Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    ICAM1 intercellular adhesion molecule 1 [ Homo sapiens (human) ]

    Gene ID: 3383, updated on 12-May-2013
    Official Symbol
    ICAM1provided by HGNC
    Official Full Name
    intercellular adhesion molecule 1provided by HGNC
    Primary source
    HGNC:5344
    See related
    Ensembl:ENSG00000090339; HPRD:00996; MIM:147840; Vega:OTTHUMG00000180403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BB2; CD54; P3.58
    Summary
    This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
    Location :
    19p13.3-p13.2
    Sequence :
    Chromosome: 19; NC_000019.9 (10381517..10397291)
    See ICAM1 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate receptor 2 Neighboring gene microRNA 4322 Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) Neighboring gene intercellular adhesion molecule 5, telencephalin

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. Foster MW, et al. Nitric Oxide, 2013 Feb 21. PMID 23438482.
    2. Maternal plasma levels of endothelial dysfunction mediators including AM, CGRP, sICAM-1 and tHcy in pre-eclampsia. Fei X, et al. Adv Clin Exp Med, 2012 Sep-Oct. PMID 23356193.
    3. Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1. Brown A, et al. J Biol Chem, 2013 Feb 22. PMID 23297413.
    4. Increased levels of soluble ICAM-1 in chronic obstructive pulmonary disease and resistant smokers are related to active smoking. Lopez-Campos JL, et al. Biomark Med, 2012 Dec. PMID 23227846.
    5. A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies. Bengtsson A, et al. J Immunol, 2013 Jan 1. PMID 23209327.

    See all (829) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. an association between sICAM-1 levels and active smoking in a group of COPD and non-COPD active smokers
      Title: Increased levels of soluble ICAM-1 in chronic obstructive pulmonary disease and resistant smokers are related to active smoking.
    2. Higher serum VCAM-1 and ICAM-1 was associated with higher risk of peripheral arterial disease in hemodialysis patients.
      Title: Higher serum levels of soluble intracellular cell adhesion molecule-1 and soluble vascular cell adhesion molecule predict peripheral artery disease in haemodialysis patients.
    3. Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1
      Title: Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1.
    4. Data indicate that antibody blockade of intercellular adhesion molecule-1 (ICAM-1) significantly reduced Toxoplasma gondii tachyzoites migration cross retinal endothelial monolayers.
      Title: Toxoplasma gondii tachyzoites cross retinal endothelium assisted by intercellular adhesion molecule-1 in vitro.
    5. The G241R and K469E single nucleotide polymorphisms of ICAM-1 gene may be related to occurrence of Hashimoto thyroiditis.
      Title: G241R and K469E polymorphisms of intercellular adhesion molecule 1 (ICAM-1) could predispose to Hashimoto thyroiditis.
    6. Data indicate that the shear stress stimulation produced a significant increase of ICAM-1 expression at protein and mRNA levels in lymphatic endothelial cells (LEC).
      Title: Pivotal roles of shear stress in the microenvironmental changes that occur within sentinel lymph nodes.
    7. Our findings support the hypothesis that ICAM-1 up-regulation stimulated by SDF-1 may play an active role in CRC cell adhesion.
      Title: CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1.
    8. Group A PfEMP1 proteins are not central to ICAM-1-specific adhesion of infected human erythrocytes; instead, the tests support development of a vaccine to prevent cerebral malaria.
      Title: A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies.
    9. Enhanced cytokine production and ICAM-1 expression are dependent on RIG-I activation in Denv infection of human brain microvascular endothelial cells (HBMECs.
      Title: Essential role of RIG-I in the activation of endothelial cells by dengue virus.
    10. papC inhibited the expression of VCAM-1 and ICAM-1, Il-8 after activation with TNF-a.
      Title: Protein C activation peptide inhibits the expression of ICAM-1, VCAM-1, and interleukin-8 induced by TNF-α in human dermal microvascular endothelial cells.
    Submit: New GeneRIF Correction See all (627)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Env, gp160, envelope glycoprotein env Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells PubMed
    env ICAM-1 promotes HIV-1 gp160-mediated syncytium formation, and the ICAM-1 contrareceptor LFA-1 attenuates the syncytium-inhibiting activity of virus-neutralizing monoclonal antibodies and soluble CD4 PubMed
    Envelope surface glycoprotein gp120 env The interaction of CD4+ T cells with HIV-1 gp120 on bilayers triggers LFA-1 activation and the LFA-1-ICAM-1 interaction rearrangement PubMed
    env HIV-1 gp120-mediated ICAM-1 expression has functional significance, as it enhances the ability of monocytic cells to bind to gp120-stimulated human astrocytes in an ICAM-1/beta 2 integrin-dependent fashion PubMed
    env HIV-1 gp120-presenting surfaces arrest the migration of primary activated CD4 T cells that occurs spontaneously in the presence of ICAM-1 and induces the formation of a virological synapse PubMed
    env Cells treated with monoclonal antibodies to ICAM-1 and LFA-1 adhesion molecules show an impaired release of IFN after HIV-1 gp120 stimulation, suggesting a crucial role of cell-to-cell interactions in the process leading to IFN production PubMed
    env Infectivity of an HIV-1 Matrix mutant that carries a suboptimal amount of HIV-1 gp120/41 is restored to a certain degree by the presence of ICAM-1 when infection is performed in cells expressing an activated form of its natural counter-ligand, LFA-1 PubMed
    env HIV-1 gp120 enhances the expression of ICAM-1 in primary human astrocytes, glioma, and endothelial cells PubMed
    env Lck phosphorylates CD3zeta and the TCR-CD3 complex is recruited to a virological synapse (VS) when cells interact with gp120+ICAM-1 bilayers, creating an F-actin-depleted zone PubMed
    env Lck is recuited to a virological synapse (VS) interface and is highly colocalized with gp120 when cells interact with gp120+ICAM-1 bilayers, leading to activation of ZAP70, LAT, SLP76, and PLCgamma PubMed
    env HIV gp120 and TNF-alpha synergistically reduce endothelial nitric oxide synthase (eNOS) expression and cause endothelial dysfunction via ICAM-1 PubMed
    env Treatment of cells with IFN reduces HIV-1 gp120 incorporation, as well as HIV-1 envelope-mediated incorporation of ICAM-1, into virions resulting in viruses that exhibit a significantly decreased ability to become bound to CD4+ target cells PubMed
    env HIV-1 gp120 activates human brain micro vascular endothelial cells (HBMEC) via CD4 in upregulating ICAM-1 and VCAM-1 expression, IL-6 secretion and increased monocyte transmigration across monolayers PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 ectodomain fragment (amino acids 550-639) upregulates ICAM-1 on the human brain micro vascular endothelial cells (HBMECs) and elicits membrane ruffling on the surface of HBMECs PubMed
    env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed
    Gag, Pr55 gag Acquisition of host ICAM-1 by HIV-1 occurs through an interaction between the cytoplasmic tail (residues 503-523) of ICAM-1 and HIV-1 Gag PubMed
    gag HIV-1 Gag virus-like particle-induced monocyte activation is shown by upregulation of molecules involved in antigen presentation (MHC II, CD80, CD86) and cell adhesion (CD54) PubMed
    gag ICAM-1 co-localizes with the Matrix protein of HIV-1 Gag at sites of cell-to-cell membrane contact and is incorporated into virus particles PubMed
    Nef, p27 nef HIV-1 Nef increases the production of exosomes, which form at the plasma membrane and co-localizes with plasma membrane-associated proteins ICAM1, CD81, and Lck in Jurkat PubMed
    nef HIV-1 Nef upregulates ICAM-1 expression on endothelial cells via Erk /Mapk signaling pathway PubMed
    nef Monoclonal antibodies to the cell surface molecule intracellular adhesion molecule (ICAM)-1 inhibit the Nef-induced B-cell differentiation response, suggesting an interaction between Nef and ICAM-1 PubMed
    nef Expression of HIV-1 Nef in macrophages induces the release of sICAM, which upregulates the expression of co-stimulatory receptors on B lymphocytes PubMed
    Tat, p14 tat Inhibition of human telomerase reverse transcriptase (hTERT) results in the upregulation of HIV-1 Tat-induced overexpression of intercellular adhesion molecule-1 (ICAM1) via the nuclear factor-kappaB-regulated mechanism PubMed
    tat Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat PubMed
    tat HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 is blocked by NADPH oxidase inhibitor PubMed
    tat Treatment of monocytes with HIV-1 Tat increases their adhesion to endothelial monolayers, an effect that is inhibited by anti-ICAM-1 Abs, suggesting an interaction between Tat and ICAM-1 PubMed
    tat HIV-1 Tat upregulates the expression of ICAM-1 in endothelial cells and astrocytes, an effect that is in part regulated by NF-kappa B and may be associated with AIDS-related Kaposi's sarcoma PubMed
    matrix gag Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma PubMed
    gag ICAM-1 co-localizes with HIV-1 Matrix at sites of cell-to-cell membrane contact and is incorporated into virus particles PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000019.8 NP_004371.1 CREBBP    BIND  PubMed CREBBP (CBP) interacts with the ICAM1 promoter. 
    P05362 P00533 EGFR    HPRD  PubMed  
    P05362 P15311 EZR    HPRD  PubMed  
    P05362 P02679 FGG    HPRD  PubMed  
    P05362 P05362 ICAM1    HPRD  PubMed  
    P05362 P01589 IL2RA    HPRD  PubMed  
    P05362 P31785 IL2RG    HPRD  PubMed  
    P05362 P20701 ITGAL    HPRD  PubMed  
    P05362 P11215 ITGAM    HPRD  PubMed  
    P05362 P05107 ITGB2    HPRD  PubMed  
    P05362 P26038 MSN    HPRD  PubMed  
    P05362 P08195 SLC3A2    HPRD  PubMed  
    P05362 P16150 SPN    HPRD  PubMed  
    BioGRID:109610 BioGRID:113271 EZR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109610 BioGRID:123208 HSD3B7    BioGRID  PubMed Two-hybrid 
    BioGRID:109610 BioGRID:109774 IL2RA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109610 BioGRID:109889 ITGAL    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex 
    BioGRID:109610 BioGRID:109890 ITGAM    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109610 BioGRID:109895 ITGB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109610 BioGRID:110906 NOS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109610 BioGRID:230642 Tubb4b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109610 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • African trypanosomiasis, organism-specific biosystem (from KEGG)
      African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • African trypanosomiasis, conserved biosystem (from KEGG)
      African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Interleukin-11 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Interleukin-11 Signaling Pathway, organism-specific biosystemIL-11 is a multifunctional cytokine that belongs to the gp130 family. It was first isolated from a primate bone marrow derived cell line, PU-34 for its ability to stimulate the proliferation of a pla...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • RANKL/RANK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      RANKL/RANK Signaling Pathway, organism-specific biosystemRANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG (Osteoprotegerin) are three important mol...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Selenium Pathway, organism-specific biosystem (from WikiPathways)
      Selenium Pathway, organism-specific biosystem
      Selenium Pathway
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Thromboxane A2 receptor signaling, organism-specific biosystem
      Thromboxane A2 receptor signaling
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      amb2 Integrin signaling, organism-specific biosystem
      amb2 Integrin signaling

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cell surface binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    T cell antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    adhesion to symbiont IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell aging IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to alkaloid IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    heterophilic cell-cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    leukocyte migration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    membrane to membrane docking IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    negative regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cellular extravasation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of immune response TAS
    Traceable Author Statement
    more info
    		  
    regulation of leukocyte mediated cytotoxicity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to copper ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to gonadotropin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to sulfur dioxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    virion attachment, binding of host cell surface receptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    immunological synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Preferred Names
    intercellular adhesion molecule 1
    Names
    intercellular adhesion molecule 1
    ICAM-1
    cell surface glycoprotein P3.58
    major group rhinovirus receptor
    intercellular adhesion molecule 1 (CD54), human rhinovirus receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012083.1 RefSeqGene

      Range
      5001..20775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000201.2 → NP_000192.2  intercellular adhesion molecule 1 precursor

      Status: REVIEWED

      Source sequence(s)
      BC015969, BG149901, BP346334
      Consensus CDS
      CCDS12231.1
      UniProtKB/Swiss-Prot
      P05362
      Related
      ENSP00000264832, OTTHUMP00000264225, ENST00000264832, OTTHUMT00000451207
      Conserved Domains (4) summary
      cd05755
      Location:113 – 207
      Blast Score: 363
      Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      pfam03921
      Location:28 – 115
      Blast Score: 309
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      pfam13895
      Location:418 – 474
      Blast Score: 89
      Ig_2; Immunoglobulin domain
      cl11960
      Location:311 – 387
      Blast Score: 101
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p10 Primary Assembly

      Range
      10381517..10397291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1

      Range
      9965426..9977270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NW_001842132.1 

      Range
      1873..2259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018930.1 Alternate CHM1_1.0

      Range
      10317928..10333705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01029939.1 (11786..22145) None
    genomic ABBA01029940.1 None
    genomic ABBA01197211.1 (1873..2259) None
    genomic AC011511.12 (85745..101257) None
    genomic AMYH01009468.1 (11216..26993) None
    genomic AY225514.1 AAO30128.1
    genomic CH471106.1 EAW84086.1
      EAW84087.1
    genomic M65001.1 AAA52710.1
    genomic U86814.1 AAB51145.1
    genomic X57151.1 CAA40441.1
    genomic X59286.1 CAA41977.1
    mRNA AF340038.1 AAQ14901.1
    mRNA AF340039.1 AAQ14902.1
    mRNA AK130659.1 None
    mRNA AK298054.1 BAG60348.1
    mRNA AK298983.1 BAG61077.1
    mRNA AK301412.1 BAG62944.1
    mRNA AK312636.1 BAG35520.1
    mRNA BC015969.2 AAH15969.1
    mRNA BG149901.1 None
    mRNA BP346334.1 None
    mRNA BT006854.1 AAP35500.1
    mRNA J03132.1 AAA52709.1
    mRNA M24283.1 AAA52708.1
    mRNA M55038.1 AAA60393.1
    mRNA M55091.1 None
    mRNA S82847.1 AAB46863.1
    mRNA X06990.1 CAA30051.1
    other-genetic DQ890615.2 ABM92232.1
    other-genetic DQ893785.2 ABM84711.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05362.2 GenPept UniProtKB/Swiss-Prot:P05362

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...