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PABPC1 poly(A) binding protein, cytoplasmic 1 [ Homo sapiens (human) ]

Gene ID: 26986, updated on 23-Oct-2014
Official Symbol
PABPC1provided by HGNC
Official Full Name
poly(A) binding protein, cytoplasmic 1provided by HGNC
Primary source
HGNC:HGNC:8554
See related
Ensembl:ENSG00000070756; HPRD:05247; MIM:604679; Vega:OTTHUMG00000164779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAB1; PABP; PABP1; PABPC2; PABPL1
Summary
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]
See PABPC1 in Epigenomics, MapViewer
Location:
8q22.2-q23
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (100702916..100722482, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (101715144..101734969, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 46 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 62 Neighboring gene sorting nexin 31 Neighboring gene microRNA 7705 Neighboring gene ribosomal protein S20 pseudogene 23 Neighboring gene ribosomal protein S26 pseudogene 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify cytoplasmic unit 1 of polyA binding protein (PABPC1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify cytoplasmic unit 1 of polyA binding protein (PABPC1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify cytoplasmic unit 1 of polyA binding protein (PABPC1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify cytoplasmic unit 1 of polyA binding protein (PABPC1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, poly(A) binding protein 1 (PABPC1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PABPC1 is increased by RRE PubMed
rev binding of PAB1 to HIV-1 mRNA requires the presence of Rev and results in polyadenylation of the mRNA which is necessary for the Rev-dependent nucleocytoplasmic transport of HIV-1 mRNA PubMed
retropepsin gag-pol HIV-1 PR-induced PABP cleavage is involved in the inhibition of poly(A)-dependent translation. However, PABP cleavage has little impact on the translation of polyadenylated encephalomyocarditis virus internal ribosome entry site-containing mRNAs PubMed
gag-pol Purified HIV-1 protease cleaves poly(A)-binding protein 1 (PABP1) directly at positions 237 and 477, separating the two first RNA-recognition motifs from the C-terminal domain of PABP PubMed

Go to the HIV-1, Human Interaction Database

  • AUF1 (hnRNP D0) destabilizes mRNA, organism-specific biosystem (from REACTOME)
    AUF1 (hnRNP D0) destabilizes mRNA, organism-specific biosystemAUF1 (hnRNP D0) dimers bind U-rich regions of AU-rich elements (AREs) in the 3' untranslated regions of mRNAs. The binding causes AUF1 dimers to assemble into higher order tetrameric complexes. Dipho...
  • Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem (from REACTOME)
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystemThe cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF...
  • Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
    Cap-dependent Translation Initiation, organism-specific biosystemTranslation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start c...
  • Deadenylation of mRNA, organism-specific biosystem (from REACTOME)
    Deadenylation of mRNA, organism-specific biosystemDeadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 compl...
  • Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
    Deadenylation-dependent mRNA decay, organism-specific biosystemAfter undergoing rounds of translation, mRNA is normally destroyed by the deadenylation-dependent pathway. Though the trigger is unclear, deadenylation likely proceeds in two steps: one catalyzed by...
  • Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
    Eukaryotic Translation Initiation, organism-specific biosystemInitiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG sta...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
    L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemWhile circularization of mRNA during translation initiation is thought to contribute to an increase in the efficiency of translation, it also appears to provide a mechanism for translational silencin...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), organism-specific biosystemDuring normal translation termination eRF3 associates with the ribosome and then interacts with PABP bound to the polyadenylate tail of the mRNA to release the ribosome and allow a new round of trans...
  • Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystem (from REACTOME)
    Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), organism-specific biosystemNonsense-mediated decay has been observed with mRNAs that do not have an exon junction complex (EJC) downstream of the termination codon (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-An...
  • Nonsense-Mediated Decay (NMD), organism-specific biosystem (from REACTOME)
    Nonsense-Mediated Decay (NMD), organism-specific biosystemThe Nonsense-Mediated Decay (NMD) pathway activates the destruction of mRNAs containing premature termination codons (PTCs) (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-Ansmant et al. ...
  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystem (from REACTOME)
    Regulation of mRNA stability by proteins that bind AU-rich elements, organism-specific biosystemRNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-eleme...
  • Translation, organism-specific biosystem (from REACTOME)
    Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
  • Translation Factors, organism-specific biosystem (from WikiPathways)
    Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
  • Translation initiation complex formation, organism-specific biosystem (from REACTOME)
    Translation initiation complex formation, organism-specific biosystemThe translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. e...
  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
poly(A) binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) binding TAS
Traceable Author Statement
more info
PubMed 
poly(U) RNA binding IDA
Inferred from Direct Assay
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation activator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
RNA metabolic process TAS
Traceable Author Statement
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
gene expression TAS
Traceable Author Statement
more info
 
gene silencing by RNA ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA metabolic process TAS
Traceable Author Statement
more info
 
mRNA polyadenylation TAS
Traceable Author Statement
more info
PubMed 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA stabilization TAS
Traceable Author Statement
more info
PubMed 
negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA poly(A) tail shortening TAS
Traceable Author Statement
more info
 
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of translation TAS
Traceable Author Statement
more info
PubMed 
translation TAS
Traceable Author Statement
more info
 
translational initiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
polyadenylate-binding protein 1
Names
polyadenylate-binding protein 1
poly(A) binding protein, cytoplasmic 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027520.1 

    Range
    5001..24172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002568.3NP_002559.2  polyadenylate-binding protein 1

    See proteins identical to NP_002559.2

    Status: REVIEWED

    Source sequence(s)
    AK130523, AL135187
    Consensus CDS
    CCDS6289.1
    UniProtKB/TrEMBL
    A0A024R9C1
    UniProtKB/Swiss-Prot
    P11940
    Related
    ENSP00000313007, OTTHUMP00000227462, ENST00000318607, OTTHUMT00000380217
    Conserved Domains (6) summary
    TIGR01628
    Location:11615
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12378
    Location:1291
    RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
    cd12379
    Location:97172
    RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
    cd12380
    Location:190269
    RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
    cd12381
    Location:293370
    RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
    pfam00658
    Location:544614
    PABP; Poly-adenylate binding protein, unique domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    100702916..100722482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250861.1XP_005250918.1  

    See proteins identical to XP_005250918.1

    UniProtKB/TrEMBL
    A0A024R9C1
    UniProtKB/Swiss-Prot
    P11940
    Conserved Domains (6) summary
    TIGR01628
    Location:11615
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12378
    Location:1291
    RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
    cd12379
    Location:97172
    RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
    cd12380
    Location:190269
    RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
    cd12381
    Location:293370
    RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
    pfam00658
    Location:544614
    PABP; Poly-adenylate binding protein, unique domain

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    96913861..96933038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    101755929..101775103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)