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    HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) [ Homo sapiens ]

    Gene ID: 3184, updated on 11-May-2012
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    Summary

    Official Symbol
    HNRNPDprovided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)provided by HGNC
    Primary source
    HGNC:5036
    See related
    Ensembl:ENSG00000138668; HPRD:03206; MIM:601324; Vega:OTTHUMG00000130290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P37; AUF1; AUF1A; HNRPD; hnRNPD0
    Summary
    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    4q21
    Sequence :
    Chromosome: 4; NC_000004.11 (83274467..83295149, complement)
    See HNRNPD in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene bridging integrator 2 pseudogene 1 Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 4 Neighboring gene heterogeneous nuclear ribonucleoprotein D-like

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Direct binding of specific AUF1 isoforms to tandem zinc finger domains of tristetraprolin (TTP) family proteins. Kedar VP, et al. J Biol Chem, 2012 Feb 17. PMID 22203679.
    2. AUF-1 and YB-1 are critical determinants of β-globin mRNA expression in erythroid cells. van Zalen S, et al. Blood, 2012 Jan 26. PMID 22134169.
    3. Identification of ubiquitinated proteins from human multiple myeloma U266 cells by proteomics. Jia H, et al. Biomed Environ Sci, 2011 Aug. PMID 22108332.
    4. The role of AUF1 in regulated mRNA decay. Gratacós FM, et al. Wiley Interdiscip Rev RNA, 2010 Nov-Dec. PMID 21956942.
    5. Proteomic dissection of the von Hippel-Lindau (VHL) interactome. Lai Y, et al. J Proteome Res, 2011 Nov 4. PMID 21942715.

    See all (100) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the ability of AUF1 isoforms to regulate the mRNA binding and decay-promoting activities of TTP
      Title: Direct binding of specific AUF1 isoforms to tandem zinc finger domains of tristetraprolin (TTP) family proteins.
    2. Data suggest that AUF-1 and YB-1 are required for normal accumulation of beta-globin mRNA in erythroid cells; YB-1 and AUF-1 exhibit sequence-specific binding to 3-prime-untranslated region of beta-globin mRNA.
      Title: AUF-1 and YB-1 are critical determinants of β-globin mRNA expression in erythroid cells.
    3. This review briefly describes the roles of mRNA decay in gene expression in general and ARE-mediated decay (AMD) in particular, with a focus on AUF1 and the different modes of regulation that govern AUF1 involvement in AMD.
      Title: The role of AUF1 in regulated mRNA decay.
    4. Knockdown AUF1 mRNA expression by AUF1 siRNA in MKP-1 WT bone marrow macrophages significantly delayed degradation of IL-6, IL-10 and TNF- alpha mRNAs compared with controls
      Title: MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1.
    5. p16( INK4a) is also a modulator of transcription and apoptosis through controlling the expression of two major transcription regulators, AUF1 and E2F1
      Title: p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.
    6. These results suggest that the p38 MAP kinase (MAPK)-MK2-Hsp27 signaling axis may target AUF1 destruction by proteasomes, thereby promoting AU-rich element mRNA stabilization.
      Title: Chaperone Hsp27 modulates AUF1 proteolysis and AU-rich element-mediated mRNA degradation.
    7. p40(AUF1) regulates a critical node within the NF-kappaB signaling pathway to permit IL10 induction for the anti-inflammatory arm of an innate immune response.
      Title: RNA-binding protein AUF1 regulates lipopolysaccharide-induced IL10 expression by activating IkappaB kinase complex in monocytes.
    8. Alternatively expressed domains of AU-rich element RNA-binding protein 1 (AUF1) regulate RNA-binding affinity, RNA-induced protein oligomerization, and the local conformation of bound RNA ligands
      Title: Alternatively expressed domains of AU-rich element RNA-binding protein 1 (AUF1) regulate RNA-binding affinity, RNA-induced protein oligomerization, and the local conformation of bound RNA ligands.
    9. the degradation of bcl-2 mRNA induced by AS1411 results from both interference with nucleolin protection of bcl-2 mRNA and recruitment of the exosome by AUF1.
      Title: Mechanism of regulation of bcl-2 mRNA by nucleolin and A+U-rich element-binding factor 1 (AUF1).
    10. Leukotriene B(4) BLT receptor signaling regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of Ras/Raf/ERK/p42 AUF1 pathway
      Title: Leukotriene B(4) BLT receptor signaling regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of Ras/Raf/ERK/p42 AUF1 pathway.
    Submit: New GeneRIF Correction See all (41)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_112737.1 NP_002958.2 SAFB    BIND  PubMed AUF1p42 interacts with SAF-B. 
    NP_112738.1 NP_002958.2 SAFB    BIND  PubMed AUF1p45 interacts with SAF-B. 
    Q14103 O75534 CSDE1    HPRD  PubMed  
    Q14103 Q9NPD3 EXOSC4    HPRD  PubMed  
    Q14103 P49841 GSK3B    HPRD  PubMed  
    Q14103 Q14103 HNRNPD    HPRD  PubMed  
    Q14103 IGF II mRNA-binding protein 2 IGF2BP2    HPRD  PubMed  
    Q14103 P00338 LDHA    HPRD  PubMed  
    Q14103 Q9Y4Y9 LSM5    HPRD  PubMed  
    Q14103 P11940 PABPC1    HPRD  PubMed  
    Q14103 Q15365 PCBP1    HPRD  PubMed  
    Q14103 Q15366 PCBP2    HPRD  PubMed  
    Q14103 Q16549 PCSK7    HPRD  PubMed  
    Q14103 P17612 PRKACA    HPRD  PubMed  
    Q14103 Q15424 SAFB    HPRD  PubMed  
    Q14103 P31947 SFN    HPRD  PubMed  
    Q14103 Q8WXA9 SREK1    HPRD  PubMed  
    Q14103 Q6EEV6 SUMO4    HPRD  PubMed  
    Q14103 O60506 SYNCRIP    HPRD  PubMed  
    Q14103 Q92973 TNPO1    HPRD  PubMed  
    Q14103 P63279 UBE2I    HPRD  PubMed  
    Q14103 P67809 YBX1    HPRD  PubMed  
    BioGRID:109425 BioGRID:114342 BANF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:221186 Cep152    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:971788 EBNA-LP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:108296 EIF4G1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109425 BioGRID:116452 GPN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109425 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:109425 HNRNPD    BioGRID  PubMed FRET 
    BioGRID:109425 BioGRID:109428 HNRNPH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109425 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109425 BioGRID:109547 HSPB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; FRET 
    BioGRID:109425 BioGRID:109548 HSPB2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; FRET 
    BioGRID:109425 BioGRID:128436 KHDRBS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:200937 Kif1c    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:117180 LSM5    BioGRID  PubMed Two-hybrid 
    BioGRID:109425 BioGRID:111583 MAPK6    BioGRID  PubMed Two-hybrid 
    BioGRID:109425 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:114652 MTA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109425 BioGRID:117939 PABPC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109425 BioGRID:111126 PCBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:109425 BioGRID:111127 PCBP2    BioGRID  PubMed Two-hybrid 
    BioGRID:109425 BioGRID:112201 SAFB    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109425 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:207949 Shoc2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:113065 TRNAN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109425 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109425 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109425 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Destabilization of mRNA by AUF1 (hnRNP D0), organism-specific biosystem (from REACTOME)
      Destabilization of mRNA by AUF1 (hnRNP D0), organism-specific biosystemAUF1 (hnRNP D0) dimers bind U-rich regions of AU-rich elements (AREs) in the 3' untranslated regions of mRNAs. The binding causes AUF1 dimers to assemble into higher order tetrameric complexes. Dipho...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Regulation of mRNA Stability by Proteins that Bind AU-rich Elements, organism-specific biosystem (from REACTOME)
      Regulation of mRNA Stability by Proteins that Bind AU-rich Elements, organism-specific biosystemRNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-eleme...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    RNA catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    RNA metabolic process TAS
    Traceable Author Statement
    more info
    		  
    RNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    RNA splicing TAS
    Traceable Author Statement
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    mRNA metabolic process TAS
    Traceable Author Statement
    more info
    		  
    mRNA stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    heterogeneous nuclear ribonucleoprotein complex NAS
    Non-traceable Author Statement
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein D0
    Names
    heterogeneous nuclear ribonucleoprotein D0
    hnRNP D0
    ARE-binding protein AUFI, type A
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029103.1 RefSeqGene

      Range
      5001..25683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001003810.1 → NP_001003810.1  heterogeneous nuclear ribonucleoprotein D0 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame segments, compared to variant 1. The resulting isoform (d), also known as p37, is shorter than isoform a.
      Source sequence(s)
      AF039575, BC023977, BF693760, BG180865, BG180941, BG325979, BM832779
      UniProtKB/Swiss-Prot
      Q14103
      Related
      ENSP00000426446, OTTHUMP00000219401, ENST00000514671, OTTHUMT00000363120
      Conserved Domains (1) summary
      cd00590
      Location:79 – 157
      Blast Score: 182
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

    2. NM_002138.3 → NP_002129.2  heterogeneous nuclear ribonucleoprotein D0 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment, compared to variant 1. The resulting isoform (c), also known as p40, is shorter than isoform a.
      Source sequence(s)
      AF039575, BC023977, BF693760, BM825808
      Consensus CDS
      CCDS3590.1
      UniProtKB/Swiss-Prot
      Q14103
      Related
      ENSP00000313327, OTTHUMP00000160799, ENST00000353341, OTTHUMT00000252631
      Conserved Domains (1) summary
      cd00590
      Location:98 – 176
      Blast Score: 186
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

    3. NM_031369.2 → NP_112737.1  heterogeneous nuclear ribonucleoprotein D0 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. The resulting isoform (b), also known as p42, is shorter than isoform a.
      Source sequence(s)
      AF039575, BC002401, BC023977, BF693760, BG180865, BG180941, BG325979, BM832779
      Consensus CDS
      CCDS3591.1
      UniProtKB/Swiss-Prot
      Q14103
      Related
      ENSP00000305860, OTTHUMP00000160800, ENST00000352301, OTTHUMT00000252632
      Conserved Domains (1) summary
      cd00590
      Location:79 – 157
      Blast Score: 184
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

    4. NM_031370.2 → NP_112738.1  heterogeneous nuclear ribonucleoprotein D0 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a), also known as p45.
      Source sequence(s)
      AF039575, BC002401, BC023977, BF693760, BG180865, BG180941, BM825808, BM832779
      Consensus CDS
      CCDS3592.1
      UniProtKB/Swiss-Prot
      Q14103
      Related
      ENSP00000313199, OTTHUMP00000160798, ENST00000313899, OTTHUMT00000252630
      Conserved Domains (1) summary
      cd00590
      Location:98 – 176
      Blast Score: 188
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      83274467..83295149, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      79014546..79035236, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC124016.3 AAY40913.1
    genomic AF026126.1 AAC23474.1
      AAC23475.1
      AAC23476.1
    genomic CH471057.1 EAX05872.1
      EAX05873.1
      EAX05874.1
      EAX05875.1
      EAX05876.1
      EAX05877.1
      EAX05878.1
      EAX05879.1
      EAX05880.1
      EAX05881.1
      EAX05882.1
      EAX05883.1
    genomic HB887011.1 CBF67662.1
    genomic HC944420.1 CBU92536.1
    mRNA AF039575.1 AAB96683.1
    mRNA AK057836.1 None
    mRNA AK292707.1 BAF85396.1
    mRNA AK300149.1 BAG61935.1
    mRNA AK303552.1 BAG64576.1
    mRNA BC002401.1 AAH02401.1
    mRNA BC023977.2 AAH23977.1
    mRNA BC026015.2 AAH26015.1
    mRNA BF693760.1 None
    mRNA BG180865.1 None
    mRNA BG180941.1 None
    mRNA BG325979.1 None
    mRNA BM825808.1 None
    mRNA BM832779.1 None
    mRNA D55671.1 BAA09522.1
    mRNA D55672.1 BAA09523.1
    mRNA D55673.1 BAA09524.1
    mRNA D55674.1 BAA09525.1
    mRNA M94630.1 AAA35781.1
    mRNA X03910.1 CAA27544.1
    other-genetic DQ892240.2 ABM83166.1
    other-genetic DQ895440.2 ABM86366.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12771 GenPept UniProtKB/TrEMBL:Q12771
    Q14103.1 GenPept UniProtKB/Swiss-Prot:Q14103
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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