HMOX1 heme oxygenase (decycling) 1 [Homo sapiens] - Gene

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Summary

Official Symbol: HMOX1provided by HGNC
Official Full Name: heme oxygenase (decycling) 1provided by HGNC
Primary source: HGNC:5013
Locus tag: CTA-286B10.6
See related: Ensembl:ENSG00000100292; HPRD:00782; MIM:141250; Vega:OTTHUMG00000150960
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HO-1; HSP32; bK286B10
Summary: Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 22q13.1

Sequence :: Chromosome: 22; NC_000022.10 (35777060..35790207)

See HMOX1 in Epigenomics, MapViewer

Chromosome 22 - NC_000022.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HO-1 expression increased resistance of K562 cells to hemin.
Title: [Effects of HO-1 gene expression on proliferation of imatinib resistant CML cells].
HO-1 system may function as a crucial negative regulator in the modulation of inflammatory proces
Title: Heme oxygenase-1 system, inflammation and ventilator-induced lung injury.
long (GT)n repeats in the microsatellite polymorphism region of the HMOX1 gene, the Hp2 allele, and the Hp2.2 genotype were associated with symptomatic malaria.
Title: Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria.
Concurrent inhibition of HO-1 expression in conjunction with chemotherapeutic treatment would improve the number of cases who reach complete remission.
Title: Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1.
we have provided evidence that in neuroblastoma cells, the Nrf2/HO-1 axis plays a crucial role as a protective factor against cellular stress
Title: Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1.
Nineteen different alleles, ranging from 17 to 39 repeats, with (GT)(23) and (GT)(30) being the most common ones, were identified in heme oxygenase-1 promoter region in a Greek cohort .
Title: Genotype and allele frequencies of heme oxygenase-1 promoter region in a Greek cohort.
study shows for the first time that GT-repeats expansion in promoter of the HO-1 gene is associated with oligospermia and azoospermia among Iranian infertile cases
Title: Study of GT-repeat expansion in Heme oxygenase-1 gene promoter as genetic cause of male infertility.
The expression level of HO enzyme is significantly decreased in the testis tissue of nonobstructive azoospermia patients.
Title: [Expression of heme oxygenase enzyme in the testis tissue and azoospermia].
These results imply that DM2 patients and individuals with MS carrying short/medium (SM) genotype of(GT)n repetition in might have higher susceptibility to develop diabetes consequences.
Title: Cross-talk between body iron stores and diabetes: iron stores are associated with activity and microsatellite polymorphism of the heme oxygenase and type 2 diabetes.
Quercetin protects primary human osteoblasts from cigarette smoke induced damage. Inhibition of HO-1 reverses protective effects of quercetin.
Title: Quercetin protects primary human osteoblasts exposed to cigarette smoke through activation of the antioxidative enzymes HO-1 and SOD-1.

Submit: New GeneRIF Correction See all (455)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Pulmonary disease, chronic obstructive, susceptibility to

MIM: 606963

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Products	Interactant	Other Gene	Source	Pubs	Description
P09601	P31749	AKT1	HPRD	PubMed
P09601	P30043	BLVRB	HPRD	PubMed
P09601	P09601	HMOX1	HPRD	PubMed
P09601	P29475	NOS1	HPRD	PubMed
P09601	P16435	POR	HPRD	PubMed
BioGRID:109405	BioGRID:109405	HMOX1	BioGRID	PubMed	Co-crystal Structure
BioGRID:109405	BioGRID:31473	HMX1	BioGRID	PubMed	Dosage Rescue
BioGRID:109405	BioGRID:111681	PSMD2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109405	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:109405	BioGRID:113200	UFD1L	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
enzyme binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
heme binding	IDA Inferred from Direct Assay more info	PubMed
heme oxygenase (decyclizing) activity	IDA Inferred from Direct Assay more info	PubMed
heme oxygenase (decyclizing) activity	IMP Inferred from Mutant Phenotype more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity	IEA Inferred from Electronic Annotation more info
phospholipase D activity	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
signal transducer activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
DNA damage response, signal transduction resulting in induction of apoptosis	IEA Inferred from Electronic Annotation more info
angiogenesis	TAS Traceable Author Statement more info	PubMed
anti-apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
cell death	ISS Inferred from Sequence or Structural Similarity more info
cellular iron ion homeostasis	TAS Traceable Author Statement more info
cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
cellular response to nutrient	IEA Inferred from Electronic Annotation more info
endothelial cell proliferation	TAS Traceable Author Statement more info	PubMed
erythrocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
excretion	IC Inferred by Curator more info	PubMed
heme catabolic process	IDA Inferred from Direct Assay more info	PubMed
heme catabolic process	TAS Traceable Author Statement more info
heme oxidation	IDA Inferred from Direct Assay more info	PubMed
intracellular protein kinase cascade	TAS Traceable Author Statement more info	PubMed
iron ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
low-density lipoprotein particle clearance	TAS Traceable Author Statement more info	PubMed
negative regulation of DNA binding	IEA Inferred from Electronic Annotation more info
negative regulation of leukocyte migration	TAS Traceable Author Statement more info	PubMed
negative regulation of mast cell cytokine production	IEA Inferred from Electronic Annotation more info
negative regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info
negative regulation of neuron apoptosis	IEA Inferred from Electronic Annotation more info
negative regulation of sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
porphyrin-containing compound metabolic process	TAS Traceable Author Statement more info
positive regulation of I-kappaB kinase/NF-kappaB cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of anti-apoptosis	IEA Inferred from Electronic Annotation more info
positive regulation of chemokine biosynthetic process	TAS Traceable Author Statement more info	PubMed
positive regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of vasodilation	IC Inferred by Curator more info	PubMed
protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
regulation of angiogenesis	TAS Traceable Author Statement more info	PubMed
regulation of blood pressure	IEA Inferred from Electronic Annotation more info
regulation of sequence-specific DNA binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
response to estrogen stimulus	IEA Inferred from Electronic Annotation more info
response to hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info
response to nicotine	IDA Inferred from Direct Assay more info	PubMed
response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
response to stimulus	IEA Inferred from Electronic Annotation more info
signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info
smooth muscle hyperplasia	TAS Traceable Author Statement more info	PubMed
transmembrane transport	TAS Traceable Author Statement more info
wound healing involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
caveola	IEA Inferred from Electronic Annotation more info
cytosol	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
endoplasmic reticulum membrane	TAS Traceable Author Statement more info
extracellular space	TAS Traceable Author Statement more info	PubMed
membrane fraction	TAS Traceable Author Statement more info	PubMed
microsome	ISS Inferred from Sequence or Structural Similarity more info
nucleolus	IEA Inferred from Electronic Annotation more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: heme oxygenase 1

Names: heme oxygenase 1; heat shock protein, 32-kD

NP_002124.1

EC 1.14.99.3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023030.1 RefSeqGene

Range

5001..18148

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002133.2 → NP_002124.1 heme oxygenase 1

Status: REVIEWED

Source sequence(s)

BP288767, CA306357, X06985

Consensus CDS

CCDS13914.1

UniProtKB/Swiss-Prot

P09601

UniProtKB/TrEMBL

Q6FH11

Related

ENSP00000216117, OTTHUMP00000198812, ENST00000216117, OTTHUMT00000320657

Conserved Domains (1) summary

cd00232
Location:12 – 218
Blast Score: 560

HemeO; Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000022.10 Reference GRCh37.p5 Primary Assembly

Range

35777060..35790207

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000154.1 Alternate HuRef

Range

18737577..18750716

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AY460337.1	AAR23262.1
genomic	CH471095.1	EAW60059.1
genomic	X14782.2	CAA32886.1
genomic	Z82244.1	CAB05109.1
		CAQ08826.1
genomic	Z82244.1	CAB05109.1
		CAQ08826.1
mRNA	AF051791.1	None
mRNA	AK313120.1	BAG35941.1
mRNA	BC001491.2	AAH01491.1
mRNA	BP288767.1	None
mRNA	BT019785.1	AAV38588.1
mRNA	CA306357.1	None
mRNA	CR456505.1	CAG30391.1
mRNA	CR541945.1	CAG46743.1
mRNA	CR541968.1	CAG46766.1
mRNA	JF323038.1	ADZ76424.1
mRNA	M23041.1	AAA50403.1
mRNA	M23042.1	None
mRNA	X06985.1	CAA30045.1
other-genetic	CU013103.1	CAK54534.1
other-genetic	CU013391.1	CAK54833.1
other-genetic	DQ892310.2	ABM83236.1
other-genetic	DQ895510.2	ABM86436.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P09601.1	GenPept	UniProtKB/Swiss-Prot:P09601
Q6FH11	GenPept	UniProtKB/TrEMBL:Q6FH11
Q96DI8	GenPept	UniProtKB/TrEMBL:Q96DI8