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    CDC5L CDC5 cell division cycle 5-like (S. pombe) [ Homo sapiens ]

    Gene ID: 988, updated on 10-May-2012
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    Summary

    Official Symbol
    CDC5Lprovided by HGNC
    Official Full Name
    CDC5 cell division cycle 5-like (S. pombe)provided by HGNC
    Primary source
    HGNC:1743
    Locus tag
    RP1-319D22.1
    See related
    Ensembl:ENSG00000096401; HPRD:04184; MIM:602868; Vega:OTTHUMG00000014767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1; KIAA0432
    Summary
    The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6p21
    Sequence :
    Chromosome: 6; NC_000006.11 (44355302..44414780)
    See CDC5L in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene alanyl-tRNA synthetase 2, mitochondrial (putative) Neighboring gene spermatogenesis associated, serine-rich 1 Neighboring gene microRNA 4642 Neighboring gene uncharacterized LOC100505862 Neighboring gene suppressor of Ty 3 homolog (S. cerevisiae) Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 19 pseudogene 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Zhao J, et al. J Proteomics, 2011 Dec 21. PMID 21907836.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    5. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. Ganesh K, et al. J Biol Chem, 2011 May 13. PMID 21385873.

    See all (59) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31
      Title: CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.
    2. Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction
      Title: Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.
    3. A central region in hnRNP-M is required for interaction with CDC5L/PLRG1.
      Title: Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.
    4. Blom7alpha is a novel splicing factor of the K homology domain family that might be implicated in alternative splicing by helping to position the CDC5L-SNEV(Prp19-Pso4) complex at the splice sites
      Title: Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4.
    5. These findings show a new function for Cdc5L in the regulation of the ATR-mediated cell-cycle checkpoint in response to genotoxic agents.
      Title: Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint.
    6. Phosphorylation of CDC5L at threonines 411 and 438 within recognition sequences for CDKs are required for CDC5L-mediated pre-mRNA splicing.
      Title: Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing.
    7. Results indicate that CDC5L is the most likely candidate oncogene for the 6p12-p21 amplicon found in osteosarcoma.
      Title: Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    9. the interaction between CDC5L and PLRG1 is essential for pre-mRNA splicing
      Title: Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1.
    10. CDC5 may function in pre-mRNA processing and cell cycle progression
      Title: Distinct domains of human CDC5 direct its nuclear import and association with the spliceosome.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001244.1 NP_002660.1 PLRG1    BIND  PubMed CDC5L interacts with PLRG1. 
    NP_001244.1 NP_003585.3 TTF2    BIND  PubMed HuF2 interacts with CDC5L. 
    Q99459 P38936 CDKN1A    HPRD  PubMed  
    Q99459 Q8N726 CDKN2A    HPRD  PubMed  
    Q99459 Q9H211 CDT1    HPRD  PubMed  
    Q99459 Q7L590 MCM10    HPRD  PubMed  
    Q99459 P25205 MCM3    HPRD  PubMed  
    Q99459 P33991 MCM4    HPRD  PubMed  
    Q99459 P33992 MCM5    HPRD  PubMed  
    Q99459 Q14680 MELK    HPRD  PubMed  
    Q99459 Q13415 ORC1    HPRD  PubMed  
    Q99459 Q13416 ORC2    HPRD  PubMed  
    Q99459 O43913 ORC5    HPRD  PubMed  
    Q99459 O43660 PLRG1    HPRD  PubMed  
    Q99459 P62136 PPP1CA    HPRD  PubMed  
    Q99459 Q12972 PPP1R8    HPRD  PubMed  
    Q99459 Q9UNY4 TTF2    HPRD  PubMed  
    Q99459 P61981 YWHAG    HPRD  PubMed  
    BioGRID:107424 BioGRID:114857 AKAP6    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:115445 AKAP9    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:115575 BCAS2    BioGRID  PubMed Co-purification 
    BioGRID:107424 BioGRID:115042 BZW1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:107252 CALM1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107424 BioGRID:122267 CCDC136    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:107452 CDK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107424 BioGRID:121123 CTNNBL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107424 BioGRID:119575 CWC15    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:214866 Cdc5l    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107424 BioGRID:118061 DISC1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:124542 DIXDC1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:107135 DST    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:108117 DYNC1H1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:120881 EXOC1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:116867 EXOC7    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:116181 GCN1L1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107424 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107424 BioGRID:119496 HOOK1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:109821 ILF2    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:114478 KALRN    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:129744 KANSL1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:116667 KDM1A    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:116808 KIAA0182    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:117053 KIAA0240    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:109998 KIF3C    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:110000 KIF5B    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:117048 MACF1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:116679 MYT1L    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:123893 PCBD2    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:115017 PDE4DIP    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:111370 PLRG1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Protein-peptide; Reconstituted Complex 
    BioGRID:107424 BioGRID:111391 PMS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107424 BioGRID:114071 PPFIA2    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:114065 PPM1D    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:111493 PPP1CA    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:116948 PPP1R13B    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:159581 PPP1R8    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:118151 PRPF19    BioGRID  PubMed Affinity Capture-MS; Co-purification; Reconstituted Complex 
    BioGRID:107424 BioGRID:114577 PRPF3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107424 BioGRID:228650 Prpf8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107424 BioGRID:118134 RBMX    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:112056 RPL12    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:112057 RPL13    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:112131 RPS16    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:112144 RPS25    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:116503 SCAF8    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:115580 SF3A1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:117017 SF3B1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:116188 SF3B2    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:115554 SF3B4    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:115153 SFI1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:112319 SFPQ    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:125639 SFR1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:114853 SH3BP5    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:112510 SNRPA    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:112511 SNRPA1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:112516 SNRPD1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:112517 SNRPD2    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:112518 SNRPD3    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:116597 SNW1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107424 BioGRID:112589 SPTBN1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:115544 SRRM1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107424 BioGRID:112324 SRSF1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:112325 SRSF2    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107424 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107424 BioGRID:116928 SYNE1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:211406 Snw1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107424 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107424 BioGRID:113006 TOP2A    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107424 BioGRID:117577 TRAF3IP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:116570 TRAK1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:113055 TRIO    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:114036 TTF2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107424 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107424 BioGRID:116884 WWC1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107424 BioGRID:116168 YWHAQ    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:113366 YWHAZ    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:113412 ZNF35    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:117502 ZNF451    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:129825 ZSCAN1    BioGRID  PubMed Two-hybrid 
    BioGRID:107424 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the CDC5L gene: The CDC5L gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, 35S U5-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, 35S U5-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, Prp19/CDC5L complex, organism-specific biosystem (from KEGG)
      Spliceosome, Prp19/CDC5L complex, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    cell division cycle 5-like protein
    Names
    cell division cycle 5-like protein
    Cdc5-related protein
    pombe cdc5-related protein
    dJ319D22.1 (CDC5-like protein)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253.3 → NP_001244.1  cell division cycle 5-like protein

      Status: REVIEWED

      Source sequence(s)
      AL133262, BC001568, BM829346, DC422730
      Consensus CDS
      CCDS4912.1
      UniProtKB/Swiss-Prot
      Q99459
      Related
      ENSP00000360532, OTTHUMP00000016529, ENST00000371477, OTTHUMT00000040743
      Conserved Domains (3) summary
      cd00167
      Location:11 – 54
      Blast Score: 131
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      COG5147
      Location:3 – 257
      Blast Score: 324
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam11831
      Location:339 – 728
      Blast Score: 996
      Myb_Cef; pre-mRNA splicing factor component

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      44355302..44414780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      44077920..44137289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL133262.8 CAI20149.1
    genomic AL353588.25 CAI40750.1
    genomic AY518540.1 AAR89913.1
    genomic CH471081.1 EAX04270.1
    mRNA AB007892.2 BAA24862.2
    mRNA AK128737.1 BAG54722.1
    mRNA AK299738.1 BAG61633.1
    mRNA BC001568.1 AAH01568.1
    mRNA BG187521.1 None
    mRNA BG497404.1 None
    mRNA BM829346.1 None
    mRNA D85423.1 BAA20885.1
    mRNA DC422730.1 None
    mRNA U86753.1 AAB61210.1
    other-genetic DQ891623.2 ABM82549.1
    other-genetic DQ894814.2 ABM85740.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99459.2 GenPept UniProtKB/Swiss-Prot:Q99459
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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