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    AP2B1 adaptor-related protein complex 2, beta 1 subunit [ Homo sapiens ]

    Gene ID: 163, updated on 12-May-2012
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    Summary

    Official Symbol
    AP2B1provided by HGNC
    Official Full Name
    adaptor-related protein complex 2, beta 1 subunitprovided by HGNC
    Primary source
    HGNC:563
    See related
    Ensembl:ENSG00000006125; HPRD:03015; MIM:601025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADTB2; AP105B; CLAPB1; AP2-BETA; DKFZp781K0743
    Summary
    The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    17q11.2-q12
    Sequence :
    Chromosome: 17; NC_000017.10 (33914282..34053436)
    See AP2B1 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene transmembrane protein 160 pseudogene Neighboring gene ribosomal protein L17 pseudogene 42 Neighboring gene RAS-like, family 10, member B Neighboring gene growth arrest-specific 2 like 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. Martins-de-Souza D, et al. J Proteome Res, 2012 Apr 6. PMID 22360420.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Purification and identification of endogenous polySUMO conjugates. Bruderer R, et al. EMBO Rep, 2011 Feb. PMID 21252943.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (58) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    2. Results suggest that autosomal recessive hypercholesterolemia (ARH) and beta-arrestin depend on a privileged AP2beta2 appendage site for proper cargo recruitment to clathrin bud sites.
      Title: The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis.
    3. multiple interactions between PIPKI gamma-p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P(2) synthesis during clathrin-mediated synaptic vesicle endocytosis
      Title: Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.
    4. EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics.
      Title: Immunohistochemical detection of EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics.
    5. AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization.
      Title: Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization.
    6. Clathrin, which interacts with the AP2beta-appendage, achieves ligand displacement in vivo by self-polymerisation as the coated pit matures.
      Title: Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.
    7. the AP-2 complex is not associated with the endocytosed plasma membrane-associated clathrin
      Title: The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin.
    8. interactions of the EGF receptor with AP-2 mediated by the receptor 974YRAL and di-leucine motifs may contribute to beta2 tyrosine phosphorylation
      Title: Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal growth factor receptor trafficking.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env Two independent motifs, a membrane proximal conserved GYxxO motif (residues 711-715) and a C-terminal dileucine motif (residues 855-856), of the HIV-1 gp41 protein mediate endocytosis through interaction with the clathrin adaptor AP-2 PubMed
    env The cytoplasmic domain (residues 707-856) of HIV-1 gp41 interacts with whole clathrin-associated AP-1 and AP-2 adaptor complexes PubMed
    Nef nef In cells expressing an HIV-1 Nef-green fluorescent protein (GFP) fusion, CD28 co-localizes with the AP-2 clathrin adaptor and Nef-GFP PubMed
    nef A dileucine-motif-containing segment of Nef binds directly to the beta subunit of the clathrin adaptor complexes AP-2, which are responsible for recruiting sorted proteins into clathrin coated pits PubMed
    nef HIV-1 Nef co-localizes with the beta subunit of the adaptor protein complexes (AP-2) in human T cells; Nef residues 174-179 are required for the co-localization of Nef with the beta subunit PubMed
    Pr55(Gag) gag HIV-1 Gag binds to AP-2, and this binding is dependent on tyrosine residue 132 and valine residue 135 at the matrix-capsid junction in the Gag polyprotein PubMed
    Tat tat HIV-1 Tat enters T cells by using clathrin/AP2-mediated endocytosis followed by low-pH-induced and Hsp90-assisted endosomal translocation, which leads to cell responses that are induced from the cytosol PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P63010 Q04771 ACVR1    HPRD  PubMed  
    P63010 Q9BXS5 AP1M1    HPRD  PubMed  
    P63010 Q9Y6Q5 AP1M2    HPRD  PubMed  
    P63010 O94973 AP2A2    HPRD  PubMed  
    P63010 Q96CW1 AP2M1    HPRD  PubMed  
    P63010 P53680 AP2S1    HPRD  PubMed  
    P63010 P49407 ARRB1    HPRD  PubMed  
    P63010 Q13315 ATM    HPRD  PubMed  
    P63010 O75348 ATP6V1G1    HPRD  PubMed  
    P63010 O43683 BUB1    HPRD  PubMed  
    P63010 O60566 BUB1B    HPRD  PubMed  
    P63010 Q14677 CLINT1    HPRD  PubMed  
    P63010 Q96C10 DHX58    HPRD  PubMed  
    P63010 Q5VWP2 FAM46C    HPRD  PubMed  
    P63010 O00291 HIP1    HPRD  PubMed  
    P63010 Q6ZU52 KIAA0408    HPRD  PubMed  
    P63010 Q5SW96 LDLRAP1    HPRD  PubMed  
    P63010 Q16626 MEA1    HPRD  PubMed  
    P63010 P40692 MLH1    HPRD  PubMed  
    P63010 Q9NVZ3 NECAP2    HPRD  PubMed  
    P63010 Q7Z3B4 NUP54    HPRD  PubMed  
    P63010 O60331 PIP5K1C    HPRD  PubMed  
    P63010 Q9Y2N3 POM121    HPRD  PubMed  
    P63010 Q9H4K1 RIBC2    HPRD  PubMed  
    P63010 Q13485 SMAD4    HPRD  PubMed  
    P63010 Q9HCE7 SMURF1    HPRD  PubMed  
    P63010 O60641 SNAP91    HPRD  PubMed  
    P63010 Q9NYB0 TERF2IP    HPRD  PubMed  
    P63010 P36897 TGFBR1    HPRD  PubMed  
    P63010 P37173 TGFBR2    HPRD  PubMed  
    P63010 Q9NVV9 THAP1    HPRD  PubMed  
    P63010 Gamma tubulin ring complex protein TUBGCP4    HPRD  PubMed  
    BioGRID:106672 BioGRID:114421 AP1M1    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:115364 AP1M2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106672 BioGRID:107587 AP2M1    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:106821 APC    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:106900 ARR3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106672 BioGRID:106902 ARRB2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106672 BioGRID:114922 ATP6V1G1    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:107166 BUB1B    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106672 BioGRID:115038 CLINT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106672 BioGRID:122553 DHX58    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:231562 Edc4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106672 BioGRID:120205 FAM46C    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:115078 KIAA0408    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:117561 LDLRAP1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106672 BioGRID:110365 MEA1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106672 BioGRID:110438 MLH1    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:120832 NECAP2    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:119759 NUP54    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:125385 OSBPL10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106672 BioGRID:115214 POM121    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:117581 RIBC2    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:116125 RNPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106672 BioGRID:220311 Rnf111    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106672 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106672 BioGRID:119942 TERF2IP    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:112904 TGFBR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106672 BioGRID:112906 TGFBR2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106672 BioGRID:120448 THAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:118078 TUBGCP4    BioGRID  PubMed Two-hybrid 
    BioGRID:106672 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • EGFR downregulation, organism-specific biosystem (from REACTOME)
      EGFR downregulation, organism-specific biosystemRegulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth...
    • Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
      Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
    • Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
      Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
      Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemExcitatory synaptic transmission in the brain is carried out by glutamate receptors through the activation of both ionotropic and metabotropic receptors. Ionotropic glutamate receptors are of three ...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Nef Mediated CD4 Down-regulation, organism-specific biosystem (from REACTOME)
      Nef Mediated CD4 Down-regulation, organism-specific biosystemThe presence of Nef accelerates endocytosis and lysosomal degradation of the transmembrane glycoprotein CD4. CD4 has its own internalization motif, though this motif is normally concealed by CD4 inte...
    • Nef Mediated CD8 Down-regulation, organism-specific biosystem (from REACTOME)
      Nef Mediated CD8 Down-regulation, organism-specific biosystemHuman immunodeficiency virus (HIV) Nef is a membrane-associated protein decreasing surface expression of CD4, CD28, and major histocompatibility complex class I on infected cells. Nef also strongly d...
    • Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystem (from REACTOME)
      Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystemThe maximal virulence of HIV-1 requires Nef, a virally encoded peripheral membrane protein. Nef binds to the adaptor protein (AP) complexes of coated vesicles, inducing an expansion of the endosomal ...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
      Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
    • Recycling pathway of L1, organism-specific biosystem (from REACTOME)
      Recycling pathway of L1, organism-specific biosystemL1 functions in many aspects of neuronal development including axon outgrowth and neuronal migration. These functions require coordination between L1 and the actin cytoskeleton. F-actin continuously ...
    • Retrograde neurotrophin signalling, organism-specific biosystem (from REACTOME)
      Retrograde neurotrophin signalling, organism-specific biosystemNeurotrophin-TRK complexes can be internalized and enter signalling vesicles, which travel retrogradely over long distances from distal nerve terminals to neuronal cell bodies. Such retrograde signal...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signal transduction by L1, organism-specific biosystem (from REACTOME)
      Signal transduction by L1, organism-specific biosystemBesides adhesive roles in cell cell interaction, L1 functions as a signal transducing receptor providing neurons with cues from their environment for axonal growth and guidance. L1 associates with be...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Synaptic vesicle cycle, organism-specific biosystem (from KEGG)
      Synaptic vesicle cycle, organism-specific biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    • Synaptic vesicle cycle, conserved biosystem (from KEGG)
      Synaptic vesicle cycle, conserved biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystem (from REACTOME)
      The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystemThe HIV-1 Nef protein is a 27-kDa myristoylated protein that is abundantly produced during the early phase of viral replication cycle. It is highly conserved in all primate lentiviruses, suggesting t...
    • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
      Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
    • Trafficking of GluR2-containing AMPA receptors, organism-specific biosystem (from REACTOME)
      Trafficking of GluR2-containing AMPA receptors, organism-specific biosystemTrafficking of GluR2-containing receptors is governed by protein protein interactions that are regulated by phosphorylation events. GluR2 binds NSF and AP2 in the proximal C terminal region and binds...
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    clathrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    axon guidance TAS
    Traceable Author Statement
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    regulation of defense response to virus by virus TAS
    Traceable Author Statement
    more info
    		  
    synaptic transmission TAS
    Traceable Author Statement
    more info
    		  
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    viral reproduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    AP-2 complex subunit beta
    Names
    AP-2 complex subunit beta
    beta-adaptin
    beta-2-adaptin
    adaptin, beta 2 (beta)
    adaptor protein complex AP-2 subunit beta
    adapter-related protein complex 2 beta subunit
    clathrin assembly protein complex 2 beta large chain
    plasma membrane adaptor HA2/AP2 adaptin beta subunit
    clathrin-associated/assembly/adaptor protein, large, beta 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030006.1 → NP_001025177.1  AP-2 complex subunit beta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AI691147, BC006201, BC012150, BQ421703, BX643620, M34175
      Consensus CDS
      CCDS32621.1
      UniProtKB/Swiss-Prot
      P63010
      UniProtKB/TrEMBL
      Q96EL6
      Related
      ENSP00000314414, ENST00000312678
      Conserved Domains (4) summary
      cd00020
      Location:118 – 230
      Blast Score: 150
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cl07618
      Location:840 – 950
      Blast Score: 420
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:38 – 534
      Blast Score: 1435
      Adaptin_N; Adaptin N terminal region
      cl03759
      Location:731 – 831
      Blast Score: 214
      Alpha_adaptinC2; Adaptin C-terminal domain

    2. NM_001282.2 → NP_001273.1  AP-2 complex subunit beta isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AI691147, BQ421703, BX643620, M34175
      Consensus CDS
      CCDS32622.1
      UniProtKB/Swiss-Prot
      P63010
      Related
      ENSP00000262325, ENST00000262325
      Conserved Domains (4) summary
      cd00020
      Location:118 – 230
      Blast Score: 150
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cl07618
      Location:826 – 936
      Blast Score: 419
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:38 – 534
      Blast Score: 1433
      Adaptin_N; Adaptin N terminal region
      cl03759
      Location:717 – 817
      Blast Score: 214
      Alpha_adaptinC2; Adaptin C-terminal domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      33914282..34053436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      30099253..30238599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC004134.1 None
    genomic AC006237.1 (61582..80165) None
    genomic AC015911.8 (174831..181560) None
    genomic CH471147.2 EAW80133.1
      EAW80134.1
      EAW80135.1
      EAW80136.1
      EAW80137.1
      EAW80138.1
      EAW80139.1
      EAW80140.1
      EAW80141.1
      EAW80142.1
    mRNA AI691147.1 None
    mRNA AK289528.1 BAF82217.1
    mRNA AK292531.1 BAF85220.1
    mRNA AK295667.1 BAG58527.1
    mRNA AK301522.1 BAG63026.1
    mRNA AK304126.1 BAG65023.1
    mRNA AY341427.1 AAQ20044.1
    mRNA BC006201.2 AAH06201.1
    mRNA BC012150.1 AAH12150.1
    mRNA BQ421703.1 None
    mRNA BX643620.1 None
    mRNA CR749392.1 CAH18240.1
    mRNA M34175.1 AAA35583.1
    other-genetic DQ893282.2 ABM84208.1
    other-genetic DQ896613.2 ABM87612.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63010.1 GenPept UniProtKB/Swiss-Prot:P63010
    Q68DI0 GenPept UniProtKB/TrEMBL:Q68DI0
    Q7Z451 GenPept UniProtKB/TrEMBL:Q7Z451
    Q96EL6 GenPept UniProtKB/TrEMBL:Q96EL6
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