1    HPRD  PubMed  
    P38936 O94921 CDK14    HPRD  PubMed  
    P38936 P24941 CDK2    HPRD  PubMed  
    P38936 Q00526 CDK3    HPRD  PubMed  
    P38936 P11802 CDK4    HPRD  PubMed  
    P38936 Q00534 CDK6    HPRD  PubMed  
    P38936 P38936 CDKN1A    HPRD  PubMed  
    P38936 P49715 CEBPA    HPRD  PubMed  
    P38936 Q9ULV3 CIZ1    HPRD  PubMed  
    P38936 P68400 CSNK2A1    HPRD  PubMed  
    P38936 P67870 CSNK2B    HPRD  PubMed  
    P38936 O43293 DAPK3    HPRD  PubMed  
    P38936 P24522 GADD45A    HPRD  PubMed  
    P38936 O75293 GADD45B    HPRD  PubMed  
    P38936 O95257 GADD45G    HPRD  PubMed  
    P38936 Q7L5D6 GET4    HPRD  PubMed  
    P38936 O75496 GMNN    HPRD  PubMed  
    P38936 P63244 GNB2L1    HPRD  PubMed  
    P38936 Q96DB2 HDAC11    HPRD  PubMed  
    P38936 Q9NPI5 ITGB1BP3    HPRD  PubMed  
    P38936 Q99683 MAP3K5    HPRD  PubMed  
    P38936 P45983 MAPK8    HPRD  PubMed  
    P38936 Q7L590 MCM10    HPRD  PubMed  
    P38936 P09874 PARP1    HPRD  PubMed  
    P38936 NP_002583.1 PCNA    BIND  PubMed PCNA interacts with p21. 
    P38936 P12004 PCNA    HPRD  PubMed  
    P38936 P11309 PIM1    HPRD  PubMed  
    P38936 P49005 POLD2    HPRD  PubMed  
    P38936 P25788 PSMA3    HPRD  PubMed  
    P38936 P62820 RAB1A    HPRD  PubMed  
    P38936 P06400 RB1    HPRD  PubMed  
    P38936 Q7Z419 RNF144B    HPRD  PubMed  
    P38936 Q01105 SET    HPRD  PubMed  
    P38936 Q02978 SLC25A11    HPRD  PubMed  
    P38936 P40763 STAT3    HPRD  PubMed  
    P38936 TEX11 TEX11    HPRD  PubMed  
    P38936 P04183 TK1    HPRD  PubMed  
    P38936 Q99816 TSG101    HPRD  PubMed  
    P38936 Q6EMB2 TTLL5    HPRD  PubMed  
    P38936 P12956 XRCC6    HPRD  PubMed  
    U24170.1 NP_004371.1 CREBBP    BIND  PubMed CREBBP (CBP) interacts with the p21 promoter. 
    U24170.1 NP_004955.2 HDAC1    BIND  PubMed HDAC1 interacts with the p21 promoter. 
    U24170.1 NP_778224.1 HIST4H4    BIND  PubMed HIST4H4 (H4) interacts with the p21 promoter. 
    U24170.1 NP_778224.1 HIST4H4    BIND  PubMed HIST4H4 (H4) interacts with the CDKN1A promoter. 
    U24170.1 MDM2    BIND  PubMed Mdm2 interacts with the p21 promoter. 
    U24170.1 NP_002447.3 MUC1    BIND  PubMed MUC1 C-ter interacts with the p21 promoter. 
    U24170.1 NP_000537.2 TP53    BIND  PubMed p53 interacts with the p21 promoter. 
    Z85996.1 HIF1A    BIND  PubMed HIF-1alpha interacts with CDKN1A promoter. 
    Z85996.1 NP_002458.1 MYC    BIND  PubMed Myc interacts with CDKN1A promoter. 
    Z85996.1 PIAS2    BIND  PubMed Miz-1 interacts with CDKN1A promoter. 
    Z85996.1 NP_612482.2 SP1    BIND  PubMed Sp1 interacts with CDKN1A promoter. 
    BioGRID:107460 BioGRID:106523 A1BG    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:106524 A2M    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:106575 ACTB    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:119529 ACTL6B    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:123586 ADAMTS10    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:106713 ALAS1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:106782 ANGPT2    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:106830 APLP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:106994 ATP5B    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:107007 ATP6V1A    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:110433 ATXN3    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:113647 BAG6    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:121161 BCCIP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107460 BioGRID:116198 CCDC85B    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:107331 CCNA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:107332 CCNB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107460 BioGRID:107067 CCND1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107460 BioGRID:107334 CCND2    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:107336 CCND3    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:107338 CCNE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:115825 CCT7    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:107427 CDC20    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:107431 CDC27    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:107433 CDC42    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107460 BioGRID:107420 CDK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107460 BioGRID:107454 CDK4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:107456 CDK6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:116359 CELF3    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:107488 CENPB    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:107536 CHEK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:107539 CHGB    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:117325 CIZ1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107460 BioGRID:112978 CLEC3B    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:107684 COL4A5    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:116176 COPS6    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:128695 CPNE2    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:114763 CPNE6    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:119512 CSAD    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:107843 CSNK2B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107460 BioGRID:107888 CTSB    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:117107 DDAH2    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:115777 DEAF1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:124527 DOCK7    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:119582 DTL    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107460 BioGRID:108118 DYNC1I1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:108201 E2F1    BioGRID  PubMed Co-localization 
    BioGRID:107460 BioGRID:108237 EEF1A1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107460 BioGRID:108403 ESR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107460 BioGRID:108433 EXT2    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:108460 F13A1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:116298 FAF1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:124100 FBN3    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:125395 FBXO32    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:108535 FGB    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:122007 FKBPL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107460 BioGRID:123221 FLAD1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:108014 GADD45A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107460 BioGRID:116117 GADD45G    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107460 BioGRID:108868 GAPDH    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:107460 BioGRID:108930 GDF9    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:119636 GET4    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:109045 GNB2    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:115671 GNB2L1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:115920 GNB5    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:109282 HADHB    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107460 BioGRID:122970 HDAC11    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:109316 HDAC2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107460 BioGRID:115106 HDAC4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107460 BioGRID:115330 HDAC6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107460 BioGRID:119365 HERC5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107460 BioGRID:116640 HMGXB3    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:109474 HOXD8    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:114089 IKBKG    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:124016 ING5    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:119720 INPP5K    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:127354 KLHL23    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:120905 LRIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:110381 MAP3K5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:111585 MAPK8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107460 BioGRID:110359 MDM4    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:107460 BioGRID:119211 MED31    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:115104 MLL4    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:110573 MSH2    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:107460 BioGRID:114974 NCOR2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:107460 BioGRID:110852 NFE2L2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:110870 NGFR    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:107460 BioGRID:115885 NPRL2    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:118995 NRBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:115436 OPTN    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107460 BioGRID:120751 OTUB1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107460 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:107460 BioGRID:115017 PDE4DIP    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:111188 PDHB    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:111310 PIM1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107460 BioGRID:111332 PKM2    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:111426 POLR2A    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:107460 BioGRID:111657 PSMA3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107460 BioGRID:111678 PSMC5    BioGRID  PubMed Co-fractionation 
    BioGRID:107460 BioGRID:111681 PSMD2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:107460 BioGRID:115492 PSME3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:111797 QARS    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:111799 RAB1A    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:115966 RAI1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:111863 RBBP4    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:123855 RBM48    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:129106 RNF144B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107460 BioGRID:112101 RPS2    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:112187 S100A8    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:119334 SDF4    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:112316 SET    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107460 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:109657 SP110    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:127800 SPRED1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107460 BioGRID:112496 SUMO3    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:117998 TAF5L    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:121093 TEX11    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:112938 TK1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107460 BioGRID:112943 TLE1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:112969 TMSB4X    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107460 BioGRID:117968 TRMT2A    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:113102 TSG101    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107460 BioGRID:113603 TUBA1A    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:131483 TUBB2B    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:115654 TUBB3    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107460 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:114548 UNC119    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:113221 USP4    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:113264 VDR    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:107460 BioGRID:113272 VIM    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:124376 WDR73    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:121845 WIZ    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:113498 ZBTB16    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:109349 ZBTB48    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:113489 ZNF135    BioGRID  PubMed Two-hybrid 
    BioGRID:107460 BioGRID:128094 ZNF431    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • AKT phosphorylates targets in the cytosol, organism-specific biosystem (from REACTOME)
      AKT phosphorylates targets in the cytosol, organism-specific biosystemFollowing activation, AKT can phosphorylate an array of target proteins in the cytoplasm, many of which are involved in cell survival control. Phosphorylation of TSC2 feeds positively to the TOR kina...
    • AMPK signaling, organism-specific biosystem (from WikiPathways)
      AMPK signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
    • Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
      Angiopoietin receptor Tie2-mediated signaling
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Class I PI3K signaling events mediated by Akt, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events mediated by Akt, organism-specific biosystem
      Class I PI3K signaling events mediated by Akt
    • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
      Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemCyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. Af...
    • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
      Cyclin D associated events in G1, organism-specific biosystemThree D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and...
    • Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
      Cyclin E associated events during G1/S transition, organism-specific biosystemThe transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphoryl...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • G1 Phase, organism-specific biosystem (from REACTOME)
      G1 Phase, organism-specific biosystemEarly cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphoryl...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
      G1/S DNA Damage Checkpoints, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding ...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • GAB1 signalosome, organism-specific biosystem (from REACTOME)
      GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Notch signaling pathway, organism-specific biosystem
      Notch signaling pathway
    • Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
      Orc1 removal from chromatin, organism-specific biosystem
      Orc1 removal from chromatin
    • PI-3K cascade, organism-specific biosystem (from REACTOME)
      PI-3K cascade, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
    • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
    • PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB4 signaling, organism-specific biosystemThe CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen e...
    • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
      PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
    • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
      PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of activation of receptor tyrosine kinases (RTKs). Following ligand binding and autophosphorylation, RTKs recruit the 85 kDa regulatory subunit of PI3K (PI...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
      Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
      Removal of licensing factors from origins, organism-specific biosystemLicensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of...
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystem (from REACTOME)
      SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemDuring G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 20...
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class III, organism-specific biosystem
      Signaling events mediated by HDAC Class III
    • Signaling events mediated by PRL, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PRL, organism-specific biosystem
      Signaling events mediated by PRL
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
      Switching of origins to a post-replicative state, organism-specific biosystem
      Switching of origins to a post-replicative state
    • Synthesis of DNA, organism-specific biosystem (from REACTOME)
      Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of ...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • Transcriptional activation of cell cycle inhibitor p21, organism-specific biosystem (from REACTOME)
      Transcriptional activation of cell cycle inhibitor p21, organism-specific biosystemBoth p53-independent and p53-dependent mechanisms of induction of p21 mRNA have been demonstrated. p21 is transcriptionally activated by p53 after DNA damage (el-Deiry et al., 1993).
    • Transcriptional activation of p53 responsive genes, organism-specific biosystem (from REACTOME)
      Transcriptional activation of p53 responsive genes, organism-specific biosystemp53 causes G1 arrest by inducing the expression of a cell cycle inhibitor, p21 (El-Deiry et al, 1993; Harper et al, 1993; Xiong et al, 1993). P21 binds and inactivates Cyclin-Cdk complexes that medi...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional repression, organism-specific biosystem
      Validated targets of C-MYC transcriptional repression
    • miRNAs involved in DDR, organism-specific biosystem (from WikiPathways)
      miRNAs involved in DDR, organism-specific biosystemMicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53-Dependent G1 DNA Damage Response, organism-specific biosystem (from REACTOME)
      p53-Dependent G1 DNA Damage Response, organism-specific biosystemMost of the damage-induced modifications of p53 are dependent on the ATM kinase. The first link between ATM and p53 was predicted based on the earlier studies that showed that AT cells exhibit a redu...
    • p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
      p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystemThe arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbi...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cyclin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin-dependent protein kinase activating kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cyclin-dependent protein kinase activity EXP
    Inferred from Experiment
    more info
    		  
    cyclin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		  
    cyclin-dependent protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinase activity TAS
    Traceable Author Statement
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
    		  
    G1 phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Ras protein signal transduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    cell cycle EXP
    Inferred from Experiment
    more info
    		  
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cellular response to extracellular stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cellular response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    organ regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphorylation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of anti-apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cyclin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein import into nucleus, translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		  
    response to UV IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to corticosterone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to hyperoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to organic nitrogen IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to toxin IEA
    Inferred from Electronic Annotation
    more info
    		  
    stress-induced premature senescence TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    PCNA-p21 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    cyclin-dependent kinase inhibitor 1
    Names
    cyclin-dependent kinase inhibitor 1
    DNA synthesis inhibitor
    CDK-interacting protein 1
    CDK-interaction protein 1
    wild-type p53-activated fragment 1
    melanoma differentiation associated protein 6
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009364.1 RefSeqGene

      Range
      2779..13658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000389.4 → NP_000380.1  cyclin-dependent kinase inhibitor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variants 2, 4 and 5 encode the same protein.
      Source sequence(s)
      BC000275, BC000312, BQ941282, DA582789
      Consensus CDS
      CCDS4824.1
      UniProtKB/Swiss-Prot
      P38936
      UniProtKB/TrEMBL
      Q6FI05
      Related
      ENSP00000244741, OTTHUMP00000016297, ENST00000244741, OTTHUMT00000040354
      Conserved Domains (1) summary
      pfam02234
      Location:19 – 69
      Blast Score: 195
      CDI; Cyclin-dependent kinase inhibitor

    2. NM_001220777.1 → NP_001207706.1  cyclin-dependent kinase inhibitor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same protein.
      Source sequence(s)
      AA534613, BC000312, DA702185
      Consensus CDS
      CCDS4824.1
      UniProtKB/Swiss-Prot
      P38936
      UniProtKB/TrEMBL
      Q6FI05
      Conserved Domains (1) summary
      pfam02234
      Location:19 – 69
      Blast Score: 195
      CDI; Cyclin-dependent kinase inhibitor

    3. NM_001220778.1 → NP_001207707.1  cyclin-dependent kinase inhibitor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same protein.
      Source sequence(s)
      AA534613, BC000312, DA552678
      Consensus CDS
      CCDS4824.1
      UniProtKB/Swiss-Prot
      P38936
      UniProtKB/TrEMBL
      Q6FI05
      Related
      ENSP00000384849, ENST00000405375
      Conserved Domains (1) summary
      pfam02234
      Location:19 – 69
      Blast Score: 195
      CDI; Cyclin-dependent kinase inhibitor

    4. NM_078467.2 → NP_510867.1  cyclin-dependent kinase inhibitor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same protein.
      Source sequence(s)
      BC000312, BQ941282, BU154329
      Consensus CDS
      CCDS4824.1
      UniProtKB/Swiss-Prot
      P38936
      UniProtKB/TrEMBL
      Q6FI05
      Conserved Domains (1) summary
      pfam02234
      Location:19 – 69
      Blast Score: 195
      CDI; Cyclin-dependent kinase inhibitor

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      36644237..36655116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      36362600..36373330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_037150.1: Suppressed sequence

      Description
      NR_037150.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF497972.1 AAM11787.1
    genomic CH471081.1 EAX03904.1
      EAX03905.1
      EAX03906.1
      EAX03907.1
    genomic CS284542.1 CAJ98559.1
    genomic CS284544.1 CAJ98560.1
    genomic HI519528.1 CBX54345.1
    genomic Z85996.1 CAB06656.1
    mRNA AA534613.1 None
    mRNA AB209881.1 BAD93118.1
    mRNA AB451290.1 BAG70104.1
    mRNA AB451422.1 BAG70236.1
    mRNA AK298901.1 BAG61011.1
    mRNA AK309512.1 None
    mRNA BC000275.1 AAH00275.1
    mRNA BC000312.2 AAH00312.1
    mRNA BC001935.1 AAH01935.1
    mRNA BC013967.2 AAH13967.1
    mRNA BQ941282.1 None
    mRNA BT006719.1 AAP35365.1
    mRNA BU154329.1 None
    mRNA BU193165.1 None
    mRNA CR536533.1 CAG38770.1
    mRNA DA552678.1 None
    mRNA DA582789.1 None
    mRNA DA699672.1 None
    mRNA DA702185.1 None
    mRNA DA838987.1 None
    mRNA L25610.1 AAA16109.1
    mRNA L26165.1 AAA19811.1
    mRNA L47232.1 AAB59559.1
    mRNA L47233.1 AAB59560.1
    mRNA S67388.1 AAB29246.1
    mRNA U03106.1 AAC04313.1
    mRNA U09579.1 AAA85641.1
    other-genetic AM392711.1 CAL37589.1
    other-genetic AM392920.1 CAL37798.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38936.3 GenPept UniProtKB/Swiss-Prot:P38936
    Q59ED0 GenPept UniProtKB/TrEMBL:Q59ED0
    Q6FI05 GenPept UniProtKB/TrEMBL:Q6FI05
    Q96LE1 GenPept UniProtKB/TrEMBL:Q96LE1
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
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