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    NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) [ Homo sapiens ]

    Gene ID: 4869, updated on 19-May-2012
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    Summary

    Official Symbol
    NPM1provided by HGNC
    Official Full Name
    nucleophosmin (nucleolar phosphoprotein B23, numatrin)provided by HGNC
    Primary source
    HGNC:7910
    See related
    Ensembl:ENSG00000181163; HPRD:01246; MIM:164040; Vega:OTTHUMG00000130465
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B23; NPM; MGC104254
    Summary
    This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
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    Genomic context

    Location :
    5q35.1
    Sequence :
    Chromosome: 5; NC_000005.9 (170814708..170837888)
    See NPM1 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10 pseudogene Neighboring gene microRNA 3912 Neighboring gene fibroblast growth factor 18 Neighboring gene chromosome 5 open reading frame 50

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. Clinical implications of non-A-type NPM1 and FLT3 mutations in patients with normal karyotype acute myeloid leukemia. Park BG, et al. Acta Haematol, 2012. PMID 22104247.
    3. New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein. Chun Y, et al. J Biol Chem, 2011 Dec 9. PMID 22002061.
    4. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    5. Nucleophosmin interacts with FOXM1 and modulates the level and localization of FOXM1 in human cancer cells. Bhat UG, et al. J Biol Chem, 2011 Dec 2. PMID 21979956.

    See all (402) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Investigation of the associations between NPM-1 mutations and acute myeloid leukemia cell differentiation as defined by a limited number of well-characterized surface membrane molecules.
      Title: The surface molecule signature of primary human acute myeloid leukemia (AML) cells is highly associated with NPM1 mutation status.
    2. Nucleophosmin mRNA and protein are expressed in glandular epithelium of human endometrium throughout the menstrual cycle.
      Title: Expression of nucleophosmin in glandular epithelium of non-pregnant human endometrium during the menstrual cycle.
    3. NPM has a tumor suppressive role in breast cancer
      Title: An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer.
    4. Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia.
      Title: Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia.
    5. normal karyotype acute myeloid leukemia patients with non- A-type NPM1mut, regardless of FLT3mut status, and patients with NPM1mut in the absence of FLT3-ITD have higher complete remission rates than patients with NPM1wt and FLT3mut
      Title: Clinical implications of non-A-type NPM1 and FLT3 mutations in patients with normal karyotype acute myeloid leukemia.
    6. nucleolar translocation of RelA is causally involved in the relocalization of nucleophosmin from the nucleolus to the cytoplasm
      Title: Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin.
    7. Data show that the presence of mutations of NPM1 and FLT3-ITD significantly decreased with age in adult acute myeloid leukemia.
      Title: Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML).
    8. B23 may function in the assembly of the kinetochore complex by interacting with CENP-W during interphase
      Title: New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein.
    9. FLT3-ITD and NPM1mut might synergistically stimulate blast proliferation.
      Title: Amount of bone marrow blasts is strongly correlated to NPM1 and FLT3-ITD mutation rate in AML with normal karyotype.
    10. in cancer cells NPM interacts with FOXM1 and their interaction is required for sustaining the level and localization of FOXM1.
      Title: Nucleophosmin interacts with FOXM1 and modulates the level and localization of FOXM1 in human cancer cells.
    Submit: New GeneRIF Correction See all (268)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Leukemia, acute myeloid

    Leukemia, acute promyelocytic, NPM/RARA type

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Rev rev during nuclear import B23 forms a specific binding complex with Rev which is dissociated by RRE RNA and phosphorylation by casein kinase II (CK2) PubMed
    rev interaction of B23 with Rev has been implicated in the cytotoxic activity of Rev PubMed
    rev amino acids 38-52 of Rev have been implicated in the association with B32 PubMed
    rev B23 is associated with the nucleolar localization of Rev PubMed
    rev B23 stimulates the nuclear import of Rev, an effect that is increased when B23 is phosphorylated by casein kinase II (CK2) PubMed
    Tat tat The nucleolar shuttle protein B23 binds to HIV-1 Tat and data indicates B23 is necessary for the nucleolar localization of Tat PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000005.8 NP_002458.1 MYC    BIND  PubMed Myc interacts with NPM1 (B23) 
    NP_002511.1 NP_056842.1 HIV2gp5    BIND  PubMed Tat-2 interacts with B23. 
    P06748 Q9UM73 ALK    HPRD  PubMed  
    P06748 P84077 ARF1    HPRD  PubMed  
    P06748 P06493 CDK1    HPRD  PubMed  
    P06748 P24941 CDK2    HPRD  PubMed  
    P06748 P19525 EIF2AK2    HPRD  PubMed  
    P06748 P24522 GADD45A    HPRD  PubMed  
    P06748 P62993 GRB2    HPRD  PubMed  
    P06748 P61296 HAND2    HPRD  PubMed  
    P06748 Q16695 HIST3H3    HPRD  PubMed  
    P06748 P35568 IRS1    HPRD  PubMed  
    P06748 Q00987 MDM2    HPRD  PubMed  
    P06748 P19338 NCL    HPRD  PubMed  
    P06748 P46087 NOP2    HPRD  PubMed  
    P06748 P09874 PARP1    HPRD  PubMed  
    P06748 P16885 PLCG2    HPRD  PubMed  
    P06748 P53350 PLK1    HPRD  PubMed  
    P06748 Q92834 RPGR    HPRD  PubMed  
    P06748 P29353 SHC1    HPRD  PubMed  
    P06748 Q8WXA9 SREK1    HPRD  PubMed  
    P06748 O14776 TCERG1    HPRD  PubMed  
    P06748 P05549 TFAP2A    HPRD  PubMed  
    P06748 P04637 TP53    HPRD  PubMed  
    P06748 O14980 XPO1    HPRD  PubMed  
    BioGRID:110929 BioGRID:106549 ACACA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:110445 AFF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110929 BioGRID:107056 BARD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:121585 CASKIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:114126 CDC14A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:107452 CDK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:110929 BioGRID:123213 CDK5RAP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:110929 BioGRID:107463 CDKN2A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110929 BioGRID:123555 CDT1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:110929 BioGRID:107487 CENPA    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110929 BioGRID:107492 CENPF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:114101 CSDA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:115906 CTCF    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110929 BioGRID:121123 CTNNBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:198654 Cdkn2a    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:114625 DDX21    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:124082 DOT1L    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110929 BioGRID:114023 DYRK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:108347 EP300    BioGRID  PubMed Biochemical Activity 
    BioGRID:110929 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110929 BioGRID:108472 FANCA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:108473 FANCC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:109143 GRB7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:114461 H1FX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110929 BioGRID:114850 HAND2    BioGRID  PubMed Two-hybrid 
    BioGRID:110929 BioGRID:1205534 HCVgp1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:110929 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:109275 HIST1H1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:109261 HIST1H1C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:113946 HIST1H3A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110929 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110929 BioGRID:113934 HIST2H2AC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110929 BioGRID:113945 HIST2H2BE    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110929 BioGRID:113895 HIST3H3    BioGRID  PubMed Far Western 
    BioGRID:110929 BioGRID:120635 HJURP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:109402 HMGA1    BioGRID  PubMed Far Western 
    BioGRID:110929 BioGRID:113763 HMGA2    BioGRID  PubMed Far Western 
    BioGRID:110929 BioGRID:110751 HNRNPM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:109433 HNRNPU    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:120780 LYAR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:122089 NCAPG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:110771 NCL    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110929 BioGRID:115783 NOP56    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:120236 NSUN2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:110980 NUMA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:110982 NUP98    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:120751 OTUB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:117111 PADI4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:110929 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:111124 PC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:111477 PPID    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:111849 RARA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:116708 RRP1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:215383 Rrp1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:117594 SENP3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:110929 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:116707 SWAP70    BioGRID  PubMed Co-purification 
    BioGRID:110929 BioGRID:116120 TCERG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:112878 TFAP2A    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:110929 BioGRID:113003 TOP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:204323 Trp53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:110929 BioGRID:113238 USF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:121651 USP36    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    NP_003391.1 XPO1    BIND  PubMed An unspecified isoform of NPM1 (NPM) interacts with XPO1 (CRM1). 
    BioGRID:110929 BioGRID:110959 YBX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110929 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110929 BioGRID:122868 ZNF668    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110929 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NF-kappaB binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NF-kappaB binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Tat protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein heterodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		  
    ribosomal large subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ribosomal small subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    CenH3-containing nucleosome assembly at centromere TAS
    Traceable Author Statement
    more info
    		  
    DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    anti-apoptosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell aging IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell aging ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleocytoplasmic transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleosome assembly TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein oligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of endodeoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ribosome assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    spindle pole centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    nucleophosmin
    Names
    nucleophosmin
    nucleolar protein NO38
    nucleophosmin/nucleoplasmin family, member 1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016018.1 RefSeqGene

      Range
      5001..28181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001037738.2 → NP_001032827.1  nucleophosmin isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) utilizes an alternate 3'-terminal exon, compared to variant 1, resulting in a shorter protein (isoform 3) with a distinct C-terminus.
      Source sequence(s)
      AC091980, BC107754
      Consensus CDS
      CCDS43399.1
      Related
      ENSP00000377408, OTTHUMP00000223397, ENST00000393820, OTTHUMT00000372224
      Conserved Domains (1) summary
      pfam03066
      Location:13 – 116
      Blast Score: 440
      Nucleoplasmin; Nucleoplasmin

    2. NM_002520.6 → NP_002511.1  nucleophosmin isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This predominant variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC091980, BC002398
      Consensus CDS
      CCDS4376.1
      UniProtKB/Swiss-Prot
      P06748
      Related
      ENSP00000296930, OTTHUMP00000161024, ENST00000296930, OTTHUMT00000252858
      Conserved Domains (1) summary
      pfam03066
      Location:13 – 116
      Blast Score: 448
      Nucleoplasmin; Nucleoplasmin

    3. NM_199185.3 → NP_954654.1  nucleophosmin isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC091980, AC093246, BC009623
      Consensus CDS
      CCDS4377.1
      UniProtKB/Swiss-Prot
      P06748
      Related
      ENSP00000341168, OTTHUMP00000161025, ENST00000351986, OTTHUMT00000252859
      Conserved Domains (1) summary
      pfam03066
      Location:13 – 116
      Blast Score: 444
      Nucleoplasmin; Nucleoplasmin

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      170814708..170837888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      165912826..165935666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC091980.4 (138096..153132) None
    genomic AC093246.3 (84188..92330) None
    genomic CH471062.2 EAW61443.1
      EAW61444.1
      EAW61445.1
      EAW61446.1
      EAW61447.1
      EAW61448.1
      EAW61449.1
    genomic U89309.1 AAB94739.1
    mRNA AB042278.1 BAB40600.1
    mRNA AB451236.1 BAG70050.1
    mRNA AB451361.1 BAG70175.1
    mRNA AI687394.1 None
    mRNA AK000472.1 BAA91188.1
    mRNA AK290652.1 BAF83341.1
    mRNA AY347529.1 AAQ24860.1
    mRNA AY740634.1 AAW67752.1
    mRNA AY740635.1 AAW67753.1
    mRNA AY740636.1 AAW67754.1
    mRNA AY740637.1 AAW67755.1
    mRNA AY740638.1 AAW67756.1
    mRNA AY740639.1 AAW67757.1
    mRNA AY740640.1 AAW67758.1
    mRNA BC002398.2 AAH02398.1
    mRNA BC003670.1 AAH03670.2
    mRNA BC008495.1 AAH08495.1
    mRNA BC009623.2 AAH09623.1
    mRNA BC012566.1 AAH12566.1
    mRNA BC014349.1 AAH14349.1
    mRNA BC016716.1 AAH16716.1
    mRNA BC016768.1 AAH16768.1
    mRNA BC016824.1 AAH16824.1
    mRNA BC020467.1 None
    mRNA BC021668.1 AAH21668.1
    mRNA BC021983.1 AAH21983.1
    mRNA BC024716.2 None
    mRNA BC050628.1 AAH50628.1
    mRNA BC107754.1 AAI07755.1
    mRNA BP291033.1 None
    mRNA BT007011.1 AAP35657.1
    mRNA BU661768.1 None
    mRNA D28343.1 BAA05709.1
    mRNA DQ303464.1 ABC40399.1
    mRNA EF429251.1 ABP97432.1
    mRNA J02590.1 AAA36473.1
    mRNA M23613.1 AAA36380.1
    mRNA M26697.1 AAA36385.1
    mRNA M28699.1 AAA58386.1
    mRNA M31004.1 AAA36474.1
    mRNA X16934.1 CAA34809.1
    other-genetic DQ892032.2 ABM82958.1
    other-genetic DQ895223.2 ABM86149.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06748.2 GenPept UniProtKB/Swiss-Prot:P06748
    Q9BTI9 GenPept UniProtKB/TrEMBL:Q9BTI9
    Q9NX34 GenPept UniProtKB/TrEMBL:Q9NX34
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