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    ICAM1 intercellular adhesion molecule 1 [ Homo sapiens ]

    Gene ID: 3383, updated on 19-May-2012
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    Summary

    Official Symbol
    ICAM1provided by HGNC
    Official Full Name
    intercellular adhesion molecule 1provided by HGNC
    Primary source
    HGNC:5344
    See related
    Ensembl:ENSG00000090339; HPRD:00996; MIM:147840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BB2; CD54; P3.58
    Summary
    This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    19p13.3-p13.2
    Sequence :
    Chromosome: 19; NC_000019.9 (10381517..10397291)
    See ICAM1 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate receptor 2 Neighboring gene microRNA 4322 Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) Neighboring gene intercellular adhesion molecule 5, telencephalin

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Intercellular adhesion molecule-1 K469E polymorphism: Is it associated with preeclampsia in the Korean population? Kwon HS, et al. J Reprod Med, 2012 Mar-Apr. PMID 22523875.
    2. Modulation of the association between plasma intercellular adhesion molecule-1 and cancer risk by n-3 PUFA intake: a nested case-control study. Touvier M, et al. Am J Clin Nutr, 2012 Apr. PMID 22378736.
    3. Effects of n-3 PUFA supplementation on plasma soluble adhesion molecules: a meta-analysis of randomized controlled trials. Yang Y, et al. Am J Clin Nutr, 2012 Apr. PMID 22378734.
    4. Polymorphisms of ICAM-1 are associated with gastric cancer risk and prognosis. Tian MM, et al. World J Gastroenterol, 2012 Jan 28. PMID 22294843.
    5. Lung cancer cell invasion and expression of intercellular adhesion molecule-1 (ICAM-1) are attenuated by secretory phospholipase A₂ inhibition. Yu JA, et al. J Thorac Cardiovasc Surg, 2012 Feb. PMID 22248682.

    See all (745) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The distribution of genotype frequencies and the frequency of the K469 allele of the preeclampsia group were not significantly different from those of the controls. A similar trend was observed between the severe preeclampsia patients and the controls.
      Title: Intercellular adhesion molecule-1 K469E polymorphism: Is it associated with preeclampsia in the Korean population?
    2. Data suggest that plasma level of soluble ICAM-1 (which is associated with cancer risk) can be modulated by diet (i.e., omega-3 fatty acid intake).
      Title: Modulation of the association between plasma intercellular adhesion molecule-1 and cancer risk by n-3 PUFA intake: a nested case-control study.
    3. Data suggest that plasma level of soluble ICAM-1 (which is a biological marker of inflammatory processes such as atherosclerosis) can be modulated by diet (i.e., omega-3 fatty acid intake).
      Title: Effects of n-3 PUFA supplementation on plasma soluble adhesion molecules: a meta-analysis of randomized controlled trials.
    4. Genetic variations at the ABO locus are associated with circulating levels of ICAM1, P-selectin, and E-selectin.
      Title: Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin: a meta-analysis.
    5. expression in melanocytes is upregulated by RNA released from necrotic keratinocytes
      Title: RNA released from necrotic keratinocytes upregulates intercellular adhesion molecule-1 expression in melanocytes.
    6. IFN-gamma and TNF-alpha synergistically enhance NK cell cytotoxicity through NF-kappaB-dependent up-regulation of ICAM-1 expression in target cells, thereby promoting their conjugate formation with NK cells.
      Title: Natural killer cell-produced IFN-γ and TNF-α induce target cell cytolysis through up-regulation of ICAM-1.
    7. Paeoniflorin suppressed the activation of the NF-kappaB pathway, which regulates the expression of ICAM-1.
      Title: Paeoniflorin suppresses the expression of intercellular adhesion molecule-1 (ICAM-1) in endotoxin-treated human monocytic cells.
    8. Data suggest that polymorphisms of ICAM-1 K469E can be a useful biomarker for identifying individuals with higher risk of GC, predicting disease progression, and guiding individualized treatment.
      Title: Polymorphisms of ICAM-1 are associated with gastric cancer risk and prognosis.
    9. Lf bound to a DNA region in the ICAM-1 promoter
      Title: Human lactoferrin suppresses TNF-α-induced intercellular adhesion molecule-1 expression via competition with NF-κB in endothelial cells.
    10. MIF may affect blood coagulation and anticoagulation through its influence on endothelial cell ICAM-1 and thrombomodulin expression.
      Title: Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro.
    Submit: New GeneRIF Correction See all (567)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.

    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

    Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels.

    Malaria, cerebral, susceptibility to

    Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of cells with IFN reduces HIV-1 gp120 incorporation, as well as HIV-1 envelope-mediated incorporation of ICAM-1, into virions resulting in viruses that exhibit a significantly decreased ability to become bound to CD4+ target cells PubMed
    env HIV-1 gp120-mediated ICAM-1 expression has functional significance, as it enhances the ability of monocytic cells to bind to gp120-stimulated human astrocytes in an ICAM-1/beta 2 integrin-dependent fashion PubMed
    env HIV-1 gp120 activates human brain microvascular endothelial cells (HBMEC) via CD4 in upregulating ICAM-1 and VCAM-1 expression, IL-6 secretion and increased monocyte transmigration across monolayers PubMed
    env Infectivity of an HIV-1 Matrix mutant that carries a suboptimal amount of HIV-1 gp120/41 is restored to a certain degree by the presence of ICAM-1 when infection is performed in cells expressing an activated form of its natural counter-ligand, LFA-1 PubMed
    env HIV-1 gp120 enhances the expression of ICAM-1 in primary human astrocytes, glioma, and endothelial cells PubMed
    env Cells treated with monoclonal antibodies to ICAM-1 and LFA-1 adhesion molecules show an impaired release of IFN after HIV-1 gp120 stimulation, suggesting a crucial role of cell-to-cell interactions in the process leading to IFN production PubMed
    Envelope surface glycoprotein gp160, precursor env ICAM-1 promotes HIV-1 gp160-mediated syncytium formation, and the ICAM-1 contrareceptor LFA-1 attenuates the syncytium-inhibiting activity of virus-neutralizing monoclonal antibodies and soluble CD4 PubMed
    env Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed
    Nef nef Expression of HIV-1 Nef in macrophages induces the release of sICAM, which upregulates the expression of co-stimulatory receptors on B lymphocytes PubMed
    nef Monoclonal antibodies to the cell surface molecule intracellular adhesion molecule (ICAM)-1 inhibit the Nef-induced B-cell differentiation response, suggesting an interaction between Nef and ICAM-1 PubMed
    Tat tat Treatment of monocytes with HIV-1 Tat increases their adhesion to endothelial monolayers, an effect that is inhibited by anti-ICAM-1 Abs, suggesting an interaction between Tat and ICAM-1 PubMed
    tat HIV-1 Tat upregulates the expression of ICAM-1 in endothelial cells and astrocytes, an effect that is in part regulated by NF-kappa B and may be associated with AIDS-related Kaposi's sarcoma PubMed
    matrix gag ICAM-1 co-localizes with HIV-1 Matrix at sites of cell-to-cell membrane contact and is incorporated into virus particles PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000019.8 NP_004371.1 CREBBP    BIND  PubMed CREBBP (CBP) interacts with the ICAM1 promoter. 
    P05362 P00533 EGFR    HPRD  PubMed  
    P05362 P15311 EZR    HPRD  PubMed  
    P05362 P02679 FGG    HPRD  PubMed  
    P05362 P05362 ICAM1    HPRD  PubMed  
    P05362 P01589 IL2RA    HPRD  PubMed  
    P05362 P31785 IL2RG    HPRD  PubMed  
    P05362 P20701 ITGAL    HPRD  PubMed  
    P05362 P11215 ITGAM    HPRD  PubMed  
    P05362 P05107 ITGB2    HPRD  PubMed  
    P05362 P26038 MSN    HPRD  PubMed  
    P05362 P08195 SLC3A2    HPRD  PubMed  
    P05362 P16150 SPN    HPRD  PubMed  
    BioGRID:109610 BioGRID:113271 EZR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109610 BioGRID:109774 IL2RA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109610 BioGRID:109889 ITGAL    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex 
    BioGRID:109610 BioGRID:109890 ITGAM    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109610 BioGRID:109895 ITGB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109610 BioGRID:230642 Tubb4b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109610 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • African trypanosomiasis, organism-specific biosystem (from KEGG)
      African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • African trypanosomiasis, conserved biosystem (from KEGG)
      African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Selenium Pathway, organism-specific biosystem (from WikiPathways)
      Selenium Pathway, organism-specific biosystem
      Selenium Pathway
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Thromboxane A2 receptor signaling, organism-specific biosystem
      Thromboxane A2 receptor signaling
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      amb2 Integrin signaling, organism-specific biosystem
      amb2 Integrin signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cell surface binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    T cell antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    adhesion to symbiont IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell aging IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to alkaloid IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    heterophilic cell-cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    leukocyte migration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    membrane to membrane docking IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    negative regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cellular extravasation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of immune response TAS
    Traceable Author Statement
    more info
    		  
    regulation of leukocyte mediated cytotoxicity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to copper ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to gonadotropin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to sulfur dioxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    virion attachment, binding of host cell surface receptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    immunological synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    intercellular adhesion molecule 1
    Names
    intercellular adhesion molecule 1
    ICAM-1
    cell surface glycoprotein P3.58
    major group rhinovirus receptor
    intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012083.1 RefSeqGene

      Range
      5001..20775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000201.2 → NP_000192.2  intercellular adhesion molecule 1 precursor

      Status: REVIEWED

      Source sequence(s)
      BC015969, BG149901, BP346334
      Consensus CDS
      CCDS12231.1
      UniProtKB/Swiss-Prot
      P05362
      Related
      ENSP00000264832, ENST00000264832
      Conserved Domains (3) summary
      cd05755
      Location:113 – 207
      Blast Score: 363
      Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      pfam03921
      Location:28 – 115
      Blast Score: 309
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl11960
      Location:311 – 387
      Blast Score: 101
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      10381517..10397291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1

      Range
      9965426..9977270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NW_001842132.1 

      Range
      1873..2259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC011511.12 (85744..101256) None
    genomic AY225514.1 AAO30128.1
    genomic CH471106.1 EAW84086.1
      EAW84087.1
    genomic M65001.1 AAA52710.1
    genomic U86814.1 AAB51145.1
    genomic X57151.1 CAA40441.1
    genomic X59286.1 CAA41977.1
    mRNA AF340038.1 AAQ14901.1
    mRNA AF340039.1 AAQ14902.1
    mRNA AK130659.1 None
    mRNA AK298054.1 BAG60348.1
    mRNA AK298983.1 BAG61077.1
    mRNA AK301412.1 BAG62944.1
    mRNA AK312636.1 BAG35520.1
    mRNA BC015969.2 AAH15969.1
    mRNA BG149901.1 None
    mRNA BP346334.1 None
    mRNA BT006854.1 AAP35500.1
    mRNA J03132.1 AAA52709.1
    mRNA M24283.1 AAA52708.1
    mRNA M55038.1 AAA60393.1
    mRNA M55091.1 None
    mRNA S82847.1 AAB46863.1
    mRNA X06990.1 CAA30051.1
    other-genetic DQ890615.2 ABM92232.1
    other-genetic DQ893785.2 ABM84711.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00177 GenPept UniProtKB/TrEMBL:O00177
    P05362.2 GenPept UniProtKB/Swiss-Prot:P05362
    Q14601 GenPept UniProtKB/TrEMBL:Q14601
    Q15463 GenPept UniProtKB/TrEMBL:Q15463
    Q5NKV8 GenPept UniProtKB/TrEMBL:Q5NKV8
    Q99930 GenPept UniProtKB/TrEMBL:Q99930
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