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    CD36 CD36 molecule (thrombospondin receptor) [ Homo sapiens ]

    Gene ID: 948, updated on 19-May-2012
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    Summary

    Official Symbol
    CD36provided by HGNC
    Official Full Name
    CD36 molecule (thrombospondin receptor)provided by HGNC
    Primary source
    HGNC:1663
    See related
    Ensembl:ENSG00000135218; HPRD:01430; MIM:173510; Vega:OTTHUMG00000155383
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10
    Summary
    The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    7q11.2
    Sequence :
    Chromosome: 7; NC_000007.13 (80231504..80308593)
    See CD36 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptides B and B1 pseudogene 1 Neighboring gene guanine nucleotide binding protein, alpha transducing 3 Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C Neighboring gene voltage-dependent anion channel 3 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. CD36 ectodomain phosphorylation blocks thrombospondin-1 binding: structure-function relationships and regulation by protein kinase C. Chu LY, et al. Arterioscler Thromb Vasc Biol, 2012 Mar. PMID 22247259.
    2. Nrf2, a PPARγ alternative pathway to promote CD36 expression on inflammatory macrophages: implication for malaria. Olagnier D, et al. PLoS Pathog, 2011 Sep. PMID 21949655.
    3. Clinical significance of serum levels of sCD36 in patients with systemic sclerosis: preliminary data. Bassyouni IH, et al. Rheumatology (Oxford), 2011 Nov. PMID 21890620.
    4. Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function. Jaqaman K, et al. Cell, 2011 Aug 19. PMID 21854984.
    5. A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36. Wilkinson K, et al. J Biol Chem, 2011 Oct 7. PMID 21835916.

    See all (244) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Genetic variation within the CD36 locus may contribute to metabolic disease via its effect on body adiposity, but not via an independent effect on insulin sensitivity.
      Title: Variants in the CD36 gene locus determine whole-body adiposity, but have no independent effect on insulin sensitivity.
    2. New protein synthesis and trafficking through the Golgi are required for protein kinase C alpha-induced CD36 phosphorylation and blocked thrombospondin-1 binding, suggesting that phosphorylation probably occurs intracellularly.
      Title: CD36 ectodomain phosphorylation blocks thrombospondin-1 binding: structure-function relationships and regulation by protein kinase C.
    3. study shows that Nrf2 transcription factor may substitute PPARgamma to promote CD36 expression and its associated functions in inflammatory conditions; only Nrf2 but not PPARgamma activators improve the outcome of severe malaria in vivo
      Title: Nrf2, a PPARγ alternative pathway to promote CD36 expression on inflammatory macrophages: implication for malaria.
    4. Immobilized TSP1 and oxLDL activate platelets partly via CD36 through a Syk kinase-dependent Ca(2+) signaling mechanism, which enhances collagen-dependent thrombus formation under flow.
      Title: Signaling role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin or oxidized low-density lipoprotein.
    5. expression in microvascular endothelial cells is attenuated by Omega-3 fatty acids
      Title: Omega-3 fatty acids attenuate constitutive and insulin-induced CD36 expression through a suppression of PPAR α/γ activity in microvascular endothelial cells.
    6. We conclude that sCD36 may be a marker for elevated pulmonary artery systolic pressure and vascular involvement in systemic sclerosis.
      Title: Clinical significance of serum levels of sCD36 in patients with systemic sclerosis: preliminary data.
    7. This is perhaps the first report from India suggesting that CD36 is one of the several important genes that need to be explored in relation to T2DM.
      Title: Preliminary studies on CD36 gene in type 2 diabetic patients from north India.
    8. ursolic acid inhibits amyloid beta protein interactions with its receptor CD36
      Title: A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.
    9. Hepatic FAT/CD36 upregulation is significantly associated with insulin resistance, hyperinsulinaemia and increased steatosis in patients with NASH and HCV G1 with fatty liver.
      Title: Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C.
    10. Study reveals that the diffusion of CD36 in the membrane of human macrophages is regulated by interactions between CD36 and the cytoskeleton.
      Title: Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function.
    Submit: New GeneRIF Correction See all (184)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Coronary heart disease, susceptibility to, 7

    Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study.

    Macrothrombocytopenia

    Malaria, cerebral, susceptibility to

    Platelet glycoprotein IV deficiency

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P16671 P21926 CD9    HPRD  PubMed  
    P16671 P02452 COL1A1    HPRD  PubMed  
    P16671 P08123 COL1A2    HPRD  PubMed  
    P16671 P06241 FYN    HPRD  PubMed  
    P16671 P08514 ITGA2B    HPRD  PubMed  
    P16671 P23229 ITGA6    HPRD  PubMed  
    P16671 P05556 ITGB1    HPRD  PubMed  
    P16671 P05106 ITGB3    HPRD  PubMed  
    P16671 P07948 LYN    HPRD  PubMed  
    P16671 P42679 MATK    HPRD  PubMed  
    P16671 P12931 SRC    HPRD  PubMed  
    P16671 P07996 THBS1    HPRD  PubMed  
    P16671 P07947 YES1    HPRD  PubMed  
    BioGRID:107386 BioGRID:107366 CD9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107386 BioGRID:108810 FYN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107386 BioGRID:109523 HSD11B1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107386 BioGRID:109881 ITGA2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107386 BioGRID:109864 ITGA6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107386 BioGRID:109894 ITGB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107386 BioGRID:109896 ITGB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107386 BioGRID:110141 LDLR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107386 BioGRID:110245 LYN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107386 BioGRID:110315 MATK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107386 BioGRID:113277 VLDLR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107386 BioGRID:113357 YES1    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the CD36 gene: The CD36 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, and C.elegans.

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
      Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Cross-presentation of particulate exogenous antigens (phagosomes), organism-specific biosystem (from REACTOME)
      Cross-presentation of particulate exogenous antigens (phagosomes), organism-specific biosystemDendritic cells (DCs) take up and process exogenous particulate or cell-associated antigens such as microbes or tumor cells for MHC-I cross-presentation. Particulate antigens have been reported to be...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Fat digestion and absorption, organism-specific biosystem (from KEGG)
      Fat digestion and absorption, organism-specific biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
    • Fat digestion and absorption, conserved biosystem (from KEGG)
      Fat digestion and absorption, conserved biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • PPAR signaling pathway, organism-specific biosystem (from KEGG)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, conserved biosystem (from KEGG)
      PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
      PPARA Activates Gene Expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
    • Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
    • Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
    • Vitamin A and carotenoid metabolism, organism-specific biosystem (from WikiPathways)
      Vitamin A and carotenoid metabolism, organism-specific biosystemThis pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Gram-negative bacterial cell surface binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Gram-positive bacterial cell surface binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    high-density lipoprotein particle binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lipoteichoic acid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    low-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    low-density lipoprotein receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    low-density lipoprotein receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    thrombospondin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    transforming growth factor beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    antigen processing and presentation of exogenous peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    apoptotic cell clearance IEA
    Inferred from Electronic Annotation
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular lipid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    cellular response to bacterial lipopeptide IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to hydroperoxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to lipoteichoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    lipid metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    lipoprotein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    lipoprotein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    low-density lipoprotein particle clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    low-density lipoprotein particle mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of growth of symbiont in host IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription factor import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    nitric oxide mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    pattern recognition receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    phagocytosis, recognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma lipoprotein particle clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    plasma membrane long-chain fatty acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    platelet activation TAS
    Traceable Author Statement
    more info
    		  
    platelet degranulation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of I-kappaB kinase/NF-kappaB cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of blood microparticle formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cholesterol storage IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of macrophage cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of macrophage derived foam cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of phagocytosis, engulfment IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to stilbenoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane fraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    phagocytic vesicle TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    platelet alpha granule membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    platelet glycoprotein 4
    Names
    platelet glycoprotein 4
    GPIIIB
    PAS IV
    PAS-4 protein
    glycoprotein IIIb
    cluster determinant 36
    fatty acid translocase
    platelet glycoprotein IV
    scavenger receptor class B, member 3
    leukocyte differentiation antigen CD36
    CD36 antigen (collagen type I receptor, thrombospondin receptor)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008192.1 RefSeqGene

      Range
      5001..82090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000072.3 → NP_000063.2  platelet glycoprotein 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 1. Variants 1 through 5 all encode the same protein.
      Source sequence(s)
      AC124834, DA857400, DC338512, L06850, M98398
      Consensus CDS
      CCDS34673.1
      UniProtKB/TrEMBL
      A4D1B1
      UniProtKB/Swiss-Prot
      P16671
      Related
      ENSP00000378268, OTTHUMP00000207938, ENST00000394788, OTTHUMT00000339913
      Conserved Domains (1) summary
      pfam01130
      Location:26 – 464
      Blast Score: 1280
      CD36; CD36 family

    2. NM_001001547.2 → NP_001001547.1  platelet glycoprotein 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' and 3' UTRs compared to variant 1. Variants 1 through 5 all encode the same protein.
      Source sequence(s)
      BP258762, BP259746, L06850, M98398
      Consensus CDS
      CCDS34673.1
      UniProtKB/TrEMBL
      A4D1B1
      UniProtKB/Swiss-Prot
      P16671
      Related
      ENSP00000308165, OTTHUMP00000207874, ENST00000309881, OTTHUMT00000339772
      Conserved Domains (1) summary
      pfam01130
      Location:26 – 464
      Blast Score: 1280
      CD36; CD36 family

    3. NM_001001548.2 → NP_001001548.1  platelet glycoprotein 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 5 all encode the same protein.
      Source sequence(s)
      AC073850, AC124834, DA857400, DC338512, M98399
      Consensus CDS
      CCDS34673.1
      UniProtKB/TrEMBL
      A4D1B1
      UniProtKB/Swiss-Prot
      P16671
      Related
      ENSP00000415743, OTTHUMP00000207881, ENST00000447544, OTTHUMT00000339781
      Conserved Domains (1) summary
      pfam01130
      Location:26 – 464
      Blast Score: 1280
      CD36; CD36 family

    4. NM_001127443.1 → NP_001120915.1  platelet glycoprotein 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTRs compared to variant 1. Variants 1 through 5 all encode the same protein.
      Source sequence(s)
      DA566475, L06850, M98398
      Consensus CDS
      CCDS34673.1
      UniProtKB/TrEMBL
      A4D1B1
      UniProtKB/Swiss-Prot
      P16671
      Related
      ENSP00000411411, ENST00000432207
      Conserved Domains (1) summary
      pfam01130
      Location:26 – 464
      Blast Score: 1280
      CD36; CD36 family

    5. NM_001127444.1 → NP_001120916.1  platelet glycoprotein 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' and 3' UTRs compared to variant 1. Variants 1 through 5 all encode the same protein.
      Source sequence(s)
      AL596924, L06850, M98398
      Consensus CDS
      CCDS34673.1
      UniProtKB/TrEMBL
      A4D1B1
      UniProtKB/Swiss-Prot
      P16671
      Related
      ENSP00000392298, OTTHUMP00000207879, ENST00000419819, OTTHUMT00000339778
      Conserved Domains (1) summary
      pfam01130
      Location:26 – 464
      Blast Score: 1280
      CD36; CD36 family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      80231504..80308593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      74834319..74911371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      79562929..79640010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC073182.4 (109178..120911) None
    genomic AC073850.4 (35287..38093) None
    genomic AC124834.1 None
    genomic AF300625.1 AAG60624.1
    genomic AF300626.1 AAG60625.1
    genomic AF300627.1 AAG60626.1
    genomic AF300628.1 AAG60627.1
    genomic AF300629.1 AAG60628.1
    genomic AF300630.1 AAG60629.1
    genomic AF300631.1 AAG60630.1
    genomic AF300632.1 AAG60631.1
    genomic AF300633.1 AAG60632.1
    genomic AF300634.1 AAG60633.1
    genomic AF300635.1 AAG60634.1
    genomic AF300636.1 AAG60635.1
    genomic AF300637.1 AAG60636.1
    genomic AF300638.1 AAG60637.1
    genomic AF300639.1 AAG60638.1
    genomic AF300640.1 AAG60639.1
    genomic AY095373.1 AAM14636.2
    genomic CH236949.1 EAL24191.1
    genomic CH471091.2 EAW76996.1
      EAW76997.1
      EAW76998.1
      EAW76999.1
      EAW77000.1
      EAW77001.1
      EAW77002.1
      EAW77003.1
      EAW77004.1
      EAW77005.1
    genomic HC025784.1 CBH19823.1
    genomic L06849.1 AAB46390.1
    genomic Z22924.1 CAA80504.1
    genomic Z32770.1 CAA83662.1
    mRNA AA846141.1 None
    mRNA AK057690.1 None
    mRNA AK096858.1 BAG53380.1
    mRNA AK129899.1 None
    mRNA AK300101.1 BAH13209.1
    mRNA AK312920.1 BAG35765.1
    mRNA AL596924.1 None
    mRNA BC008406.1 AAH08406.1
    mRNA BP258762.1 None
    mRNA BP259746.1 None
    mRNA CR749465.1 None
    mRNA DA566475.1 None
    mRNA DA857400.1 None
    mRNA DC338512.1 None
    mRNA HM217020.1 ADI80540.1
    mRNA HM217021.1 ADI80541.1
    mRNA HM217022.1 ADI80542.1
    mRNA HM217023.1 ADI80543.1
    mRNA HM217024.1 ADI80544.1
    mRNA HM217025.1 ADI80545.1
    mRNA HM217026.1 ADI80546.1
    mRNA L06850.1 AAA16068.1
    mRNA M24795.1 AAA35534.1
    mRNA M98398.1 AAA58412.1
    mRNA M98399.1 AAA58413.1
    mRNA S60720.1 AAD14933.1
    mRNA S67044.1 AAB28992.1
    mRNA S67532.1 AAD13993.1
    other-genetic DQ893062.2 ABM83988.1
    other-genetic DQ896314.2 ABM87313.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16671.2 GenPept UniProtKB/Swiss-Prot:P16671
    Q13965 GenPept UniProtKB/TrEMBL:Q13965
    Q9BQA7 GenPept UniProtKB/TrEMBL:Q9BQA7
    Q9BZM7 GenPept UniProtKB/TrEMBL:Q9BZM7
    Q9BZM9 GenPept UniProtKB/TrEMBL:Q9BZM9
    Q9BZN0 GenPept UniProtKB/TrEMBL:Q9BZN0
    Q9BZN1 GenPept UniProtKB/TrEMBL:Q9BZN1
    Q9BZN2 GenPept UniProtKB/TrEMBL:Q9BZN2
    Q9BZN6 GenPept UniProtKB/TrEMBL:Q9BZN6
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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