Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    RARA retinoic acid receptor, alpha [ Homo sapiens (human) ]

    Gene ID: 5914, updated on 14-May-2013
    Official Symbol
    RARAprovided by HGNC
    Official Full Name
    retinoic acid receptor, alphaprovided by HGNC
    Primary source
    HGNC:9864
    See related
    HPRD:06769; MIM:180240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAR; NR1B1
    Summary
    This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
    Location :
    17q21
    Sequence :
    Chromosome: 17; NC_000017.10 (38465423..38513895)
    See RARA in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene WAS/WASL interacting protein family, member 2 Neighboring gene RNA, Ro-associated Y4 pseudogene 8 Neighboring gene cell division cycle 6 Neighboring gene uncharacterized LOC100287525 Neighboring gene peptidylprolyl isomerase A (cyclophilin A) pseudogene Neighboring gene gap junction protein, delta 3, 31.9kDa

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability. Yang WC, et al. Oncogene, 2012 Dec 3. PMID 23208507.
    2. Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression. Le May N, et al. Mol Cell, 2012 Dec 14. PMID 23102699.
    3. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. Hu Q, et al. Nat Struct Mol Biol, 2012 Nov. PMID 23064648.
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    5. CAC1 negatively regulates RARα activity through cooperation with HDAC. Moon M, et al. Biochem Biophys Res Commun, 2012 Oct 12. PMID 22982681.

    See all (311) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results define PARG as a coactivator regulating chromatin remodeling during retinoic acid receptor-dependent gene expression.
      Title: Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression.
    2. The RAR-dependent and Pol III-dependent DR2 Alu transcriptional events in stem cells functionally complement the Pol II-dependent neuronal transcriptional program.
      Title: DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation.
    3. analysis of a cryptic PML-RARA translocation in a patient with acute promyelocytic leukemia [case report]
      Title: Microarray, gene sequencing, and reverse transcriptase-polymerase chain reaction analyses of a cryptic PML-RARA translocation.
    4. a novel paradigm in which a fraction of the cellular RARalpha pool is present in membrane lipid rafts, where it forms complexes with G protein alpha Q (Galphaq) in response to RA
      Title: A retinoic acid receptor RARα pool present in membrane lipid rafts forms complexes with G protein αQ to activate p38MAPK.
    5. HK3 is: (1) directly activated by PU.1, (2) repressed by PML-RARA, and (3) functionally involved in neutrophil differentiation and cell viability of acute promyelocytic leukemia cells.
      Title: PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells.
    6. FGF8f
      Title: Retinoid-regulated FGF8f secretion by osteoblasts bypasses retinoid stimuli to mediate granulocytic differentiation of myeloid leukemia cells.
    7. Data show that RORalpha is mainly located in human Jurkat T-cell nucleus, and it is co-immunoprecipitated with melatonin.
      Title: Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor.
    8. APL lacking an RARalpha rearrangement may possess an alternative mechanism mediating the differentiation block that causes APL.
      Title: Infantile acute promyelocytic leukemia without an RARα rearrangement.
    9. Coregulator exchange and chromatin binding affect retinoic acid receptor mobility.
      Title: Live-cell fluorescence correlation spectroscopy dissects the role of coregulator exchange and chromatin binding in retinoic acid receptor mobility.
    10. These findings suggest that TRIM32 functions as one of the coactivators for RARalpha-mediated transcription in acute promyelogenous leukemia cells.
      Title: TRIM32 promotes retinoic acid receptor α-mediated differentiation in human promyelogenous leukemic cell line HL60.
    Submit: New GeneRIF Correction See all (134)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Nef, p27 nef HIV-1 Nef induces loss of F-actin assembly and inhibits retinoid receptor-mediated transcription PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    AF283809.1 NP_006302.2 NCOR1    BIND  PubMed NCOR1 (N-CoR) interacts with p-RAR-alpha2 (RAR-alpha2 promoter). 
    AF283809.1 NP_006303.2 NCOR2    BIND  PubMed NCOR2 (SMRT) interacts with p-RAR-alpha2 (RAR-alpha2 promoter). 
    NP_000955.1 NP_006296.1 ANP32A    BIND  PubMed RAR-alpha interacts with pp32. 
    NP_000955.1 NP_001722.1 BTG1    BIND  PubMed BTG1 interacts with RARA (RAR-alpha). 
    NP_000955.1 NP_001790.1 CDK7    BIND  PubMed RAR-alpha interacts with hMo15. 
    NP_000955.1 NP_005047.1 KDM5A    BIND  PubMed Rbp2 interacts with RAR. 
    NP_000955.1 NP_005457.2 MED6    BIND  PubMed Med6 interacts with RAR-alpha. 
    NP_000955.1 AAC50305.1 NCOA1    BIND  PubMed RAR-alpha interacts with SRC-1. 
    NP_000955.1 NP_006531.1 NCOA2    BIND  PubMed GRIP1 interacts with RAR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human RAR. 
    NP_000955.1 AAC51663.1 NCOA3    BIND  PubMed RAC3 interacts with RAR-alpha. 
    NP_000955.1 NP_001609.1 PARP1    BIND  PubMed PARP-1 interacts with RAR-alpha. 
    NP_000955.1 NP_996845.1 PRMT2    BIND  PubMed PRMT2 interacts with RAR. 
    NP_000955.1 NC_000008.9 TNFRSF10B    BIND  PubMed RARA (RAR-alpha) interacts with TNFRSF10B (DR5) RARE. 
    P10276 Q99933 BAG1    HPRD  PubMed  
    P10276 P62324 BTG1    HPRD  PubMed  
    P10276 P30281 CCND3    HPRD  PubMed  
    P10276 P50613 CDK7    HPRD  PubMed  
    P10276 CCR4NOT transcription complex subunit 1 CNOT1    HPRD  PubMed  
    P10276 P61201 COPS2    HPRD  PubMed  
    P10276 P03372 ESR1    HPRD  PubMed  
    P10276 Q12778 FOXO1    HPRD  PubMed  
    P10276 O95257 GADD45G    HPRD  PubMed  
    P10276 P23769 GATA2    HPRD  PubMed  
    P10276 P78413 IRX4    HPRD  PubMed  
    P10276 Q9UKP3 ITGB1BP2    HPRD  PubMed  
    P10276 Q92831 KAT2B    HPRD  PubMed  
    P10276 P29375 KDM5A    HPRD  PubMed  
    P10276 Q13887 KLF5    HPRD  PubMed  
    P10276 Q9BV79 MECR    HPRD  PubMed  
    P10276 Q15648 MED1    HPRD  PubMed  
    P10276 O75586 MED6    HPRD  PubMed  
    P10276 Q15788 NCOA1    HPRD  PubMed  
    P10276 Q9Y6Q9 NCOA3    HPRD  PubMed  
    P10276 Q14686 NCOA6    HPRD  PubMed  
    P10276 O75376 NCOR1    HPRD  PubMed  
    P10276 Q9Y618 NCOR2    HPRD  PubMed  
    P10276 P43699 NKX2-1    HPRD  PubMed  
    P10276 Q99743 NPAS2    HPRD  PubMed  
    P10276 Q15466 NR0B2    HPRD  PubMed  
    P10276 P55055 NR1H2    HPRD  PubMed  
    P10276 Q13133 NR1H3    HPRD  PubMed  
    P10276 Q9Y5X4 NR2E3    HPRD  PubMed  
    P10276 Q96F24 NRBF2    HPRD  PubMed  
    P10276 P48552 NRIP1    HPRD  PubMed  
    P10276 Q9BQI9 NRIP2    HPRD  PubMed  
    P10276 Q96L73 NSD1    HPRD  PubMed  
    P10276 P09874 PARP1    HPRD  PubMed  
    P10276 P29590 PML    HPRD  PubMed  
    P10276 Q9NPJ4 PNRC2    HPRD  PubMed  
    P10276 P14859 POU2F1    HPRD  PubMed  
    P10276 P30041 PRDX6    HPRD  PubMed  
    P10276 P17252 PRKCA    HPRD  PubMed  
    P10276 P19793 RXRA    HPRD  PubMed  
    P10276 P28702 RXRB    HPRD  PubMed  
    P10276 P48443 RXRG    HPRD  PubMed  
    P10276 Q13573 SNW1    HPRD  PubMed  
    P10276 P08047 SP1    HPRD  PubMed  
    P10276 Q96T58 SPEN    HPRD  PubMed  
    P10276 P51692 STAT5B    HPRD  PubMed  
    P10276 O75528 TADA3    HPRD  PubMed  
    P10276 O15164 TRIM24    HPRD  PubMed  
    P10276 Q15650 TRIP4    HPRD  PubMed  
    P10276 Q05086 UBE3A    HPRD  PubMed  
    P10276 Q05516 ZBTB16    HPRD  PubMed  
    BioGRID:111849 BioGRID:124393 AJUBA    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:111849 BioGRID:113894 ARID1A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:116074 ARID5A    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:106899 ARNTL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:128104 ASXL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111849 BioGRID:120543 ASXL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111849 BioGRID:107049 BAG1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:107336 CCND3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:114944 CLOCK    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:199230 Dlg4    BioGRID  PubMed Protein-peptide 
    BioGRID:111849 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:108446 EZH2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:106851 FAS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:108621 FN1    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:108597 FOXO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:108014 GADD45A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:116117 GADD45G    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:201638 Gadd45b    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:121590 HACE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:109315 HDAC1    BioGRID  PubMed Positive Genetic 
    BioGRID:111849 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:111849 BioGRID:114368 HDAC3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:115106 HDAC4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:109402 HMGA1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:109433 HNRNPU    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111849 BioGRID:120917 HR    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:119125 IRX4    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:117742 ITGB1BP2    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:108918 KAT2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111849 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:111862 KDM5A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:107153 KLF5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:120990 KMT2E    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111849 BioGRID:114475 LIMD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:120905 LRIF1    BioGRID  PubMed Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111849 BioGRID:111583 MAPK6    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:119291 MECR    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:111465 MED1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:123607 MED25    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:115319 MED6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:119337 MRTO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111849 BioGRID:114200 NCOA1    BioGRID  PubMed Affinity Capture-Western; FRET; Reconstituted Complex 
    BioGRID:111849 BioGRID:115761 NCOA2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:113841 NCOA3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:116691 NCOA6    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:114974 NCOR2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:112936 NKX2-1    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:110923 NPAS2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111849 BioGRID:114012 NR0B2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:113222 NR1H2    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:115320 NR2E3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:110983 NR4A2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:119009 NRBF2    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:113843 NRIP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111849 BioGRID:204818 Nr0b2    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:201855 Nsd1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:116751 PHF8    BioGRID  PubMed FRET 
    BioGRID:111849 BioGRID:111317 PIN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex 
    BioGRID:111849 BioGRID:111447 POU2F1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:123894 PRAM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:117078 PRAME    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:114956 PRDX6    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:111678 PSMC5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:248111 Pdia3    BioGRID  PubMed Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:111819 RAC3    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:111849 RARA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111849 BioGRID:111916 RFC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111849 BioGRID:119724 RSF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111849 BioGRID:107309 RUNX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:112168 RXRA    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Co-localization; Co-purification; Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:112169 RXRB    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:112170 RXRG    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:122735 SAP130    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111849 BioGRID:118845 SETD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111849 BioGRID:112372 SIAH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:112388 SKI    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:111849 BioGRID:112488 SMARCD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:111849 BioGRID:112489 SMARCE1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:114805 SNRNP40    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111849 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:111849 BioGRID:112566 SPI1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:111849 BioGRID:114397 SQSTM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:112592 SRC    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:112706 SUV39H1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:117059 SUZ12    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:115737 TADA3    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:122834 TBL1XR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:112855 TDG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:125247 TMEM54    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:115602 TNIP1    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:113008 TOP2B    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:111849 BioGRID:114333 TRIM24    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:116608 TRIM32    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:114735 TRIP4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111849 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:111849 BioGRID:113185 UBE3A    BioGRID  PubMed Two-hybrid 
    BioGRID:111849 BioGRID:119007 UBQLN1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:111849 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:111849 BioGRID:125985 WTIP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111849 BioGRID:113498 ZBTB16    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
      Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Acute myeloid leukemia, conserved biosystem (from KEGG)
      Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
      Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...
    • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
      Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
    • Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem (from WikiPathways)
      Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Retinoic acid receptors-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      Retinoic acid receptors-mediated signaling, organism-specific biosystem
      Retinoic acid receptors-mediated signaling
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Vitamin A and carotenoid metabolism, organism-specific biosystem (from WikiPathways)
      Vitamin A and carotenoid metabolism, organism-specific biosystemThis pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some ...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    phosphatidylinositol 3-kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein kinase A binding IDA
    Inferred from Direct Assay
    more info
    		  
    protein kinase B binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    retinoic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    retinoic acid receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    retinoic acid-responsive element binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		  
    transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		  
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    Sertoli cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		  
    cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chondroblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    germ cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    growth plate cartilage development IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular estrogen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cartilage development IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of granulocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		  
    negative regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of T-helper 2 cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of binding IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of interleukin-13 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of interleukin-4 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of interleukin-5 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of phosphatidylinositol 3-kinase cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of protein kinase B signaling cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    retinoic acid receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		  
    ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
    		  
    ventricular cardiac muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cell surface IC
    Inferred by Curator
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    retinoic acid receptor alpha
    Names
    retinoic acid receptor alpha
    RAR-alpha
    retinoic acid receptor, alpha polypeptide
    nuclear receptor subfamily 1 group B member 1
    retinoic acid nuclear receptor alpha variant 1
    retinoic acid nuclear receptor alpha variant 2
    nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027701.1 RefSeqGene

      Range
      5001..53473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000964.3 → NP_000955.1  retinoic acid receptor alpha isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1). Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      BC008727, BM992549, DA061829, X06614
      Consensus CDS
      CCDS11366.1
      UniProtKB/Swiss-Prot
      P10276
      UniProtKB/TrEMBL
      Q6I9R7
      Conserved Domains (2) summary
      cd06937
      Location:186 – 416
      Blast Score: 1195
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:82 – 166
      Blast Score: 476
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

    2. NM_001024809.3 → NP_001019980.1  retinoic acid receptor alpha isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) reflects the use of an alternate promoter and has a distinct 5' exon, compared to transcript variant 1. Translation is predicted to initiate from this alternate exon, and the resulting protein (isoform 2) has a shorter and a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC080112, BC071733, BM838347, BM992549, CB105313
      Consensus CDS
      CCDS42317.1
      UniProtKB/TrEMBL
      F1D8N9
      UniProtKB/Swiss-Prot
      P10276
      Conserved Domains (2) summary
      cd06937
      Location:181 – 411
      Blast Score: 1198
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:77 – 161
      Blast Score: 476
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

    3. NM_001145301.2 → NP_001138773.1  retinoic acid receptor alpha isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) reflects the use of an alternate promoter and contains a different 5' UTR segment, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AK292205, BG394590, BM992549, X06614
      Consensus CDS
      CCDS11366.1
      UniProtKB/TrEMBL
      A8K840
      UniProtKB/Swiss-Prot
      P10276
      UniProtKB/TrEMBL
      Q6I9R7
      Conserved Domains (2) summary
      cd06937
      Location:186 – 416
      Blast Score: 1195
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily
      cd06964
      Location:82 – 166
      Blast Score: 476
      NR_DBD_RAR; DNA-binding domain of retinoic acid receptor (RAR) is composed of two C4-type zinc fingers

    4. NM_001145302.2 → NP_001138774.1  retinoic acid receptor alpha isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) reflects the use of an alternate promoter and contains a different 5' UTR segment. This variant also lacks two in-frame coding exons, compared to variant 1. The resulting protein (isoform 4) is shorter compared to isoform 1.
      Source sequence(s)
      AC080112, BG394590, BM992549, FJ487576
      Consensus CDS
      CCDS45671.1
      UniProtKB/Swiss-Prot
      P10276
      Conserved Domains (1) summary
      cd06937
      Location:89 – 319
      Blast Score: 1173
      NR_LBD_RAR; The ligand binding domain (LBD) of retinoic acid receptor (RAR), a members of the nuclear receptor superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p10 Primary Assembly

      Range
      38465423..38513895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      34258584..34307018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018928.1 Alternate CHM1_1.0

      Range
      39252359..39300831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033603.1: Suppressed sequence

      Description
      NM_001033603.1: This RefSeq was permanently suppressed because the 3'UTR is not supported and the transcript is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01031831.1 (19629..43062) None
    genomic ABBA01031832.1 None
    genomic AC080112.15 (66057..114505) None
    genomic AF088895.2 AAD05222.1
    genomic AF283809.1 AAF87249.1
    genomic AMYH01008384.1 (76971..125443) None
    genomic CH471152.1 EAW60652.1
      EAW60653.1
      EAW60654.1
      EAW60655.1
      EAW60656.1
      EAW60657.1
      EAW60658.1
    genomic CS542437.1 CAM91168.1
    genomic X56058.1 CAA39533.1
    mRNA AK098172.1 BAG53585.1
    mRNA AK130192.1 None
    mRNA AK292205.1 BAF84894.1
    mRNA AK303868.1 BAG64806.1
    mRNA AK312564.1 BAG35459.1
    mRNA AL522713.3 None
    mRNA AL834159.1 CAH56277.1
    mRNA BC008727.2 AAH08727.1
    mRNA BC071733.1 AAH71733.1
    mRNA BG394590.1 None
    mRNA BM838347.1 None
    mRNA BM992549.1 None
    mRNA BY799725.2 None
    mRNA CB105313.1 None
    mRNA CR457438.1 CAG33719.1
    mRNA DA061829.1 None
    mRNA DA541711.1 None
    mRNA FJ487576.1 ACK86665.1
    mRNA HQ692826.1 ADZ17337.1
    mRNA HQ692827.1 ADZ17338.1
    mRNA S50916.1 AAB19602.2
    mRNA X06538.1 CAA29787.1
    mRNA X06614.1 CAA29829.1
    mRNA X58685.1 CAA41532.1
    other-genetic DQ893531.2 ABM84457.1
    other-genetic DQ893744.2 ABM84670.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10276.2 GenPept UniProtKB/Swiss-Prot:P10276

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Books
        Links between Entrez Gene and 'Books' are established if a GeneID is explicitly referenced in a book.
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...