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CPSF1 cleavage and polyadenylation specific factor 1 [ Homo sapiens (human) ]

Gene ID: 29894, updated on 8-May-2016
Official Symbol
CPSF1provided by HGNC
Official Full Name
cleavage and polyadenylation specific factor 1provided by HGNC
Primary source
HGNC:HGNC:2324
See related
Ensembl:ENSG00000071894 HPRD:05823; MIM:606027; Vega:OTTHUMG00000174612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPSF160; P/cl.18; HSU37012
Summary
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
8q24.23
Exon count:
42
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (144393231..144409400, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145618446..145634733, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 52 member 2 Neighboring gene uncharacterized LOC101928902 Neighboring gene aarF domain containing kinase 5 Neighboring gene microRNA 939 Neighboring gene microRNA 1234 Neighboring gene microRNA 6849 Neighboring gene solute carrier family 39 member 4 Neighboring gene VPS28, ESCRT-I subunit

NHGRI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify cleavage and polyadenylation specific factor 1 (CPSF1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify cleavage and polyadenylation specific factor 1 (CPSF1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify cleavage and polyadenylation specific factor 1 (CPSF1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify cleavage and polyadenylation specific factor 1 (CPSF1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA cleavage IBA
Inferred from Biological aspect of Ancestor
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
mRNA polyadenylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
pre-mRNA cleavage required for polyadenylation IC
Inferred by Curator
more info
PubMed 
tRNA splicing, via endonucleolytic cleavage and ligation TAS
Traceable Author Statement
more info
 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
cleavage and polyadenylation specificity factor subunit 1
Names
CPSF 160 kDa subunit
cleavage and polyadenylation specific factor 1, 160kDa
cleavage and polyadenylation specificity factor 160 kDa subunit
polyadenylation specificity factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013291.2NP_037423.2  cleavage and polyadenylation specificity factor subunit 1

    See identical proteins and their annotated locations for NP_037423.2

    Status: VALIDATED

    Source sequence(s)
    BC017232, CD299980
    Consensus CDS
    CCDS34966.1
    UniProtKB/Swiss-Prot
    Q10570
    Related
    ENSP00000484669, ENST00000616140
    Conserved Domains (3) summary
    COG5161
    Location:11437
    SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
    pfam03178
    Location:10731408
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:92672
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    144393231..144409400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716548.2XP_006716611.1  

    Conserved Domains (3) summary
    COG5161
    Location:11434
    SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
    pfam03178
    Location:10731405
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:92672
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
  2. XM_011516997.1XP_011515299.1  

    See identical proteins and their annotated locations for XP_011515299.1

    UniProtKB/TrEMBL
    D3DWL9
    Conserved Domains (3) summary
    COG5161
    Location:231359
    SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
    pfam03178
    Location:9951330
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:14594
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
  3. XM_006716549.2XP_006716612.1  

    See identical proteins and their annotated locations for XP_006716612.1

    UniProtKB/TrEMBL
    D3DWL9
    Conserved Domains (3) summary
    COG5161
    Location:231359
    SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
    pfam03178
    Location:9951330
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:14594
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
  4. XM_011516999.1XP_011515301.1  

    See identical proteins and their annotated locations for XP_011515301.1

    UniProtKB/TrEMBL
    D3DWL9
    Conserved Domains (3) summary
    COG5161
    Location:231359
    SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
    pfam03178
    Location:9951330
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:14594
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
  5. XM_011516998.1XP_011515300.1  

    See identical proteins and their annotated locations for XP_011515300.1

    UniProtKB/TrEMBL
    D3DWL9
    Conserved Domains (3) summary
    COG5161
    Location:231359
    SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
    pfam03178
    Location:9951330
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:14594
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
  6. XM_006716550.2XP_006716613.1  

    Conserved Domains (1) summary
    pfam03178
    Location:415750
    CPSF_A; CPSF A subunit region

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    145656550..145673024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)