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LYZ lysozyme [ Homo sapiens (human) ]

Gene ID: 4069, updated on 8-May-2016
Official Symbol
LYZprovided by HGNC
Official Full Name
lysozymeprovided by HGNC
Primary source
HGNC:HGNC:6740
See related
Ensembl:ENSG00000090382 HPRD:01085; MIM:153450; Vega:OTTHUMG00000169342
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LZM; LYZF1
Summary
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
Orthologs
Location:
12q15
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (69348354..69354233)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (69742134..69748013)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene cleavage and polyadenylation specific factor 6 Neighboring gene microRNA 1279 Neighboring gene core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 pseudogene 1 Neighboring gene YEATS domain containing 4 Neighboring gene uncharacterized LOC105369822 Neighboring gene ribosomal protein S26 pseudogene 45

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Familial visceral amyloidosis, Ostertag type
MedGen: C0268389 OMIM: 105200 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify lysozyme (LYZ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify lysozyme (LYZ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify lysozyme (LYZ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify lysozyme (LYZ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat HIV-1 Tat downregulates the expression of lysozyme (LYZ) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

  • Amyloid fiber formation, organism-specific biosystem (from REACTOME)
    Amyloid fiber formation, organism-specific biosystemAmyloid is a term used to describe deposits of fibrillar proteins, typically extracellular. The abnormal accumulation of amyloid, amyloidosis, is a term associated with tissue damage caused by amyloi...
  • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    C-MYB transcription factor network, organism-specific biosystem
    C-MYB transcription factor network
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lysozyme activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cytolysis IEA
Inferred from Electronic Annotation
more info
 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
retina homeostasis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
lysozyme C
Names
1,4-beta-N-acetylmuramidase C
c-type lysozyme
lysozyme F1
NP_000230.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008195.1 RefSeqGene

    Range
    5001..10880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_768

mRNA and Protein(s)

  1. NM_000239.2NP_000230.1  lysozyme C precursor

    See identical proteins and their annotated locations for NP_000230.1

    Status: REVIEWED

    Source sequence(s)
    AK130149, J03801
    Consensus CDS
    CCDS8989.1
    UniProtKB/Swiss-Prot
    P61626
    UniProtKB/TrEMBL
    B2R4C5
    Related
    ENSP00000261267, OTTHUMP00000240861, ENST00000261267, OTTHUMT00000403624
    Conserved Domains (1) summary
    cd00119
    Location:19143
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    69348354..69354233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    69710537..69716432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)