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ATF3 activating transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 467, updated on 19-Jul-2016
Official Symbol
ATF3provided by HGNC
Official Full Name
activating transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:785
See related
Ensembl:ENSG00000162772 HPRD:04395; MIM:603148; Vega:OTTHUMG00000036747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
Orthologs
Location:
1q32.3
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (212565334..212620777)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (212738676..212794119)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372908 Neighboring gene uncharacterized LOC101929565 Neighboring gene uncharacterized LOC102723761 Neighboring gene uncharacterized LOC105372909 Neighboring gene family with sequence similarity 71 member A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef nef Expression of activating transcription factor 3 (ATF-3) is upregulated by HIV-1 Nef in HeLa cells PubMed
Tat tat HIV-1 and the viral protein Tat modulate the expression of activating transcription factor 3 (ATF3) in immature dendritic cells and monocyte-derived macrophages PubMed
tat HIV-1 Tat upregulates ATF3 expression in Tat-infected Jurkat T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ41705

Gene Ontology Provided by GOA

Component Evidence Code Pubs
CHOP-ATF3 complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cyclic AMP-dependent transcription factor ATF-3
Names
cAMP-dependent transcription factor ATF-3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029871.1 RefSeqGene

    Range
    4980..60423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001030287.3NP_001025458.1  cyclic AMP-dependent transcription factor ATF-3 isoform 1

    See identical proteins and their annotated locations for NP_001025458.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1), which represses rather than activates transcription from promoters with ATF-binding elements.
    Source sequence(s)
    AC092803, AI949953, BC006322, CD638624, CD641946, CD742713
    Consensus CDS
    CCDS1506.1
    UniProtKB/Swiss-Prot
    P18847
    Related
    ENSP00000355954, ENST00000366987
    Conserved Domains (1) summary
    cd14722
    Location:96149
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
  2. NM_001040619.2NP_001035709.1  cyclic AMP-dependent transcription factor ATF-3 isoform 2

    See identical proteins and their annotated locations for NP_001035709.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as deltaZip2a) contains an alternate terminal exon, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2, also known as deltaZip2) has a distinct and shorter C-terminus, compared to isoform 1. Isoform 2 lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter.
    Source sequence(s)
    AB078026, AI949953, AL560585, BC006322, CD742713, DB197400
    Consensus CDS
    CCDS41464.1
    UniProtKB/Swiss-Prot
    P18847
    Related
    ENSP00000355950, OTTHUMP00000034890, ENST00000366983, OTTHUMT00000089299
    Conserved Domains (1) summary
    cl21462
    Location:96116
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  3. NM_001206484.2NP_001193413.2  cyclic AMP-dependent transcription factor ATF-3 isoform 3

    See identical proteins and their annotated locations for NP_001193413.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1. Both variants 5 and 8 encode isoform 3.
    Source sequence(s)
    AB078026, AI949953, AL560585, BC006322, CD742713, DA589280
    Consensus CDS
    CCDS58059.1
    UniProtKB/Swiss-Prot
    P18847
    Conserved Domains (1) summary
    cd14722
    Location:3992
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
  4. NM_001206486.2NP_001193415.1  cyclic AMP-dependent transcription factor ATF-3 isoform 5

    See identical proteins and their annotated locations for NP_001193415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks an in-frame segment of the 5' coding region, and contains an alternate terminal exon, thus differing in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5, also known as deltaZip2c) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB078026, AI949953, AY313927, BC006322, CD742713
    Consensus CDS
    CCDS55688.1
    UniProtKB/Swiss-Prot
    P18847
    Related
    ENSP00000336908, OTTHUMP00000038593, ENST00000336937, OTTHUMT00000098523
    Conserved Domains (1) summary
    cl21462
    Location:6787
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  5. NM_001206488.2NP_001193417.2  cyclic AMP-dependent transcription factor ATF-3 isoform 3

    See identical proteins and their annotated locations for NP_001193417.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1. Both variants 5 and 8 encode isoform 3.
    Source sequence(s)
    AI949953, AL560585, BC006322, BI524020, CD742713
    Consensus CDS
    CCDS58059.1
    UniProtKB/Swiss-Prot
    P18847
    Related
    ENSP00000483576, ENST00000613954
    Conserved Domains (1) summary
    cd14722
    Location:3992
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
  6. NM_001674.3NP_001665.1  cyclic AMP-dependent transcription factor ATF-3 isoform 1

    See identical proteins and their annotated locations for NP_001665.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1), which represses rather than activates transcription from promoters with ATF-binding elements. Both variants 1 and 3 encode isoform 1.
    Source sequence(s)
    AI949953, AL560585, BC006322, CD742713
    Consensus CDS
    CCDS1506.1
    UniProtKB/Swiss-Prot
    P18847
    Related
    ENSP00000344352, OTTHUMP00000034887, ENST00000341491, OTTHUMT00000089296
    Conserved Domains (1) summary
    cd14722
    Location:96149
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

    Range
    212565334..212620777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509579.1XP_011507881.1  

    See identical proteins and their annotated locations for XP_011507881.1

    UniProtKB/Swiss-Prot
    P18847
    Conserved Domains (1) summary
    cd14722
    Location:96149
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
  2. XM_005273146.1XP_005273203.1  

    See identical proteins and their annotated locations for XP_005273203.1

    UniProtKB/Swiss-Prot
    P18847
    Conserved Domains (1) summary
    cd14722
    Location:96149
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

RNA

  1. XR_001737203.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    214011558..214066986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001206485.1: Suppressed sequence

    Description
    NM_001206485.1: This RefSeq was permanently suppressed because the transcript is incompletely processed.
  2. NM_004024.4: Suppressed sequence

    Description
    NM_004024.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.