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    HNRNPK heterogeneous nuclear ribonucleoprotein K [ Homo sapiens ]

    Gene ID: 3190, updated on 11-May-2012

    Summary

    Official Symbol
    HNRNPKprovided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Kprovided by HGNC
    Primary source
    HGNC:5044
    Locus tag
    RP11-575L7.1
    See related
    Ensembl:ENSG00000165119; HPRD:02834; MIM:600712; Vega:OTTHUMG00000020107
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSBP; TUNP; HNRPK; FLJ41122
    Summary
    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    9q21.32-q21.33
    Sequence :
    Chromosome: 9; NC_000009.11 (86582998..86595569, complement)
    See HNRNPK in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene kinesin family member 27 Neighboring gene chromosome 9 open reading frame 64 Neighboring gene microRNA 7-1 Neighboring gene RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) Neighboring gene solute carrier family 28 (sodium-coupled nucleoside transporter), member 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Rev rev hnRNP K forms a complex with Sam68 and HIV-1 RRE RNA and inhibits Sam68-mediated, RRE-dependent gene expression suggesting a possible interaction with Rev PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002131.2 NP_001524.2 HNRNPL    BIND  PubMed hnRNP L interacts with hnRNP K. This interaction was modeled on a demonstrated interaction between hnRNP K from an unspecified source and human hnRNP L. 
    NP_002131.2 NP_003008.1 SRSF3    BIND  PubMed SRp20 interacts with hnRNP K. This interaction was modeled on a demonstrated interaction between hnRNP K from an unspecified source and human SRp20. 
    NP_002131.2 P10238 UL54    BIND  PubMed Human herpes simplex virus type 1 IE63 interacts with the human host protein hnRNP K. 
    NP_112552.1 NP_751919.1 HCVgp1    BIND  PubMed Hepatitis C virus core protein interacts with hnRNP K. 
    NP_112552.1 NP_002119.1 HMGB1    BIND  PubMed HMGB1 interacts with HNRPK (hnRNPK). This interaction was modelled on a demonstrated interaction between rat HMGB1 and human HNRPK (hnRNPK). 
    NP_112552.1 NP_006550.1 KHDRBS1    BIND  PubMed Sam68 interacts with hnRNP K. This interaction was modeled on a demonstrated interaction between Sam68 from an unspecified source and human hnRNP K. 
    NP_112552.1 NP_006550.1 KHDRBS1    BIND  PubMed Sam68 interacts with hnRNP K 
    NP_112553.1 NP_004930.1 DDX1    BIND  PubMed DDX1 interacts with hnRNP K. 
    NP_112553.1 NP_002028.1 FYN    BIND  PubMed Fyn interacts with hnRNPK. This interaction was modeled on a demonstrated interaction between Fyn from an unspecified source and human hnRNPK. 
    NP_112553.1 NP_005537.3 ITK    BIND  PubMed Itk interacts with hnRNPK. This interaction was modeled on a demonstrated interaction between mouse Itk and human hnRNPK. 
    NP_112553.1 NP_852664.1 PIK3R1    BIND  PubMed p85 interacts with hnRNPK. This interaction was modeled on a demonstrated interaction between p85 from an unspecified source and human hnRNPK. 
    NP_112553.1 NP_002958.2 SAFB    BIND  PubMed hnRNP K interacts with SAFB. This interaction was modeled on a demonstrated interaction between mouse proteins. 
    NP_112553.1 NP_005408.1 SRC    BIND  PubMed Src interacts with hnRNPK. This interaction was modeled on a demonstrated interaction between Src from an unspecified source and human hnRNPK. 
    NP_112553.1 NP_004550.2 YBX1    BIND  PubMed YB-1 interacts with hnRNP K. This interaction was modeled on a demonstrated interaction between human hnRNP K and murineYB-1. 
    P61978 P17676 CEBPB    HPRD  PubMed  
    P61978 Cyclin M3 CNNM3    HPRD  PubMed  
    P61978 P41240 CSK    HPRD  PubMed  
    P61978 Q92499 DDX1    HPRD  PubMed  
    P61978 Q96D72 DIDO1    HPRD  PubMed  
    P61978 P06241 FYN    HPRD  PubMed  
    P61978 Growth factor independent 1B GFI1B    HPRD  PubMed  
    P61978 O75791 GRAP2    HPRD  PubMed  
    P61978 P08631 HCK    HPRD  PubMed  
    P61978 P09429 HMGB1    HPRD  PubMed  
    P61978 P61978 HNRNPK    HPRD  PubMed  
    P61978 P14866 HNRNPL    HPRD  PubMed  
    P61978 Q08881 ITK    HPRD  PubMed  
    P61978 Q07666 KHDRBS1    HPRD  PubMed  
    P61978 Sam68 like mammalian protein 1 KHDRBS2    HPRD  PubMed  
    P61978 O75525 KHDRBS3    HPRD  PubMed  
    P61978 P07948 LYN    HPRD  PubMed  
    P61978 P53779 MAPK10    HPRD  PubMed  
    P61978 P43243 MATR3    HPRD  PubMed  
    P61978 O43639 NCK2    HPRD  PubMed  
    P61978 Q9NQX5 NPDC1    HPRD  PubMed  
    P61978 Q15365 PCBP1    HPRD  PubMed  
    P61978 Q15366 PCBP2    HPRD  PubMed  
    P61978 Q05655 PRKCD    HPRD  PubMed  
    P61978 Q99873 PRMT1    HPRD  PubMed  
    P61978 Q96PU8 QKI    HPRD  PubMed  
    P61978 Q96IZ5 RBM41    HPRD  PubMed  
    P61978 RNA binding motif protein 42 RBM42    HPRD  PubMed  
    P61978 Q9Y580 RBM7    HPRD  PubMed  
    P61978 P38159 RBMX    HPRD  PubMed  
    P61978 Q15424 SAFB    HPRD  PubMed  
    P61978 O60504 SORBS3    HPRD  PubMed  
    P61978 P12931 SRC    HPRD  PubMed  
    P61978 Q8WXA9 SREK1    HPRD  PubMed  
    P61978 P84103 SRSF3    HPRD  PubMed  
    P61978 P20226 TBP    HPRD  PubMed  
    P61978 P63279 UBE2I    HPRD  PubMed  
    P61978 P15498 VAV1    HPRD  PubMed  
    P61978 P67809 YBX1    HPRD  PubMed  
    BioGRID:109431 BioGRID:223223 AI837181    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:106819 APBB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:120548 C20orf20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:107480 CEBPB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109431 BioGRID:117712 CNNM3    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:107832 CSK    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:109431 BioGRID:232850 Ccdc15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:198624 Cdk1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:205180 Csnk1e    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:108019 DDX1    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:109431 BioGRID:116266 DIDO1    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:971788 EBNA-LP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109431 BioGRID:108325 EMD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:114799 GRAP2    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:109142 GRB2    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:109272 H3F3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:109389 HMGB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109431 BioGRID:109420 HNRNPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:109428 HNRNPH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:109431 HNRNPK    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109431 BioGRID:109432 HNRNPL    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109431 BioGRID:109907 ITK    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109431 BioGRID:115900 KHDRBS1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid 
    BioGRID:109431 BioGRID:128436 KHDRBS2    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:109431 BioGRID:115899 KHDRBS3    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:115126 MATR3    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:116134 MORF4L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:115001 MORF4L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:114020 NCK2    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:121167 NPDC1    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:117939 PABPC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109431 BioGRID:111127 PCBP2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109431 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:111456 POU5F1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:109431 BioGRID:109512 PRMT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:109431 BioGRID:120792 PRPF40A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:111697 PTBP1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109431 BioGRID:214756 Pds5a    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:238351 Poc1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:114834 QKI    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:120573 RBM41    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:122588 RBM42    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:115478 RBM7    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:118134 RBMX    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:115475 SORBS3    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:112781 TCEA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:116120 TCERG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:113003 TOP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:109431 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:109431 BioGRID:113252 VAV1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109431 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:116363 WBP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:119707 WWOX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109431 BioGRID:204613 Ybx1    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    heterogeneous nuclear ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
     
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein K
    Names
    heterogeneous nuclear ribonucleoprotein K
    dC-stretch binding protein
    transformation upregulated nuclear protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029577.1 RefSeqGene

      Range
      5001..17572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002140.3NP_002131.2  heterogeneous nuclear ribonucleoprotein K isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Transcript variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AB209562, BC000355, BU736090, DC407458
      Consensus CDS
      CCDS6668.1
      UniProtKB/Swiss-Prot
      P61978
      UniProtKB/TrEMBL
      Q6IBN1
      Related
      ENSP00000365458, OTTHUMP00000021557, ENST00000376281, OTTHUMT00000052855
      Conserved Domains (2) summary
      cd02396
      Location:44105
      Blast Score: 164
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam08067
      Location:143
      Blast Score: 142
      ROKNT; ROKNT (NUC014) domain
    2. NM_031262.2NP_112552.1  heterogeneous nuclear ribonucleoprotein K isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate acceptor splice site at the last coding exon compared to transcript variant 1. This results in a frame-shift and an isoform (b) with a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AB209562, BC014980, BU736090, DC407458
      Consensus CDS
      CCDS6667.1
      UniProtKB/Swiss-Prot
      P61978
      Related
      ENSP00000365440, ENST00000376264
      Conserved Domains (2) summary
      cd02396
      Location:44105
      Blast Score: 164
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam08067
      Location:143
      Blast Score: 143
      ROKNT; ROKNT (NUC014) domain
    3. NM_031263.2NP_112553.1  heterogeneous nuclear ribonucleoprotein K isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to transcript variant 1. Transcript variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AB209562, BC000355, BU736090, DA394419
      Consensus CDS
      CCDS6668.1
      UniProtKB/Swiss-Prot
      P61978
      UniProtKB/TrEMBL
      Q6IBN1
      Related
      ENSP00000365439, ENST00000376263
      Conserved Domains (2) summary
      cd02396
      Location:44105
      Blast Score: 164
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam08067
      Location:143
      Blast Score: 142
      ROKNT; ROKNT (NUC014) domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      86582998..86595569, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      56408631..56421199, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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