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AP2B1 adaptor-related protein complex 2, beta 1 subunit [ Homo sapiens (human) ]

Gene ID: 163, updated on 12-Apr-2014
Official Symbol
AP2B1provided by HGNC
Official Full Name
adaptor-related protein complex 2, beta 1 subunitprovided by HGNC
Primary source
HGNC:563
See related
Ensembl:ENSG00000006125; HPRD:03015; MIM:601025; Vega:OTTHUMG00000179924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADTB2; AP105B; CLAPB1; AP2-BETA
Summary
The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Location :
17q11.2-q12
Sequence :
Chromosome: 17; NC_000017.11 (35586899..35726417)
See AP2B1 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene transmembrane protein 160 pseudogene Neighboring gene ribosomal protein L17 pseudogene 42 Neighboring gene RAS-like, family 10, member B Neighboring gene growth arrest-specific 2 like 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
New gene functions in megakaryopoiesis and platelet formation.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env The cytoplasmic domain (residues 707-856) of HIV-1 gp41 interacts with whole clathrin-associated AP-1 and AP-2 adaptor complexes PubMed
env Two independent motifs, a membrane proximal conserved GYxxO motif (residues 711-715) and a C-terminal dileucine motif (residues 855-856), of the HIV-1 gp41 protein mediate endocytosis through interaction with the clathrin adaptor AP-2 PubMed
Gag, Pr55 gag HIV-1 Gag binds to AP-2, and this binding is dependent on tyrosine residue 132 and valine residue 135 at the matrix-capsid junction in the Gag polyprotein PubMed
Nef, p27 nef A dileucine-motif-containing segment of Nef binds directly to the beta subunit of the clathrin adaptor complexes AP-2, which are responsible for recruiting sorted proteins into clathrin coated pits PubMed
nef Clathrin and the clathrin-associated, plasma membrane-localized AP2 complexes are required for the HIV-1 Nef-mediated downregulation of CD4 PubMed
nef In cells expressing an HIV-1 Nef-green fluorescent protein (GFP) fusion, CD28 co-localizes with the AP-2 clathrin adaptor and Nef-GFP PubMed
nef HIV-1 Nef co-localizes with the beta subunit of the adaptor protein complexes (AP-2) in human T cells; Nef residues 174-179 are required for the co-localization of Nef with the beta subunit PubMed
Tat, p14 tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of adaptor-related protein complex 2, beta 1 subunit (AP2B1) in U-937 macrophages PubMed
tat HIV-1 Tat enters T cells by using clathrin/AP2-mediated endocytosis followed by low-pH-induced and Hsp90-assisted endosomal translocation, which leads to cell responses that are induced from the cytosol PubMed

Go to the HIV-1, Human Protein Interaction Database

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  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
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  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
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    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
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    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • Nef Mediated CD4 Down-regulation, organism-specific biosystem (from REACTOME)
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  • Nef Mediated CD8 Down-regulation, organism-specific biosystem (from REACTOME)
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  • Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystem (from REACTOME)
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  • Neuronal System, organism-specific biosystem (from REACTOME)
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  • WNT5A-dependent internalization of FZD2, FZD5 and ROR2, organism-specific biosystem (from REACTOME)
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  • WNT5A-dependent internalization of FZD4, organism-specific biosystem (from REACTOME)
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  • beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
clathrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
protein transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
regulation of defense response to virus by virus TAS
Traceable Author Statement
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
coated pit IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
AP-2 complex subunit beta
Names
AP-2 complex subunit beta
beta-adaptin
beta-2-adaptin
adaptin, beta 2 (beta)
adaptor protein complex AP-2 subunit beta
adapter-related protein complex 2 beta subunit
adapter-related protein complex 2 subunit beta
clathrin assembly protein complex 2 beta large chain
plasma membrane adaptor HA2/AP2 adaptin beta subunit
clathrin-associated/assembly/adaptor protein, large, beta 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030006.1NP_001025177.1  AP-2 complex subunit beta isoform a

    See proteins identical to NP_001025177.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI691147, BC006201, BC012150, BQ421703, BX643620, M34175
    Consensus CDS
    CCDS32621.1
    UniProtKB/Swiss-Prot
    P63010
    UniProtKB/TrEMBL
    Q96EL6
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Blast Score: 223
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    Blast Score: 426
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    cd00020
    Location:118230
    Blast Score: 162
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01602
    Location:11534
    Blast Score: 1502
    Adaptin_N; Adaptin N terminal region
  2. NM_001282.2NP_001273.1  AP-2 complex subunit beta isoform b

    See proteins identical to NP_001273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AI691147, BQ421703, BX643620, M34175
    Consensus CDS
    CCDS32622.1
    UniProtKB/Swiss-Prot
    P63010
    Related
    ENSP00000262325, OTTHUMP00000262972, ENST00000262325, OTTHUMT00000448969
    Conserved Domains (4) summary
    smart00809
    Location:717817
    Blast Score: 224
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:826936
    Blast Score: 426
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    cd00020
    Location:118230
    Blast Score: 162
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01602
    Location:11534
    Blast Score: 1502
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11

    Range
    35586899..35726417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257941.1XP_005257998.1  

    Conserved Domains (2) summary
    cd00020
    Location:118230
    Blast Score: 161
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01602
    Location:11534
    Blast Score: 1477
    Adaptin_N; Adaptin N terminal region
  2. XM_005257937.1XP_005257994.1  

    See proteins identical to XP_005257994.1

    UniProtKB/Swiss-Prot
    P63010
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Blast Score: 223
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    Blast Score: 426
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    cd00020
    Location:118230
    Blast Score: 162
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01602
    Location:11534
    Blast Score: 1502
    Adaptin_N; Adaptin N terminal region
  3. XM_005257938.1XP_005257995.1  

    See proteins identical to XP_005257995.1

    UniProtKB/Swiss-Prot
    P63010
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Blast Score: 223
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    Blast Score: 426
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    cd00020
    Location:118230
    Blast Score: 162
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01602
    Location:11534
    Blast Score: 1502
    Adaptin_N; Adaptin N terminal region

Alternate HuRef

Genomic

  1. AC_000149.1 Alternate HuRef

    Range
    30099253..30238599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    33978907..34118050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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