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    TRAF2 TNF receptor-associated factor 2 [ Homo sapiens ]

    Gene ID: 7186, updated on 19-May-2012
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    Summary

    Official Symbol
    TRAF2provided by HGNC
    Official Full Name
    TNF receptor-associated factor 2provided by HGNC
    Primary source
    HGNC:12032
    See related
    Ensembl:ENSG00000127191; HPRD:03538; MIM:601895; Vega:OTTHUMG00000020952
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRAP; TRAP3; MGC:45012
    Summary
    The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    9q34
    Sequence :
    Chromosome: 9; NC_000009.11 (139780965..139821067)
    See TRAF2 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene MAM domain containing 4 Neighboring gene endothelial differentiation-related factor 1 Neighboring gene microRNA 4479 Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene complement component 8, gamma polypeptide

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Identification of F-box only protein 7 as a negative regulator of NF-kappaB signaling. Kuiken HJ, et al. J Cell Mol Med, 2012 Jan 2. PMID 22212761.
    2. Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation. Liu J, et al. Proc Natl Acad Sci U S A, 2012 Jan 3. PMID 22184250.
    3. De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF. Mahul-Mellier AL, et al. Cell Death Differ, 2012 May. PMID 22179575.
    4. [Identification and expression analysis of a novel splice variant of human tumor necrosis factor receptor associated factor 2]. Luo HY, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2011 Nov. PMID 22078441.
    5. Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration. Xiao N, et al. Biochem J, 2012 Feb 1. PMID 22029577.

    See all (249) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. results suggest that CHIP regulates NF-kappaB-mediated cell invasion via the down-regulation of TRAF2
      Title: Ubiquitin ligase CHIP induces TRAF2 proteasomal degradation and NF-κB inactivation to regulate breast cancer cell invasion.
    2. USP4 deubiquitinates both TRAF2 and TRAF6 in vivo and in vitro in a deubiquitinase activity-dependent manner.
      Title: Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration.
    3. Identification and expression analysis of a novel splice variant of human tumor necrosis factor receptor associated factor 2.
      Title: [Identification and expression analysis of a novel splice variant of human tumor necrosis factor receptor associated factor 2].
    4. Results reported here revealed TRAF2 as a new possible cellular interactor of Nef.
      Title: HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.
    5. Novel phosphorylation-dependent ubiquitination of tristetraprolin by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1) and tumor necrosis factor receptor-associated factor 2 (TRAF2)
      Title: Novel phosphorylation-dependent ubiquitination of tristetraprolin by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1) and tumor necrosis factor receptor-associated factor 2 (TRAF2).
    6. Interaction was observed between LMP1 and TRAF2 or TRAF3 and mutation of the LMP1 signaling domains reduced the interaction.
      Title: Characterization of the latent membrane protein 1 signaling complex of Epstein-Barr virus in the membrane of mammalian cells with bimolecular fluorescence complementation.
    7. TRAF2 phosphorylation in response to oxidative stress significantly promotes cell survival by inducing prolonged IKK activation and by inhibiting the prolonged phase of JNK activation.
      Title: TRAF2 phosphorylation promotes NF-κB-dependent gene expression and inhibits oxidative stress-induced cell death.
    8. TNFalpha-duced NF-kappaB activation is attenuated by RIP1 through stabilization of TRAF2.
      Title: TNFα induced noncanonical NF-κB activation is attenuated by RIP1 through stabilization of TRAF2.
    9. Together these data suggest that Epstein-Barr virus BRRF1 plays an important role in regulating the switch between latent and lytic infection in epithelial cells and that this effect requires both the TRAF2 and p53 cellular proteins.
      Title: The Epstein-Barr virus BRRF1 protein, Na, induces lytic infection in a TRAF2- and p53-dependent manner.
    10. OX40 after ligation by OX40L assembled a signaling complex that contained the adapter TRAF2 as well as protein kinase B and its upstream activator phosphoinositide 3-kinase (PI3K).
      Title: OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling.
    Submit: New GeneRIF Correction See all (69)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_066961.2 NP_001157.1 BIRC2    BIND  PubMed c-IAP1 interacts with and ubiquitinates TRAF2. 
    NP_066961.2 NP_001156.1 BIRC3    BIND  PubMed c-IAP2 interacts with TRAF2. 
    NP_066961.2 NP_001241.1 CD40    BIND  PubMed CD40 interacts with TRAF2. 
    NP_066961.2 NP_056062.1 CYLD    BIND  PubMed CYLD interacts with TRAF2. 
    NP_066961.2 NP_751927.1 HCVgp1    BIND  PubMed NS5A interacts with TRAF2. This interaction was modeled on a demonstrated interaction between NS5A HCV Korean isolate and TRAF2 from an unspecified species. 
    NP_066961.2 NP_002333.1 LTBR    BIND  PubMed TRAF2 interacts with LTBR. 
    NP_066961.2 NP_006776.1 MALT1    BIND  PubMed TRAF2 interacts with MALT1. 
    NP_066961.2 NP_003945.1 MAP3K14    BIND  PubMed NIK interacts with TRAF2. This interaction was modeled on a demonstrated interaction between human NIK and TRAF2 from an unspecified species. 
    NP_066961.2 NP_004570.2 MAP4K2    BIND  PubMed The carboxy-terminal TRAF domain of TRAF2 interacts with the carboxy-terminal domain of GCK. 
    NP_066961.2 PTPN2    BIND  PubMed PTPN2 (TCPTP) interacts with TRAF2. 
    NP_066961.2 NP_003795.1 RIPK1    BIND  PubMed TRAF2 interacts with RIP. 
    NP_066961.2 NP_003795.1 RIPK1    BIND  PubMed TRAF2 ubiquitinates RIP. 
    NP_066961.2 NP_001057.1 TNFRSF1B    BIND  PubMed TRAF2 interacts with TRAF1. This interaction was modeled on a demonstrated interaction between human TRAF2 and TNF-R2 from an unspecified species. 
    NP_066961.2 NP_001234.1 TNFRSF8    BIND  PubMed TRAF2 interacts with CD30. 
    NP_066961.2 NP_003780.1 TRADD    BIND  PubMed TRAF2 interacts with TRADD. This interaction was modeled on a demonstrated interaction between human TRAF2 and TRADD from an unspecified species. 
    NP_066961.2 TRADD    BIND  PubMed TRADD interacts with TRAF2. This interaction was modeled on a demonstrated interaction between TRADD and TRAF2, both from an unspecified species. 
    NP_066961.2 NP_005649.1 TRAF1    BIND  PubMed TRAF2 interacts with TRAF1. This interaction was modeled on a demonstrated interaction between human TRAF2 and mouse TRAF1. 
    NP_066961.2     BIND  PubMed TRAF2 interacts with and is ubiquitinated by the UBE2J1-BIRC2 (hUbc6e-c-IAP1) complex. 
    Q12933 Q9NRN7 AASDHPPT    HPRD  PubMed  
    Q12933 O14639 ABLIM1    HPRD  PubMed  
    Q12933 Q9UHB7 AFF4    HPRD  PubMed  
    Q12933 P05186 ALPL    HPRD  PubMed  
    Q12933 Q9UBZ4 APEX2    HPRD  PubMed  
    Q12933 Q9UKG1 APPL1    HPRD  PubMed  
    Q12933 P54253 ATXN1    HPRD  PubMed  
    Q12933 Bromo adjacent homology domain containing 1 BAHD1    HPRD  PubMed  
    Q12933 BTG3 associated nuclear protein BANP    HPRD  PubMed  
    Q12933 O95999 BCL10    HPRD  PubMed  
    Q12933 Q13490 BIRC2    HPRD  PubMed  
    Q12933 Q13489 BIRC3    HPRD  PubMed  
    Q12933 Q9H0I2 C16orf48    HPRD  PubMed  
    Q12933 NDP52 CALCOCO2    HPRD  PubMed  
    Q12933 Q14790 CASP8    HPRD  PubMed  
    Q12933 Q9UKL3 CASP8AP2    HPRD  PubMed  
    Q12933 Q03135 CAV1    HPRD  PubMed  
    Q12933 P13994 CCDC130    HPRD  PubMed  
    Q12933 Coiled-coil domain containing 33 CCDC33    HPRD  PubMed  
    Q12933 P26842 CD27    HPRD  PubMed  
    Q12933 P25942 CD40    HPRD  PubMed  
    Q12933 Cell division cycle associated 3 CDCA3    HPRD  PubMed  
    Q12933 P50750 CDK9    HPRD  PubMed  
    Q12933 P46527 CDKN1B    HPRD  PubMed  
    Q12933 O15519 CFLAR    HPRD  PubMed  
    Q12933 Q9UQN3 CHMP2B    HPRD  PubMed  
    Q12933 O15111 CHUK    HPRD  PubMed  
    Q12933 Q16526 CRY1    HPRD  PubMed  
    Q12933 Q9NQC7 CYLD    HPRD  PubMed  
    Q12933 Q15398 DLGAP5    HPRD  PubMed  
    Q12933 O60941 DTNB    HPRD  PubMed  
    Q12933 O14641 DVL2    HPRD  PubMed  
    Q12933 Q9UNE0 EDAR    HPRD  PubMed  
    Q12933 O75460 ERN1    HPRD  PubMed  
    Q12933 Q13158 FADD    HPRD  PubMed  
    Q12933 O95990 FAM107A    HPRD  PubMed  
    Q12933 KIAA1838 FAM120B    HPRD  PubMed  
    Q12933 Q969F0 FATE1    HPRD  PubMed  
    Q12933 Fas binding protein 1 FBF1    HPRD  PubMed  
    Q12933 Q9NVF7 FBXO28    HPRD  PubMed  
    Q12933 P21333 FLNA    HPRD  PubMed  
    Q12933 P51116 FXR2    HPRD  PubMed  
    Q12933 Q9H8Y8 GORASP2    HPRD  PubMed  
    Q12933 P09211 GSTP1    HPRD  PubMed  
    Q12933 Q9BQA5 HINFP    HPRD  PubMed  
    Q12933 HIVEP3 HIVEP3    HPRD  PubMed  
    Q12933 O14920 IKBKB    HPRD  PubMed  
    Q12933 Q13261 IL15RA    HPRD  PubMed  
    Q12933 Q9UI26 IPO11    HPRD  PubMed  
    Q12933 Q15306 IRF4    HPRD  PubMed  
    Q12933 Q13572 ITPK1    HPRD  PubMed  
    Q12933 Q7Z3B3 KANSL1    HPRD  PubMed  
    Q12933 Q6ZU52 KIAA0408    HPRD  PubMed  
    Q12933 Q8TBB1 LNX1    HPRD  PubMed  
    Q12933 P36941 LTBR    HPRD  PubMed  
    Q12933 Q9BRK4 LZTS2    HPRD  PubMed  
    Q12933 Q9UDY8 MALT1    HPRD  PubMed  
    Q12933 Q99558 MAP3K14    HPRD  PubMed  
    Q12933 Q99683 MAP3K5    HPRD  PubMed  
    Q12933 P41279 MAP3K8    HPRD  PubMed  
    Q12933 Q12851 MAP4K2    HPRD  PubMed  
    Q12933 Q9Y4K4 MAP4K5    HPRD  PubMed  
    Q12933 P45984 MAPK9    HPRD  PubMed  
    Q12933 Q6P0Q8 MAST2    HPRD  PubMed  
    Q12933 Q9NVZ3 NECAP2    HPRD  PubMed  
    Q12933 P08138 NGFR    HPRD  PubMed  
    Q12933 Q00994 NGFRAP1    HPRD  PubMed  
    Q12933 Q9GZT8 NIF3L1    HPRD  PubMed  
    Q12933 P49116 NR2C2    HPRD  PubMed  
    Q12933 P48552 NRIP1    HPRD  PubMed  
    Q12933 NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 NUDT18    HPRD  PubMed  
    Q12933 Q9GZU2 PEG3    HPRD  PubMed  
    Q12933 Q13526 PIN1    HPRD  PubMed  
    Q12933 Q16512 PKN1    HPRD  PubMed  
    Q12933 Q92530 PSMF1    HPRD  PubMed  
    Q12933 P47897 QARS    HPRD  PubMed  
    Q12933 P54725 RAD23A    HPRD  PubMed  
    Q12933 Q15311 RALBP1    HPRD  PubMed  
    Q12933 P48380 RFX3    HPRD  PubMed  
    Q12933 O43566 RGS14    HPRD  PubMed  
    Q12933 Q9H4K1 RIBC2    HPRD  PubMed  
    Q12933 Q13546 RIPK1    HPRD  PubMed  
    Q12933 O43353 RIPK2    HPRD  PubMed  
    Q12933 Q9Y572 RIPK3    HPRD  PubMed  
    Q12933 Q9C0A6 SETD5    HPRD  PubMed  
    Q12933 O43255 SIAH2    HPRD  PubMed  
    Q12933 O94993 SOX30    HPRD  PubMed  
    Q12933 P48436 SOX9    HPRD  PubMed  
    Q12933 Q9UM82 SPATA2    HPRD  PubMed  
    Q12933 Q9NZD8 SPG21    HPRD  PubMed  
    Q12933 Q9NYA1 SPHK1    HPRD  PubMed  
    Q12933 O43597 SPRY2    HPRD  PubMed  
    Q12933 Q15750 TAB1    HPRD  PubMed  
    Q12933 Q9NYJ8 TAB2    HPRD  PubMed  
    Q12933 Q8N5C8 TAB3    HPRD  PubMed  
    Q12933 Q92844 TANK    HPRD  PubMed  
    Q12933 Q9H2K8 TAOK3    HPRD  PubMed  
    Q12933 Q9UHD2 TBK1    HPRD  PubMed  
    Q12933 Q15560 TCEA2    HPRD  PubMed  
    Q12933 Q8IYF1 TCEB3B    HPRD  PubMed  
    Q12933 O95551 TDP2    HPRD  PubMed  
    Q12933 Q9BT49 THAP7    HPRD  PubMed  
    Q12933 T2BP TIFA    HPRD  PubMed  
    Q12933 P01375 TNF    HPRD  PubMed  
    Q12933 P21580 TNFAIP3    HPRD  PubMed  
    Q12933 Q9Y6Q6 TNFRSF11A    HPRD  PubMed  
    Q12933 Q9NP84 TNFRSF12A    HPRD  PubMed  
    Q12933 O14836 TNFRSF13B    HPRD  PubMed  
    Q12933 Q92956 TNFRSF14    HPRD  PubMed  
    Q12933 Q02223 TNFRSF17    HPRD  PubMed  
    Q12933 Q9Y5U5 TNFRSF18    HPRD  PubMed  
    Q12933 Q9NS68 TNFRSF19    HPRD  PubMed  
    Q12933 P19438 TNFRSF1A    HPRD  PubMed  
    Q12933 P20333 TNFRSF1B    HPRD  PubMed  
    Q12933 Q93038 TNFRSF25    HPRD  PubMed  
    Q12933 P43489 TNFRSF4    HPRD  PubMed  
    Q12933 P28908 TNFRSF8    HPRD  PubMed  
    Q12933 Q07011 TNFRSF9    HPRD  PubMed  
    Q12933 P23510 TNFSF4    HPRD  PubMed  
    Q12933 P41273 TNFSF9    HPRD  PubMed  
    Q12933 Q9UKE5 TNIK    HPRD  PubMed  
    Q12933 Q15628 TRADD    HPRD  PubMed  
    Q12933 Q13077 TRAF1    HPRD  PubMed  
    Q12933 Q12933 TRAF2    HPRD  PubMed  
    Q12933 O43734 TRAF3IP2    HPRD  PubMed  
    Q12933 Q9Y4K3 TRAF6    HPRD  PubMed  
    Q12933 Q9BWF2 TRAIP    HPRD  PubMed  
    Q12933 Q9BZY9 TRIM31    HPRD  PubMed  
    Q12933 O94972 TRIM37    HPRD  PubMed  
    Q12933 Q8TEL6 TRPC4AP    HPRD  PubMed  
    Q12933 Q86TN4 TRPT1    HPRD  PubMed  
    Q12933 Q9NRR5 UBQLN4    HPRD  PubMed  
    Q12933 Socius UBXN11    HPRD  PubMed  
    Q12933 O75604 USP2    HPRD  PubMed  
    Q12933 Q70EK8 USP53    HPRD  PubMed  
    Q12933 Q93009 USP7    HPRD  PubMed  
    Q12933 Q96MR6 WDR65    HPRD  PubMed  
    Q12933 Q05516 ZBTB16    HPRD  PubMed  
    Q12933 P24278 ZBTB25    HPRD  PubMed  
    Q12933 O43298 ZBTB43    HPRD  PubMed  
    Q12933 Q6FIF0 ZFAND6    HPRD  PubMed  
    Q12933 O95201 ZNF205    HPRD  PubMed  
    Q12933 O15015 ZNF646    HPRD  PubMed  
    Q12933 Hypothetical protein BC014011     HPRD  PubMed  
    BioGRID:113038 BioGRID:121927 AASDHPPT    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:110171 ABLIM1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:118016 AFF4    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:124286 ANKRD36BP1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:118124 APEX2    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:117522 APPL1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:112221 ATXN7    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:116558 BAHD1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:120308 BANP    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:114429 BCL10    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113038 BioGRID:106826 BIRC2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:113038 BioGRID:106827 BIRC3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113038 BioGRID:123875 C16orf48    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:125499 C5orf55    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:115535 CALCOCO2    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:125680 CASP12    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:107291 CASP8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:115315 CASP8AP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113038 BioGRID:107305 CAV1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:123536 CCDC130    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:123126 CCDC33    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:107377 CD27    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:107396 CD40    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:113038 BioGRID:123657 CDCA3    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:107461 CDKN1B    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:114364 CFLAR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:117462 CHMP2B    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:107569 CHUK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113038 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:107797 CRY1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:107920 CYLD    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:113038 BioGRID:121157 DIABLO    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113038 BioGRID:115131 DLGAP5    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:108171 DTNB    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:108189 DVL2    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:126096 EDARADD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:108391 ERN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:205062 Ern2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113038 BioGRID:116341 FAM107A    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:124101 FAM120B    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:124636 FATE1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:124465 FBF1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:116826 FBXO28    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:117326 FBXO7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:108605 FLNA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:114890 FXR2    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:108916 GCKR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113038 BioGRID:109064 GOLGA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113038 BioGRID:117479 GORASP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:109187 GSK3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113038 BioGRID:117469 HINFP    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:121861 HIVEP3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113038 BioGRID:109548 HSPB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:118165 HTRA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113038 BioGRID:109767 IKBKB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113038 BioGRID:114089 IKBKG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:109814 IL15RA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:119368 IPO11    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:109870 IRF4    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:109910 ITPK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:129744 KANSL1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:115078 KIAA0408    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:203068 Khdrbs1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:124219 LNX1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:110233 LTBR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113038 BioGRID:124083 LZTS2    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:116098 MALT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113038 BioGRID:110378 MAP3K1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:113038 BioGRID:110442 MAP3K11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:114487 MAP3K14    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113038 BioGRID:110381 MAP3K5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:112748 MAP3K7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:107719 MAP3K8    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:113038 BioGRID:111809 MAP4K2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113038 BioGRID:116353 MAP4K5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:116756 MAST2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:121570 MAVS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113038 BioGRID:120832 NECAP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:110870 NGFR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113038 BioGRID:121922 NIF3L1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:113843 NRIP1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:122961 NUDT18    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:114523 PIAS2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113038 BioGRID:111317 PIN1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:114872 PSMF1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:111797 QARS    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:111823 RAD23A    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:115160 RB1CC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:111923 RFX3    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:115880 RGS14    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:117581 RIBC2    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:114274 RIPK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:113038 BioGRID:114300 RIPK2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113038 BioGRID:116224 RIPK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:120505 SETD5    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:112373 SIAH2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113038 BioGRID:121411 SMURF1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:113038 BioGRID:122265 SMURF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:116247 SOX30    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:115163 SPATA2    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:119474 SPG21    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:114396 SPHK1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113038 BioGRID:115547 SPRY2    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:115717 TAB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113038 BioGRID:116740 TAB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:129216 TAB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:115328 TANK    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:113038 BioGRID:119490 TAOK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:118878 TBK1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113038 BioGRID:112781 TCEA2    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:127996 TCEANC    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:119388 TCEB3B    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:119615 TDP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:123298 THAP7    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:127114 TICAM1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:113038 BioGRID:124962 TIFA    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:112979 TNF    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113038 BioGRID:112983 TNFAIP3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113038 BioGRID:114320 TNFRSF11A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113038 BioGRID:119478 TNFRSF12A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113038 BioGRID:117046 TNFRSF13B    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113038 BioGRID:114298 TNFRSF14    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113038 BioGRID:107080 TNFRSF17    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:114312 TNFRSF18    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:112986 TNFRSF1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:112987 TNFRSF1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113038 BioGRID:114258 TNFRSF25    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:113144 TNFRSF4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113038 BioGRID:107381 TNFRSF8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113038 BioGRID:109817 TNFRSF9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113038 BioGRID:114277 TNFSF14    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113038 BioGRID:114281 TNFSF9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113038 BioGRID:116682 TNIK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:114257 TRADD    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:113038 BioGRID:113037 TRAF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113038 BioGRID:113038 TRAF2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:113038 BioGRID:113039 TRAF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113038 BioGRID:115979 TRAF3IP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:113040 TRAF5    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:113038 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:113038 BioGRID:115581 TRAIP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113038 BioGRID:116257 TRIM31    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:110678 TRIM37    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113038 BioGRID:117569 TRPC4AP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:123736 TRPT1    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:231064 Tnfrsf14    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:247144 Tnfrsf8    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113038 BioGRID:113182 UBE2N    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:113038 BioGRID:113183 UBE2V1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113038 BioGRID:124844 UBXN11    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:114553 USP2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:113038 BioGRID:121548 USP31    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:113221 USP4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113038 BioGRID:120020 USP53    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:113622 USP7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113038 BioGRID:106828 XIAP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113038 BioGRID:113498 ZBTB16    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:113422 ZBTB25    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:116727 ZBTB43    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:119975 ZFAND6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113038 BioGRID:113539 ZNF205    BioGRID  PubMed Two-hybrid 
    BioGRID:113038 BioGRID:115075 ZNF646    BioGRID  PubMed Two-hybrid 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of Pro-Caspase 8, organism-specific biosystem (from REACTOME)
      Activation of Pro-Caspase 8, organism-specific biosystemPro-caspase-8 is known to be activated by various factors in response to a variety of external and internal stimuli. These include FAS, TRAIL, and TNF.
    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • CD40/CD40L signaling, organism-specific biosystem (from Pathway Interaction Database)
      CD40/CD40L signaling, organism-specific biosystem
      CD40/CD40L signaling
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Caspase-8 is formed from procaspase-8, organism-specific biosystem (from REACTOME)
      Caspase-8 is formed from procaspase-8, organism-specific biosystemCaspase-8 is formed from the precursor protein pro-Caspase-8 as a cleavage product.
    • Ceramide signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Ceramide signaling pathway, organism-specific biosystem
      Ceramide signaling pathway
    • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
      Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Extrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Extrinsic Pathway for Apoptosis, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
    • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
      HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
      HIV-1 Nef: Negative effector of Fas and TNF-alpha
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TNF receptor signaling pathway, organism-specific biosystem
      TNF receptor signaling pathway
    • TNF signaling, organism-specific biosystem (from REACTOME)
      TNF signaling, organism-specific biosystemThe Tumor Necrosis Factor alpha (TNF-alpha) mediated apoptosis pathway has been implicated in the pathogenesis of a number of diseases including sepsis, diabetes, cancer, osteoporosis, multiple scler...
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • TRAF6 mediated IRF7 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated IRF7 activation, organism-specific biosystemTRAF6 is crucial for both RIG-I- and MDA5-mediated antiviral responses. The absence of TRAF6 resulted in enhanced viral replication and a significant reduction in the production of type I IFNs and IL...
    • TRAF6 mediated NF-kB activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated NF-kB activation, organism-specific biosystemThe TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in To...
    • TRAIL signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TRAIL signaling pathway, organism-specific biosystem
      TRAIL signaling pathway
    • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...
    • p38 MAPK signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      p38 MAPK signaling pathway, organism-specific biosystem
      p38 MAPK signaling pathway

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    CD40 receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    signal transducer activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    sphingolipid binding IDA
    Inferred from Direct Assay
    more info
    		  
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    activation of NF-kappaB-inducing kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    activation of pro-apoptotic gene products TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cellular protein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    induction of apoptosis by extracellular signals TAS
    Traceable Author Statement
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of T cell activation IC
    Inferred by Curator
    more info
    		 PubMed 
    positive regulation of T cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		  
    protein autoubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein complex assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein homotrimerization IPI
    Inferred from Physical Interaction
    more info
    		  
    regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    CD40 receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    internal side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    TNF receptor-associated factor 2
    Names
    TNF receptor-associated factor 2
    E3 ubiquitin-protein ligase TRAF2
    tumor necrosis factor type 2 receptor associated protein 3
    tumor necrosis factor type 2 receptor-associated protein 3
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021138.3 → NP_066961.2  TNF receptor-associated factor 2

      Status: REVIEWED

      Source sequence(s)
      BC043492, BC064662
      Consensus CDS
      CCDS7013.1
      UniProtKB/Swiss-Prot
      Q12933
      Related
      ENSP00000247668, OTTHUMP00000022625, ENST00000247668, OTTHUMT00000055166
      Conserved Domains (4) summary
      cd03778
      Location:334 – 497
      Blast Score: 887
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam04582
      Location:234 – 353
      Blast Score: 98
      Reo_sigmaC; Reovirus sigma C capsid protein
      pfam02176
      Location:178 – 235
      Blast Score: 187
      zf-TRAF; TRAF-type zinc finger
      cl15348
      Location:34 – 72
      Blast Score: 95
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      139780965..139821067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      109252590..109280516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL355987.31 CAI12701.1
      CAI12702.1
      CAI12703.1
      CAI12704.1
      CAI12705.1
    genomic AL449425.15 CAI15103.1
      CAI15104.1
      CAI15105.1
      CAI15106.1
    genomic AY623660.1 AAT27320.1
    genomic CH471090.1 EAW88299.1
      EAW88300.1
      EAW88301.1
      EAW88302.1
      EAW88303.1
      EAW88304.1
      EAW88305.1
    mRNA AK054686.1 BAB70792.1
    mRNA AK222961.1 None
    mRNA AK289722.1 BAF82411.1
    mRNA AK294607.1 BAG57794.1
    mRNA AK298370.1 BAG60609.1
    mRNA BC032410.1 AAH32410.1
    mRNA BC033810.1 AAH33810.1
    mRNA BC043492.1 AAH43492.1
    mRNA BC064662.1 AAH64662.1
    mRNA BM785733.1 None
    mRNA BX538160.1 CAD98040.1
    mRNA HM991672.1 ADQ89802.1
    other-genetic DQ893616.2 ABM84542.1
    other-genetic DQ894764.2 ABM85690.1
    other-genetic EU831941.1 ACE87382.1
    other-genetic EU831961.1 ACE87402.1
    other-genetic EU832036.1 ACE86698.1
    other-genetic EU832054.1 ACE86716.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12933.2 GenPept UniProtKB/Swiss-Prot:Q12933
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