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    DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 [ Homo sapiens ]

    Gene ID: 1665, updated on 11-May-2012
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    Summary

    Official Symbol
    DHX15provided by HGNC
    Official Full Name
    DEAH (Asp-Glu-Ala-His) box polypeptide 15provided by HGNC
    Primary source
    HGNC:2738
    See related
    Ensembl:ENSG00000109606; HPRD:04553; MIM:603403; Vega:OTTHUMG00000160304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DBP1; HRH2; DDX15; PRP43; PRPF43; PrPp43p
    Summary
    The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    4p15.3
    Sequence :
    Chromosome: 4; NC_000004.11 (24529087..24586184, complement)
    See DHX15 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC729175 Neighboring gene microRNA 573 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit g, pseudogene 3 Neighboring gene superoxide dismutase 3, extracellular

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    4. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Zhao J, et al. J Proteomics, 2011 Dec 21. PMID 21907836.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (31) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O43143 P31946 YWHAB    HPRD  PubMed  
    O43143 P61981 YWHAG    HPRD  PubMed  
    BioGRID:108029 BioGRID:223223 AI837181    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:106819 APBB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:203509 Nhp2l1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:120319 PINX1    BioGRID  PubMed Two-hybrid 
    BioGRID:108029 BioGRID:120792 PRPF40A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:228650 Prpf8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:117873 RNU11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:117872 RNU12-2P    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:113826 SF3A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:212207 Sf3a1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:211406 Snw1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:112744 TAF10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:115505 TOPORS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:108029 BioGRID:116363 WBP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108029 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the DHX15 gene: The DHX15 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, rice, and P.falciparum.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATP-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA helicase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    RNA splicing IC
    Inferred by Curator
    more info
    		 PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    U12-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    Names
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    DEAD/H box-15
    RNA helicase 2
    DEAH box protein 15
    ATP-dependent RNA helicase #46
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15
    NP_001349.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358.2 → NP_001349.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15

      Status: REVIEWED

      Source sequence(s)
      AA771922, BC035974, BU158645
      Consensus CDS
      CCDS33966.1
      UniProtKB/Swiss-Prot
      O43143
      Related
      ENSP00000336741, OTTHUMP00000217985, ENST00000336812, OTTHUMT00000360143
      Conserved Domains (5) summary
      cd00046
      Location:154 – 295
      Blast Score: 257
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:662 – 765
      Blast Score: 328
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
      smart00487
      Location:149 – 322
      Blast Score: 264
      DEXDc; DEAD-like helicases superfamily
      cl04503
      Location:556 – 628
      Blast Score: 282
      HA2; Helicase associated domain (HA2)
      cl09099
      Location:382 – 441
      Blast Score: 122
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      24529087..24586184, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      23871170..23928446, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC115110.3 (59052..116149) None
    genomic CH471069.1 EAW92814.1
      EAW92815.1
      EAW92816.1
      EAW92817.1
      EAW92818.1
      EAW92819.1
      EAW92820.1
      EAW92821.1
    mRNA AA771922.1 None
    mRNA AB001636.1 BAA23987.1
    mRNA AF279891.1 AAF90182.1
    mRNA AK054614.1 None
    mRNA AK055898.1 None
    mRNA AK056726.1 None
    mRNA AK303506.1 BAG64538.1
    mRNA BC035974.1 AAH35974.1
    mRNA BC047577.1 None
    mRNA BU158645.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43143.2 GenPept UniProtKB/Swiss-Prot:O43143
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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