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GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 [ Homo sapiens (human) ]

Gene ID: 23062, updated on 8-May-2016
Official Symbol
GGA2provided by HGNC
Official Full Name
golgi associated, gamma adaptin ear containing, ARF binding protein 2provided by HGNC
Primary source
HGNC:HGNC:16064
See related
Ensembl:ENSG00000103365 HPRD:09347; MIM:606005; Vega:OTTHUMG00000096957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VEAR
Summary
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
Orthologs
Location:
16p12
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (23463542..23510494, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23474863..23521815, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene sodium channel epithelial 1 beta subunit Neighboring gene component of oligomeric golgi complex 7 Neighboring gene cyclin Y like 1 pseudogene Neighboring gene glutamyl-tRNA synthetase 2, mitochondrial Neighboring gene SUB1 homolog, transcriptional regulator pseudogene 4 Neighboring gene uncharacterized LOC105371140 Neighboring gene ubiquitin family domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies GGA2, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
Pr55(Gag) gag siRNA-mediated depletion of GGA2 leads to a significant increase in particle release in an HIV-1 Gag late domain-dependent manner, while GGA2 overexpression severely reduces virus particle production by impairing Gag trafficking to the membrane PubMed
Vpr vpr Expression of a patient-derived HIV-1 Vpr protein reveals a significant reduction in Vpr nuclear import. Vpr F72L mutation is responsible for this decreased Vpr nuclear import and the F72L mutant is co-localized with gamma-adaptin in the Golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

  • Amyloid fiber formation, organism-specific biosystem (from REACTOME)
    Amyloid fiber formation, organism-specific biosystemAmyloid is a term used to describe deposits of fibrillar proteins, typically extracellular. The abnormal accumulation of amyloid, amyloidosis, is a term associated with tissue damage caused by amyloi...
  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20966, KIAA1080

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP-ribosylation factor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
intracellular protein transport NAS
Non-traceable Author Statement
more info
PubMed 
vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane TAS
Traceable Author Statement
more info
 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ADP-ribosylation factor-binding protein GGA2
Names
VHS domain and ear domain of gamma-adaptin
VHS domain and ear domain-containing protein
gamma-adaptin-related protein 2
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
golgi-localized, gamma ear-containing, ARF-binding protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015044.4NP_055859.1  ADP-ribosylation factor-binding protein GGA2

    See identical proteins and their annotated locations for NP_055859.1

    Status: REVIEWED

    Source sequence(s)
    AC008915, AF165531, DA439738
    Consensus CDS
    CCDS10611.1
    UniProtKB/Swiss-Prot
    Q9UJY4
    Related
    ENSP00000311962, OTTHUMP00000122425, ENST00000309859, OTTHUMT00000214019
    Conserved Domains (4) summary
    smart00809
    Location:491605
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd03567
    Location:25163
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    cd14239
    Location:227315
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl21478
    Location:168240
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    23463542..23510494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545771.1XP_011544073.1  

    Conserved Domains (4) summary
    smart00809
    Location:454568
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd03567
    Location:1126
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    cd14239
    Location:190278
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl21478
    Location:131203
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    24486438..24533673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)