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CEBPA CCAAT/enhancer binding protein (C/EBP), alpha [ Homo sapiens (human) ]

Gene ID: 1050, updated on 26-Oct-2014
Official Symbol
CEBPAprovided by HGNC
Official Full Name
CCAAT/enhancer binding protein (C/EBP), alphaprovided by HGNC
Primary source
HGNC:HGNC:1833
See related
Ensembl:ENSG00000245848; HPRD:00296; MIM:116897; Vega:OTTHUMG00000161461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEBP; C/EBP-alpha
Summary
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
See CEBPA in Epigenomics, MapViewer
Location:
19q13.1
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (33299934..33302564, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (33790840..33793430, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transfer RNA-Thr (AGT) 1-3 Neighboring gene low density lipoprotein receptor-related protein 3 Neighboring gene solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 Neighboring gene CEBPA antisense RNA 1 (head to head) Neighboring gene ribosomal protein S3a pseudogene 50

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA) in peptide-treated PBMCs PubMed
Tat tat Specific C/EBP and NF-kappaB transcription factor binding elements within the IL-1beta promoter are involved in Tat regulation of IL-1beta production PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cellular response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
inner ear development IEA
Inferred from Electronic Annotation
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
macrophage differentiation IEA
Inferred from Electronic Annotation
more info
 
mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
myeloid cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
organ regeneration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase III promoter IDA
Inferred from Direct Assay
more info
PubMed 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to vitamin B2 IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
urea cycle IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
white fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Rb-E2F complex IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
CCAAT/enhancer-binding protein alpha
Names
CCAAT/enhancer-binding protein alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012022.1 

    Range
    4961..7591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_456

mRNA and Protein(s)

  1. NM_001285829.1NP_001272758.1  CCAAT/enhancer-binding protein alpha isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (GUG) site, and also from three downstream, in-frame AUG sites. The isoform (b, also known as C/EBP-30) represented in this RefSeq results from translation initiation at the third AUG start codon. Isoform b has a shorter N-terminus, compared to isoform c.
    Source sequence(s)
    AC008738
    Conserved Domains (1) summary
    cd12193
    Location:169217
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  2. NM_001287424.1NP_001274353.1  CCAAT/enhancer-binding protein alpha isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (GUG) site, and also from three downstream, in-frame AUG sites. The isoform (c, also known as extended) represented in this RefSeq results from translation initiation at the upstream GUG start codon. Isoform c is the longest isoform.
    Source sequence(s)
    AC008738
    Conserved Domains (1) summary
    cd12193
    Location:323371
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  3. NM_001287435.1NP_001274364.1  CCAAT/enhancer-binding protein alpha isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (GUG) site, and also from three downstream, in-frame AUG sites. The isoform (d) represented in this RefSeq results from translation initiation at the second AUG start codon. Isoform d has a shorter N-terminus, compared to isoform c.
    Source sequence(s)
    AC008738
    Conserved Domains (1) summary
    cd12193
    Location:274322
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  4. NM_004364.4NP_004355.2  CCAAT/enhancer-binding protein alpha isoform a

    See proteins identical to NP_004355.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (GUG) site, and also from three downstream, in-frame AUG sites. The isoform (a, also known as C/EBP-42) represented in this RefSeq results from translation initiation at the first AUG start codon. Isoform a has a shorter N-terminus, compared to isoform c.
    Source sequence(s)
    AC008738
    Consensus CDS
    CCDS54243.1
    UniProtKB/Swiss-Prot
    P49715
    Related
    ENSP00000427514, OTTHUMP00000220269, ENST00000498907, OTTHUMT00000365012
    Conserved Domains (1) summary
    cd12193
    Location:288336
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    33299934..33302564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    30291676..30294205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    33791795..33794425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)