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    ZYX zyxin [ Homo sapiens ]

    Gene ID: 7791, updated on 11-May-2012
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    Summary

    Official Symbol
    ZYXprovided by HGNC
    Official Full Name
    zyxinprovided by HGNC
    Primary source
    HGNC:13200
    See related
    Ensembl:ENSG00000159840; HPRD:03592; MIM:602002; Vega:OTTHUMG00000023822
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESP-2; HED-2
    Summary
    Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    7q32
    Sequence :
    Chromosome: 7; NC_000007.13 (143078360..143088204)
    See ZYX in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 131, member B Neighboring gene uncharacterized LOC100507507 Neighboring gene EPH receptor A1 Neighboring gene uncharacterized LOC285965 Neighboring gene taste receptor, type 2, member 62, pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A zyxin-nectin interaction facilitates zyxin localization to cell-cell adhesions. Gregory Call S, et al. Biochem Biophys Res Commun, 2011 Nov 25. PMID 22056563.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. The LIM domain of zyxin is sufficient for force-induced accumulation of zyxin during cell migration. Uemura A, et al. Biophys J, 2011 Sep 7. PMID 21889443.

    See all (53) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Depletion of nectin-2 from L cells expressing E-cadherin results in a loss of zyxin localization to cell-cell contacts, demonstrating that the zyxin-nectin interaction plays a critical role in zyxin targeting to these sites.
      Title: A zyxin-nectin interaction facilitates zyxin localization to cell-cell adhesions.
    2. LIM domain of zyxin recruits zyxin to force-bearing sites at the leading edge of migrating cells
      Title: The LIM domain of zyxin is sufficient for force-induced accumulation of zyxin during cell migration.
    3. When myosin II contractility was inhibited, the k(off) values for all three proteins changed rapidly, in a highly protein-specific manner: dissociation of vinculin from FAs was facilitated, whereas dissociation of paxillin and zyxin was attenuated.
      Title: Actomyosin-generated tension controls the molecular kinetics of focal adhesions.
    4. Findings suggest an unforeseen role for Zyxin in DNA damage-induced cell fate control through modulating the HIPK2-p53 signaling axis.
      Title: Zyxin is a critical regulator of the apoptotic HIPK2-p53 signaling axis.
    5. Zyxin, whose expression is negatively regulated by microRNA-16 (miR-16), is confirmed to be a direct target gene of miR-16. Overexpression of zyxin could also restrain cell movement and enhance cell-cell adhesion.
      Title: MicroRNA-16 targets zyxin and promotes cell motility in human laryngeal carcinoma cell line HEp-2.
    6. Stretch appears to be an important factor in the development of endothelial dysfunction with zyxin as a potential therapeutic target to interfere with these early changes in endothelial cell phenotype
      Title: Zyxin mediation of stretch-induced gene expression in human endothelial cells.
    7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    9. The LIM domain protein zyxin was identified as an interaction partner for human synemin.
      Title: Synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration.
    10. This study establishes a crucial role of zyxin in thrombin signaling in endothelial cells and provides evidence for a novel PAR-1 signaling pathway mediated by zyxin.
      Title: Zyxin is involved in thrombin signaling via interaction with PAR-1 receptor.
    Submit: New GeneRIF Correction See all (16)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q15942 P12814 ACTN1    HPRD  PubMed  
    Q15942 P54253 ATXN1    HPRD  PubMed  
    Q15942 Q5W0U4 BSPRY    HPRD  PubMed  
    Q15942 Q8N8S7 ENAH    HPRD  PubMed  
    Q15942 Q9H422 HIPK3    HPRD  PubMed  
    Q15942 Q14847 LASP1    HPRD  PubMed  
    Q15942 O95835 LATS1    HPRD  PubMed  
    Q15942 O76041 NEBL    HPRD  PubMed  
    Q15942 Q14511 NEDD9    HPRD  PubMed  
    Q15942 Q9UNE2 RPH3AL    HPRD  PubMed  
    Q15942 Q9UGI8 TES    HPRD  PubMed  
    Q15942 P50552 VASP    HPRD  PubMed  
    Q15942 P15498 VAV1    HPRD  PubMed  
    Q15942 Q9UKW4 VAV3    HPRD  PubMed  
    Q15942 Q8TF68 ZNF384    HPRD  PubMed  
    BioGRID:113569 BioGRID:106602 ACTN1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113569 BioGRID:114934 BCAR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113569 BioGRID:120858 ENAH    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Two-hybrid 
    BioGRID:113569 BioGRID:110120 LASP1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113569 BioGRID:114563 LATS1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113569 BioGRID:115784 NEBL    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113569 BioGRID:110816 NEDD9    BioGRID  PubMed Two-hybrid 
    BioGRID:113569 BioGRID:115538 RABEPK    BioGRID  PubMed Two-hybrid 
    BioGRID:113569 BioGRID:111929 RGS2    BioGRID  PubMed Two-hybrid 
    BioGRID:113569 BioGRID:112599 SREBF2    BioGRID  PubMed Two-hybrid 
    BioGRID:113569 BioGRID:117572 TES    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113569 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113569 BioGRID:113251 VASP    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113569 BioGRID:122403 WNK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113569 BioGRID:116406 ZHX1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • E-cadherin signaling in keratinocytes, organism-specific biosystem (from Pathway Interaction Database)
      E-cadherin signaling in keratinocytes, organism-specific biosystem
      E-cadherin signaling in keratinocytes
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
      Stabilization and expansion of the E-cadherin adherens junction

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    zyxin
    Names
    zyxin
    zyxin-2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010972.1 → NP_001010972.1  zyxin

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC008743, BC009360, BC017183, BU844538
      Consensus CDS
      CCDS5883.1
      UniProtKB/Swiss-Prot
      Q15942
      UniProtKB/TrEMBL
      Q96AF9
      Related
      ENSP00000346417, OTTHUMP00000208858, ENST00000354434, OTTHUMT00000342163
      Conserved Domains (3) summary
      cd09349
      Location:372 – 437
      Blast Score: 261
      LIM1_Zyxin; The first LIM domain of Zyxin
      cd09435
      Location:504 – 570
      Blast Score: 355
      LIM3_Zyxin; The third LIM domain of Zyxin
      cl02475
      Location:444 – 503
      Blast Score: 277
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers.

    2. NM_003461.4 → NP_003452.1  zyxin

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC008743, BC017183
      Consensus CDS
      CCDS5883.1
      UniProtKB/Swiss-Prot
      Q15942
      UniProtKB/TrEMBL
      Q96AF9
      Related
      ENSP00000324422, OTTHUMP00000081863, ENST00000322764, OTTHUMT00000156296
      Conserved Domains (3) summary
      cd09349
      Location:372 – 437
      Blast Score: 261
      LIM1_Zyxin; The first LIM domain of Zyxin
      cd09435
      Location:504 – 570
      Blast Score: 355
      LIM3_Zyxin; The third LIM domain of Zyxin
      cl02475
      Location:444 – 503
      Blast Score: 277
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers.

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      143078360..143088204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      137415678..137425520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      142480492..142490336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC092214.3 AAS07459.1
    genomic CH236959.1 EAL23788.1
    genomic CH471198.2 EAW51848.1
      EAW51849.1
      EAW51850.1
      EAW51851.1
    genomic HI573962.1 CBX47470.1
    genomic HI573964.1 CBX47471.1
    mRNA AK130138.1 None
    mRNA AK298925.1 BAG61030.1
    mRNA AK299005.1 BAG61089.1
    mRNA AK302309.1 BAG63647.1
    mRNA AK316227.1 BAH14598.1
    mRNA BC002323.2 AAH02323.2
    mRNA BC008743.2 AAH08743.1
    mRNA BC009360.2 AAH09360.1
    mRNA BC010031.2 AAH10031.1
    mRNA BC017183.2 AAH17183.2
    mRNA BU844538.1 None
    mRNA CR457431.1 CAG33712.1
    mRNA U15158.1 AAA78902.1
    mRNA X94991.1 CAA64447.1
    mRNA X95735.1 CAA65050.1
    other-genetic DQ892925.2 ABM83851.1
    other-genetic DQ896174.2 ABM87173.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15942.1 GenPept UniProtKB/Swiss-Prot:Q15942
    Q28617 GenPept UniProtKB/TrEMBL:Q28617
    Q96AF9 GenPept UniProtKB/TrEMBL:Q96AF9
    Q9BUS0 GenPept UniProtKB/TrEMBL:Q9BUS0
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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