MKI67 antigen identified by monoclonal antibody Ki-67 [Homo sapiens] - Gene

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Summary

Official Symbol: MKI67provided by HGNC
Official Full Name: antigen identified by monoclonal antibody Ki-67provided by HGNC
Primary source: HGNC:7107
Locus tag: RP11-380J17.2
See related: Ensembl:ENSG00000148773; HPRD:08902; MIM:176741; Vega:OTTHUMG00000019255
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KIA
Summary: This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

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Genomic context

Location :: 10q26.2

Sequence :: Chromosome: 10; NC_000010.10 (129894923..129924468, complement)

See MKI67 in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Women with a HER2/neu/neu+/Ki67+ ductal carcinoma in situ (DCIS) have a higher risk of developing DCIS local recurrence after breast-conserving surgery.
Title: HER2/neu and Ki-67 expression predict non-invasive recurrence following breast-conserving therapy for ductal carcinoma in situ.
The Ki-67 index predicts progression-free survival of patients with ileal well-differentiated neuroendocrine tumors.
Title: Ki-67 proliferative index predicts progression-free survival of patients with well-differentiated ileal neuroendocrine tumors.
Low expression of Ki-67 was correlated with multiple lesions and high expression of KI-67 may be related with tumor across the midline in patients with glioblastoma multiforme.
Title: Relationship between magnetic resonance imaging and molecular pathology in patients with glioblastoma multiforme.
Proliferation marker Ki-67 is an independent prognostic indicator in Chinese GBM patients.
Title: Gene expression profiling reveals Ki-67 associated proliferation signature in human glioblastoma.
The high-grade serous carcinomas had a significantly higher expression level of p53 and Ki-67, while low-grade carcinomas had a significantly higher expression level of Pax2.
Title: [Clinicopathologic study and immunohistochemistry comparison of Pax2, p53 and Ki-67 in low- and high-grade ovarian serous carcinomas].
Ki-67 staining percentage may represent a marker to select hepatocellular carcinoma patients for liver transplantation and to follow posttransplant recurrence.
Title: Effects of risk factors and Ki-67 on rates of recurrence on patients who have undergone liver transplant for hepatocellular carcinoma.
analysis of Aurora A and B kinases, Ki-67 and the estrogen and progesterone receptors from an endometriosis tissue microarray model
Title: Expression patterns of Aurora A and B kinases, Ki-67 and the estrogen and progesterone receptors determined using an endometriosis tissue microarray model.
Ki-67 expression was higher in patients with high-grade endometrioid carcinomas.
Title: The use of an immunocytochemical double-labeling staining can display the distribution of Bcl-2/Ki-67 cells in endometrial adenocarcinomas as well as in normal endometrium.
Data suggest that there is no correlation between Ki-67 LI or cytokeratin distribution pattern and MGMT immunoreactivity in GH-secreting pituitary adenomas. These data may have implications in drug resistance regarding treatment with temozolomide.
Title: MGMT immunoexpression in growth hormone-secreting pituitary adenomas and its correlation with Ki-67 labeling index and cytokeratin distribution pattern.
Ki-67, but not proliferating cell nuclear antigen, has a role in poor disease free survival in patients with adenocarcinoma of the lung
Title: The expression of Ki-67, but not proliferating cell nuclear antigen, predicts poor disease free survival in patients with adenocarcinoma of the lung.

Submit: New GeneRIF Correction See all (252)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association with select biomarker traits in the Framingham Heart Study.

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	Podocyte-specific expression of HIV-1 Nef induces loss of synaptopodin and WT1, and expression of Ki-67 in podocytes, which is essential for the dedifferentiation and proliferation of podocytes in HIV-associated nephropathy	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_002408.2	NP_006798.1	CBX1	BIND	PubMed	pKi-67 interacts with the CS domain of HP1 protein via its C-terminus. This interaction was modeled on a demonstrated interaction between pKi-67 from human and HP1-beta from mouse.
NP_002408.2	NP_009207.2	CBX3	BIND	PubMed	pKi-67 interacts with HP1-gamma via its C-terminus. This interaction was modeled on a demonstrated interaction between pKi-67 from human and HP1-gamma from mouse.
NP_002408.2	NP_036249.1	CBX5	BIND	PubMed	pKi-67 interacts with HP1-alpha protein via its C-terminus. This interaction was modeled on a demonstrated interaction between pKi-67 from human and HP1-alpha from mouse.
P46013	Q13185	CBX3	HPRD	PubMed
P46013	P45973	CBX5	HPRD	PubMed
P46013	Kinesin like 7	KIF15	HPRD	PubMed
P46013	P46013	MKI67	HPRD	PubMed
P46013	Q9BYG3	MKI67IP	HPRD	PubMed
P46013	P05771	PRKCB	HPRD	PubMed
BioGRID:110434	BioGRID:116463	CBX3	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110434	BioGRID:107420	CDK1	BioGRID	PubMed	Biochemical Activity
BioGRID:110434	BioGRID:218144	Haus8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110434	BioGRID:121307	KIF15	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110434	BioGRID:201430	Mki67	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110434	BioGRID:215383	Rrp1b	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110434	BioGRID:112490	SMN1	BioGRID	PubMed	Two-hybrid
BioGRID:110434	BioGRID:113188	SUMO1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110434	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110434	BioGRID:112938	TK1	BioGRID	PubMed	Two-hybrid
BioGRID:110434	BioGRID:113003	TOP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110434	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein C-terminus binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
DNA metabolic process	IEA Inferred from Electronic Annotation more info
cell cycle	IEA Inferred from Electronic Annotation more info
cell proliferation	TAS Traceable Author Statement more info	PubMed
cellular response to heat	IEA Inferred from Electronic Annotation more info
meiosis	IEA Inferred from Electronic Annotation more info
organ regeneration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
condensed chromosome	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
intracellular	IEA Inferred from Electronic Annotation more info
nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: antigen KI-67

Names: antigen KI-67; proliferation-related Ki-67 antigen

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145966.1 → NP_001139438.1 antigen KI-67 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AL355529, AL390236, BU632619, BU855841, X65551

Consensus CDS

CCDS53588.1

UniProtKB/Swiss-Prot

P46013

Related

ENSP00000357642, OTTHUMP00000020740, ENST00000368653, OTTHUMT00000051000

Conserved Domains (2) summary

cd00060
Location:8 – 98
Blast Score: 184

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam08065
Location:764 – 875
Blast Score: 406

K167R; K167R (NUC007) repeat
NM_002417.4 → NP_002408.3 antigen KI-67 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL355529, AL390236, BU632619, BU855841, X65550

Consensus CDS

CCDS7659.1

UniProtKB/Swiss-Prot

P46013

Related

ENSP00000357643, OTTHUMP00000020739, ENST00000368654, OTTHUMT00000050999

Conserved Domains (2) summary

cd00060
Location:8 – 98
Blast Score: 183

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam08065
Location:1124 – 1235
Blast Score: 410

K167R; K167R (NUC007) repeat

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p5 Primary Assembly

Range

129894923..129924468, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

123469633..123499187, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL355529.21	CAI16902.1
		CAI16903.1
genomic	AL355529.21	CAI16902.1
		CAI16903.1
genomic	AL390236.21	CAH73169.1
		CAH73170.1
genomic	AL390236.21	CAH73169.1
		CAH73170.1
genomic	CH471066.2	EAW49177.1
		EAW49178.1
		EAW49179.1
genomic	HI179092.1	CBX53854.1
genomic	X74107.1	None
genomic	X94762.1	CAA64388.1
mRNA	AJ567755.1	CAD99005.1
mRNA	AJ567756.1	CAD99006.1
mRNA	AJ567757.1	CAD99007.1
mRNA	AK299254.1	BAG61285.1
mRNA	BM699306.1	None
mRNA	BU632619.1	None
mRNA	BU855841.1	None
mRNA	X65550.1	CAA46519.1
mRNA	X65551.1	CAA46520.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P46013.2	GenPept	UniProtKB/Swiss-Prot:P46013
Q70L72	GenPept	UniProtKB/TrEMBL:Q70L72
Q70L73	GenPept	UniProtKB/TrEMBL:Q70L73
Q70L74	GenPept	UniProtKB/TrEMBL:Q70L74