VEGFA vascular endothelial growth factor A [Homo sapiens (human)] - Gene

Summary

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Official Symbol: VEGFAprovided by HGNC
Official Full Name: vascular endothelial growth factor Aprovided by HGNC
Primary source: HGNC:12680
Locus tag: RP1-261G23.1
See related: Ensembl:ENSG00000112715; HPRD:01889; MIM:192240; Vega:OTTHUMG00000014745
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: VPF; VEGF; MVCD1
Summary: This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 6p12

Sequence :: Chromosome: 6; NC_000006.11 (43737946..43754224)

See VEGFA in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

This manuscript reviews the role and relevance of VEGF-A and VEGF-C and its downstream signaling in acute myeloid leukemia. [review]
Title: Vascular endothelial growth factor signaling in acute myeloid leukemia.
G-CSF and VEGF levels in sera might be associated with an early phase of brain protection after birth in severe asphyxia treated with head cooling.
Title: Temporal alteration of serum G-CSF and VEGF levels in perinatal asphyxia treated with head cooling.
In normal pregnancies, midgestation amniotic fluid VEGF and PlGF concentrations positively correlate with gestational age.
Title: Midtrimester amniotic fluid concentrations of angiogenic factors in relation to maternal, gestational and neonatal characteristics in normal pregnancies.
Genetic variations at VEGF-460C and IFN-gamma +874T might accelerate the pathogenesis of retinal neovascularization in proliferative diabetic retinopathy.
Title: Association of vascular endothelial growth factor, transforming growth factor beta, and interferon gamma gene polymorphisms with proliferative diabetic retinopathy in patients with type 2 diabetes.
endometriosis is not associated with gene mutations for VEGF at codon 1154 G/A
Title: A search to identify genetic risk factors for endometriosis.
VEGF expression may have potential value for predicting distant metastasis and disease-free survival in stage III rectal cancer after 30-Gy/10-f preoperative radiotherapy.
Title: Expression of vascular endothelial growth factor can predict distant metastasis and disease-free survival for clinical stage III rectal cancer following 30-Gy/10-f preoperative radiotherapy.
VEGF induced angiogenesis in nasopharyngeal carcinoma tissue, and plays an important role in disease progression. There was positive correlation between VEGF and microvessel density in nasopharyngeal carcinoma tissue.
Title: [Detection and clinical significance of vascular endothelium growth factor and microvessel density in patients with nasopharyngeal carcinoma].
Report VEGF staining in kidney glomerulus/tubules from lupus nephritis patients.
Title: Toll-like receptor 9 and vascular endothelial growth factor levels in human kidneys from lupus nephritis patients.
VEGF was reduced in the CSF of suicide attempters. CSF VEGF showed a significant negative correlation with depression severity.
Title: Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters.
Hyperbaric oxygenation combined with As(2)O(3) can increase the expression of caspase 3 mRNA and decrease the expression of HIF-1a and VEGF mRNA in K562 cells.
Title: [Effects of hyperbaric oxygenation combined with As(2)O(3) on proliferation of K562 cells and associated mechanism].

Submit: New GeneRIF Correction See all (2379)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Microvascular complications of diabetes 1

MIM: 603933

Genetic Testing Registry

NHGRI GWAS Catalog

A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.

Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs	PubMed
Nef, p27	nef	HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner	PubMed
Tat, p14	tat	HIV-1 Tat inhibits the differentiation of mesenchymal stem cells (MSCs) to endothelial cells by downregulating the expression of VEGF-induced endothelial markers such as Flt-1, KDR and vWF	PubMed
	tat	The chemokine like region of HIV-1 Tat (amino acids 24-51) induces the release of angiogenic factors, including vascular endothelial growth factor (VEGF), an effect linked to Tat induced angiogenesis	PubMed
	tat	VEGF can compete with HIV-1 Tat chemotactic activity in Kaposi's sarcoma (KS) cells, indicating Tat may cooperate with VEGF in activation of VEGFR-2 on KS precursor spindle and endothelial cells and contribute to the aggressiveness of AIDS-KS lesions	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
AF095785.1	NP_001521.1	HIF1A	BIND	PubMed	HIF1A (HIF-1-alpha) interacts with the VEGF promoter.
AF095785.1	NP_000312.1	RB1	BIND	PubMed	RB1 (pRB) interacts with the VEGF promoter.
NP_003367.3	AAD48080.1	ADAMTS1	BIND	PubMed	ADAMTS1 interacts with VEGF165
NP_003367.3	NP_002010.1	FLT1	BIND	PubMed	VEGF-A interacts with VEGFR-1. This interaction was modeled on a demonstrated interaction between human VEGF-A and VEGFR-1 from an unspecified species.
NP_003367.3	NP_002010.1	FLT1	BIND	PubMed	VEGF165 interacts with Flt-1. This interaction was modeled on a demonstrated interaction between human VEGF165 and Flt-1 from an unspecified species.
NP_003367.3	NP_002244.1	KDR	BIND	PubMed	VEGF interacts with KDR.
NP_003367.3	NP_002244.1	KDR	BIND	PubMed	VEGF-A interacts with VEGFR-2. This interaction was modeled on a demonstrated interaction between human VEGF-A and VEGFR-2 from an unspecified species.
NP_003367.3	NP_002244.1	KDR	BIND	PubMed	VEGF165 interacts with KDR. This interaction was modeled on a demonstrated interaction between human VEGF165 and KDR from an unspecified species.
NP_003367.3	NP_003864.2	NRP1	BIND	PubMed	VEGF165 interacts with neuropilin-1. This interaction was modeled on a demonstrated interaction between human VEGF165 and neuropilin-1 from an unspecified species.
NP_003367.3	NP_003864.2	NRP1	BIND	PubMed	NRP1 interacts with VEGF165.
NP_003367.3	NP_957718.1	NRP2	BIND	PubMed	NP-2 interacts with VEGF165.
NP_003367.3		NRP2	BIND	PubMed	NP-2 interacts with VEGF145.
NP_003367.3			BIND	PubMed	GFB-204 interacts with VEGF.
P15692	Q9UHI8	ADAMTS1	HPRD	PubMed
P15692	P31749	AKT1	HPRD	PubMed
P15692	P29279	CTGF	HPRD	PubMed
P15692	P29323	EPHB2	HPRD	PubMed
P15692	P17948	FLT1	HPRD	PubMed
P15692	P35052	GPC1	HPRD	PubMed
P15692	Q16270	IGFBP7	HPRD	PubMed
P15692	P35968	KDR	HPRD	PubMed
P15692	O14786	NRP1	HPRD	PubMed
P15692	O60462	NRP2	HPRD	PubMed
P15692	P49763	PGF	HPRD	PubMed
P15692	Q13275	SEMA3F	HPRD	PubMed
P15692	P09486	SPARC	HPRD	PubMed
P15692	P22105	TNXB	HPRD	PubMed
P15692	P15692	VEGFA	HPRD	PubMed
P15692	P49765	VEGFB	HPRD	PubMed
P15692	P04004	VTN	HPRD	PubMed
P15692	P67809	YBX1	HPRD	PubMed
P15692	P16989	YBX3	HPRD	PubMed
BioGRID:113265	BioGRID:114888	ADAMTS1	BioGRID	PubMed	Affinity Capture-Western; Co-purification; Reconstituted Complex
BioGRID:113265	BioGRID:107800	CRYAB	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide
BioGRID:113265	BioGRID:107872	CTGF	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:113265	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-RNA; Protein-RNA
BioGRID:113265	BioGRID:199709	Flt4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113265	BioGRID:109079	GPC1	BioGRID	PubMed	Reconstituted Complex
BioGRID:113265	BioGRID:114593	HGS	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113265	BioGRID:109425	HNRNPD	BioGRID	PubMed	Affinity Capture-RNA; Protein-RNA
BioGRID:113265	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113265	BioGRID:109540	HSPA4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113265	BioGRID:109711	IGFBP7	BioGRID	PubMed	Reconstituted Complex
BioGRID:113265	BioGRID:109992	KDR	BioGRID	PubMed	Biochemical Activity
BioGRID:113265	BioGRID:114356	NRP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:113265	BioGRID:111249	PGF	BioGRID	PubMed	Co-purification
BioGRID:113265	BioGRID:122514	PRRG4	BioGRID	PubMed	Two-hybrid
BioGRID:113265	BioGRID:112560	SPARC	BioGRID	PubMed	Far Western
BioGRID:113265	BioGRID:113157	U2AF1	BioGRID	PubMed	Two-hybrid
BioGRID:113265	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113265	BioGRID:113265	VEGFA	BioGRID	PubMed	Co-crystal Structure; Co-purification
BioGRID:113265	BioGRID:120855	VPS35	BioGRID	PubMed	Two-hybrid
BioGRID:113265	BioGRID:113287	VTN	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Angiogenesis, organism-specific biosystem (from WikiPathways)
Angiogenesis, organism-specific biosystemThis pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, ...
Bladder cancer, organism-specific biosystem (from KEGG)
Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
Bladder cancer, conserved biosystem (from KEGG)
Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
Cellular response to hypoxia, organism-specific biosystem (from REACTOME)
Cellular response to hypoxia, organism-specific biosystemOxygen plays a central role in the functioning of human cells: it is both essential for normal metabolism and toxic. To begin the annotation of stress responses in Reactome, we have annotated one asp...
Cellular responses to stress, organism-specific biosystem (from REACTOME)
Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Endochondral Ossification, organism-specific biosystem (from WikiPathways)
Endochondral Ossification, organism-specific biosystem
Endochondral Ossification
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Glypican 1 network, organism-specific biosystem (from Pathway Interaction Database)
Glypican 1 network, organism-specific biosystem
Glypican 1 network
HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
HIF-1-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
HIF-1-alpha transcription factor network, organism-specific biosystem
HIF-1-alpha transcription factor network
HIF-2-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
HIF-2-alpha transcription factor network, organism-specific biosystem
HIF-2-alpha transcription factor network
Heart Development, organism-specific biosystem (from WikiPathways)
Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
Integrins in angiogenesis, organism-specific biosystem
Integrins in angiogenesis
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Pancreatic cancer, organism-specific biosystem (from KEGG)
Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
Pancreatic cancer, conserved biosystem (from KEGG)
Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
Platelet degranulation, organism-specific biosystem (from REACTOME)
Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Regulation of Gene Expression by Hypoxia-inducible Factor, organism-specific biosystem (from REACTOME)
Regulation of Gene Expression by Hypoxia-inducible Factor, organism-specific biosystemHIF-alpha (HIF1A, HIF2A (EPAS1), HIF3A) is translocated to the nucleus, possibly by two pathways: importin 4/7 (Chachami et al. 2009) and importin alpha/beta (Depping et al. 2008). Once in the nucleu...
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen, organism-specific biosystem (from REACTOME)
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen, organism-specific biosystemIn the presence of oxygen members of the transcription factor family HIF-alpha, comprising HIF1A, HIF2A (EPAS1), and HIF3A, are hydroxylated on proline residues by PHD1 (EGLN2), PHD2 (EGLN1), and PHD...
Renal cell carcinoma, organism-specific biosystem (from KEGG)
Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
Renal cell carcinoma, conserved biosystem (from KEGG)
Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Rheumatoid arthritis, conserved biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
S1P1 pathway, organism-specific biosystem (from Pathway Interaction Database)
S1P1 pathway, organism-specific biosystem
S1P1 pathway
S1P3 pathway, organism-specific biosystem (from Pathway Interaction Database)
S1P3 pathway, organism-specific biosystem
S1P3 pathway
SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by VEGF, organism-specific biosystem (from REACTOME)
Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
Signaling events mediated by TCPTP, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by TCPTP, organism-specific biosystem
Signaling events mediated by TCPTP
Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
Signaling events mediated by VEGFR1 and VEGFR2
VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystem (from REACTOME)
VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystemThe binding of VEGF ligands to VEGFR receptors in the cell membrane induces dimerization and activation of the latter, initiating intracellular signaling cascades that result in proliferation, surviv...
VEGF ligand-receptor interactions, organism-specific biosystem (from REACTOME)
VEGF ligand-receptor interactions, organism-specific biosystemThe VEGF family is encoded by seven genes (VEGF-A, B, C, D, E: PLGF (Placenta Growth Factor)-1, 2). Six isoforms of VEGF-A protein, containing 121, 145, 165, 183, 189, and 206 amino acid residues, an...
VEGF signaling pathway, organism-specific biosystem (from KEGG)
VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
VEGF signaling pathway, conserved biosystem (from KEGG)
VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
VEGFR1 specific signals, organism-specific biosystem (from Pathway Interaction Database)
VEGFR1 specific signals, organism-specific biosystem
VEGFR1 specific signals
mTOR signaling pathway, organism-specific biosystem (from KEGG)
mTOR signaling pathway, organism-specific biosystem
mTOR signaling pathway
mTOR signaling pathway, conserved biosystem (from KEGG)
mTOR signaling pathway, conserved biosystem
mTOR signaling pathway

General gene information

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Markers

Vegfa (e-PCR), detects polymorphism
- UniSTS:471318

RH46691 (e-PCR)
- UniSTS:68409

RH16204 (e-PCR)
- UniSTS:45656

STS-M32977 (e-PCR)
- UniSTS:34914

VEGF_1127 (e-PCR)
- UniSTS:277860

VEGF_V308 (e-PCR)
- UniSTS:277860

SHGC-32834 (e-PCR)
- UniSTS:41068

Vegf (e-PCR), detects polymorphism
- UniSTS:144751

SHGC-142757 (e-PCR)
- UniSTS:171637

GDB:580706 (e-PCR)
- UniSTS:157849

PMC25276P1 (e-PCR)
- UniSTS:272284

PMC25276P2 (e-PCR)
- UniSTS:272285

D6S2083 (e-PCR)
- UniSTS:9645

ha2182 (e-PCR)
- UniSTS:515503

D2Wox60 (e-PCR)
- UniSTS:240057

SHGC-78839 (e-PCR)
- UniSTS:95700

Homology

Homologs of the VEGFA gene: The VEGFA gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
cell surface binding	IDA Inferred from Direct Assay more info	PubMed
chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed
cytokine activity	IDA Inferred from Direct Assay more info	PubMed
cytokine activity	ISS Inferred from Sequence or Structural Similarity more info
extracellular matrix binding	IC Inferred by Curator more info	PubMed
fibronectin binding	IDA Inferred from Direct Assay more info	PubMed
growth factor activity	IDA Inferred from Direct Assay more info
growth factor activity	ISS Inferred from Sequence or Structural Similarity more info
heparin binding	IDA Inferred from Direct Assay more info	PubMed
heparin binding	IMP Inferred from Mutant Phenotype more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info
platelet-derived growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
receptor agonist activity	IPI Inferred from Physical Interaction more info	PubMed
vascular endothelial growth factor receptor 1 binding	IPI Inferred from Physical Interaction more info	PubMed
vascular endothelial growth factor receptor 2 binding	IPI Inferred from Physical Interaction more info	PubMed
vascular endothelial growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
activation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
angiogenesis	IDA Inferred from Direct Assay more info	PubMed
artery morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
basophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
blood coagulation	TAS Traceable Author Statement more info
branching morphogenesis of an epithelial tube	ISS Inferred from Sequence or Structural Similarity more info
camera-type eye morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
cardiac muscle fiber development	ISS Inferred from Sequence or Structural Similarity more info
cardiac vascular smooth muscle cell development	ISS Inferred from Sequence or Structural Similarity more info
cell maturation	ISS Inferred from Sequence or Structural Similarity more info
cell migration involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
cellular response to hypoxia	TAS Traceable Author Statement more info
cellular response to stress	TAS Traceable Author Statement more info
cellular response to vascular endothelial growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
coronary artery morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
coronary vein morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
dopaminergic neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
endothelial cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
eye photoreceptor cell development	ISS Inferred from Sequence or Structural Similarity more info
growth	ISS Inferred from Sequence or Structural Similarity more info
heart morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
in utero embryonic development	ISS Inferred from Sequence or Structural Similarity more info
induction of positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
induction of positive chemotaxis	NAS Non-traceable Author Statement more info	PubMed
kidney development	ISS Inferred from Sequence or Structural Similarity more info
lactation	ISS Inferred from Sequence or Structural Similarity more info
lung development	ISS Inferred from Sequence or Structural Similarity more info
lymph vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
macrophage differentiation	IDA Inferred from Direct Assay more info
mammary gland alveolus development	ISS Inferred from Sequence or Structural Similarity more info
mesoderm development	ISS Inferred from Sequence or Structural Similarity more info
monocyte differentiation	IDA Inferred from Direct Assay more info
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
nervous system development	TAS Traceable Author Statement more info	PubMed
outflow tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
ovarian follicle development	ISS Inferred from Sequence or Structural Similarity more info
patterning of blood vessels	ISS Inferred from Sequence or Structural Similarity more info
platelet activation	TAS Traceable Author Statement more info
platelet degranulation	TAS Traceable Author Statement more info
positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of CREB transcription factor activity	IDA Inferred from Direct Assay more info
positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of blood vessel endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell division	IEA Inferred from Electronic Annotation more info
positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell migration involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info
positive regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cellular component movement	IDA Inferred from Direct Assay more info	PubMed
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed
positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
positive regulation of histone deacetylase activity	IDA Inferred from Direct Assay more info
positive regulation of intracellular protein kinase cascade	IDA Inferred from Direct Assay more info
positive regulation of leukocyte migration	TAS Traceable Author Statement more info	PubMed
positive regulation of mast cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of mesenchymal cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of neuroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-tyrosine autophosphorylation	IDA Inferred from Direct Assay more info
positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein complex assembly	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein kinase C signaling cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of receptor internalization	IDA Inferred from Direct Assay more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of vascular permeability	IDA Inferred from Direct Assay more info	PubMed
post-embryonic camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info
primitive erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription from RNA polymerase II promoter in response to hypoxia	TAS Traceable Author Statement more info
response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
surfactant homeostasis	ISS Inferred from Sequence or Structural Similarity more info
tube formation	IDA Inferred from Direct Assay more info	PubMed
vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info
vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info
vasculogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cell surface	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISS Inferred from Sequence or Structural Similarity more info
membrane	IEA Inferred from Electronic Annotation more info
platelet alpha granule lumen	TAS Traceable Author Statement more info
proteinaceous extracellular matrix	NAS Non-traceable Author Statement more info	PubMed
secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vascular endothelial growth factor A

Names: vascular endothelial growth factor A; vascular permeability factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008732.1 RefSeqGene

Range

4994..21272

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025366.2 → NP_001020537.2 vascular endothelial growth factor A isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (a) represented in this RefSeq is derived from the 5'-most CUG start codon. This is the longest isoform.

Source sequence(s)

AF024710, BF700556, BM661679, BU153227, CN256173, DA237741, S85192

Consensus CDS

CCDS34457.1

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:230 – 313
Blast Score: 284

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001025367.2 → NP_001020538.2 vascular endothelial growth factor A isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (c) represented in this RefSeq is derived from the 5'-most CUG start codon, and is shorter than isoform a.

Source sequence(s)

AF024710, AJ010438, BF700556, BM661679, BU153227, CN256173, DA237741

Consensus CDS

CCDS47433.1

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:230 – 313
Blast Score: 284

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001025368.2 → NP_001020539.2 vascular endothelial growth factor A isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (d) represented in this RefSeq is derived from the 5'-most CUG start codon, and is shorter than isoform a.

Source sequence(s)

AB021221, AF024710, BF700556, BM661679, BU153227, CN256173, DA237741

Consensus CDS

CCDS34458.1

UniProtKB/Swiss-Prot

P15692

Related

ENSP00000361137, OTTHUMP00000016487, ENST00000372067, OTTHUMT00000040681

Conserved Domains (1) summary

cd00135
Location:230 – 313
Blast Score: 285

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001025369.2 → NP_001020540.2 vascular endothelial growth factor A isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon, and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (e) represented in this RefSeq is derived from the 5'-most CUG start codon, and has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AF024710, AF091352, BF700556, BM661679, BU153227, CN256173, DA237741

Consensus CDS

CCDS47435.1

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:230 – 313
Blast Score: 289

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001025370.2 → NP_001020541.2 vascular endothelial growth factor A isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (f) represented in this RefSeq is derived from the 5'-most CUG start codon, and is shorter than isoform a.

Source sequence(s)

AF024710, AF214570, BF700556, BM661679, BU153227, CN256173, DA237741

Consensus CDS

CCDS47434.1

UniProtKB/Swiss-Prot

P15692

Related

ENSP00000361134, OTTHUMP00000016488, ENST00000372064, OTTHUMT00000040682

Conserved Domains (1) summary

cd00135
Location:230 – 313
Blast Score: 306

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001033756.2 → NP_001028928.1 vascular endothelial growth factor A isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an alternate in-frame exon and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (g) represented in this RefSeq is derived from the 5'-most CUG start codon, and has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AF024710, AF430806, BF700556, BM661679, BU153227, CN256173, DA237741

Consensus CDS

CCDS47432.1

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:230 – 313
Blast Score: 288

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001171622.1 → NP_001165093.1 vascular endothelial growth factor A isoform h

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks three alternate in-frame exons in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (h) represented in this RefSeq is derived from the 5'-most CUG start codon, and is shorter than isoform a.

Source sequence(s)

AF024710, BF700556, BM661679, BU153227, CN256173, DA237741, DQ229900

Consensus CDS

CCDS55007.1

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:230 – 312
Blast Score: 303

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001171623.1 → NP_001165094.1 vascular endothelial growth factor A isoform i precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (i, also referred to as VEGF206) represented in this RefSeq is derived from the AUG start codon, and is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AF024710, BF700556, BM661679, BU153227, CN256173, DA237741, S85192

Consensus CDS

CCDS55010.1

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:50 – 133
Blast Score: 270

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001171624.1 → NP_001165095.1 vascular endothelial growth factor A isoform j precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (j, also referred to as VEGF189) represented in this RefSeq is derived from the AUG start codon, and is shorter than isoform a.

Source sequence(s)

AF024710, BF700556, BM661679, BU153227, CN256173, DA237741, M27281

Consensus CDS

CCDS55009.1

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:50 – 133
Blast Score: 270

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001171625.1 → NP_001165096.1 vascular endothelial growth factor A isoform k precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (k, also referred to as VEGF183) represented in this RefSeq is derived from the AUG start codon, and is shorter than isoform a.

Source sequence(s)

AF024710, AJ010438, BF700556, BM661679, BU153227, CN256173, DA237741

Consensus CDS

CCDS55008.1

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:50 – 133
Blast Score: 269

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001171626.1 → NP_001165097.1 vascular endothelial growth factor A isoform l precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (l, also referred to as VEGF165) represented in this RefSeq is derived from the AUG start codon, and is shorter than isoform a.

Source sequence(s)

AB021221, AF024710, BF700556, BM661679, BU153227, CN256173, DA237741

Consensus CDS

CCDS55012.1

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:50 – 133
Blast Score: 270

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001171627.1 → NP_001165098.1 vascular endothelial growth factor A isoform m precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon, and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (m, also referred to as VEGF148) represented in this RefSeq is derived from the AUG start codon, and has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AF024710, AF091352, BF700556, BM661679, BU153227, CN256173, DA237741

Consensus CDS

CCDS55011.1

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:50 – 133
Blast Score: 274

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001171628.1 → NP_001165099.1 vascular endothelial growth factor A isoform n precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (n, also referred to as VEGF121) represented in this RefSeq is derived from the AUG start codon, and is shorter than isoform a.

Source sequence(s)

AF024710, AF214570, BF700556, BM661679, BU153227, CN256173, DA237741

Consensus CDS

CCDS55014.1

UniProtKB/Swiss-Prot

P15692

Related

ENSP00000361148, OTTHUMP00000224424, ENST00000372077, OTTHUMT00000374458

Conserved Domains (1) summary

cd00135
Location:50 – 133
Blast Score: 291

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001171629.1 → NP_001165100.1 vascular endothelial growth factor A isoform o precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an alternate in-frame exon and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (o, also referred to as VEGF165b) represented in this RefSeq is derived from the AUG start codon, and has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AF024710, AF430806, BF700556, BM661679, BU153227, CN256173, DA237741

Consensus CDS

CCDS55013.1

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:50 – 133
Blast Score: 273

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001171630.1 → NP_001165101.1 vascular endothelial growth factor A isoform p precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks three alternate in-frame exons in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (p, also referred to as VEGF111) represented in this RefSeq is derived from the AUG start codon, and is shorter than isoform a.

Source sequence(s)

AF024710, BF700556, BM661679, BU153227, CN256173, DA237741, DQ229900

Consensus CDS

CCDS55015.1

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:50 – 132
Blast Score: 287

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001204384.1 → NP_001191313.1 vascular endothelial growth factor A isoform q precursor

Status: REVIEWED

Description

Transcript Variant: This variant (9) uses an alternate in-frame splice site in the 3' coding region and lacks an alternate in-frame exon compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform (q, also referred to as VEGF145) represented in this RefSeq is derived from the AUG start codon, and is shorter than isoform a.

Source sequence(s)

AL136131, BC065522, M27281

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:50 – 133
Blast Score: 293

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001204385.1 → NP_001191314.1 vascular endothelial growth factor A isoform r

Status: REVIEWED

Description

Transcript Variant: This variant (9) uses an alternate in-frame splice site in the 3' coding region and lacks an alternate in-frame exon compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform represented in this RefSeq (isoform r) is derived from the 5'-most CUG start codon, and is shorter than isoform a.

Source sequence(s)

AL136131, BC065522, M27281

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:230 – 313
Blast Score: 307

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_003376.5 → NP_003367.4 vascular endothelial growth factor A isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This variant can initiate translation from four non-AUG (CUG) sites, and also from a downstream, in-frame AUG. The isoform represented in this RefSeq (isoform b) is derived from the 5'-most CUG start codon, and is shorter than isoform a.

Source sequence(s)

AF024710, BF700556, BM661679, BU153227, CN256173, DA237741, M27281

Consensus CDS

CCDS4907.2

UniProtKB/Swiss-Prot

P15692

Conserved Domains (1) summary

cd00135
Location:230 – 313
Blast Score: 285

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p10 Primary Assembly

Range

43737946..43754224

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

43458106..43474385

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018917.1 Alternate CHM1_1.0

Range

43648511..43664790

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01050660.1 (224613..240892)	None
genomic	AF095785.1	AAD04918.1
genomic	AF437895.1	AAL27630.1
genomic	AL136131.15 (135927..152205)	None
genomic	AMYH01016316.1 (188273..204552)	None
genomic	CH471081.1	EAX04227.1
		EAX04228.1
		EAX04229.1
		EAX04230.1
		EAX04231.1
		EAX04232.1
		EAX04233.1
		EAX04234.1
		EAX04235.1
genomic	CQ858312.1	CAH23417.1
genomic	CS067226.1	CAI84576.1
genomic	CS172363.1	CAJ32889.1
genomic	CS172373.1	CAJ33665.1
genomic	CS367293.1	CAL32723.1
genomic	CS367438.1	CAL33850.1
genomic	HC040683.1	CBH30534.1
genomic	HC040693.1	CBH30539.1
genomic	M63978.1	AAA36804.1
mRNA	AB021221.1	BAA78418.1
mRNA	AB209485.1	BAD92722.1
mRNA	AB451322.1	BAG70136.1
mRNA	AB451451.1	BAG70265.1
mRNA	AF022375.1	AAC63143.1
mRNA	AF024710.1	None
mRNA	AF062645.1	AAC16730.1
mRNA	AF091352.1	AAD55345.1
mRNA	AF214570.1	AAF19659.1
mRNA	AF323587.1	AAQ14857.1
mRNA	AF430806.1	AAL27435.1
mRNA	AF486837.1	AAM03108.1
mRNA	AJ010438.1	CAA09179.1
mRNA	AK056914.1	None
mRNA	AK125666.1	None
mRNA	AY047581.1	AAK95847.1
mRNA	AY263145.1	AAP86646.1
mRNA	AY500353.1	None
mRNA	AY766116.1	AAV34601.1
mRNA	BC011177.1	AAH11177.2
mRNA	BC019867.2	None
mRNA	BC058855.1	None
mRNA	BC065522.1	AAH65522.2
mRNA	BF700556.1	None
mRNA	BM661679.1	None
mRNA	BQ880667.1	None
mRNA	BU153227.1	None
mRNA	CN256173.1	None
mRNA	CX756573.1	None
mRNA	DA237741.1	None
mRNA	DQ229900.1	ABB58912.1
mRNA	M27281.1	AAA36807.1
mRNA	M32977.1	AAA35789.1
mRNA	S85192.1	AAC63102.1
mRNA	X62568.1	CAA44447.1
other-genetic	BC172307.1	AAI72307.1
other-genetic	EU832814.1	ACE87825.1
other-genetic	GQ129408.1	ACT64542.1