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    TEC tec protein tyrosine kinase [ Homo sapiens ]

    Gene ID: 7006, updated on 19-May-2012
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    Summary

    Official Symbol
    TECprovided by HGNC
    Official Full Name
    tec protein tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:11719
    See related
    Ensembl:ENSG00000135605; HPRD:02786; MIM:600583; Vega:OTTHUMG00000128623
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSCTK4; MGC126760; MGC126762
    Summary
    The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    4p12
    Sequence :
    Chromosome: 4; NC_000004.11 (48137800..48271814, complement)
    See TEC in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene NIPA-like domain containing 1 Neighboring gene TXK tyrosine kinase Neighboring gene SLAIN motif family, member 2 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    4. Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. Ebert AD, et al. Traffic, 2010 Jun. PMID 20230531.
    5. Expanding the substantial interactome of NEMO using protein microarrays. Fenner BJ, et al. PLoS One, 2010 Jan 20. PMID 20098747.

    See all (55) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    2. Overexpression of Tec is associated with the tumorigenesis and development of liver cancer.
      Title: [The expression of Tec and the level of its phosphorylation in primary hepatic carcinomas].
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. Tec kinase has a crucial role in regulating FGF2 secretion under various physiological conditions
      Title: Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion.
    5. inhibits CD25 expression in human T-lymphocytes
      Title: Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte.
    6. LPS-induced actin polymerization as well as MCP-1, tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta expression are dependent on Tec kinase activity.
      Title: Tec kinases regulate actin assembly and cytokine expression in LPS-stimulated human neutrophils via JNK activation.
    7. Tec is the principal kinase of the Tec family that plays a major role in the responses of human neutrophils to monosodium urate crystals, which are likely to be involved in the initiation and perpetuation of gout
      Title: Crystal-induced neutrophil activation: X. Proinflammatory role of the tyrosine kinase Tec.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    9. specificity in tyrosine phosphorylation of SH3 domains in vitro is high and, therefore, SH3 domain phosphorylation is required for a distinct function in signaling
      Title: Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.
    10. The AF2 domain of the orphan nuclear receptor is essential for the transcriptional activity of the oncogenic fusion protein EWS
      Title: The AF2 domain of the orphan nuclear receptor TEC is essential for the transcriptional activity of the oncogenic fusion protein EWS/TEC.
    Submit: New GeneRIF Correction See all (14)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P42680 P51813 BMX    HPRD  PubMed  
    P42680 Q06187 BTK    HPRD  PubMed  
    P42680 Q99704 DOK1    HPRD  PubMed  
    P42680 Q03113 GNA12    HPRD  PubMed  
    P42680 P23458 JAK1    HPRD  PubMed  
    P42680 O60674 JAK2    HPRD  PubMed  
    P42680 P10721 KIT    HPRD  PubMed  
    P42680 P07948 LYN    HPRD  PubMed  
    P42680 P27986 PIK3R1    HPRD  PubMed  
    P42680 Q92569 PIK3R3    HPRD  PubMed  
    P42680 P48426 PIP4K2A    HPRD  PubMed  
    P42680 Q99755 PIP5K1A    HPRD  PubMed  
    P42680 P19174 PLCG1    HPRD  PubMed  
    P42680 P16885 PLCG2    HPRD  PubMed  
    P42680 O00444 PLK4    HPRD  PubMed  
    P42680 P16471 PRLR    HPRD  PubMed  
    P42680 Q99952 PTPN18    HPRD  PubMed  
    P42680 Q16825 PTPN21    HPRD  PubMed  
    P42680 P29353 SHC1    HPRD  PubMed  
    P42680 O15524 SOCS1    HPRD  PubMed  
    P42680 BCR downstream signaling 1 STAP1    HPRD  PubMed  
    P42680 P42680 TEC    HPRD  PubMed  
    P42680 P04637 TP53    HPRD  PubMed  
    P42680 P15498 VAV1    HPRD  PubMed  
    P42680 P42768 WAS    HPRD  PubMed  
    BioGRID:112865 BioGRID:116945 ARHGEF12    BioGRID  PubMed Biochemical Activity; Phenotypic Enhancement 
    BioGRID:112865 BioGRID:108131 DOK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:112865 BioGRID:109030 GNA12    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement 
    BioGRID:112865 BioGRID:115914 GNA13    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:112865 BioGRID:114089 IKBKG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112865 BioGRID:109919 JAK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112865 BioGRID:109920 JAK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:112865 BioGRID:110015 KIT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112865 BioGRID:110245 LYN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112865 BioGRID:247522 Nedd4    BioGRID  PubMed Biochemical Activity 
    BioGRID:112865 BioGRID:111314 PIK3R2    BioGRID  PubMed Two-hybrid 
    BioGRID:112865 BioGRID:111603 PRLR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112865 BioGRID:111817 RAC1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:112865 BioGRID:106880 RHOA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112865 BioGRID:114203 SOCS1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112865 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112865 BioGRID:113252 VAV1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112865 BioGRID:113293 WAS    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • EPO signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      EPO signaling pathway, organism-specific biosystem
      EPO signaling pathway
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
      Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
      Signaling events mediated by Stem cell factor receptor (c-Kit)
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intracellular protein kinase cascade TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of platelet activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    tyrosine-protein kinase Tec
    Names
    tyrosine-protein kinase Tec
    NP_003206.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003215.2 → NP_003206.2  tyrosine-protein kinase Tec

      Status: REVIEWED

      Source sequence(s)
      AC079118, BC101713
      Consensus CDS
      CCDS3481.1
      UniProtKB/Swiss-Prot
      P42680
      Related
      ENSP00000370912, OTTHUMP00000158787, ENST00000381501, OTTHUMT00000250492
      Conserved Domains (6) summary
      cd00174
      Location:183 – 235
      Blast Score: 161
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cl02465
      Location:120 – 147
      Blast Score: 150
      BTK; BTK motif
      cd05114
      Location:365 – 620
      Blast Score: 1412
      PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
      cd01238
      Location:6 – 103
      Blast Score: 439
      PH_Tec; Tec pleckstrin homology (PH) domain
      cd10396
      Location:240 – 346
      Blast Score: 560
      SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
      pfam07714
      Location:370 – 619
      Blast Score: 1006
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      48137800..48271814, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      47457565..47591606, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC079118.5 (44586..137464) None
    genomic AC098873.3 (2000..21800) None
    genomic CH471069.1 EAW93054.1
      EAW93055.1
    genomic U34367.1 AAB60411.1
    mRNA BC101711.1 AAI01712.1
    mRNA BC101713.1 AAI01714.1
    mRNA BC143487.1 AAI43488.1
    mRNA D29767.1 BAA06171.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42680.2 GenPept UniProtKB/Swiss-Prot:P42680
    Q14219 GenPept UniProtKB/TrEMBL:Q14219
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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