TNFRSF1B tumor necrosis factor receptor superfamily, member 1B [Homo sapiens (human)] - Gene

Summary

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Official Symbol: TNFRSF1Bprovided by HGNC
Official Full Name: tumor necrosis factor receptor superfamily, member 1Bprovided by HGNC
Primary source: HGNC:11917
See related: Ensembl:ENSG00000028137; HPRD:01862; MIM:191191; Vega:OTTHUMG00000001829
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 1p36.22

Sequence :: Chromosome: 1; NC_000001.10 (12227060..12269277)

See TNFRSF1B in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The TNFRSF1B 587G allele is not associated with the severity of heart failure phenotype or clinical outcomes in patients with chronic congestive heart failure.
Title: The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.
TNF-R75 was higher in anorexia nervosa patients with duration of disease longer than one year as compared to controls and patients with shorter duration. TNF-R75 inversely correlated with BMI and directly with disease duration.
Title: Tumour necrosis factor alpha and oxidative stress as maintaining factors in the evolution of anorexia nervosa.
Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b .... are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease
Title: Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease.
Suggest the effects of chronic E(2) to be dependent on TNFR2 signaling in endothelial cells.
Title: Estradiol modulates tumor necrosis factor-induced endothelial inflammation: role of tumor necrosis factor receptor 2.
Individuals in the Chinese Han population with the TNFRSF1B 15 bp insertion allele may be at higher risk for migraine, warranting further replication association studies and follow-up functional experiments.
Title: Association analysis of TNFRSF1B polymorphism with susceptibility for migraine in the Chinese Han population.
The high frequency of 196R allele in the functional M196R polymorphism of TNFR2 is a risk factor for acne vulgaris in Han Chinese.
Title: TNFR 2 M196R polymorphism and acne vulgaris in Han Chinese: a case-control study.
results suggest that TNFR2 expressed on podocytes and its canonical NF-kappaB signaling may directly interpose the compound pathogenic responses by podocytes to TNF-alpha, in the absence of other TNFR2-positive renal cell types in proliferative podocytopathies
Title: TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α.
No significant associations were found between TNFalpha -857C-->T and TNFR2 676T-->G polymorphisms and semen quality. TNFR1 36A allele is associated with increased sperm concentration and motility, supporting the significance of TNFR1 gene in semen quality
Title: Association of TNFα, TNFR1, and TNFR2 polymorphisms with sperm concentration and motility.
potential biomarker in predicting preeclampsia
Title: A positive correlation between hydrogen peroxide and soluble TNF-alpha receptor 2 early in maternal blood and at term in placenta of pregnant women with preeclampsia.
Both internalization and ASK1-interacting protein-1 association are required for TNFR2-dependent JNK and apoptotic signaling in endothelial cells.
Title: Both internalization and AIP1 association are required for tumor necrosis factor receptor 2-mediated JNK signaling.

Submit: New GeneRIF Correction See all (188)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates mu opioid receptor (MOR) expression in TPA-differentiated HL-60 cells; treatment with TNF-alpha neutralizing antibody as well as anti-TNF-alpha receptor type II (TNFR-II) antibody, inhibits gp120-induced upregulation of MOR	PubMed
	env	Apoptosis of CD8+ cells is mediated by the interaction between TNF-alpha bound to the membrane of macrophages (mbTNF) and a receptor on CD8+ T cells (TNF-receptor II, or TNFRII), which is upregulated by treatment with recombinant HIV-1 gp120 or SDF-1	PubMed
Tat, p14	tat	HIV-1 Tat downregulates the cell surface expression of the p80 form of the tumor necrosis factor receptor (TNFR2)	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001057.1	NP_000585.2	TNF	BIND	PubMed	TNF-alpha interacts with TNFR-2.
NP_001057.1	NP_066961.2	TRAF2	BIND	PubMed	TRAF2 interacts with TRAF1. This interaction was modeled on a demonstrated interaction between human TRAF2 and TNF-R2 from an unspecified species.
P20333	P51813	BMX	HPRD	PubMed
P20333	Q03135	CAV1	HPRD	PubMed
P20333	P48729	CSNK1A1	HPRD	PubMed
P20333	Q9BXW9	FANCD2	HPRD	PubMed
P20333	HIVEP3	HIVEP3	HPRD	PubMed
P20333	P05783	KRT18	HPRD	PubMed
P20333	P01374	LTA	HPRD	PubMed
P20333	P42224	STAT1	HPRD	PubMed
P20333	O95551	TDP2	HPRD	PubMed
P20333	P01375	TNF	HPRD	PubMed
P20333	Q13077	TRAF1	HPRD	PubMed
P20333	Q12933	TRAF2	HPRD	PubMed
P20333	Q13114	TRAF3	HPRD	PubMed
P20333	Q9BWF2	TRAIP	HPRD	PubMed
BioGRID:112987	BioGRID:119317	ASB3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112987	BioGRID:107305	CAV1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112987	BioGRID:107367	CD14	BioGRID	PubMed	Two-hybrid
BioGRID:112987	BioGRID:107569	CHUK	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112987	BioGRID:107836	CSNK1A1	BioGRID	PubMed	Biochemical Activity
BioGRID:112987	BioGRID:108474	FANCD2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112987	BioGRID:110073	KRT18	BioGRID	PubMed	Reconstituted Complex
BioGRID:112987	BioGRID:111571	PKN1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112987	BioGRID:114274	RIPK1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112987	BioGRID:122265	SMURF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112987	BioGRID:119615	TDP2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:112987	BioGRID:112979	TNF	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112987	BioGRID:112986	TNFRSF1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112987	BioGRID:112987	TNFRSF1B	BioGRID	PubMed	Affinity Capture-Western; FRET
BioGRID:112987	BioGRID:114257	TRADD	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112987	BioGRID:113037	TRAF1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:112987	BioGRID:113038	TRAF2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
BioGRID:112987	BioGRID:113039	TRAF3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112987	BioGRID:113041	TRAF6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112987	BioGRID:115581	TRAIP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112987	BioGRID:110678	TRIM37	BioGRID	PubMed	Reconstituted Complex
BioGRID:112987	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112987	BioGRID:119007	UBQLN1	BioGRID	PubMed	Two-hybrid
BioGRID:112987	BioGRID:127098	ZNF420	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

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Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Adipocytokine signaling pathway, conserved biosystem (from KEGG)
Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
Apoptosis, organism-specific biosystem (from WikiPathways)
Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
Inflammatory Response Pathway, organism-specific biosystem
Inflammatory Response Pathway
TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
TNF receptor signaling pathway, organism-specific biosystem
TNF receptor signaling pathway
TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...

General gene information

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Markers

RH63769 (e-PCR)
- UniSTS:14599

PMC156606P3 (e-PCR)
- UniSTS:271410

GDB:315093 (e-PCR)
- UniSTS:15167

TNFRSF1B_287 (e-PCR)
- UniSTS:277829

G15915 (e-PCR)
- UniSTS:32079

SHGC-31494 (e-PCR)
- UniSTS:31588

Genotypes

See TNFRSF1B SNP Geneview Report
See TNFRSF1B SNP Genotype Report
See TNFRSF1B SNP Variation Viewer Report

Homology

Homologs of the TNFRSF1B gene: The TNFRSF1B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
tumor necrosis factor-activated receptor activity	IEA Inferred from Electronic Annotation more info
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
RNA destabilization	IEA Inferred from Electronic Annotation more info
apoptotic process	IEA Inferred from Electronic Annotation more info
cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info
immune response	IEA Inferred from Electronic Annotation more info
inflammatory response	IEA Inferred from Electronic Annotation more info
negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
positive regulation of membrane protein ectodomain proteolysis	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane raft	IDA Inferred from Direct Assay more info	PubMed
neuronal cell body	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
varicosity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 1B

Names: tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; soluble TNFR1B variant 1; tumor necrosis factor receptor 2; tumor necrosis factor beta receptor; tumor necrosis factor receptor type II; tumor necrosis factor binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029791.1 RefSeqGene

Range

5001..47218

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001066.2 → NP_001057.1 tumor necrosis factor receptor superfamily member 1B precursor

Status: REVIEWED

Source sequence(s)

M32315

Consensus CDS

CCDS145.1

UniProtKB/Swiss-Prot

P20333

Related

ENSP00000365435, OTTHUMP00000001784, ENST00000376259, OTTHUMT00000005133

Conserved Domains (2) summary

cd00185
Location:40 – 141
Blast Score: 243

TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

cl12111
Location:142 – 200
Blast Score: 113

TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p10 Primary Assembly

Range

12227060..12269277

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

11380310..11422542

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018912.1 Alternate CHM1_1.0

Range

12245361..12287698

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB030949.1	BAA89052.1
genomic	AB030950.1	BAA89053.1
genomic	AB030951.1	BAA89054.1
genomic	AB030952.1	BAA89055.1
genomic	ABBA01003075.1 (12556..54788)	None
genomic	AL031276.1 (102394..113601)	None
genomic	AL357835.11 (120488..151497)	None
genomic	AMYH01000261.1 (147762..190099)	None
genomic	AY264804.1	AAO89076.1
genomic	AY342040.1	AAP88939.1
genomic	CH471130.1	EAW71731.1
		EAW71732.1
		EAW71733.1
		EAW71734.1
		EAW71735.1
genomic	CS068584.1	CAI84623.1
genomic	GN344135.1	CAY56003.1
genomic	HI179124.1	CBX53870.1
genomic	JA362586.1	CCA94575.1
genomic	U52165.1	AAC50622.1
genomic	X80021.1	CAA56324.1
mRNA	AY148473.1	AAN72434.1
mRNA	BC011844.2	AAH11844.1
mRNA	BC042167.1	AAH42167.1
mRNA	BC052977.1	AAH52977.1
mRNA	BT019927.1	AAV38730.1
mRNA	EU826615.1	ACF47651.1
mRNA	M32315.1	AAA59929.1
mRNA	M35857.1	AAA63262.1
mRNA	M55994.1	AAA36755.1
mRNA	S63368.1	AAB19824.2