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CD164 CD164 molecule [ Homo sapiens (human) ]

Gene ID: 8763, updated on 8-May-2016
Official Symbol
CD164provided by HGNC
Official Full Name
CD164 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1632
See related
Ensembl:ENSG00000135535 HPRD:04523; MIM:603356; Vega:OTTHUMG00000015339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DFNA66; MGC-24; MUC-24; endolyn
Summary
Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play 2 key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor (Watt et al., 1998 [PubMed 9680353]; Forde et al., 2007 [PubMed 17077324]).[supplied by OMIM, Aug 2008]
Orthologs
Location:
6q21
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (109366514..109382559, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (109687717..109703762, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927538 Neighboring gene ribosomal protein L7 pseudogene 28 Neighboring gene peptidylprolyl isomerase like 6 Neighboring gene sphingomyelin phosphodiesterase 2 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 1 Neighboring gene zinc finger and BTB domain containing 24

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of CD164 molecule (sialomucin) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD164 PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD164 PubMed

Go to the HIV-1, Human Interaction Database

  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
hemopoiesis NAS
Non-traceable Author Statement
more info
PubMed 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
muscle organ development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
sialomucin core protein 24
Names
CD164 antigen, sialomucin
CD164 molecule, sialomucin
CD164 variant C
MGC-24v
deafness, autosomal dominant 66
multi-glycosylated core protein 24

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142401.1NP_001135873.1  sialomucin core protein 24 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001135873.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AF299343, BM668503, DC403839
    Consensus CDS
    CCDS47464.1
    UniProtKB/Swiss-Prot
    Q04900
    Related
    ENSP00000275080, OTTHUMP00000016957, ENST00000275080, OTTHUMT00000041743
    Conserved Domains (1) summary
    pfam05283
    Location:4176
    MGC-24; Multi-glycosylated core protein 24 (MGC-24)
  2. NM_001142402.1NP_001135874.1  sialomucin core protein 24 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001135874.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
    Source sequence(s)
    AF299342, BM668503, DC403839
    Consensus CDS
    CCDS47465.1
    UniProtKB/Swiss-Prot
    Q04900
    Related
    ENSP00000314177, OTTHUMP00000016955, ENST00000324953, OTTHUMT00000041741
    Conserved Domains (1) summary
    pfam05283
    Location:4170
    MGC-24; Multi-glycosylated core protein 24 (MGC-24)
  3. NM_001142403.1NP_001135875.1  sialomucin core protein 24 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001135875.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses alternate splice sites in the 3' coding region, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC011522, BM668503, D14043, DC403839
    Consensus CDS
    CCDS47463.1
    UniProtKB/Swiss-Prot
    Q04900
    Related
    ENSP00000402237, OTTHUMP00000016954, ENST00000413644, OTTHUMT00000041740
    Conserved Domains (1) summary
    pfam05283
    Location:4174
    MGC-24; Multi-glycosylated core protein 24 (MGC-24)
  4. NM_001142404.1NP_001135876.1  sialomucin core protein 24 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001135876.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 5 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK298684, BM817924, BM830140, DC403839, EB388947
    Consensus CDS
    CCDS47462.1
    UniProtKB/Swiss-Prot
    Q04900
    Related
    ENSP00000427546, OTTHUMP00000220523, ENST00000512821, OTTHUMT00000365625
    Conserved Domains (1) summary
    pfam05283
    Location:4130
    MGC-24; Multi-glycosylated core protein 24 (MGC-24)
  5. NM_006016.4NP_006007.2  sialomucin core protein 24 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006007.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC011522, BM668503, DC403839
    Consensus CDS
    CCDS5073.1
    UniProtKB/Swiss-Prot
    Q04900
    Related
    ENSP00000309376, OTTHUMP00000016956, ENST00000310786, OTTHUMT00000041742
    Conserved Domains (1) summary
    pfam05283
    Location:4189
    MGC-24; Multi-glycosylated core protein 24 (MGC-24)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    109366514..109382559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    109950828..109966874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)