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NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) [ Homo sapiens (human) ]

Gene ID: 4869, updated on 22-May-2013

Summary

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Official Symbol: NPM1provided by HGNC
Official Full Name: nucleophosmin (nucleolar phosphoprotein B23, numatrin)provided by HGNC
Primary source: HGNC:7910
See related: Ensembl:ENSG00000181163; HPRD:01246; MIM:164040; Vega:OTTHUMG00000130465
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: B23; NPM
Summary: This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

Genomic context

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Location :: 5q35.1

Sequence :: Chromosome: 5; NC_000005.9 (170814708..170837888)

See NPM1 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

NPM1 mutations are associated with better complete remission in pediatric acute myeloid leukemia.
Title: NPM1, FLT3, and c-KIT mutations in pediatric acute myeloid leukemia in Russian population.
A direct correlation between NPM1 G-quadruplex binding at rDNA and its nucleolar localization.
Title: Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA.
Association of cup-like nuclei in blasts with FLT3 and NPM1 mutations in acute myeloid leukemia.
Title: Association of cup-like nuclei in blasts with FLT3 and NPM1 mutations in acute myeloid leukemia.
detection of recurrent gene rearrangements,or NPM1 and FLT3 gene mutations in AML patients with both NK or without cytogenetic result add clinically relevant information, and thus enable reclassification of patients to a different prognostic risk group.
Title: Refining the diagnosis and prognostic categorization of acute myeloid leukemia patients with an integrated use of cytogenetic and molecular studies.
Study indicates that allo-HSCT and auto-HSCT provide similar outcomes compared with chemotherapy as consolidation for NPM1+/FLT3-ITD- NK-AML patients.
Title: Role of autologous hematopoietic stem cell transplantation according to the NPM1/FLT3-ITD molecular status for cytogenetically normal AML patients: a GOELAMS study.
inhibition of PDGFRA and PDGFRB in a patient with refractory late-stage NPM-ALK+ Anaplastic large cell lymphoma resulted in rapid, complete and sustained remission
Title: PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas.
NPM1 mutations occur rarely or not at all in chronic myeloid leukemia patients in chronic phase or blast crisis.
Title: NPM1 mutations occur rarely or not at all in chronic myeloid leukaemia patients in chronic phase or blast crisis.
Mutations in NMP1 gene is associated with pediatric acute myeloid leukemia.
Title: Whole-genome-amplified DNA as a source for mutational analysis underestimates the frequency of mutations in pediatric acute myeloid leukemia.
High NPM1 expression is associated with multiple myeloma.
Title: A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma.
Findings define a mechanism through which control of the DDX31-NPM1 complex is likely to play critical roles in renal carcinogenesis.
Title: DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with NPM1 in renal cell carcinomas.

Submit: New GeneRIF Correction See all (304)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Familial acute myeloid leukemia (AML) with mutated CEBPA is defined as AML in which a germline CEBPA mutation is present in a family in which multiple individuals have AML. In contrast, sporadic AML with mutated CEBPA is defined as AML in which a CEBPA mutation is identified in somatic (i.e., leukemic) cells but not in germline (i.e., non-leukemic) cells. Too few persons with familial AML with mutated CEBPA have been reported to be certain about the natural history of the disease. The age of onset of familial AML with mutated CEBPA appears to be earlier than sporadic AML; disease onset has been reported in persons as young as age four years and older than age 50 years. The prognosis of individuals with familial AML with mutated CEBPA appears to be favorable (~50%-65% overall survival) compared to the ~25%-40% overall survival of those who have normal karyotype AML but no germline CEPBA mutation. Individuals with familial AML with mutated CEBPA who have been cured of their initial disease may be at greater risk of developing additional malignant clones than persons with sporadic disease.

Diagnosis Testing

CEBPA mutations are found in the leukemic cells of approximately 9% of persons with AML, including 15%-18% of persons with normal-karyotype AML; however, few of these individuals have a germline mutation. Detection of a germline CEBPA mutation in a specimen that contains only non-leukemic cells from an individual with AML or detection of a germline CEBPA mutation in a member of a pedigree in which more than one family member has had AML or myelodysplastic syndrome (MDS) establishes the diagnosis of familial AML with mutated CEBPA. Molecular genetic testing of CEBPA is available on a clinical basis.

Genetic Counseling

Familial AML with mutated CEBPA is inherited in an autosomal dominant manner. The proportion of cases caused by a de novo germline mutation is unknown; currently, all seven reported affected individuals have had an affected parent. Each child of an affected individual has a 50% chance of inheriting the germline mutation. No laboratories offering molecular genetic testing for prenatal diagnosis of familial AML with mutated CEBPA are listed in the GeneTests Laboratory Directory; however, prenatal testing may be available through laboratories offering custom prenatal testing for families in which the disease-causing germline mutation has been identified. Requests for prenatal testing for conditions that do not affect intellect and have treatment available are not common.

References

PMID: 20963938

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Rev, p19	rev	HIV-1 Rev interacting protein, nucleophosmin 1 (NPM1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with NPM1 is decreased by RRE	PubMed
	rev	HIV-1 Rev has a nucleolar distribution which is similar to B23.1, but with different trafficking rates	PubMed
	rev	B23 is associated with the nucleolar localization of Rev	PubMed
	rev	during nuclear import B23 forms a specific binding complex with Rev which is dissociated by RRE RNA and phosphorylation by casein kinase II (CK2)	PubMed
	rev	B23 stimulates the nuclear import of Rev, an effect that is increased when B23 is phosphorylated by casein kinase II (CK2)	PubMed
	rev	interaction of B23 with Rev has been implicated in the cytotoxic activity of Rev	PubMed
	rev	amino acids 38-52 of Rev have been implicated in the association with B32	PubMed
Tat, p14	tat	Acetylation of human histone chaperone NPK1 regulates nuclear localization of HIV-1 Tat and modulates Tat-mediated LTR-transactivation	PubMed
	tat	Overexpression of NPM1 enhances HIV-1 Tat-mediated transactivation by reducing the histone H1 occupancy on the chromatinized template of HIV-1 LTR	PubMed
	tat	The nucleolar shuttle protein B23 binds to HIV-1 Tat and data indicates B23 is necessary for the nucleolar localization of Tat	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000005.8	NP_002458.1	MYC	BIND	PubMed	Myc interacts with NPM1 (B23)
NP_002511.1	NP_056842.1	HIV2gp5	BIND	PubMed	Tat-2 interacts with B23.
P06748	Q9UM73	ALK	HPRD	PubMed
P06748	P84077	ARF1	HPRD	PubMed
P06748	P06493	CDK1	HPRD	PubMed
P06748	P24941	CDK2	HPRD	PubMed
P06748	P19525	EIF2AK2	HPRD	PubMed
P06748	P24522	GADD45A	HPRD	PubMed
P06748	P62993	GRB2	HPRD	PubMed
P06748	P61296	HAND2	HPRD	PubMed
P06748	Q16695	HIST3H3	HPRD	PubMed
P06748	P35568	IRS1	HPRD	PubMed
P06748	Q00987	MDM2	HPRD	PubMed
P06748	P19338	NCL	HPRD	PubMed
P06748	P46087	NOP2	HPRD	PubMed
P06748	P09874	PARP1	HPRD	PubMed
P06748	P16885	PLCG2	HPRD	PubMed
P06748	P53350	PLK1	HPRD	PubMed
P06748	Q92834	RPGR	HPRD	PubMed
P06748	P29353	SHC1	HPRD	PubMed
P06748	Q8WXA9	SREK1	HPRD	PubMed
P06748	O14776	TCERG1	HPRD	PubMed
P06748	P05549	TFAP2A	HPRD	PubMed
P06748	P04637	TP53	HPRD	PubMed
P06748	O14980	XPO1	HPRD	PubMed
BioGRID:110929	BioGRID:110503	ABCC1	BioGRID	PubMed	Two-hybrid
BioGRID:110929	BioGRID:106549	ACACA	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:106610	ACY1	BioGRID	PubMed	Two-hybrid
BioGRID:110929	BioGRID:110445	AFF1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:106710	AKT1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110929	BioGRID:106825	APEX1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:110929	BioGRID:119614	ARMCX3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:106901	ARRB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:106902	ARRB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:107056	BARD1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:107140	BRCA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:120937	CAND1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:121585	CASKIN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:124228	CBX2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:114105	CBX4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:121487	CBX8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:107358	CD4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:114126	CDC14A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:107452	CDK2	BioGRID	PubMed	Biochemical Activity
BioGRID:110929	BioGRID:123213	CDK5RAP3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:107460	CDKN1A	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:110929	BioGRID:107463	CDKN2A	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:110929	BioGRID:123555	CDT1	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:110929	BioGRID:107487	CENPA	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110929	BioGRID:107492	CENPF	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:114729	COPS2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:116183	COPS5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:116176	COPS6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:118946	CPSF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:119826	CPSF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:119680	CPSF3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:116104	CPSF4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:116238	CPSF6	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:110929	BioGRID:107841	CSNK2A1	BioGRID	PubMed	Biochemical Activity
BioGRID:110929	BioGRID:115906	CTCF	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110929	BioGRID:121123	CTNNBL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:114032	CUL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:114031	CUL2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:114029	CUL4A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:113743	CUL5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:198654	Cdkn2a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:119920	DCUN1D1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:114625	DDX21	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:110929	BioGRID:124082	DOT1L	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110929	BioGRID:114023	DYRK2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:109857	EIF3E	BioGRID	PubMed	Two-hybrid
BioGRID:110929	BioGRID:108347	EP300	BioGRID	PubMed	Biochemical Activity
BioGRID:110929	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110929	BioGRID:108472	FANCA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:108473	FANCC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:117646	FBXO25	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:117654	FBXO6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:107208	FMNL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:108621	FN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:108868	GAPDH	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:109033	GNAI2	BioGRID	PubMed	Two-hybrid
BioGRID:110929	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:110929	BioGRID:109143	GRB7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:122164	GZF1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:114461	H1FX	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:109268	H2AFX	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110929	BioGRID:114850	HAND2	BioGRID	PubMed	Two-hybrid
BioGRID:110929	BioGRID:1205534	HCVgp1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:110929	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:109316	HDAC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:109275	HIST1H1A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:109261	HIST1H1C	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:113946	HIST1H3A	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:110929	BioGRID:113955	HIST1H4A	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:110929	BioGRID:113934	HIST2H2AC	BioGRID	PubMed	Reconstituted Complex
BioGRID:110929	BioGRID:113945	HIST2H2BE	BioGRID	PubMed	Reconstituted Complex
BioGRID:110929	BioGRID:113895	HIST3H3	BioGRID	PubMed	Far Western
BioGRID:110929	BioGRID:109344	HIVEP2	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:110929	BioGRID:120635	HJURP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:109402	HMGA1	BioGRID	PubMed	Far Western
BioGRID:110929	BioGRID:113763	HMGA2	BioGRID	PubMed	Far Western
BioGRID:110929	BioGRID:109428	HNRNPH1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:110929	BioGRID:110751	HNRNPM	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:115530	HNRNPR	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:109433	HNRNPU	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation
BioGRID:110929	BioGRID:109444	HOXA7	BioGRID	PubMed	Two-hybrid
BioGRID:110929	BioGRID:109867	IRF1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110929	BioGRID:109883	ITGA4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:109929	JUNB	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:110929	BioGRID:115114	KIAA0101	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:110034	KPNA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:110114	LAMP2	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:116645	LIMCH1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:120780	LYAR	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:110330	MC4R	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:110929	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide; Reconstituted Complex
BioGRID:110929	BioGRID:110427	MID1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:110754	NAP1L1	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:110757	NAP1L4	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:122089	NCAPG	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:110771	NCL	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:110929	BioGRID:115783	NOP56	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:110906	NOS2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:110929	NPM1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:115640	NPM3	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:110929	BioGRID:120236	NSUN2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:110980	NUMA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:115982	NUP50	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:117165	NUP62	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:110982	NUP98	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:111048	OSBP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:120751	OTUB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:111075	PA2G4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110929	BioGRID:117111	PADI4	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:110929	BioGRID:122338	PAPOLG	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:110929	BioGRID:106652	PARP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:111124	PC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:111264	PHB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:111313	PIK3R1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:111351	PLCG1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110929	BioGRID:111384	PML	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:111477	PPID	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:111510	PPP2R1A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:117298	PRPF6	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:111677	PSMC4	BioGRID	PubMed	Two-hybrid
BioGRID:110929	BioGRID:111697	PTBP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:111849	RARA	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:111902	RELA	BioGRID	PubMed	Two-hybrid
BioGRID:110929	BioGRID:126711	RPL10L	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:114507	RPL14	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:112071	RPL24	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:112045	RPL5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:112048	RPL6	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:112105	RPS4X	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:112108	RPS6	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:116708	RRP1B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:112171	RYK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:215383	Rrp1b	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:117594	SENP3	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Two-hybrid
BioGRID:110929	BioGRID:112372	SIAH1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:116983	SIRT1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:119602	SIRT7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:112481	SMARCA4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:112490	SMN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:126754	SREK1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:112324	SRSF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110929	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:112496	SUMO3	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110929	BioGRID:112703	SURF4	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:116707	SWAP70	BioGRID	PubMed	Co-purification
BioGRID:110929	BioGRID:116120	TCERG1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:112878	TFAP2A	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:110929	BioGRID:113003	TOP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110929	BioGRID:125450	TRMT61A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:204323	Trp53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:110929	BioGRID:113885	UBL4A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:113234	UQCRH	BioGRID	PubMed	Two-hybrid
BioGRID:110929	BioGRID:113238	USF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:121651	USP36	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110929	BioGRID:113255	VCAM1	BioGRID	PubMed	Affinity Capture-MS
	NP_003391.1	XPO1	BIND	PubMed	An unspecified isoform of NPM1 (NPM) interacts with XPO1 (CRM1).
BioGRID:110929	BioGRID:110959	YBX1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:114101	YBX3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:113363	YWHAE	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:113366	YWHAZ	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:113360	YY1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110929	BioGRID:122868	ZNF668	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110929	BioGRID:113569	ZYX	BioGRID	PubMed	Co-fractionation
BioGRID:110929	BioGRID:1205542	rev	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110929	BioGRID:1205541	tat	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
Aurora B signaling, organism-specific biosystem
Aurora B signaling
BARD1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
BARD1 signaling events, organism-specific biosystem
BARD1 signaling events
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystem
Cell Cycle
Chromosome Maintenance, organism-specific biosystem (from REACTOME)
Chromosome Maintenance, organism-specific biosystemChromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells. Aspects of telomere maintenance and nucleosome assembly are covered here.
Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystem (from REACTOME)
Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystemEukaryotic centromeres are marked by a unique form of histone H3, designated CENPA in humans. In human cells newly synthesized CENPA is deposited in nucleosomes at the centromere during late telophas...
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
HIF-1-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
HIF-1-alpha transcription factor network, organism-specific biosystem
HIF-1-alpha transcription factor network
HIV Infection, organism-specific biosystem (from REACTOME)
HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
Interactions of Rev with host cellular proteins, organism-specific biosystem (from REACTOME)
Interactions of Rev with host cellular proteins, organism-specific biosystemIn order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nucl...
Nuclear import of Rev protein, organism-specific biosystem (from REACTOME)
Nuclear import of Rev protein, organism-specific biosystemNuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev pr...
Nucleosome assembly, organism-specific biosystem (from REACTOME)
Nucleosome assembly, organism-specific biosystemThe formation of centromeric chromatin assembly outside the context of DNA replication involves the assembly of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A).
Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
Validated targets of C-MYC transcriptional activation, organism-specific biosystem
Validated targets of C-MYC transcriptional activation

General gene information

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Markers

RH80894 (e-PCR)
- UniSTS:92753

D16S2968 (e-PCR)
- UniSTS:3283

REN60444 (e-PCR)
- UniSTS:385244

Genotypes

See NPM1 SNP Geneview Report
See NPM1 SNP Genotype Report
See NPM1 SNP Variation Viewer Report

Related pseudogene(s)

49 found Review record(s) in Gene

Homology

Homologs of the NPM1 gene: The NPM1 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Clone Names

MGC104254

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NF-kappaB binding	IDA Inferred from Direct Assay more info	PubMed
NF-kappaB binding	ISS Inferred from Sequence or Structural Similarity more info
RNA binding	IDA Inferred from Direct Assay more info	PubMed
Tat protein binding	IDA Inferred from Direct Assay more info	PubMed
histone binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info
protein kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
ribosomal large subunit binding	IDA Inferred from Direct Assay more info	PubMed
ribosomal small subunit binding	IDA Inferred from Direct Assay more info	PubMed
transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed
unfolded protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
CENP-A containing nucleosome assembly at centromere	TAS Traceable Author Statement more info
DNA repair	IDA Inferred from Direct Assay more info	PubMed
cell aging	IMP Inferred from Mutant Phenotype more info	PubMed
cell aging	ISS Inferred from Sequence or Structural Similarity more info
centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
intracellular protein transport	TAS Traceable Author Statement more info	PubMed
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of protein kinase activity by regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
nucleocytoplasmic transport	IDA Inferred from Direct Assay more info	PubMed
nucleocytoplasmic transport	TAS Traceable Author Statement more info	PubMed
nucleosome assembly	IDA Inferred from Direct Assay more info	PubMed
nucleosome assembly	TAS Traceable Author Statement more info
positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
protein localization	IDA Inferred from Direct Assay more info	PubMed
protein oligomerization	IDA Inferred from Direct Assay more info	PubMed
regulation of centriole replication	IMP Inferred from Mutant Phenotype more info
regulation of eIF2 alpha phosphorylation by dsRNA	IDA Inferred from Direct Assay more info	PubMed
regulation of endodeoxyribonuclease activity	IDA Inferred from Direct Assay more info	PubMed
regulation of endoribonuclease activity	IDA Inferred from Direct Assay more info	PubMed
response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
ribosome assembly	TAS Traceable Author Statement more info	PubMed
signal transduction	NAS Non-traceable Author Statement more info	PubMed
viral reproduction	TAS Traceable Author Statement more info
virus-host interaction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
centrosome	IDA Inferred from Direct Assay more info	PubMed
centrosome	ISS Inferred from Sequence or Structural Similarity more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
cytosol	TAS Traceable Author Statement more info
nucleolus	IDA Inferred from Direct Assay more info
nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info
ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
spindle pole centrosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nucleophosmin

Names: nucleophosmin; nucleolar protein NO38; nucleophosmin/nucleoplasmin family, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016018.1 RefSeqGene

Range

5001..28181

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001037738.2 → NP_001032827.1 nucleophosmin isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) utilizes an alternate 3'-terminal exon, compared to variant 1, resulting in a shorter protein (isoform 3) with a distinct C-terminus.

Source sequence(s)

AC091980, BC107754

Consensus CDS

CCDS43399.1

UniProtKB/Swiss-Prot

P06748

Conserved Domains (1) summary

pfam03066
Location:13 – 116
Blast Score: 440

Nucleoplasmin; Nucleoplasmin
NM_002520.6 → NP_002511.1 nucleophosmin isoform 1

Status: REVIEWED

Description

Transcript Variant: This predominant variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC091980, BC002398

Consensus CDS

CCDS4376.1

UniProtKB/Swiss-Prot

P06748

Related

ENSP00000296930, OTTHUMP00000161024, ENST00000296930, OTTHUMT00000252858

Conserved Domains (1) summary

pfam03066
Location:13 – 116
Blast Score: 448

Nucleoplasmin; Nucleoplasmin
NM_199185.3 → NP_954654.1 nucleophosmin isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC091980, AC093246, BC009623

Consensus CDS

CCDS4377.1

UniProtKB/Swiss-Prot

P06748

Related

ENSP00000341168, OTTHUMP00000161025, ENST00000351986, OTTHUMT00000252859

Conserved Domains (1) summary

pfam03066
Location:13 – 116
Blast Score: 444

Nucleoplasmin; Nucleoplasmin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p10 Primary Assembly

Range

170814708..170837888

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

165912826..165935666

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018916.1 Alternate CHM1_1.0

Range

171042325..171065506

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01044078.1	None
genomic	ABBA01044079.1	None
genomic	ABBA01044080.1	None
genomic	AC091980.4 (138097..153133)	None
genomic	AC093246.3 (84189..92331)	None
genomic	AMYH01015806.1 (201029..217050)	None
genomic	AMYH01015807.1	None
genomic	CH471062.2	EAW61443.1
		EAW61444.1
		EAW61445.1
		EAW61446.1
		EAW61447.1
		EAW61448.1
		EAW61449.1
genomic	U89309.1	AAB94739.1
mRNA	AB042278.1	BAB40600.1
mRNA	AB451236.1	BAG70050.1
mRNA	AB451361.1	BAG70175.1
mRNA	AI687394.1	None
mRNA	AK000472.1	BAA91188.1
mRNA	AK290652.1	BAF83341.1
mRNA	AY347529.1	AAQ24860.1
mRNA	AY740634.1	AAW67752.1
mRNA	AY740635.1	AAW67753.1
mRNA	AY740636.1	AAW67754.1
mRNA	AY740637.1	AAW67755.1
mRNA	AY740638.1	AAW67756.1
mRNA	AY740639.1	AAW67757.1
mRNA	AY740640.1	AAW67758.1
mRNA	BC002398.2	AAH02398.1
mRNA	BC003670.1	AAH03670.2
mRNA	BC008495.1	AAH08495.1
mRNA	BC009623.2	AAH09623.1
mRNA	BC012566.1	AAH12566.1
mRNA	BC014349.1	AAH14349.1
mRNA	BC016716.1	AAH16716.1
mRNA	BC016768.1	AAH16768.1
mRNA	BC016824.1	AAH16824.1
mRNA	BC020467.1	None
mRNA	BC021668.1	AAH21668.1
mRNA	BC021983.1	AAH21983.1
mRNA	BC024716.2	None
mRNA	BC050628.1	AAH50628.1
mRNA	BC107754.1	AAI07755.1
mRNA	BP291033.1	None
mRNA	BT007011.1	AAP35657.1
mRNA	BU661768.1	None
mRNA	D28343.1	BAA05709.1
mRNA	DQ303464.1	ABC40399.1
mRNA	EF429251.1	ABP97432.1
mRNA	J02590.1	AAA36473.1
mRNA	M23613.1	AAA36380.1
mRNA	M26697.1	AAA36385.1
mRNA	M28699.1	AAA58386.1
mRNA	M31004.1	AAA36474.1
mRNA	X16934.1	CAA34809.1
other-genetic	DQ892032.2	ABM82958.1
other-genetic	DQ895223.2	ABM86149.1