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    CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa [ Homo sapiens ]

    Gene ID: 1499, updated on 20-May-2012
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    Summary

    Official Symbol
    CTNNB1provided by HGNC
    Official Full Name
    catenin (cadherin-associated protein), beta 1, 88kDaprovided by HGNC
    Primary source
    HGNC:2514
    Locus tag
    OK/SW-cl.35
    See related
    Ensembl:ENSG00000168036; HPRD:00286; MIM:116806; Vega:OTTHUMG00000131393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CTNNB; FLJ25606; FLJ37923; DKFZp686D02253
    Summary
    The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]
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    Genomic context

    Location :
    3p21
    Sequence :
    Chromosome: 3; NC_000003.11 (41240942..41281939)
    See CTNNB1 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27 pseudogene 4 Neighboring gene mitochondrial ribosomal protein S31 pseudogene 1 Neighboring gene unc-51-like kinase 4 (C. elegans) Neighboring gene uncharacterized LOC100287063 Neighboring gene ribosomal protein L36 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4. Davidson KC, et al. Proc Natl Acad Sci U S A, 2012 Mar 20. PMID 22392999.
    2. Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). Zhou B, et al. J Biol Chem, 2012 Mar 2. PMID 22241478.
    3. Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. Biechele TL, et al. Sci Signal, 2012 Jan 10. PMID 22234612.
    4. A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling. Imajo M, et al. EMBO J, 2012 Jan 10. PMID 22234184.
    5. Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma. Schulten HJ, et al. Anticancer Res, 2011 Dec. PMID 22199277.

    See all (1145) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Gene and protein expression studies have confirmed the central role of the beta catenin of the TGFbeta pathways in the pathogenesis of Dupuytren's disease.
      Title: Genetics of Dupuytren's disease.
    2. The TR/DKK4/Wnt/beta-catenin cascade influences the proliferation and migration of hepatoma cells during the metastasis process and support a tumor suppressor role of the thyroid hormone receptor.
      Title: Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells.
    3. Oncogenic mutations of CTNNB1 were found in hepatoblastoma. Wnt/beta-catenin target genes were significantly activated in the tumors without mutations. The clinical course in patients without CTNNB1 mutations seemed to be unfavorable.
      Title: Wnt signaling and telomerase activation of hepatoblastoma: correlation with chemosensitivity and surgical resectability.
    4. Wnt/beta-catenin pathway forms a negative feedback loop during TGF-beta1 induced human normal skin fibroblast-to-myofibroblast transition
      Title: Wnt/β-catenin pathway forms a negative feedback loop during TGF-β1 induced human normal skin fibroblast-to-myofibroblast transition.
    5. beta-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.
      Title: β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.
    6. Our data suggest that the miR-1826 plays an important role as a tumor suppressor by downregulating beta-catenin and MEK1 in von Hippel-Lindau-inactivated renal cancers.
      Title: MicroRNA-1826 directly targets beta-catenin (CTNNB1) and MEK1 (MAP2K1) in VHL-inactivated renal cancer.
    7. Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of beta-catenin.
      Title: Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin.
    8. Wnt/beta-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4
      Title: Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4.
    9. The regulation, function, and implications of E-cadherin expression in these central orchestrators of the immune system.
      Title: Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs.
    10. The authors show that YAP and TAZ, the transcriptional co-activators in the Hippo pathway, suppress Wnt signalling without suppressing the stability of beta-catenin but through preventing its nuclear translocation.
      Title: A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling.
    Submit: New GeneRIF Correction See all (773)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Colorectal cancer

    Hepatocellular carcinoma

    Medulloblastoma

    Ovarian cancer

    Pilomatricoma

    Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is a strong competitive inhibitor of beta-TrCP and impairs the degradation of SCF-beta-TrCP substrates such as IKBalpha, ATF4 and beta-catenin PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001895.1 NP_000029.2 APC    BIND  PubMed APC interacts with Beta-catenin. 
    NP_001895.1 NP_000029.2 APC    BIND  PubMed Beta-catenin interacts with APC. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse Apc. 
    NP_001895.1 NC_000017.9 AXIN2    BIND  PubMed beta-catenin interacts with the Axin2 promoter. 
    NP_001895.1 NP_005169.1 BCL3    BIND  PubMed CTNNB1 (beta-catenin) interacts with BCL3. 
    NP_001895.1 NP_004317.1 BCL9    BIND  PubMed Beta-catenin interacts with LGS1. 
    NP_001895.1 BTRC    BIND  PubMed BTRC (Beta-TrCP1) interacts with CTNNB1 (Beta-catenin). 
    NP_001895.1 NC_000011.8 CCND1    BIND  PubMed CTNNB1 (beta-catenin) interacts with the CCND1 promoter. 
    NP_001895.1 NC_000011.8 CD82    BIND  PubMed CTNNB1 (beta-catenin) interacts with the CD82 (KAI1) promoter. 
    NP_001895.1 NP_004351.1 CDH1    BIND  PubMed Beta-catenin interacts with E-cadherin. This interaction was modelled on a demonstrated interaction between beta-catenin from an unspecified species and human E-cadherin. 
    NP_001895.1 NP_004351.1 CDH1    BIND  PubMed Beta-catenin interacts with E-cadherin. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse E-cadherin. 
    NP_001895.1 NP_004351.1 CDH1    BIND  PubMed E-cadherin interacts with beta-catenin. 
    NP_001895.1 NP_001894.1 CTNNA1    BIND  PubMed Beta-catenin interacts with alpha-catenin. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse alpha-catenin. 
    NP_001895.1 NC_000010.8 DKK1    BIND  PubMed CTNNB1 (beta-catenin) interacts with the DKK1 promoter. 
    NP_001895.1 NP_000116.1 ESR1    BIND  PubMed beta-catenin interacts with ER-alpha. 
    NP_001895.1 NC_000010.8 FAS    BIND  PubMed CTNNB1 (beta-catenin) interacts with the FAS promoter. 
    NP_001895.1 NC_000008.9 FGF20    BIND  PubMed CTNNB1 (beta-catenin) interacts with the FGF20 promoter. 
    NP_001895.1 NP_002006.2 FOXO1    BIND  PubMed beta-catenin interacts with FOXO1. This interaction was modelled on a demonstrated interaction between beta-catenin from an unspecified species and human FOXO1. 
    NP_001895.1 FOXO3    BIND  PubMed beta-catenin interacts with FOXO3a. 
    NP_001895.1 NP_005929.1 FOXO4    BIND  PubMed beta-catenin interacts with FOXO4. This interaction was modelled on a demonstrated interaction between human FOXO4 and beta-catenin from an unspecified species. 
    NP_001895.1 NP_002084.2 GSK3B    BIND  PubMed GSK3B (GSK3-Beta) interacts with and phosphorylates CTNNB1 (Beta-catenin). 
    NP_001895.1 NC_000002.9 IGFBP2    BIND  PubMed CTNNB1 (beta-catenin) interacts with the IGFBP2 promoter. 
    NP_001895.1 NC_000019.8 KLK3    BIND  PubMed CTNNB1 (beta-catenin) interacts with the KLK3 (PSA) promoter. 
    NP_001895.1 NP_057353.1 LEF1    BIND  PubMed LEF-1 interacts with Beta-catenin. This interaction was modeled on a demonstrated interaction between human LEF-1 and mouse Beta-catenin. 
    NP_001895.1 NP_877418.1 MUC1    BIND  PubMed MUC1 interacts with beta-catenin. 
    NP_001895.1 NP_003989.2 NFKB1    BIND  PubMed NFKB1 (p50) interacts with CTNNB1 (beta-catenin). 
    NP_001895.1 AAD03155.1 NR5A2    BIND  PubMed beta-catenin interacts with LRH-1. 
    NP_001895.1 NP_000287.2 PKD1    BIND  PubMed Polycystin-1 interacts with beta-catenin. 
    NP_001895.1 NP_000012.1 PSEN1    BIND  PubMed PS1 interacts with beta-catenin. 
    NP_001895.1 NP_006657.1 RUVBL2    BIND  PubMed CTNNB1 (beta-catenin) interacts with RUVBL2 (reptin). 
    NP_001895.1 NC_000006.9 SGK1    BIND  PubMed CTNNB1 (beta-catenin) interacts with the SGK promoter. 
    NP_001895.1 NP_110383.1 TCF7L2    BIND  PubMed TCF-4 interacts with Beta-catenin. 
    NP_001895.1 NP_110383.1 TCF7L2    BIND  PubMed Beta-catenin interacts with TCF4. 
    NP_001895.1 NC_000021.7 TFF1    BIND  PubMed beta-catenin interacts with the pS2 promoter. 
    NP_001895.1     BIND  PubMed CTNNB1 (beta-catenin) interacts with the HTATIP-CD82 promoter complex. 
    P35222 P24666 ACP1    HPRD  PubMed  
    P35222 Transmembrane protein SHREW1 AJAP1    HPRD  PubMed  
    P35222 P25054 APC    HPRD  PubMed  
    P35222 Adenomatosis polyposis coli 2 APC2    HPRD  PubMed  
    P35222 P10275 AR    HPRD  PubMed  
    P35222 RICS ARHGAP32    HPRD  PubMed  
    P35222 O15169 AXIN1    HPRD  PubMed  
    P35222 Q9Y2T1 AXIN2    HPRD  PubMed  
    P35222 P20749 BCL3    HPRD  PubMed  
    P35222 O00512 BCL9    HPRD  PubMed  
    P35222 B cell CLL/lymphoma 9 like BCL9L    HPRD  PubMed  
    P35222 Brother of CDON BOC    HPRD  PubMed  
    P35222 Q9Y297 BTRC    HPRD  PubMed  
    P35222 Q16790 CA9    HPRD  PubMed  
    P35222 P42574 CASP3    HPRD  PubMed  
    P35222 Q14790 CASP8    HPRD  PubMed  
    P35222 Q9Y3M2 CBY1    HPRD  PubMed  
    P35222 P24385 CCND1    HPRD  PubMed  
    P35222 Q6P1J9 CDC73    HPRD  PubMed  
    P35222 P12830 CDH1    HPRD  PubMed  
    P35222 P55287 CDH11    HPRD  PubMed  
    P35222 P55291 CDH15    HPRD  PubMed  
    P35222 O75309 CDH16    HPRD  PubMed  
    P35222 P19022 CDH2    HPRD  PubMed  
    P35222 Q86UP0 CDH24    HPRD  PubMed  
    P35222 P22223 CDH3    HPRD  PubMed  
    P35222 P33151 CDH5    HPRD  PubMed  
    P35222 Q9ULB5 CDH7    HPRD  PubMed  
    P35222 P55286 CDH8    HPRD  PubMed  
    P35222 Q9ULB4 CDH9    HPRD  PubMed  
    P35222 Q15078 CDK5R1    HPRD  PubMed  
    P35222 Q00534 CDK6    HPRD  PubMed  
    P35222 Q4KMG0 CDON    HPRD  PubMed  
    P35222 P49715 CEBPA    HPRD  PubMed  
    P35222 Q9HCK8 CHD8    HPRD  PubMed  
    P35222 O15111 CHUK    HPRD  PubMed  
    P35222 Q92793 CREBBP    HPRD  PubMed  
    P35222 P48729 CSNK1A1    HPRD  PubMed  
    P35222 P48730 CSNK1D    HPRD  PubMed  
    P35222 P68400 CSNK2A1    HPRD  PubMed  
    P35222 P67870 CSNK2B    HPRD  PubMed  
    P35222 P35221 CTNNA1    HPRD  PubMed  
    P35222 Q9UI47 CTNNA3    HPRD  PubMed  
    P35222 Q9NSA3 CTNNBIP1    HPRD  PubMed  
    P35222 Q9UQB3 CTNND2    HPRD  PubMed  
    P35222 Q8TDM6 DLG5    HPRD  PubMed  
    P35222 Q14574 DSC3    HPRD  PubMed  
    P35222 O14640 DVL1    HPRD  PubMed  
    P35222 Q92997 DVL3    HPRD  PubMed  
    P35222 P00533 EGFR    HPRD  PubMed  
    P35222 Q09472 EP300    HPRD  PubMed  
    P35222 P04626 ERBB2    HPRD  PubMed  
    P35222 P03372 ESR1    HPRD  PubMed  
    P35222 P15311 EZR    HPRD  PubMed  
    P35222 P16591 FER    HPRD  PubMed  
    P35222 Q14192 FHL2    HPRD  PubMed  
    P35222 P17948 FLT1    HPRD  PubMed  
    P35222 Q12778 FOXO1    HPRD  PubMed  
    P35222 P98177 FOXO4    HPRD  PubMed  
    P35222 Q16658 FSCN1    HPRD  PubMed  
    P35222 P06241 FYN    HPRD  PubMed  
    P35222 GLIS family zinc finger 2 GLIS2    HPRD  PubMed  
    P35222 Q14344 GNA13    HPRD  PubMed  
    P35222 Q13002 GRIK2    HPRD  PubMed  
    P35222 Q05586 GRIN1    HPRD  PubMed  
    P35222 O15399 GRIN2D    HPRD  PubMed  
    P35222 P49841 GSK3B    HPRD  PubMed  
    P35222 Q16665 HIF1A    HPRD  PubMed  
    P35222 P20823 HNF1A    HPRD  PubMed  
    P35222 CRDBP IGF2BP1    HPRD  PubMed  
    P35222 O14920 IKBKB    HPRD  PubMed  
    P35222 P46940 IQGAP1    HPRD  PubMed  
    P35222 P35968 KDR    HPRD  PubMed  
    P35222 Q9UJU2 LEF1    HPRD  PubMed  
    P35222 Q8WVC0 LEO1    HPRD  PubMed  
    P35222 Q96QZ7 MAGI1    HPRD  PubMed  
    P35222 Q86UL8 MAGI2    HPRD  PubMed  
    P35222 P08581 MET    HPRD  PubMed  
    P35222 O75030 MITF    HPRD  PubMed  
    P35222 P15941 MUC1    HPRD  PubMed  
    P35222 Q15596 NCOA2    HPRD  PubMed  
    P35222 Q92597 NDRG1    HPRD  PubMed  
    P35222 Q9BR09 NEURL2    HPRD  PubMed  
    P35222 P35240 NF2    HPRD  PubMed  
    P35222 P19838 NFKB1    HPRD  PubMed  
    P35222 Q13285 NR5A1    HPRD  PubMed  
    P35222 P16284 PECAM1    HPRD  PubMed  
    P35222 Q9NRD5 PICK1    HPRD  PubMed  
    P35222 P27986 PIK3R1    HPRD  PubMed  
    P35222 Q13526 PIN1    HPRD  PubMed  
    P35222 Q99697 PITX2    HPRD  PubMed  
    P35222 P98161 PKD1    HPRD  PubMed  
    P35222 Q99959 PKP2    HPRD  PubMed  
    P35222 P53350 PLK1    HPRD  PubMed  
    P35222 P35813 PPM1A    HPRD  PubMed  
    P35222 P49768 PSEN1    HPRD  PubMed  
    P35222 P49810 PSEN2    HPRD  PubMed  
    P35222 P18031 PTPN1    HPRD  PubMed  
    P35222 Q12923 PTPN13    HPRD  PubMed  
    P35222 Q15678 PTPN14    HPRD  PubMed  
    P35222 P29350 PTPN6    HPRD  PubMed  
    P35222 P10586 PTPRF    HPRD  PubMed  
    P35222 Q12913 PTPRJ    HPRD  PubMed  
    P35222 Q15262 PTPRK    HPRD  PubMed  
    P35222 P28827 PTPRM    HPRD  PubMed  
    P35222 Q92729 PTPRU    HPRD  PubMed  
    P35222 P23471 PTPRZ1    HPRD  PubMed  
    P35222 Q9Y3Y4 PYGO1    HPRD  PubMed  
    P35222 Rap guanine nucleotide exchange factor (GEF) 2 RAPGEF2    HPRD  PubMed  
    P35222 Q9Y265 RUVBL1    HPRD  PubMed  
    P35222 Q9Y230 RUVBL2    HPRD  PubMed  
    P35222 P19793 RXRA    HPRD  PubMed  
    P35222 Q9NSC2 SALL1    HPRD  PubMed  
    P35222 O14745 SLC9A3R1    HPRD  PubMed  
    P35222 Q15796 SMAD2    HPRD  PubMed  
    P35222 P84022 SMAD3    HPRD  PubMed  
    P35222 Q13485 SMAD4    HPRD  PubMed  
    P35222 O15105 SMAD7    HPRD  PubMed  
    P35222 P51532 SMARCA4    HPRD  PubMed  
    P35222 O00570 SOX1    HPRD  PubMed  
    P35222 Q9H6I2 SOX17    HPRD  PubMed  
    P35222 P16150 SPN    HPRD  PubMed  
    P35222 P12931 SRC    HPRD  PubMed  
    P35222 O14907 TAX1BP3    HPRD  PubMed  
    P35222 O60907 TBL1X    HPRD  PubMed  
    P35222 P15923 TCF3    HPRD  PubMed  
    P35222 P15884 TCF4    HPRD  PubMed  
    P35222 Q9HCS4 TCF7L1    HPRD  PubMed  
    P35222 Q9NQB0 TCF7L2    HPRD  PubMed  
    P35222 P05549 TFAP2A    HPRD  PubMed  
    P35222 P36897 TGFBR1    HPRD  PubMed  
    P35222 P37173 TGFBR2    HPRD  PubMed  
    P35222 Q15642 TRIP10    HPRD  PubMed  
    P35222 Q93008 USP9X    HPRD  PubMed  
    P35222 O95405 ZFYVE9    HPRD  PubMed  
    BioGRID:107880 BioGRID:106568 ACP1    BioGRID  PubMed Co-localization 
    BioGRID:107880 BioGRID:106699 AHR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:121012 AJAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:106821 APC    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:115585 APC2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107880 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107880 BioGRID:114528 ASH2L    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107880 BioGRID:113909 AXIN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107880 BioGRID:113910 AXIN2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:67803 Apc2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:246396 Ar    BioGRID  PubMed Two-hybrid 
    BioGRID:107880 BioGRID:249455 Axin1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107880 BioGRID:198287 Axin1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:107074 BCL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:124859 BOC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:107880 BioGRID:219776 Bcl9l    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107880 BioGRID:107223 CA9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:118001 CACYBP    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107880 BioGRID:115760 CARM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107880 BioGRID:117311 CBY1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:107431 CDC27    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107880 BioGRID:107434 CDH1    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure 
    BioGRID:107880 BioGRID:107443 CDH10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:107444 CDH11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:107450 CDH17    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:107451 CDH18    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:107435 CDH2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107880 BioGRID:107436 CDH3    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107880 BioGRID:107438 CDH5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:107439 CDH6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:107440 CDH7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:107441 CDH8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:107442 CDH9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:114376 CDK5R1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:119165 CDON    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:107479 CEBPA    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement 
    BioGRID:107880 BioGRID:121709 CHD8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:107569 CHUK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:114103 COPS3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:116124 COPS8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement 
    BioGRID:107880 BioGRID:107876 CTNNA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:118885 CTNNA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:121313 CTNNBIP1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:107880 BioGRID:107881 CTNND1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:115143 DAZAP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:114662 DLG5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:114660 DLGAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:108159 DSC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:108188 DVL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:108189 DVL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:108190 DVL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:108347 EP300    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:107880 BioGRID:121676 EP400    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107880 BioGRID:108376 ERBB2    BioGRID  PubMed Affinity Capture-Western; Co-localization; Far Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:108446 EZH2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:113271 EZR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:116298 FAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:126556 FAM123B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107880 BioGRID:116887 FBXW11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:108532 FER    BioGRID  PubMed Biochemical Activity 
    BioGRID:107880 BioGRID:108565 FHL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107880 BioGRID:108598 FOXO3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:110449 FOXO4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:108810 FYN    BioGRID  PubMed Biochemical Activity 
    BioGRID:107880 BioGRID:124182 GLIS2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107880 BioGRID:109187 GSK3B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107880 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:115106 HDAC4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:115330 HDAC6    BioGRID  PubMed Biochemical Activity 
    BioGRID:107880 BioGRID:119613 HDAC7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization 
    BioGRID:107880 BioGRID:109261 HIST1H1C    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:109414 HNF4A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:109697 IFRD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:109767 IKBKB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:114353 IQGAP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107880 BioGRID:109931 JUP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:108918 KAT2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107880 BioGRID:119354 LEF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107880 BioGRID:110156 LGALS9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107880 BioGRID:110186 LMNA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:114655 MAGI1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107880 BioGRID:110384 MEN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:110391 MET    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:110443 MLL    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:107880 BioGRID:113758 MLL2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107880 BioGRID:110669 MUC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:110731 MYO7A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:115669 NDRG1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107880 BioGRID:110857 NFKB1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107880 BioGRID:119685 NLK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:110913 NOTCH1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:109407 NR4A1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:108792 NR5A1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid 
    BioGRID:107880 BioGRID:111151 PCSK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:111201 PECAM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:116459 PHB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107880 BioGRID:123029 PHF17    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107880 BioGRID:111313 PIK3R1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107880 BioGRID:111317 PIN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107880 BioGRID:111325 PITX2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:111362 PLK1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107880 BioGRID:111564 PRKCA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:111610 PROP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:111642 PSEN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:111731 PTN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:111736 PTPN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107880 BioGRID:111745 PTPN11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:111747 PTPN13    BioGRID  PubMed Biochemical Activity 
    BioGRID:107880 BioGRID:111748 PTPN14    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107880 BioGRID:111756 PTPRF    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:111759 PTPRJ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:111760 PTPRK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:115386 PTPRU    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:111767 PTPRZ1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:119719 RAB8B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:111864 RBBP5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization 
    BioGRID:107880 BioGRID:112168 RXRA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107880 BioGRID:112211 SATB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:112372 SIAH1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107880 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:112391 SKP1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Protein-peptide 
    BioGRID:107880 BioGRID:114769 SLC9A3R1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:110264 SMAD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:110267 SMAD7    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107880 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107880 BioGRID:114045 SMARCA5    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:107880 BioGRID:120714 SOX6    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:107880 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:115737 TADA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:112770 TBL1X    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107880 BioGRID:112787 TCF4    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    BioGRID:107880 BioGRID:123642 TCF7L1    BioGRID  PubMed Co-crystal Structure 
    BioGRID:107880 BioGRID:112795 TCF7L2    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:107880 BioGRID:112878 TFAP2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:112906 TGFBR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:112943 TLE1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107880 BioGRID:115443 TOB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:113900 TRRAP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107880 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107880 BioGRID:113192 UCHL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:125434 UHRF2    BioGRID  PubMed Far Western 
    BioGRID:107880 BioGRID:113867 USP9X    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:107880 BioGRID:113257 VCL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107880 BioGRID:120736 VEZT    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
      Adherens junctions interactions, organism-specific biosystemThe adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (...
    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptotic cleavage of cell adhesion proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cell adhesion proteins, organism-specific biosystemApoptotic cells show dramatic rearrangements of tight junctions, adherens junctions, and desmosomes (Abreu et al., 2000). Desmosome-specific members of the cadherin superfamily of cell adhesion mole...
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 trafficking events, organism-specific biosystem
      Arf6 trafficking events
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Basal cell carcinoma, organism-specific biosystem (from KEGG)
      Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Basal cell carcinoma, conserved biosystem (from KEGG)
      Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Beta-catenin phosphorylation cascade, organism-specific biosystem (from REACTOME)
      Beta-catenin phosphorylation cascade, organism-specific biosystemDegradation of beta-catenin is initiated following amino-terminal serine/threonine phosphorylation. Phosphorylation of B-catenin at S45 by CK1 alpha primes the subsequent sequential GSK-3-mediated p...
    • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CDC42 signaling events, organism-specific biosystem
      CDC42 signaling events
    • CDO in myogenesis, organism-specific biosystem (from REACTOME)
      CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
    • Canonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Canonical Wnt signaling pathway, organism-specific biosystem
      Canonical Wnt signaling pathway
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystem
      Cell junction organization
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
      Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • DNA damage response (only ATM dependent), organism-specific biosystem (from WikiPathways)
      DNA damage response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
    • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
      Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • E-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
      E-cadherin signaling events, organism-specific biosystem
      E-cadherin signaling events
    • E-cadherin signaling in the nascent adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      E-cadherin signaling in the nascent adherens junction, organism-specific biosystem
      E-cadherin signaling in the nascent adherens junction
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Heart Development, organism-specific biosystem (from WikiPathways)
      Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
    • Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem (from REACTOME)
      Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystemIncretins are peptide hormones produced by the gut that enhance the ability of glucose to stimulate insulin secretion from beta cells in the pancreas. Two incretins have been identified: Glucagon-lik...
    • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
      Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Melanogenesis, organism-specific biosystem (from KEGG)
      Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Melanogenesis, conserved biosystem (from KEGG)
      Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
    • Myogenesis, organism-specific biosystem (from REACTOME)
      Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...
    • N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
      N-cadherin signaling events, organism-specific biosystem
      N-cadherin signaling events
    • Nectin adhesion pathway, organism-specific biosystem (from Pathway Interaction Database)
      Nectin adhesion pathway, organism-specific biosystem
      Nectin adhesion pathway
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
      Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
      Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Presenilin action in Notch and Wnt signaling, organism-specific biosystem (from Pathway Interaction Database)
      Presenilin action in Notch and Wnt signaling, organism-specific biosystem
      Presenilin action in Notch and Wnt signaling
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • RAC1 signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RAC1 signaling pathway, organism-specific biosystem
      RAC1 signaling pathway
    • Regulation of Insulin Secretion, organism-specific biosystem (from REACTOME)
      Regulation of Insulin Secretion, organism-specific biosystemPancreatic beta cells integrate signals from several metabolites and hormones to control the secretion of insulin. In general, glucose triggers insulin secretion while other factors can amplify or in...
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2
    • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
      Stabilization and expansion of the E-cadherin adherens junction
    • Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem (from REACTOME)
      Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystemIn L cells of the intestine the transcription factors TCF-4 (TCF7L2) and Beta-catenin form a heterodimer and bind the G2 enhancer of the Proglucagon gene GCG,activating its transcription to yield Pro...
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling
    • Thyroid cancer, organism-specific biosystem (from KEGG)
      Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Thyroid cancer, conserved biosystem (from KEGG)
      Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    I-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    R-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		  
    RPTP-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    alpha-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    androgen receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cadherin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ionotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    nuclear hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    nuclear hormone receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    repressing transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transducer activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		  
    transcription factor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    Schwann cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    T cell differentiation in thymus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Wnt receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    adherens junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		  
    androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    anterior/posterior axis specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    bone resorption IEA
    Inferred from Electronic Annotation
    more info
    		  
    branching involved in ureteric bud morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    canonical Wnt receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell fate specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    cellular component disassembly involved in apoptosis TAS
    Traceable Author Statement
    more info
    		  
    cellular response to growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cellular response to indole-3-methanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    central nervous system vasculogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    cytoskeletal anchoring at plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    determination of dorsal/ventral asymmetry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    dorsal/ventral axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    ectoderm development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    embryonic arm morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic foregut morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    embryonic heart tube development IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic limb morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    embryonic skeletal limb joint morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    endoderm formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    endodermal cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    endothelial tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    epithelial cell differentiation involved in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
    		  
    epithelial to mesenchymal transition TAS
    Traceable Author Statement
    more info
    		 PubMed 
    forebrain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    fungiform papilla formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    gastrulation with mouth forming second IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    genitalia morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    glial cell fate determination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    hair cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    hair follicle morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    hair follicle placode formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    hindbrain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    lens morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
    		  
    limb development IEA
    Inferred from Electronic Annotation
    more info
    		  
    liver development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    lung cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    lung induction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    lung-associated mesenchyme development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    male genitalia development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    mesenchymal cell proliferation involved in lung development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    mesenchymal to epithelial transition involved in metanephros morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    metanephros morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    midgut development IEA
    Inferred from Electronic Annotation
    more info
    		  
    morphogenesis of embryonic epithelium IEA
    Inferred from Electronic Annotation
    more info
    		  
    muscle cell differentiation TAS
    Traceable Author Statement
    more info
    		  
    myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of chondrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    negative regulation of heart induction by canonical Wnt receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    negative regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    negative regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nephron tubule formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    odontogenesis of dentin-containing tooth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    oocyte development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    oviduct development IEA
    Inferred from Electronic Annotation
    more info
    		  
    pancreas development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    patterning of blood vessels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    patterning of blood vessels IC
    Inferred by Curator
    more info
    		  
    positive regulation of I-kappaB kinase/NF-kappaB cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    positive regulation of anti-apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of branching involved in lung morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    positive regulation of determination of dorsal identity IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of epithelial cell proliferation involved in prostate gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    positive regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    positive regulation of heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of mesenchymal cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of muscle cell differentiation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of osteoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein localization at cell surface IMP
    Inferred from Mutant Phenotype
    more info
    		  
    proximal/distal pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    regulation of angiogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of calcium ion import IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of centriole-centriole cohesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of centromeric sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of fibroblast proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of nephron tubule epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of protein localization at cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of secondary heart field cardioblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    renal inner medulla development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    renal outer medulla development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    renal vesicle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to cytokine stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    skin development IEA
    Inferred from Electronic Annotation
    more info
    		  
    smooth muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    thymus development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    tongue morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    trachea formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    APC-Axin-1-beta-catenin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Axin-APC-beta-catenin-GSK3B complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Scrib-APC-beta-catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    beta-catenin-TCF7L2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    catenin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell junction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell-substrate adherens junction IDA
    Inferred from Direct Assay
    more info
    		  
    centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    dendritic shaft IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    desmosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    fascia adherens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    internal side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    membrane fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    microvillus membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zonula adherens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    catenin beta-1
    Names
    catenin beta-1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013302.1 RefSeqGene

      Range
      5001..45998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001098209.1 → NP_001091679.1  catenin beta-1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC104307, DA216720, X87838
      Consensus CDS
      CCDS2694.1
      UniProtKB/Swiss-Prot
      P35222
      Related
      ENSP00000379488, OTTHUMP00000165222, ENST00000396185, OTTHUMT00000258209
      Conserved Domains (2) summary
      cd00020
      Location:399 – 518
      Blast Score: 191
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cl02500
      Location:350 – 390
      Blast Score: 110
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

    2. NM_001098210.1 → NP_001091680.1  catenin beta-1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC104307, DA216720, Z19054
      Consensus CDS
      CCDS2694.1
      UniProtKB/Swiss-Prot
      P35222
      Related
      ENSP00000379486, OTTHUMP00000165223, ENST00000396183, OTTHUMT00000258210
      Conserved Domains (2) summary
      cd00020
      Location:399 – 518
      Blast Score: 191
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cl02500
      Location:350 – 390
      Blast Score: 110
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

    3. NM_001904.3 → NP_001895.1  catenin beta-1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC104307, DA216720, X87838
      Consensus CDS
      CCDS2694.1
      UniProtKB/Swiss-Prot
      P35222
      Related
      ENSP00000344456, OTTHUMP00000162082, ENST00000349496, OTTHUMT00000254182
      Conserved Domains (2) summary
      cd00020
      Location:399 – 518
      Blast Score: 191
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cl02500
      Location:350 – 390
      Blast Score: 110
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      41240942..41281939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      41285983..41326988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC104307.2 (83769..84862) None
    genomic AY081165.1 AAL89457.1
    genomic AY463360.1 AAR18817.1
    genomic CH471055.1 EAW64625.1
      EAW64626.1
      EAW64627.1
      EAW64628.1
    genomic JA780904.1 CCH22596.1
    genomic JN314422.1 AEW16366.1
    mRNA AB062292.1 BAB93475.1
    mRNA AB451264.1 BAG70078.1
    mRNA AB451392.1 BAG70206.1
    mRNA AK095242.1 None
    mRNA AK289932.1 BAF82621.1
    mRNA AK294778.1 BAG57905.1
    mRNA AK296790.1 BAG59368.1
    mRNA AK299954.1 BAG61781.1
    mRNA AK314776.1 None
    mRNA BC058926.1 AAH58926.1
    mRNA BX648430.1 None
    mRNA DA216720.1 None
    mRNA X87838.1 CAA61107.1
    mRNA Z19054.1 CAA79497.1
    other-genetic EU446854.1 ABZ92383.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35222.1 GenPept UniProtKB/Swiss-Prot:P35222
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    Additional Links

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