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RARG retinoic acid receptor, gamma [ Homo sapiens (human) ]

Gene ID: 5916, updated on 17-Apr-2014
Official Symbol
RARGprovided by HGNC
Official Full Name
retinoic acid receptor, gammaprovided by HGNC
Primary source
HGNC:9866
See related
Ensembl:ENSG00000172819; HPRD:01573; MIM:180190; Vega:OTTHUMG00000048077
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RARC; NR1B3
Summary
This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Location :
12q13
Sequence :
Chromosome: 12; NC_000012.12 (53210566..53232256, complement)
See RARG in Epigenomics, MapViewer

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene zinc finger protein 740 Neighboring gene integrin, beta 7 Neighboring gene major facilitator superfamily domain containing 5 Neighboring gene extra spindle pole bodies homolog 1 (S. cerevisiae)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef, p27 nef HIV-1 Nef induces loss of F-actin assembly and inhibits retinoid receptor-mediated transcription PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
    Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...
  • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
    Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
  • Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem (from WikiPathways)
    Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
  • Vitamin A and Carotenoid Metabolism, organism-specific biosystem (from WikiPathways)
    Vitamin A and Carotenoid Metabolism, organism-specific biosystemThis pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some ...
  • Vitamin A and carotenoid metabolism, organism-specific biosystem (from WikiPathways)
    Vitamin A and carotenoid metabolism, organism-specific biosystemThis pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoic acid receptor activity IEA
Inferred from Electronic Annotation
more info
 
retinoid X receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Harderian gland development IEA
Inferred from Electronic Annotation
more info
 
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
embryonic eye morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic hindlimb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
gene expression TAS
Traceable Author Statement
more info
 
growth plate cartilage chondrocyte growth IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cartilage development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of programmed cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
prostate gland epithelium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of cell size TAS
Traceable Author Statement
more info
PubMed 
regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
retinoic acid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
trachea cartilage development IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
retinoic acid receptor gamma
Names
retinoic acid receptor gamma
RAR-gamma
nuclear receptor subfamily 1 group B member 3
retinoic acid nuclear receptor gamma variant 1
retinoic acid nuclear receptor gamma variant 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029822.1 RefSeqGene

    Range
    5001..26691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000966.5NP_000957.1  retinoic acid receptor gamma isoform 1

    See proteins identical to NP_000957.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AW002722, BC072462, DA436501
    Consensus CDS
    CCDS8850.1
    UniProtKB/TrEMBL
    A8K3H3
    UniProtKB/Swiss-Prot
    P13631
    Related
    ENSP00000388510, OTTHUMP00000045736, ENST00000425354, OTTHUMT00000109404
    Conserved Domains (2) summary
    cd06937
    Location:188418
    Blast Score: 1181
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cd06964
    Location:85165
    Blast Score: 469
    NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
  2. NM_001042728.2NP_001036193.1  retinoic acid receptor gamma isoform 2

    See proteins identical to NP_001036193.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an alternate start codon, and a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK297277, AK316259, AW002722, BC072462, DC294855
    Consensus CDS
    CCDS41790.1
    UniProtKB/TrEMBL
    F1D8P1
    UniProtKB/Swiss-Prot
    P13631
    Conserved Domains (2) summary
    cd06937
    Location:177407
    Blast Score: 1185
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cd06964
    Location:74154
    Blast Score: 460
    NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
  3. NM_001243730.1NP_001230659.1  retinoic acid receptor gamma isoform 4

    See proteins identical to NP_001230659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon containing the start codon used in variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (4) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK297023, AW002722, BC072462, DA436501
    Consensus CDS
    CCDS58236.1
    UniProtKB/Swiss-Prot
    P13631
    Conserved Domains (2) summary
    cd06937
    Location:116346
    Blast Score: 1176
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cd06964
    Location:1393
    Blast Score: 456
    NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
  4. NM_001243731.1NP_001230660.1  retinoic acid receptor gamma isoform 5

    See proteins identical to NP_001230660.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two consecutive exons compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (5) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK297110, AW002722, BC072462, DA436501
    UniProtKB/TrEMBL
    B7Z4B4
    Conserved Domains (2) summary
    cd06937
    Location:67297
    Blast Score: 1158
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cl02596
    Location:144
    Blast Score: 252
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  5. NM_001243732.1NP_001230661.1  retinoic acid receptor gamma isoform 3

    See proteins identical to NP_001230661.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and lacks another coding exon compared to variant 1. This results in translation initiation from an alternate start codon, and a shorter isoform (3) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK297277, AW002722, BC072462, DC294855
    Consensus CDS
    CCDS58237.1
    UniProtKB/Swiss-Prot
    P13631
    Conserved Domains (2) summary
    cd06937
    Location:166396
    Blast Score: 1176
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cl02596
    Location:88143
    Blast Score: 316
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12

    Range
    53210566..53232256, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269056.2XP_005269113.1  

    See proteins identical to XP_005269113.1

    UniProtKB/TrEMBL
    A8K3H3
    UniProtKB/Swiss-Prot
    P13631
    Related
    ENSP00000377947
    Conserved Domains (2) summary
    cd06937
    Location:188418
    Blast Score: 1181
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cd06964
    Location:85165
    Blast Score: 469
    NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
  2. XM_005269055.2XP_005269112.1  

    See proteins identical to XP_005269112.1

    Conserved Domains (2) summary
    cd06937
    Location:275505
    Blast Score: 1194
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cd06964
    Location:172252
    Blast Score: 477
    NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
  3. XM_005269054.2XP_005269111.1  

    See proteins identical to XP_005269111.1

    Conserved Domains (2) summary
    cd06937
    Location:275505
    Blast Score: 1194
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cd06964
    Location:172252
    Blast Score: 477
    NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers
  4. XM_005269057.1XP_005269114.1  

    See proteins identical to XP_005269114.1

    UniProtKB/TrEMBL
    A8K3H3
    UniProtKB/Swiss-Prot
    P13631
    Conserved Domains (2) summary
    cd06937
    Location:188418
    Blast Score: 1181
    NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
    cd06964
    Location:85165
    Blast Score: 469
    NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

Alternate HuRef

Genomic

  1. AC_000144.1 Alternate HuRef

    Range
    50646458..50668146, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    53570785..53592447, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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