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    IL8 interleukin 8 [ Homo sapiens ]

    Gene ID: 3576, updated on 20-May-2012
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    Summary

    Official Symbol
    IL8provided by HGNC
    Official Full Name
    interleukin 8provided by HGNC
    Primary source
    HGNC:6025
    See related
    Ensembl:ENSG00000169429; HPRD:00909; MIM:146930; Vega:OTTHUMG00000151316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NAF; GCP1; LECT; LUCT; NAP1; CXCL8; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
    Summary
    The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    4q13-q21
    Sequence :
    Chromosome: 4; NC_000004.11 (74606223..74609433)
    See IL8 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene afamin Neighboring gene Ras association (RalGDS/AF-6) domain family member 6 Neighboring gene pro-platelet basic protein pseudogene 1 Neighboring gene chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Interleukin-8, a promising predictor for prognosis of pancreatic cancer. Chen Y, et al. World J Gastroenterol, 2012 Mar 14. PMID 22416189.
    2. Interleukin-8 associates with adhesion, migration, invasion and chemosensitivity of human gastric cancer cells. Kuai WX, et al. World J Gastroenterol, 2012 Mar 7. PMID 22408359.
    3. The diagnostic value of interleukin-6 and interleukin-8 for early prediction of bacteremia and sepsis in children with febrile neutropenia and cancer. Urbonas V, et al. J Pediatr Hematol Oncol, 2012 Mar. PMID 22367386.
    4. Effect of Helicobacter pylori cdrA on interleukin-8 secretions and nuclear factor kappa B activation. Takeuchi H, et al. World J Gastroenterol, 2012 Feb 7. PMID 22346248.
    5. Upregulation of thromboxane synthase mediates visfatin-induced interleukin-8 expression and angiogenic activity in endothelial cells. Kim SR, et al. Biochem Biophys Res Commun, 2012 Feb 24. PMID 22293189.

    See all (1261) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Report role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells.
      Title: The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells.
    2. CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling.
      Title: CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling.
    3. Data suggest that IL-8 can be a fine serum marker for predicting the prognosis pancreatic cancer.
      Title: Interleukin-8, a promising predictor for prognosis of pancreatic cancer.
    4. In whole genome analysis of the epithelial response to Helicobacter pylori exposure, IL-8 demonstrated the most marked up-regulation, and was involved in many of the most important cellular response processes to the infection.
      Title: Interleukin-8 is the single most up-regulated gene in whole genome profiling of H. pylori exposed gastric epithelial cells.
    5. Identify cadmium as a potent activator of the proinflammatory cytokine IL-8 in lung epithelial cells and reveal the role of an NF-kappaB-independent but Erk1/2-dependent pathway in cadmium-induced lung inflammation.
      Title: An NF-κB-independent and Erk1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmium.
    6. Normal human, skin-derived mast cells (MC) communicate with cutaneous tumor cells. MC released TNF-alpha and histamine increase IL-8 and IL-6 secretion from these tumor cells.
      Title: Mast cell-derived TNF-α and histamine modify IL-6 and IL-8 expression and release from cutaneous tumor cells.
    7. Results show that LPS-induced NF-kappaB activation and IL-8 synthesis in endothelial cells are regulated by the MyD88 pathway and GEF-H1-RhoA pathway.
      Title: GEF-H1-RhoA signaling pathway mediates LPS-induced NF-κB transactivation and IL-8 synthesis in endothelial cells.
    8. conclude that IL-8 is the major factor regulating the expression of CD11b activation epitope in neutrophils
      Title: IL-8 from local subcutaneous wounds regulates CD11b activation.
    9. The N-terminal and third extracellular loop (E3) regions of CXCR1 interact synergistically to achieve optimal binding interactions with interleukin (IL)-8; however, binding of IL-8 to CXCR2, followed by activation, does not occur.
      Title: Synergistic interactions between chemokine receptor elements in recognition of interleukin-8 by soluble receptor mimics.
    10. In terms of their ability to induce neutrophil recruitment in vivo, the multiple CXCL8 forms may be divided in three groups.
      Title: Biological activity of CXCL8 forms generated by alternative cleavage of the signal peptide or by aminopeptidase-mediated truncation.
    Submit: New GeneRIF Correction See all (998)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env In endometrial epithelium-derived cells, gp120 from CCR5-tropic HIV-1 increases the release of monocytes/chemokines-attracting chemokines (IL-8 and GRO) and proinflammatory cytokines (TNF-beta and IL-1alpha) PubMed
    env Interleukin 8 (IL-8) gene expression is enhanced in monocytes treated with HIV-1 gp120 PubMed
    Envelope transmembrane glycoprotein gp41 env The interaction between HIV-1 gp41 fusion peptide and lymphocyte membrane is blocked by interleukin-8 and abolished by pre-treating the cells with heparin sulfate (HS) PubMed
    Nef nef HIV-1 Nef expression by immature human and macaque dendritic cells (DCs) upregulates IL-6, IL-12, TNF-alpha, CXCL8, CCL3, and CCL4 release, but without upregulating co-stimulatory and other molecules characteristic of mature DCs PubMed
    Tat tat HIV-1 Tat upregulates IL-8 expression in astrocytes, monocytes, monocyte derived macrophages, Jurkat T-cells, HeLa cells, and human brain endothelial cells, an effect that likely contributes to the immune dysregulation observed during HIV-1 infection PubMed
    tat HIV-1 Tat protein upregulates expression of IL-6 and IL-8 in human breast cancer cells by an NF-kappaB-dependent pathway PubMed
    tat HIV-1 Tat upregulates IL-8 and VEGF production and release from polymorphonuclear leukocytes (PMNL), indicating that PMNL recruitment by Tat is linked to angiogenesis PubMed
    tat HIV-1 Tat upregulation of IL-8 is linked to the cell cycle and involves NF-kappa B, RelA, c-rel, and CREB-binding protein PubMed
    tat Upregulation of IL-8 by HIV-1 Tat is implicated in the pathogenesis of Kaposi's sarcoma PubMed
    tat HIV-1 Tat downregulates IL-8 expression in the Raji B-cell line, however in the presence of PMA+PHA Tat induced IL-8 expression PubMed
    tat Upregulation of IL-8 by HIV-1 Tat in astrocytes is inhibited by the MEK1/2 inhibitor UO126, indicating a role for MEK1/2 in Tat-mediated chemokine induction PubMed
    Vpr vpr HIV-1 Vpr regulates interleukin 8 (IL-8) expression, with reports showing both up- and downregulation of IL-8 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000004.9 NP_001269.2 CHUK    BIND  PubMed The IL-8 promoter interacts with IKK-alpha. 
    NC_000004.9 NP_001420.2 EP300    BIND  PubMed The IL-8 promoter interacts with p300. 
    NC_000004.9 NP_003874.2 HDAC3    BIND  PubMed The IL-8 promoter interacts with HDAC3. 
    NC_000004.9 NP_003484.1 HIST3H3    BIND  PubMed The IL-8 promoter interacts with phosphorylated and/or acetylated H3. 
    NC_000004.9 NP_001547.1 IKBKB    BIND  PubMed The IL-8 promoter interacts with IKK-beta. 
    NC_000004.9 NP_006303.1 NCOR2    BIND  PubMed The IL-8 promoter interacts with SMRT. 
    NC_000004.9 NP_003989.2 NFKB1    BIND  PubMed The IL-8 promoter interacts with p50. 
    NC_000004.9 NP_000928.1 POLR2A    BIND  PubMed The IL-8 promoter interacts with Pol II. 
    NC_000004.9 NP_068810.2 RELA    BIND  PubMed The IL-8 promoter interacts with p65. 
    NP_000575.1 NP_000625.1 CXCR1    BIND  PubMed The amino terminus of CXCR1 interacts with IL-8. This interaction was modeled on a demonstrated interaction between rabbit CXCR1 and human IL-8. 
    P10145 Chemokine, CC motif, ligand 4 CCL4    HPRD  PubMed  
    P10145 P07711 CTSL1    HPRD  PubMed  
    P10145 P25024 CXCR1    HPRD  PubMed  
    P10145 P25025 CXCR2    HPRD  PubMed  
    P10145 Q16570 DARC    HPRD  PubMed  
    P10145 P04899 GNAI2    HPRD  PubMed  
    P10145 P29459 IL12A    HPRD  PubMed  
    P10145 P10145 IL8    HPRD  PubMed  
    P10145 P14780 MMP9    HPRD  PubMed  
    P10145 P02776 PF4    HPRD  PubMed  
    P10145 P18827 SDC1    HPRD  PubMed  
    P10145 Q92558 WASF1    HPRD  PubMed  
    BioGRID:109790 BioGRID:112255 CCL5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109790 BioGRID:107841 CSNK2A1    BioGRID  PubMed Biochemical Activity 
    BioGRID:109790 BioGRID:109793 CXCR2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109790 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109790 BioGRID:109790 IL8    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109790 BioGRID:112284 SDC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109790 BioGRID:1205541 tat    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • ATF-2 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      ATF-2 transcription factor network, organism-specific biosystem
      ATF-2 transcription factor network
    • Activation of Genes by ATF4, organism-specific biosystem (from REACTOME)
      Activation of Genes by ATF4, organism-specific biosystemATF4 is a transcription factor and activates expression of IL-8, MCP1, IGFBP-1, CHOP, HERP1 and ATF3.
    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
      Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Diabetes pathways, organism-specific biosystem (from REACTOME)
      Diabetes pathways, organism-specific biosystemThis module groups several normal processes that have key roles in the synthesis and function of insulin, insulin-like growth factors and ghrelin, and whose derangement is thus central to the pathoge...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
    • Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, conserved biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
      LPA receptor mediated events, organism-specific biosystem
      LPA receptor mediated events
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • PERK regulated gene expression, organism-specific biosystem (from REACTOME)
      PERK regulated gene expression, organism-specific biosystemPERK is a single-pass transmembrane protein located in the endoplasmic reticulum (ER) membrane such that the N-terminus of PERK is luminal and the C-terminus is cytosolic. PERK is maintained in an in...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Shigellosis, organism-specific biosystem (from KEGG)
      Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-2-mediated signaling events, organism-specific biosystem
      Syndecan-2-mediated signaling events
    • Syndecan-3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-3-mediated signaling events, organism-specific biosystem
      Syndecan-3-mediated signaling events
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Unfolded Protein Response, organism-specific biosystem (from REACTOME)
      Unfolded Protein Response, organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...
    • Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway Interaction Database)
      Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
      Validated transcriptional targets of AP1 family members Fra1 and Fra2

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chemokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    interleukin-8 receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    activation of signaling protein activity involved in unfolded protein response TAS
    Traceable Author Statement
    more info
    		  
    angiogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    calcium-mediated signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular component movement TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular response to fibroblast growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic digestive tract development IEP
    Inferred from Expression Pattern
    more info
    		  
    endoplasmic reticulum unfolded protein response TAS
    Traceable Author Statement
    more info
    		  
    immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of positive chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of G-protein coupled receptor protein signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    neutrophil activation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    neutrophil chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of neutrophil chemotaxis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of retroviral genome replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to molecule of bacterial origin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    interleukin-8
    Names
    interleukin-8
    emoctakin
    T-cell chemotactic factor
    neutrophil-activating peptide 1
    chemokine (C-X-C motif) ligand 8
    beta-thromboglobulin-like protein
    granulocyte chemotactic protein 1
    tumor necrosis factor-induced gene 1
    alveolar macrophage chemotactic factor I
    monocyte-derived neutrophil chemotactic factor
    monocyte-derived neutrophil-activating peptide
    small inducible cytokine subfamily B, member 8
    lymphocyte derived neutrophil activating peptide
    lung giant cell carcinoma-derived chemotactic protein
    beta endothelial cell-derived neutrophil activating peptide
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029889.1 RefSeqGene

      Range
      5001..8211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000584.3 → NP_000575.1  interleukin-8 precursor

      Status: REVIEWED

      Source sequence(s)
      BC013615, BG497712
      Consensus CDS
      CCDS34005.1
      UniProtKB/Swiss-Prot
      P10145
      Related
      ENSP00000306512, OTTHUMP00000199824, ENST00000307407, OTTHUMT00000322211
      Conserved Domains (1) summary
      cd00273
      Location:31 – 94
      Blast Score: 210
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      74606223..74609433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      70417707..70420917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC112518.1 (36729..39887) None
    genomic AF385628.2 AAK60276.1
    genomic CH471057.1 EAX05687.1
      EAX05688.1
      EAX05689.1
    genomic D14283.1 BAA03245.1
    genomic HC462818.1 CBK51144.1
    genomic HI519526.1 CBX54344.1
    genomic M28130.1 AAA59158.1
    mRNA AJ227913.1 None
    mRNA AK131067.1 None
    mRNA AK311874.1 BAG34815.1
    mRNA BC013615.1 AAH13615.1
    mRNA BG497712.1 None
    mRNA BT007067.1 AAP35730.1
    mRNA CR542151.1 CAG46948.1
    mRNA M17017.1 AAA35611.1
    mRNA M26383.1 AAA36323.1
    mRNA Y00787.1 CAA68742.1
    mRNA Z11686.1 CAA77745.1
    other-genetic DQ890564.2 ABM92181.1
    other-genetic DQ893727.2 ABM84653.1
    other-genetic M23344.1 AAA74722.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10145.1 GenPept UniProtKB/Swiss-Prot:P10145
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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    Tools
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