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    TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase [ Homo sapiens ]

    Gene ID: 7189, updated on 19-May-2012
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    Summary

    Official Symbol
    TRAF6provided by HGNC
    Official Full Name
    TNF receptor-associated factor 6, E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:12036
    See related
    Ensembl:ENSG00000175104; HPRD:03833; MIM:602355; Vega:OTTHUMG00000166391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF85; MGC:3310
    Summary
    The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]
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    Genomic context

    Location :
    11p12
    Sequence :
    Chromosome: 11; NC_000011.9 (36505317..36531863, complement)
    See TRAF6 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene COMM domain containing 9 Neighboring gene proline rich 5 like Neighboring gene recombination activating gene 1 Neighboring gene chromosome 11 open reading frame 74 Neighboring gene recombination activating gene 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. TRAF6 inhibits proangiogenic signals in endothelial cells and regulates the expression of vascular endothelial growth factor. Bruneau S, et al. Biochem Biophys Res Commun, 2012 Mar 2. PMID 22326918.
    2. TRAF6 and IRF7 control HIV replication in macrophages. Sirois M, et al. PLoS One, 2011. PMID 22140520.
    3. Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7. Hu Y, et al. J Immunol, 2011 Dec 15. PMID 22095711.
    4. IRAK-1-mediated negative regulation of Toll-like receptor signaling through proteasome-dependent downregulation of TRAF6. Muroi M, et al. Biochim Biophys Acta, 2012 Feb. PMID 22033459.
    5. Increased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjögren's syndrome. Zilahi E, et al. Immunol Lett, 2012 Jan 30. PMID 22033216.

    See all (286) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results indicate that stimulation of TLRs induces proteasome-dependent downregulation of TRAF6, and that TRAF6 associated with ubiquitinated IRAK-1 is degraded together by the proteasome.
      Title: IRAK-1-mediated negative regulation of Toll-like receptor signaling through proteasome-dependent downregulation of TRAF6.
    2. these findings define a novel pro-angiogenic signaling response in endothelial cells that is regulated by TRAF6.
      Title: TRAF6 inhibits proangiogenic signals in endothelial cells and regulates the expression of vascular endothelial growth factor.
    3. overexpressed in the peripheral mononuclear cells of patients with Sjogren's syndrome
      Title: Increased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjögren's syndrome.
    4. TRAF6 can regulate HIV-1 production and expression of IRF7 promotes HIV-1 replication.
      Title: TRAF6 and IRF7 control HIV replication in macrophages.
    5. Blocking TRAF6 activity can be used as a therapeutic approach to preserve skeletal muscle mass and function in different disease states and conditions.
      Title: TRAF6 coordinates the activation of autophagy and ubiquitin-proteasome systems in atrophying skeletal muscle.
    6. USP4 deubiquitinates both TRAF2 and TRAF6 in vivo and in vitro in a deubiquitinase activity-dependent manner.
      Title: Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration.
    7. results suggested that TRAF6 may be key molecule to control proinflammatory cytokine production induced by P gingivalis and its LPS. TRAF6 suppression may inhibit inflammatory responses in HPDLCs infected by P gingivalis and its LPS.
      Title: TNF receptor-associated factor 6 suppression inhibits inflammatory response to Porphyromonas gingivialis in human periodontal ligament cells.
    8. the protein associates with TGF-beta receptors and components of the TRAF6-TAK1 signaling module
      Title: TTRAP is a novel component of the non-canonical TRAF6-TAK1 TGF-β signaling pathway.
    9. It is of great importance to elucidate how TRAF6 (as signal mediator) and CLM-3 (as the regulator) cooperate with each other and how they are controlled.
      Title: CMRF-35-like molecule 3 preferentially promotes TLR9-triggered proinflammatory cytokine production in macrophages by enhancing TNF receptor-associated factor 6 ubiquitination.
    10. Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation.
      Title: Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation.
    Submit: New GeneRIF Correction See all (102)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004611.1 NP_001560.1 IRAK1    BIND  PubMed TRAF6 interacts with IRAK1. This interaction was modeled on a demonstrated interaction between TRAF6 and IRAK1, both from unspecified species. 
    NP_004611.1 NP_001561.2 IRAK2    BIND  PubMed IRAK-2 interacts with TRAF6. 
    NP_004611.1 NP_009130.1 IRAK3    BIND  PubMed IRAK-M interacts with TRAF6. 
    NP_004611.1 NP_001563.2 IRF7    BIND  PubMed IRF7 intereacts with TRAF6. This interaction was modeled on a demonstrated interaction between mouse IRF7 and human TRAF6. 
    NP_004611.1 NP_006776.1 MALT1    BIND  PubMed TRAF6 interacts with MALT1. This interaction was modeled on a demonstrated interaction between TRAF6 from mouse and MALT1 from human. 
    NP_004611.1 NP_003945.1 MAP3K14    BIND  PubMed NIK interacts with TRAF6. This interaction was modeled on a demonstrated interaction between human NIK and TRAF6 from an unspecified species. 
    NP_004611.1 NP_690000.1 TAB3    BIND  PubMed TAB3 interacts with TRAF6. 
    NP_004611.1 NP_891549.1 TICAM1    BIND  PubMed TRIF interacts with TRAF6. 
    NP_004611.1 TICAM1    BIND  PubMed An unspecified isoform of TRIF interacts with TRAF6. This interaction was modeled on a demonstrated interaction between TRIF from an unspecified species and TRAF from an unspecified species. 
    NP_004611.1 NP_067681.1 TICAM2    BIND  PubMed TIRP interacts with TRAF6. This interaction was modeled on a demonstrated interaction between human TIRP and TRAF6 from an unspecified species. 
    NP_004611.1 NP_004611.1 TRAF6    BIND  PubMed TRAF6 interacts with itself and forms an oligomer. 
    NP_004611.1 NP_061828.1 UBB    BIND  PubMed TRAF6 interacts with Ub. This interaction was modeled on a demonstrated interaction between TRAF6 from mouse and Ub from an unspecified source. 
    NP_004611.1 NP_061828.1 UBB    BIND  PubMed TRAF6 interacts with Ub. This interaction was modeled on a demonstrated interaction between TRAF6 from mouse and Ub from an unspecified source. 
    NP_004611.1 NP_005998.1 ZFAND5    BIND  PubMed ZNF216 interacts with TRAF6. This interaction was modeled on a demonstrated interaction between human ZNF216 and TRAF6 from an unspecified species. 
    NP_004611.1     BIND  PubMed Kinase inactive IRAK[Lys239Ser] interacts with TRAF6, whilst the interaction between wildtype IRAK and TRAF6 was not captured because TRAF6 expresses poorly when coexpressed with wildtype IRAK. 
    Q9Y4K3 P00519 ABL1    HPRD  PubMed  
    Q9Y4K3 P36543 ATP6V1E1    HPRD  PubMed  
    Q9Y4K3 Q03135 CAV1    HPRD  PubMed  
    Q9Y4K3 P22681 CBL    HPRD  PubMed  
    Q9Y4K3 P25942 CD40    HPRD  PubMed  
    Q9Y4K3 Q9NQC7 CYLD    HPRD  PubMed  
    Q9Y4K3 Signaling intermediate in Toll pathway evolutionarily conserved ECSIT    HPRD  PubMed  
    Q9Y4K3 Q9HAV5 EDA2R    HPRD  PubMed  
    Q9Y4K3 Q14192 FHL2    HPRD  PubMed  
    Q9Y4K3 P34932 HSPA4    HPRD  PubMed  
    Q9Y4K3 Q9NRM6 IL17RB    HPRD  PubMed  
    Q9Y4K3 P51617 IRAK1    HPRD  PubMed  
    Q9Y4K3 O43187 IRAK2    HPRD  PubMed  
    Q9Y4K3 Q9Y616 IRAK3    HPRD  PubMed  
    Q9Y4K3 Q9NWZ3 IRAK4    HPRD  PubMed  
    Q9Y4K3 Q13568 IRF5    HPRD  PubMed  
    Q9Y4K3 Q92985 IRF7    HPRD  PubMed  
    Q9Y4K3 Q02556 IRF8    HPRD  PubMed  
    Q9Y4K3 P51787 KCNQ1    HPRD  PubMed  
    Q9Y4K3 Q9UDY8 MALT1    HPRD  PubMed  
    Q9Y4K3 Q02750 MAP2K1    HPRD  PubMed  
    Q9Y4K3 P52564 MAP2K6    HPRD  PubMed  
    Q9Y4K3 O14733 MAP2K7    HPRD  PubMed  
    Q9Y4K3 Q99558 MAP3K14    HPRD  PubMed  
    Q9Y4K3 Q99759 MAP3K3    HPRD  PubMed  
    Q9Y4K3 Q99683 MAP3K5    HPRD  PubMed  
    Q9Y4K3 O43318 MAP3K7    HPRD  PubMed  
    Q9Y4K3 P41279 MAP3K8    HPRD  PubMed  
    Q9Y4K3 Q16539 MAPK14    HPRD  PubMed  
    Q9Y4K3 P45983 MAPK8    HPRD  PubMed  
    Q9Y4K3 Q6P0Q8 MAST2    HPRD  PubMed  
    Q9Y4K3 KIAA1271 protein MAVS    HPRD  PubMed  
    Q9Y4K3 P02686 MBP    HPRD  PubMed  
    Q9Y4K3 P08138 NGFR    HPRD  PubMed  
    Q9Y4K3 Q00994 NGFRAP1    HPRD  PubMed  
    Q9Y4K3 Q6GQQ9 OTUD7B    HPRD  PubMed  
    Q9Y4K3 Q8N2H9 PELI3    HPRD  PubMed  
    Q9Y4K3 Q05513 PRKCZ    HPRD  PubMed  
    Q9Y4K3 P28074 PSMB5    HPRD  PubMed  
    Q9Y4K3 P62191 PSMC1    HPRD  PubMed  
    Q9Y4K3 P35998 PSMC2    HPRD  PubMed  
    Q9Y4K3 P17980 PSMC3    HPRD  PubMed  
    Q9Y4K3 Q99460 PSMD1    HPRD  PubMed  
    Q9Y4K3 O00232 PSMD12    HPRD  PubMed  
    Q9Y4K3 Q9UNM6 PSMD13    HPRD  PubMed  
    Q9Y4K3 Q15008 PSMD6    HPRD  PubMed  
    Q9Y4K3 P51665 PSMD7    HPRD  PubMed  
    Q9Y4K3 P29350 PTPN6    HPRD  PubMed  
    Q9Y4K3 O43353 RIPK2    HPRD  PubMed  
    Q9Y4K3 Q6IA17 SIGIRR    HPRD  PubMed  
    Q9Y4K3 Q9NYA1 SPHK1    HPRD  PubMed  
    Q9Y4K3 Q13501 SQSTM1    HPRD  PubMed  
    Q9Y4K3 P12931 SRC    HPRD  PubMed  
    Q9Y4K3 Q9C0K7 STRADB    HPRD  PubMed  
    Q9Y4K3 P43405 SYK    HPRD  PubMed  
    Q9Y4K3 Q15750 TAB1    HPRD  PubMed  
    Q9Y4K3 Q9NYJ8 TAB2    HPRD  PubMed  
    Q9Y4K3 Q8N5C8 TAB3    HPRD  PubMed  
    Q9Y4K3 Q86VP1 TAX1BP1    HPRD  PubMed  
    Q9Y4K3 O95551 TDP2    HPRD  PubMed  
    Q9Y4K3 Toll-like receptor adaptor molecule 1 TICAM1    HPRD  PubMed  
    Q9Y4K3 Toll like receptor adaptor molecule 2 TICAM2    HPRD  PubMed  
    Q9Y4K3 T2BP TIFA    HPRD  PubMed  
    Q9Y4K3 P58753 TIRAP    HPRD  PubMed  
    Q9Y4K3 O15455 TLR3    HPRD  PubMed  
    Q9Y4K3 Ubiquitin conjugating enzyme E2 Kua-UEV TMEM189-UBE2V1    HPRD  PubMed  
    Q9Y4K3 P21580 TNFAIP3    HPRD  PubMed  
    Q9Y4K3 Q9Y6Q6 TNFRSF11A    HPRD  PubMed  
    Q9Y4K3 O14836 TNFRSF13B    HPRD  PubMed  
    Q9Y4K3 Q9NS68 TNFRSF19    HPRD  PubMed  
    Q9Y4K3 O14788 TNFSF11    HPRD  PubMed  
    Q9Y4K3 Q12933 TRAF2    HPRD  PubMed  
    Q9Y4K3 O43734 TRAF3IP2    HPRD  PubMed  
    Q9Y4K3 Q9BUZ4 TRAF4    HPRD  PubMed  
    Q9Y4K3 Q9Y4K3 TRAF6    HPRD  PubMed  
    Q9Y4K3 Q6Q0C0 TRAF7    HPRD  PubMed  
    Q9Y4K3 O14545 TRAFD1    HPRD  PubMed  
    Q9Y4K3 Q15629 TRAM1    HPRD  PubMed  
    Q9Y4K3 O94972 TRIM37    HPRD  PubMed  
    Q9Y4K3 Ubiquitin B UBB    HPRD  PubMed  
    Q9Y4K3 P61088 UBE2N    HPRD  PubMed  
    Q9Y4K3 Q93009 USP7    HPRD  PubMed  
    Q9Y4K3 P98170 XIAP    HPRD  PubMed  
    Q9Y4K3 O76080 ZFAND5    HPRD  PubMed  
    Q9Y4K3 Q15326 ZMYND11    HPRD  PubMed  
    Q9Y4K3 TRAF6 inhibitory zinc finger protein ZNF675    HPRD  PubMed  
    Q9Y4K3 Q9UGI0 ZRANB1    HPRD  PubMed  
    BioGRID:113041 BioGRID:120543 ASXL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:106962 ATM    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113041 BioGRID:110433 ATXN3    BioGRID  PubMed Biochemical Activity 
    BioGRID:113041 BioGRID:114226 BECN1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113041 BioGRID:106826 BIRC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:106827 BIRC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:107126 BMPR1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:107396 CD40    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113041 BioGRID:107569 CHUK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:107883 CTPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:107920 CYLD    BioGRID  PubMed Biochemical Activity 
    BioGRID:113041 BioGRID:108020 DDX3X    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:121904 EDA2R    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:114856 EIF4E2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:123666 EPPK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:205076 Ecsit    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:108565 FHL2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113041 BioGRID:108580 FOXG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:116802 GANAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:109548 HSPB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:109314 HTT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:109605 IARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:114089 IKBKG    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113041 BioGRID:109818 IL17A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:117265 IL17RA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:109863 IRAK1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113041 BioGRID:109865 IRAK2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113041 BioGRID:116382 IRAK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:119322 IRAK4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:109873 IRF7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:109621 IRF8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:109985 KCNQ1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:116098 MALT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113041 BioGRID:110442 MAP3K11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:114487 MAP3K14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:110379 MAP3K3    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:113041 BioGRID:110381 MAP3K5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:112748 MAP3K7    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113041 BioGRID:120105 MARCH5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:116756 MAST2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:121570 MAVS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:110344 MCM7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:110587 MSR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:110622 MTHFD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:110700 MYD88    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:113041 BioGRID:204962 Map3k7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:110759 NASP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:110870 NGFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:122796 NLRX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:114012 NR0B2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:110969 NTRK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113041 BioGRID:110970 NTRK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:114677 NUMBL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113041 BioGRID:120751 OTUB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113041 BioGRID:122461 OTUB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:121281 OTUD7B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:115852 PAICS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:116446 PARK7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:111076 PEBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:128900 PELI3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:111221 PFAS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:111523 PPP4C    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113041 BioGRID:111576 PRKCZ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:111642 PSEN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:111666 PSMB5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:111673 PSMC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:111674 PSMC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:111675 PSMC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:111680 PSMD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:111690 PSMD12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:111691 PSMD13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:111682 PSMD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:111685 PSMD7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:115359 RANBP9    BioGRID  PubMed Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:113041 BioGRID:114300 RIPK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:107309 RUNX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:117155 RUSC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:208378 Rsad2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:112287 SDCBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:121873 SIGIRR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:121411 SMURF1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:113041 BioGRID:112506 SNCA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:114488 SOCS3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:113993 SPOP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113041 BioGRID:114397 SQSTM1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:113041 BioGRID:112592 SRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:115863 STAMBP    BioGRID  PubMed Biochemical Activity 
    BioGRID:113041 BioGRID:120668 STRADB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:115563 STUB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113041 BioGRID:112717 SYK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:115717 TAB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:116740 TAB2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113041 BioGRID:129216 TAB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:112760 TARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:114405 TAX1BP1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113041 BioGRID:119615 TDP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:112904 TGFBR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:127114 TICAM1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113041 BioGRID:124962 TIFA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:125325 TIRAP    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:113041 BioGRID:114809 TJP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:112953 TLR3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:112954 TLR4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:119902 TLR9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:112983 TNFAIP3    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113041 BioGRID:114320 TNFRSF11A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113041 BioGRID:117046 TNFRSF13B    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113041 BioGRID:113038 TRAF2    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:113041 BioGRID:117577 TRAF3IP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113041 BioGRID:115979 TRAF3IP2    BioGRID  PubMed Biochemical Activity 
    BioGRID:113041 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; FRET 
    BioGRID:113041 BioGRID:115581 TRAIP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:110678 TRIM37    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113041 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113041 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:113041 BioGRID:113170 UBE2D2    BioGRID  PubMed Two-hybrid 
    BioGRID:113041 BioGRID:113171 UBE2D3    BioGRID  PubMed Two-hybrid 
    BioGRID:113041 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:113041 BioGRID:113182 UBE2N    BioGRID  PubMed Co-crystal Structure; Co-fractionation; Phenotypic Suppression; Reconstituted Complex; Two-hybrid 
    BioGRID:113041 BioGRID:113183 UBE2V1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113041 BioGRID:120580 UEVLD    BioGRID  PubMed Two-hybrid 
    BioGRID:113041 BioGRID:115283 USP15    BioGRID  PubMed Biochemical Activity 
    BioGRID:113041 BioGRID:114553 USP2    BioGRID  PubMed Biochemical Activity 
    BioGRID:113041 BioGRID:117950 USP21    BioGRID  PubMed Biochemical Activity 
    BioGRID:113041 BioGRID:113221 USP4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113041 BioGRID:113751 USP5    BioGRID  PubMed Biochemical Activity 
    BioGRID:113041 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113041 BioGRID:113250 VARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:113259 VDAC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113041 BioGRID:116272 WDR5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:106828 XIAP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:113546 ZFAND5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:115989 ZMYND11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113041 BioGRID:128116 ZNF675    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex; Two-hybrid 
    BioGRID:113041 BioGRID:120139 ZRANB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
      Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      BCR signaling pathway, organism-specific biosystem
      BCR signaling pathway
    • CD40/CD40L signaling, organism-specific biosystem (from Pathway Interaction Database)
      CD40/CD40L signaling, organism-specific biosystem
      CD40/CD40L signaling
    • Canonical NF-kappaB pathway, organism-specific biosystem (from Pathway Interaction Database)
      Canonical NF-kappaB pathway, organism-specific biosystem
      Canonical NF-kappaB pathway
    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Downstream TCR signaling, organism-specific biosystem (from REACTOME)
      Downstream TCR signaling, organism-specific biosystemChanges in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • IL-1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-1 Signaling Pathway, organism-specific biosystemThe interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor,...
    • IL1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL1-mediated signaling events, organism-specific biosystem
      IL1-mediated signaling events
    • IRAK1 recruits IKK complex, organism-specific biosystem (from REACTOME)
      IRAK1 recruits IKK complex, organism-specific biosystemThe role of IRAK-1 kinase activity in the activation of NFkB by IL-1/TLR is still uncertain. It has been shown that a kinase-dead IRAK-1 mutants can still activate NFkB. Furthermore, stimulation of ...
    • IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, organism-specific biosystem (from REACTOME)
      IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, organism-specific biosystemThe role of IRAK-1 kinase activity in the activation of NFkB by IL-1/TLR is still uncertain. It has been shown that a kinase-dead IRAK-1 mutants can still activate NFkB. Furthermore, stimulation of ...
    • IRAK2 mediated activation of TAK1 complex, organism-specific biosystem (from REACTOME)
      IRAK2 mediated activation of TAK1 complex, organism-specific biosystemAlthough IRAK-1 was originally thought to be a key mediator of TRAF6 activation in the IL1R/TLR signaling (Dong W et al. 2006), recent studies showed that IRAK-2, but not IRAK-1, led to TRAF6 polyubi...
    • IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, organism-specific biosystem (from REACTOME)
      IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, organism-specific biosystemAlthough IRAK-1 was originally thought to be a key mediator of TRAF6 activation in the IL1R/TLR signaling (Dong W et al. 2006), recent studies showed that IRAK-2, but not IRAK-1, led to TRAF6 polyubi...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
    • JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, organism-specific biosystem (from REACTOME)
      JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, organism-specific biosystemC-Jun NH2 terminal kinases (JNKs) are an evolutionarily conserved family of serine/threonine protein kinases, that belong to mitogen activated protein kinase family (MAPKs - also known as stress-acti...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • MAP kinase activation in TLR cascade, organism-specific biosystem (from REACTOME)
      MAP kinase activation in TLR cascade, organism-specific biosystemMitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascade tr...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
    • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
      MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
    • MyD88-independent cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88-independent cascade initiated on plasma membrane, organism-specific biosystemThe MyD88-independent signaling route utilizes TRAM and TRIF adapters, that are essential for production of both type 1 interferons(IFNs) and pro-inflammatory cytokines. TRAM is thought to bridge bet...
    • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
    • NF-kB is activated and signals survival, organism-specific biosystem (from REACTOME)
      NF-kB is activated and signals survival, organism-specific biosystemUpon activation in response to NGF, NF-kB moves to the nucleus, where it turns on genes that promote survival, and triggers the expression of HES1/5 to modulate dendritic growth.
    • NFkB and MAP kinases activation mediated by TLR4 signaling repertoire, organism-specific biosystem (from REACTOME)
      NFkB and MAP kinases activation mediated by TLR4 signaling repertoire, organism-specific biosystemMitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascade tr...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD1/2 Signaling Pathway, organism-specific biosystem (from REACTOME)
      NOD1/2 Signaling Pathway, organism-specific biosystemNOD1 is ubiquitously expressed, while NOD2 expression is restricted to monocytes, macrophages, dendritic cells, and intestinal Paneth cells (Inohara et al. 2005). NOD1 and NOD2 activation induces tra...
    • NRIF signals cell death from the nucleus, organism-specific biosystem (from REACTOME)
      NRIF signals cell death from the nucleus, organism-specific biosystemNRIF (nuclear receptor-interacting factor) is a DNA binding protein that is essential for p75-mediated apoptosis in retina and sympathetic neurons. Neurotrophin or proneurotrophin binding to p75TR in...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • Regulated proteolysis of p75NTR, organism-specific biosystem (from REACTOME)
      Regulated proteolysis of p75NTR, organism-specific biosystemp75NTR undergoes a process of regulated intramembrane proteolysis (RIP) similar to other transmembrane proteins such as NOTCH, beta-amyloid precursor protein (APP), and ERBB4. Each of these proteins ...
    • Regulation of p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of p38-alpha and p38-beta, organism-specific biosystem
      Regulation of p38-alpha and p38-beta
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
      TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemNF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • TRAF6 Mediated Induction of proinflammatory cytokines, organism-specific biosystem (from REACTOME)
      TRAF6 Mediated Induction of proinflammatory cytokines, organism-specific biosystemIn human, together with ubiquitin-conjugating E2-type enzymes UBC13 and UEV1A (also known as UBE2V1), TRAF6 catalyses Lys63-linked ubiquitination. It is believed that auto polyubiquitination and oli...
    • TRAF6 mediated IRF7 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated IRF7 activation, organism-specific biosystemTRAF6 is crucial for both RIG-I- and MDA5-mediated antiviral responses. The absence of TRAF6 resulted in enhanced viral replication and a significant reduction in the production of type I IFNs and IL...
    • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, organism-specific biosystem (from REACTOME)
      TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, organism-specific biosystemIn plasmacytoid dendritic cell induction of type I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005). IRF-7, but not IRF3, interacts with MyD88, TRAF6, and...
    • TRAF6 mediated NF-kB activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated NF-kB activation, organism-specific biosystemThe TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in To...
    • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
    • TRAF6 mediated induction of TAK1 complex, organism-specific biosystem (from REACTOME)
      TRAF6 mediated induction of TAK1 complex, organism-specific biosystemIn human, together with ubiquitin-conjugating E2-type enzymes UBC13 and UEV1A (also known as UBE2V1), TRAF6 catalyses Lys63-linked ubiquitination. It is believed that auto polyubiquitination and oli...
    • TRIF mediated TLR3 signaling, organism-specific biosystem (from REACTOME)
      TRIF mediated TLR3 signaling, organism-specific biosystemTIR-domain-containing adaptor inducing interferon-beta (TRIF or TIKAM1) is known to be an essential and exclusive adaptor used by TLR3; all the poly(I:C)-induced pathways leading to NFkB and IRF3 act...
    • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
    • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
    • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
    • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
    • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
    • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
    • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
    • Toll Receptor Cascades, organism-specific biosystem (from REACTOME)
      Toll Receptor Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • activated TAK1 mediates p38 MAPK activation, organism-specific biosystem (from REACTOME)
      activated TAK1 mediates p38 MAPK activation, organism-specific biosystemp38 mitogen-activated protein kinase (MAPK) belongs to a highly conserved family of serine/threonine protein kinases. The p38 MAPK-dependent signaling cascade is activated by pro-inflammatory or stre...
    • p38 MAPK signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      p38 MAPK signaling pathway, organism-specific biosystem
      p38 MAPK signaling pathway
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...
    • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      p75(NTR)-mediated signaling, organism-specific biosystem
      p75(NTR)-mediated signaling
    • p75NTR recruits signalling complexes, organism-specific biosystem (from REACTOME)
      p75NTR recruits signalling complexes, organism-specific biosystemNF-kB activation involves recruitment at the cell membrane of several proteins such as RIP2, MYD88, IRAK1, TRAF6, p62 and atypical PKC by the NGF:p75NTR complex.
    • p75NTR signals via NF-kB, organism-specific biosystem (from REACTOME)
      p75NTR signals via NF-kB, organism-specific biosystemThe NF-kB pathway is an important pro-survival signalling pathway activated by mature NGF, but not BDNF or NT-3, through p75NTR. It is unclear whether TRKA activity also affects NF-kB activation.

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase B binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin-protein ligase activity EXP
    Inferred from Experiment
    more info
    		  
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ubiquitin-protein ligase activity TAS
    Traceable Author Statement
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    I-kappaB kinase/NF-kappaB cascade TAS
    Traceable Author Statement
    more info
    		  
    JNK cascade TAS
    Traceable Author Statement
    more info
    		  
    MyD88-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    MyD88-independent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    TRIF-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Toll signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    activation of MAPK activity TAS
    Traceable Author Statement
    more info
    		  
    activation of NF-kappaB-inducing kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    anti-apoptosis TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    induction of apoptosis by extracellular signals TAS
    Traceable Author Statement
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    membrane protein intracellular domain proteolysis TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    nucleotide-binding oligomerization domain containing signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of I-kappaB kinase/NF-kappaB cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB cascade TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of JUN kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of NF-kappaB transcription factor activity TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of T cell activation IC
    Inferred by Curator
    more info
    		 PubMed 
    positive regulation of T cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein K63-linked ubiquitination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein autoubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein ubiquitination EXP
    Inferred from Experiment
    more info
    		  
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to interleukin-1 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    stress-activated MAPK cascade TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 1 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 2 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 3 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 4 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    CD40 receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    internal side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    TNF receptor-associated factor 6
    Names
    TNF receptor-associated factor 6
    RING finger protein 85
    interleukin-1 signal transducer
    E3 ubiquitin-protein ligase TRAF6
    NP_004611.1
    NP_665802.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004620.3 → NP_004611.1  TNF receptor-associated factor 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC009656, AK292978, BQ187062, DA855021
      Consensus CDS
      CCDS7901.1
      UniProtKB/Swiss-Prot
      Q9Y4K3
      Related
      ENSP00000433623, OTTHUMP00000232772, ENST00000526995, OTTHUMT00000389530
      Conserved Domains (5) summary
      cd00162
      Location:69 – 107
      Blast Score: 99
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03776
      Location:351 – 500
      Blast Score: 645
      MATH_TRAF6; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF6, including the Drosophila protein DTRAF2. TRAF molecules serve as adapter ...
      PRK04778
      Location:287 – 348
      Blast Score: 92
      PRK04778; septation ring formation regulator EzrA; Provisional
      pfam02176
      Location:204 – 261
      Blast Score: 183
      zf-TRAF; TRAF-type zinc finger
      pfam13923
      Location:66 – 107
      Blast Score: 101
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    2. NM_145803.2 → NP_665802.1  TNF receptor-associated factor 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC009656, AC061999, BC031052, BQ187062
      Consensus CDS
      CCDS7901.1
      UniProtKB/Swiss-Prot
      Q9Y4K3
      Related
      ENSP00000337853, OTTHUMP00000232773, ENST00000348124, OTTHUMT00000389531
      Conserved Domains (5) summary
      cd00162
      Location:69 – 107
      Blast Score: 99
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03776
      Location:351 – 500
      Blast Score: 645
      MATH_TRAF6; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF6, including the Drosophila protein DTRAF2. TRAF molecules serve as adapter ...
      PRK04778
      Location:287 – 348
      Blast Score: 92
      PRK04778; septation ring formation regulator EzrA; Provisional
      pfam02176
      Location:204 – 261
      Blast Score: 183
      zf-TRAF; TRAF-type zinc finger
      pfam13923
      Location:66 – 107
      Blast Score: 101
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      36505317..36531863, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      36207402..36234755, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC009656.11 (97082..104421) None
    genomic AC061999.6 (70729..89374) None
    genomic AY228337.1 AAO38054.1
    genomic CH471064.2 EAW68119.1
      EAW68120.1
      EAW68121.1
      EAW68122.1
    mRNA AK128396.1 None
    mRNA AK292978.1 BAF85667.1
    mRNA BC031052.1 AAH31052.1
    mRNA BI463192.1 None
    mRNA BQ187062.1 None
    mRNA DA855021.1 None
    mRNA U78798.1 AAB38751.1
    other-genetic DQ891209.2 ABM82135.1
    other-genetic DQ894392.2 ABM85318.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y4K3.1 GenPept UniProtKB/Swiss-Prot:Q9Y4K3
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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