NMT2 N-myristoyltransferase 2 [Homo sapiens] - Gene

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Summary

Official Symbol: NMT2provided by HGNC
Official Full Name: N-myristoyltransferase 2provided by HGNC
Primary source: HGNC:7858
Locus tag: RP11-455B2.2
See related: Ensembl:ENSG00000152465; HPRD:11948; MIM:603801; Vega:OTTHUMG00000017723
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The predicted 498-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 10p13

Sequence :: Chromosome: 10; NC_000010.10 (15147771..15210695, complement)

See NMT2 in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Nef is preferentially myristoylated by NMT2, suggesting that selective inhibition of NMT2 may provide a novel means of blocking HIV virulence.
Title: N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef.
Disruption of the gene for NMT2 by a t(8;10) translocation in a male with hypogonadism.
Title: Is the disruption of an N-myristoyltransferase (NMT2) associated with hypoplastic testes?
Protein-protein interaction of NMTs revealed that m-calpain interacts with NMT1 while caspase-3 interacts with NMT2.
Title: N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system.
Involved in progression and regulation of telomerase
Title: Genes associated with telomerase activity levels in esophageal carcinoma cell lines.
induction of NMT2 may play a central role in dioxin carcinogenicity.
Title: Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2.
NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation
Title: Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
matrix	gag	HIV-1 Matrix is myristoylated on its N-terminal glycine residue by N-myristoyltransferase, a chemical modification important for membrane targeting of Gag/Matrix, for facilitating Matrix multimerization, and for virus particle formation and budding	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
O60551	P10415	BCL2	HPRD	PubMed
O60551	P42574	CASP3	HPRD	PubMed
O60551	P04637	TP53	HPRD	PubMed
BioGRID:114794	BioGRID:106804	ANXA4	BioGRID	PubMed	Two-hybrid
BioGRID:114794	BioGRID:106807	ANXA7	BioGRID	PubMed	Two-hybrid
BioGRID:114794	BioGRID:107843	CSNK2B	BioGRID	PubMed	Two-hybrid
BioGRID:114794	BioGRID:111576	PRKCZ	BioGRID	PubMed	Two-hybrid
BioGRID:114794	BioGRID:112490	SMN1	BioGRID	PubMed	Two-hybrid
BioGRID:114794	BioGRID:112938	TK1	BioGRID	PubMed	Two-hybrid
BioGRID:114794	BioGRID:1205537	gag	BioGRID	PubMed	Biochemical Activity

Function	Evidence Code	Pubs
catalytic activity	TAS Traceable Author Statement more info	PubMed
glycylpeptide N-tetradecanoyltransferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring acyl groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
N-terminal protein myristoylation	IEA Inferred from Electronic Annotation more info
egress of virus within host cell	TAS Traceable Author Statement more info
protein lipoylation	TAS Traceable Author Statement more info	PubMed
viral reproduction	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: glycylpeptide N-tetradecanoyltransferase 2

Names: glycylpeptide N-tetradecanoyltransferase 2; NMT 2; type II N-myristoyltransferase; peptide N-myristoyltransferase 2; myristoyl-CoA:protein N-myristoyltransferase 2

NP_004799.1

EC 2.3.1.97

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004808.2 → NP_004799.1 glycylpeptide N-tetradecanoyltransferase 2

Status: REVIEWED

Source sequence(s)

AF043325, AL590365

Consensus CDS

CCDS7109.1

UniProtKB/Swiss-Prot

O60551

Related

ENSP00000367407, OTTHUMP00000019188, ENST00000378165, OTTHUMT00000046958

Conserved Domains (2) summary

pfam01233
Location:138 – 296
Blast Score: 778

NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain

pfam02799
Location:310 – 497
Blast Score: 920

NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p5 Primary Assembly

Range

15147771..15210695, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

15057910..15120095, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL590365.14	CAH73971.1
		CAH73972.1
		CAH73973.1
genomic	CH471072.2	EAW86238.1
		EAW86239.1
genomic	EF445001.1	ACA06028.1
		ACA06029.1
mRNA	AF043325.1	AAC09295.1
mRNA	AF086423.1	None
mRNA	AK094904.1	BAG52951.1
mRNA	AK123732.1	None
mRNA	AK295277.1	BAG58261.1
mRNA	AK302101.1	BAG63483.1
mRNA	AK315085.1	BAG37550.1
mRNA	BC005232.1	AAH05232.1
mRNA	BC006376.2	AAH06376.1
mRNA	BT007024.1	AAP35670.1
other-genetic	DQ890667.2	ABM81593.1
other-genetic	DQ893848.2	ABM84774.1