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NCL nucleolin [ Homo sapiens (human) ]

Gene ID: 4691, updated on 14-Apr-2016
Official Symbol
NCLprovided by HGNC
Official Full Name
nucleolinprovided by HGNC
Primary source
HGNC:HGNC:7667
See related
Ensembl:ENSG00000115053 HPRD:01245; MIM:164035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C23
Summary
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
Orthologs
Location:
2q37.1
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (231454748..231464494, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (232319459..232329208, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene HIG1 hypoxia inducible domain family member 2A pseudogene Neighboring gene zinc finger and BTB domain containing 8 opposite strand pseudogene 2 Neighboring gene small nucleolar RNA, H/ACA box 75 Neighboring gene small nucleolar RNA, C/D box 20 Neighboring gene small nucleolar RNA, C/D box 82 Neighboring gene long intergenic non-protein coding RNA 471 Neighboring gene neuromedin U receptor 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of nucleolin and modulates the expression of LC3, leading to autophage and cell death of uninfected CD4 T cells PubMed
env Tandem affinity purification and mass spectrometry analysis identify nucleolin (NCL), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify nucleolin (NCL), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify nucleolin (NCL), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag The presence of HIV-1 Gag protein upregulates the levels of cytoplasmic nucleolin in Gag expression 293T cells PubMed
gag Tandem affinity purification and mass spectrometry analysis identify nucleolin (NCL), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
gag Nucleolin binds HIV-1 Gag and enhances the release of HIV-1 virions containing viral genomic RNA with the RNA packaging signal, psi PubMed
gag Nucleolin is incorporated into HIV-1 particles during budding of HIV-1 from lipid rafts and following virus entry into cells is recovered in fractions containing HIV-1 DNA, the Matrix protein of HIV-1 Gag and HIV-1 Reverse Transcriptase PubMed
Tat tat Nucleolin is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
matrix gag Nucleolin is incorporated into HIV-1 particles during budding of HIV-1 from lipid rafts and following virus entry into cells is recovered in fractions containing HIV-1 DNA, Matrix and Reverse Transcriptase proteins PubMed
nucleocapsid gag Nucleolin is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
reverse transcriptase gag-pol After HIV entry into cells, equilibrium density fractionation of cellular extracts revealed cell surface nucleolin is recovered in fractions containing actin, HIV DNA, viral matrix, and reverse transcriptase, suggesting nucleolin accompanies viral entry PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ45706, FLJ59041

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ErbB-4 class receptor binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
histone binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
laminin binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA primary transcript binding IEA
Inferred from Electronic Annotation
more info
 
selenocysteine insertion sequence binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
telomeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
liver regeneration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
regulation of rRNA processing IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
dense fibrillar component IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
fibrillar center IEA
Inferred from Electronic Annotation
more info
 
intracellular ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005381.2NP_005372.2  nucleolin

    See identical proteins and their annotated locations for NP_005372.2

    Status: REVIEWED

    Source sequence(s)
    AK000221, AK001314, BM761058, BQ001029
    Consensus CDS
    CCDS33397.1
    UniProtKB/Swiss-Prot
    P19338
    UniProtKB/TrEMBL
    A0A024R4A0, B3KM80
    Related
    ENSP00000318195, OTTHUMP00000204507, ENST00000322723, OTTHUMT00000332731
    Conserved Domains (5) summary
    smart00360
    Location:573642
    RRM; RNA recognition motif
    cd12403
    Location:307381
    RRM1_NCL; RNA recognition motif 1 in vertebrate nucleolin
    cd12404
    Location:390465
    RRM2_NCL; RNA recognition motif 2 in vertebrate nucleolin
    cd12405
    Location:485557
    RRM3_NCL; RNA recognition motif 3 in vertebrate nucleolin
    cd12406
    Location:572649
    RRM4_NCL; RNA recognition motif 4 in vertebrate nucleolin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    231454748..231464494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    232325275..232335021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)