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    LUC7L2 LUC7-like 2 (S. cerevisiae) [ Homo sapiens ]

    Gene ID: 51631, updated on 4-Feb-2012

    Summary

    Official Symbol
    LUC7L2provided by HGNC
    Official Full Name
    LUC7-like 2 (S. cerevisiae)provided by HGNC
    Primary source
    HGNC:21608
    Locus tag
    CGI-59
    See related
    Ensembl:ENSG00000146963; HPRD:17456; MIM:613056; Vega:OTTHUMG00000151717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-59; CGI-74; LUC7B2
    Summary
    This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

    Genomic context

    Location :
    7q34
    Sequence :
    Chromosome: 7; NC_000007.13 (139044634..139108200)
    See LUC7L2 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene ubinuclein 2 Neighboring gene chromosome 7 open reading frame 55 Neighboring gene uncharacterized LOC100129148 Neighboring gene killer cell lectin-like receptor subfamily G, member 2 Neighboring gene suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 17

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9Y383 P02768 ALB    HPRD  PubMed  
    Q9Y383 Activating transcription factor 7 interacting protein ATF7IP    HPRD  PubMed  
    Q9Y383 P46100 ATRX    HPRD  PubMed  
    Q9Y383 Q9ULU8 CADPS    HPRD  PubMed  
    Q9Y383 Q9Y3C0 CCDC53    HPRD  PubMed  
    Q9Y383 Q96SN8 CDK5RAP2    HPRD  PubMed  
    Q9Y383 Q12873 CHD3    HPRD  PubMed  
    Q9Y383 Q9BQD7 FAM173A    HPRD  PubMed  
    Q9Y383 P51114 FXR1    HPRD  PubMed  
    Q9Y383 O95257 GADD45G    HPRD  PubMed  
    Q9Y383 Haloacid dehalogenase like hydrolase domain containing 2 HDHD2    HPRD  PubMed  
    Q9Y383 Q9P2H0 KIAA1377    HPRD  PubMed  
    Q9Y383 Q9Y2M5 KLHL20    HPRD  PubMed  
    Q9Y383 P06858 LPL    HPRD  PubMed  
    Q9Y383 Q9Y383 LUC7L2    HPRD  PubMed  
    Q9Y383 P49641 MAN2A2    HPRD  PubMed  
    Q9Y383 Q9GZQ8 MAP1LC3B    HPRD  PubMed  
    Q9Y383 Nucleosome assembly protein 1-like 5 NAP1L5    HPRD  PubMed  
    Q9Y383 P49321 NASP    HPRD  PubMed  
    Q9Y383 Embryo brain specific protein NAT9    HPRD  PubMed  
    Q9Y383 Q9NRX3 NDUFA4L2    HPRD  PubMed  
    Q9Y383 NF kappaB activating protein NKAP    HPRD  PubMed  
    Q9Y383 P46459 NSF    HPRD  PubMed  
    Q9Y383 P61970 NUTF2    HPRD  PubMed  
    Q9Y383 O75665 OFD1    HPRD  PubMed  
    Q9Y383 Q15121 PEA15    HPRD  PubMed  
    Q9Y383 Pentatricopeptide repeat domain 3 PTCD3    HPRD  PubMed  
    Q9Y383 P21246 PTN    HPRD  PubMed  
    Q9Y383 P21673 SAT1    HPRD  PubMed  
    Q9Y383 P28290 SSFA2    HPRD  PubMed  
    Q9Y383 O95425 SVIL    HPRD  PubMed  
    Q9Y383 Q8IYT8 ULK2    HPRD  PubMed  
    Q9Y383 Q13432 UNC119    HPRD  PubMed  
    Q9Y383 P61981 YWHAG    HPRD  PubMed  
    Q9Y383 Q8TBK6 ZCCHC10    HPRD  PubMed  
    Q9Y383 C14orf139 protein     HPRD  PubMed  
    BioGRID:119646 BioGRID:113684 AIMP2    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:106715 ALB    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:107028 ATRX    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:119225 CCDC53    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:116312 CDC37    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:107454 CDK4    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:120873 CDK5RAP2    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:107532 CHD3    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:120881 EXOC1    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:122439 FAM173A    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:113760 FXR1    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:116117 GADD45G    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:109187 GSK3B    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:109314 HTT    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:114089 IKBKG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119646 BioGRID:121617 KIAA1377    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:118100 KLHL20    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:122809 LINC00341    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:110205 LPL    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:119646 LUC7L2    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:110295 MAN2A2    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:123565 MAP1LC3B    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119646 BioGRID:129344 NAP1L5    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:110759 NASP    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:117582 NAT9    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:123527 NDEL1    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:121231 NDUFA4L2    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:122723 NKAP    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:115783 NOP56    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119646 BioGRID:110960 NSF    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:115499 NUTF2    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:114055 OFD1    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:111196 PDPK1    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:114230 PEA15    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:114075 PIK3R3    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:120366 PTCD3    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:111731 PTN    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:114952 RBM39    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119646 BioGRID:116125 RNPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119646 BioGRID:116708 RRP1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119646 BioGRID:215383 Rrp1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119646 BioGRID:112210 SAT1    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:112622 SSFA2    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:112707 SVIL    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:115058 ULK2    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:114548 UNC119    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119646 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119646 BioGRID:120174 ZCCHC10    BioGRID  PubMed Two-hybrid 
    BioGRID:119646 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10657

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative RNA-binding protein Luc7-like 2
    Names
    putative RNA-binding protein Luc7-like 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030012.1 RefSeqGene

      Range
      4981..88079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001244584.1NP_001231513.1  putative RNA-binding protein Luc7-like 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK297642, AU144525, BC017163
      UniProtKB/TrEMBL
      B7Z4Q3
      UniProtKB/Swiss-Prot
      Q9Y383
      Conserved Domains (2) summary
      COG5200
      Location:89294
      Blast Score: 321
      LUC7; U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]
      cl05087
      Location:9101
      Blast Score: 109
      Complex1_LYR_1; Complex1_LYR-like
    2. NM_001244585.1NP_001231514.1  putative RNA-binding protein Luc7-like 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC083880, AK298166, AU144525, BC017163
      UniProtKB/TrEMBL
      B7Z500
      UniProtKB/Swiss-Prot
      Q9Y383
      Conserved Domains (1) summary
      COG5200
      Location:14225
      Blast Score: 320
      LUC7; U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]
    3. NM_016019.3NP_057103.2  putative RNA-binding protein Luc7-like 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AU144525, BC050708, DB086483
      Consensus CDS
      CCDS43656.1
      UniProtKB/Swiss-Prot
      Q9Y383
      Related
      ENSP00000347005, OTTHUMP00000200420, ENST00000354926, OTTHUMT00000323618
      Conserved Domains (2) summary
      COG5200
      Location:5228
      Blast Score: 353
      LUC7; U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]
      pfam03194
      Location:4233
      Blast Score: 763
      LUC7; LUC7 N_terminus

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      139044634..139108200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      133354515..133418082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      138389189..138452742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC083880.5 AAS07477.1
    genomic AC083883.6 (1999..53155) None
    genomic CH236950.1 (2627466..2690644) None
    genomic CH471070.1 EAW83916.1
      EAW83917.1
      EAW83918.1
    mRNA AF151817.1 AAD34054.1
    mRNA AF151832.1 AAD34069.1
    mRNA AK001476.1 BAA91713.1
    mRNA AK001519.1 BAA91737.1
    mRNA AK022895.1 BAB14297.1
    mRNA AK092044.1 BAG52473.1
    mRNA AK093864.1 BAG52777.1
    mRNA AK094081.1 BAG52810.1
    mRNA AK095839.1 None
    mRNA AK297642.1 BAH12639.1
    mRNA AK298166.1 BAH12736.1
    mRNA AU144525.2 None
    mRNA BC017163.2 AAH17163.1
    mRNA BC041001.2 None
    mRNA BC042625.1 AAH42625.1
    mRNA BC050708.2 AAH50708.1
    mRNA BC056886.1 AAH56886.1
    mRNA DA342563.1 None
    mRNA DB086483.1 None
    other-genetic EU832106.1 ACE87456.1
    other-genetic EU832200.1 ACE86770.1
    other-genetic HQ448242.1 ADQ32722.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q75M91 GenPept UniProtKB/TrEMBL:Q75M91
    Q9Y383.2 GenPept UniProtKB/Swiss-Prot:Q9Y383

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