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    CD22 CD22 molecule [ Homo sapiens ]

    Gene ID: 933, updated on 19-May-2012
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    Summary

    Official Symbol
    CD22provided by HGNC
    Official Full Name
    CD22 moleculeprovided by HGNC
    Primary source
    HGNC:1643
    See related
    Ensembl:ENSG00000012124; HPRD:00114; MIM:107266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIGLEC2; SIGLEC-2; FLJ22814; MGC130020
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    Genomic context

    Location :
    19q13.1
    Sequence :
    Chromosome: 19; NC_000019.9 (35820072..35838264)
    See CD22 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene hepcidin antimicrobial peptide Neighboring gene myelin associated glycoprotein Neighboring gene free fatty acid receptor 1 Neighboring gene free fatty acid receptor 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. CD22 Exon 12 deletion is a characteristic genetic defect of therapy-refractory clones in paediatric acute lymphoblastic leukaemia. Ma H, et al. Br J Haematol, 2012 Jan. PMID 22017452.
    2. Association study of B-cell marker gene polymorphisms in European Caucasian patients with systemic sclerosis. Dawidowicz K, et al. Clin Exp Rheumatol, 2011 Sep-Oct. PMID 21961844.
    3. Anti-CD22 antibody targeting of pH-responsive micelles enhances small interfering RNA delivery and gene silencing in lymphoma cells. Palanca-Wessels MC, et al. Mol Ther, 2011 Aug. PMID 21629223.
    4. Flow cytometric study of potential target antigens (CD19, CD20, CD22, CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: analysis of 552 cases. Raponi S, et al. Leuk Lymphoma, 2011 Jun. PMID 21348573.
    5. CD22 regulates adaptive and innate immune responses of B cells. Kawasaki N, et al. J Innate Immun, 2011. PMID 21178327.

    See all (59) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Our study implicates the CD22DeltaE12 genetic defect in the aggressive biology of relapsed or therapy-refractory paediatric B-lineage ALL.
      Title: CD22 Exon 12 deletion is a characteristic genetic defect of therapy-refractory clones in paediatric acute lymphoblastic leukaemia.
    2. This CD22-targeted polymer carrier may be useful for siRNA delivery to lymphoma cells.
      Title: Anti-CD22 antibody targeting of pH-responsive micelles enhances small interfering RNA delivery and gene silencing in lymphoma cells.
    3. Results obtained through a large cohort of European caucasian patients with systemic sclerosis do not support the contribution of CD19, CD20, CD22, CD24 variants to the genetic susceptibility.
      Title: Association study of B-cell marker gene polymorphisms in European Caucasian patients with systemic sclerosis.
    4. Taken together, these results suggest that negative regulation of TLR signaling of B cells is an intrinsic property of CD22.
      Title: CD22 regulates adaptive and innate immune responses of B cells.
    5. Studies showed the qualitative and quantitative expression of four target surface antigens, CD19, CD20, CD22, and CD33, for which MoAbs are currently available for clinical use, in ALL.
      Title: Flow cytometric study of potential target antigens (CD19, CD20, CD22, CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: analysis of 552 cases.
    6. The efficacy of a ligand-targeting approach to B cell-specific depletion therapy for cancer may be the ability of CD22 to recycle and accumulate ligand-decorated cargo intracellularly, as an endocytic receptor.
      Title: CD22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of B cells.
    7. These striking findings implicate CD22DeltaE12 as a previously undescribed pathogenic mechanism in human B-precursor leukemia.
      Title: CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia.
    8. B cell surface receptors CD20 and CD22 are significantly affected in patients with SLE, pointing to their possible involvement in the aetiopathogenesis of the disease and in the regulatory mechanisms in response to the immune disturbance.
      Title: Altered CD19/CD22 balance in Egyptian children and adolescents with systemic lupus erythematosus.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    10. The B-cell receptor IgM was found to be a major in situ trans ligand of CD22.
      Title: In situ trans ligands of CD22 identified by glycan-protein photocross-linking-enabled proteomics.
    Submit: New GeneRIF Correction See all (23)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Nef nef B lymphocytes exposed to supernatants from HIV-1 Nef-expressing macrophages have upregulated expression of receptors CD22, CD54, and CD58 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P20273 Q96CW1 AP2M1    HPRD  PubMed  
    P20273 P23634 ATP2B4    HPRD  PubMed  
    P20273 P15391 CD19    HPRD  PubMed  
    P20273 P62993 GRB2    HPRD  PubMed  
    P20273 P00738 HP    HPRD  PubMed  
    P20273 P01871 IGHM    HPRD  PubMed  
    P20273 O00145 INPP5D    HPRD  PubMed  
    P20273 Q13094 LCP2    HPRD  PubMed  
    P20273 P07948 LYN    HPRD  PubMed  
    P20273 P27986 PIK3R1    HPRD  PubMed  
    P20273 P19174 PLCG1    HPRD  PubMed  
    P20273 P29350 PTPN6    HPRD  PubMed  
    P20273 P08575 PTPRC    HPRD  PubMed  
    P20273 P29353 SHC1    HPRD  PubMed  
    P20273 P15907 ST6GAL1    HPRD  PubMed  
    P20273 P43405 SYK    HPRD  PubMed  
    BioGRID:107371 BioGRID:106669 AP2A1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107371 BioGRID:107587 AP2M1    BioGRID  PubMed Two-hybrid 
    BioGRID:107371 BioGRID:107368 CD19    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107371 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107371 BioGRID:109847 INPP5D    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107371 BioGRID:110245 LYN    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107371 BioGRID:111351 PLCG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107371 BioGRID:111742 PTPN6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107371 BioGRID:111752 PTPRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107371 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107371 BioGRID:112717 SYK    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Potential readthrough

    Included gene: MAG

    Homology

    Pathways from BioSystems

    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      BCR signaling pathway, organism-specific biosystem
      BCR signaling pathway
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sugar binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    B-cell receptor CD22
    Names
    B-cell receptor CD22
    BL-CAM
    CD22 antigen
    T-cell surface antigen Leu-14
    B-lymphocyte cell adhesion molecule
    sialic acid binding Ig-like lectin 2
    sialic acid-binding Ig-like lectin 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185099.1 → NP_001172028.1  B-cell receptor CD22 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK225625, AK225694, DA989528, X59350
      Consensus CDS
      CCDS54248.1
      UniProtKB/TrEMBL
      F5H7U3
      UniProtKB/Swiss-Prot
      P20273
      Related
      ENSP00000442279, ENST00000536635
      Conserved Domains (2) summary
      pfam07679
      Location:242 – 327
      Blast Score: 162
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:248 – 327
      Blast Score: 119
      Ig; Immunoglobulin domain

    2. NM_001185100.1 → NP_001172029.1  B-cell receptor CD22 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC109306, BC109307, DA989528, DB333800, U62631, X59350
      Consensus CDS
      CCDS54247.1
      UniProtKB/TrEMBL
      F5GYU4
      UniProtKB/Swiss-Prot
      P20273
      UniProtKB/TrEMBL
      Q32M46
      Related
      ENSP00000441237, ENST00000544992
      Conserved Domains (2) summary
      pfam07679
      Location:242 – 327
      Blast Score: 163
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:248 – 327
      Blast Score: 120
      Ig; Immunoglobulin domain

    3. NM_001185101.1 → NP_001172030.1  B-cell receptor CD22 isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC109306, DA989528, DB333800, X52785, X59350
      Consensus CDS
      CCDS54249.1
      UniProtKB/Swiss-Prot
      P20273
      UniProtKB/TrEMBL
      Q32M46
      Related
      ENSP00000339349, ENST00000341773
      Conserved Domains (2) summary
      pfam07679
      Location:333 – 412
      Blast Score: 117
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:143 – 228
      Blast Score: 172
      Ig; Immunoglobulin domain

    4. NM_001771.3 → NP_001762.2  B-cell receptor CD22 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK225625, AK225694, BC109306, DA989528, DB333800, X59350
      Consensus CDS
      CCDS12457.1
      UniProtKB/Swiss-Prot
      P20273
      UniProtKB/TrEMBL
      Q0EAF5
      UniProtKB/TrEMBL
      Q32M46
      Related
      ENSP00000085219, ENST00000085219
      Conserved Domains (2) summary
      pfam07679
      Location:242 – 327
      Blast Score: 163
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:248 – 327
      Blast Score: 119
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      35820072..35838264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      32328562..32346758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024916.1: Suppressed sequence

      Description
      NM_024916.1: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a protein.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB012995.1 BAA36564.1
    genomic AB012996.1 BAA36565.1
    genomic AB012997.1 BAA36566.1
    genomic AB012998.1 BAA36567.1
    genomic AB012999.1 BAA36568.1
    genomic AB013000.1 BAA36569.1
    genomic AB013002.1 BAA36571.1
    genomic AB013003.1 BAA36572.1
    genomic AB013004.1 BAA36573.1
    genomic AB013005.1 BAA36574.1
    genomic AB013006.1 BAA36575.1
    genomic AB013007.1 BAA36576.1
    genomic AB253793.1 BAF32756.1
    genomic AB253794.1 BAF32757.1
    genomic AB253795.1 BAF32758.1
    genomic EF064756.1 ABK41939.1
    genomic HC042771.1 CBH30554.1
    genomic S61375.1 AAC18956.1
    genomic U62631.2 AAB06448.1
      AAB06449.1
    mRNA AK026467.1 BAB15489.1
    mRNA AK225625.1 None
    mRNA AK225694.1 None
    mRNA AK301177.1 BAH13422.1
    mRNA BC109306.1 AAI09307.1
    mRNA BC109307.1 None
    mRNA DA931592.1 None
    mRNA DA989528.1 None
    mRNA DB333800.1 None
    mRNA X52785.1 CAA36988.1
    mRNA X59350.1 CAA42006.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60926 GenPept UniProtKB/TrEMBL:O60926
    P20273.2 GenPept UniProtKB/Swiss-Prot:P20273
    Q0EAF5 GenPept UniProtKB/TrEMBL:Q0EAF5
    Q32M46 GenPept UniProtKB/TrEMBL:Q32M46
    Q9H5X8 GenPept UniProtKB/TrEMBL:Q9H5X8
    Q9UQB1 GenPept UniProtKB/TrEMBL:Q9UQB1
    Q9UQB2 GenPept UniProtKB/TrEMBL:Q9UQB2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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