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NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) [ Homo sapiens (human) ]

Gene ID: 4869, updated on 11-Sep-2014
Official Symbol
NPM1provided by HGNC
Official Full Name
nucleophosmin (nucleolar phosphoprotein B23, numatrin)provided by HGNC
Primary source
HGNC:HGNC:7910
See related
Ensembl:ENSG00000181163; HPRD:01246; MIM:164040; Vega:OTTHUMG00000130465
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B23; NPM
Summary
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
See NPM1 in Epigenomics, MapViewer
Location:
5q35.1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (171387648..171410884)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (170814652..170837888)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10 pseudogene Neighboring gene microRNA 3912 Neighboring gene fibroblast growth factor 18 Neighboring gene small integral membrane protein 23

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify nucleophosmin (NPM1; nucleolar phosphoprotein B23), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify nucleophosmin (NPM1; nucleolar phosphoprotein B23), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify nucleophosmin (NPM1; nucleolar phosphoprotein B23), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify nucleophosmin (NPM1; nucleolar phosphoprotein B23), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, nucleophosmin 1 (NPM1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with NPM1 is decreased by RRE PubMed
rev HIV-1 Rev has a nucleolar distribution which is similar to B23.1, but with different trafficking rates PubMed
rev interaction of B23 with Rev has been implicated in the cytotoxic activity of Rev PubMed
rev amino acids 38-52 of Rev have been implicated in the association with B32 PubMed
rev B23 is associated with the nucleolar localization of Rev PubMed
rev during nuclear import B23 forms a specific binding complex with Rev which is dissociated by RRE RNA and phosphorylation by casein kinase II (CK2) PubMed
rev B23 stimulates the nuclear import of Rev, an effect that is increased when B23 is phosphorylated by casein kinase II (CK2) PubMed
Tat tat HIV-1 Tat upregulates the expression of nucleophosmin (NPM1, nucleolar phosphoprotein B23, numatrin) in Jurkat cells PubMed
tat Acetylation of human histone chaperone NPK1 regulates nuclear localization of HIV-1 Tat and modulates Tat-mediated LTR-transactivation PubMed
tat Overexpression of NPM1 enhances HIV-1 Tat-mediated transactivation by reducing the histone H1 occupancy on the chromatinized template of HIV-1 LTR PubMed
tat The nucleolar shuttle protein B23 binds to HIV-1 Tat and data indicates B23 is necessary for the nucleolar localization of Tat PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of nucleophosmin (NPM1, nucleolar phosphoprotein B23, numatrin) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC104254

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NF-kappaB binding IDA
Inferred from Direct Assay
more info
PubMed 
NF-kappaB binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Tat protein binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
 
protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
ribosomal large subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
ribosomal small subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell aging ISS
Inferred from Sequence or Structural Similarity
more info
 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase activity by regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
nucleocytoplasmic transport TAS
Traceable Author Statement
more info
PubMed 
nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome assembly TAS
Traceable Author Statement
more info
 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
protein localization IDA
Inferred from Direct Assay
more info
PubMed 
protein oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
 
regulation of eIF2 alpha phosphorylation by dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
regulation of endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosome assembly TAS
Traceable Author Statement
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
viral process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole centrosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
nucleophosmin
Names
nucleophosmin
nucleolar protein NO38
nucleophosmin/nucleoplasmin family, member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016018.1 

    Range
    5001..28181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_458

mRNA and Protein(s)

  1. NM_001037738.2NP_001032827.1  nucleophosmin isoform 3

    See proteins identical to NP_001032827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) utilizes an alternate 3'-terminal exon, compared to variant 1, resulting in a shorter protein (isoform 3) with a distinct C-terminus.
    Source sequence(s)
    AC091980, BC107754
    Consensus CDS
    CCDS43399.1
    UniProtKB/Swiss-Prot
    P06748
    Conserved Domains (1) summary
    pfam03066
    Location:13119
    Blast Score: 470
    Nucleoplasmin; Nucleoplasmin
  2. NM_002520.6NP_002511.1  nucleophosmin isoform 1

    See proteins identical to NP_002511.1

    Status: REVIEWED

    Description
    Transcript Variant: This predominant variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC091980, BC002398
    Consensus CDS
    CCDS4376.1
    UniProtKB/Swiss-Prot
    P06748
    Related
    ENSP00000296930, OTTHUMP00000161024, ENST00000296930, OTTHUMT00000252858
    Conserved Domains (1) summary
    pfam03066
    Location:13119
    Blast Score: 478
    Nucleoplasmin; Nucleoplasmin
  3. NM_199185.3NP_954654.1  nucleophosmin isoform 2

    See proteins identical to NP_954654.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC091980, AC093246, BC009623
    Consensus CDS
    CCDS4377.1
    UniProtKB/Swiss-Prot
    P06748
    Related
    ENSP00000341168, OTTHUMP00000161025, ENST00000351986, OTTHUMT00000252859
    Conserved Domains (1) summary
    pfam03066
    Location:13119
    Blast Score: 474
    Nucleoplasmin; Nucleoplasmin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    171387648..171410884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714869.1XP_006714932.1  

    Conserved Domains (1) summary
    pfam03066
    Location:13170
    Blast Score: 415
    Nucleoplasmin; Nucleoplasmin
  2. XM_005265920.1XP_005265977.1  

    Conserved Domains (1) summary
    pfam03066
    Location:13119
    Blast Score: 465
    Nucleoplasmin; Nucleoplasmin

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    165912826..165935666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    170247232..170270413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)