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Traf2 TNF receptor-associated factor 2 [ Mus musculus (house mouse) ]

Gene ID: 22030, updated on 20-Feb-2024

Summary

Official Symbol
Traf2provided by MGI
Official Full Name
TNF receptor-associated factor 2provided by MGI
Primary source
MGI:MGI:101835
See related
Ensembl:ENSMUSG00000026942 AllianceGenome:MGI:101835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables CD40 receptor binding activity. Involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to nitric oxide; programmed necrotic cell death; and regulation of JNK cascade. Located in several cellular components, including cytoplasmic side of plasma membrane; membrane raft; and vesicle membrane. Part of CD40 receptor complex and IRE1-TRAF2-ASK1 complex. Is expressed in several structures, including genitourinary system; lower jaw tooth; and mandibular process. Orthologous to human TRAF2 (TNF receptor associated factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 9.5), spleen adult (RPKM 6.5) and 28 other tissues See more
Orthologs
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Genomic context

See Traf2 in Genome Data Viewer
Location:
2 A3; 2 17.32 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25407994..25436952, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25517982..25546940, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene lipocalin 12 Neighboring gene STARR-positive B cell enhancer ABC_E9193 Neighboring gene complement component 8, gamma polypeptide Neighboring gene F-box and WD-40 domain protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E273 Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:25404685-25404887 Neighboring gene STARR-positive B cell enhancer ABC_E11127 Neighboring gene predicted gene, 35476 Neighboring gene endothelial differentiation-related factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CD40 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables sphingolipid binding ISO
Inferred from Sequence Orthology
more info
 
enables thioesterase binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tumor necrosis factor binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of NF-kappaB-inducing kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to nitric oxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_positive_effect innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-17-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-17-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within programmed necrotic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction involved in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of CD40 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of IRE1-TRAF2-ASK1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of IRE1-TRAF2-ASK1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of TRAF2-GSTP1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
part_of plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of tumor necrosis factor receptor superfamily complex ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TNF receptor-associated factor 2
Names
E3 ubiquitin-protein ligase TRAF2
RING-type E3 ubiquitin transferase TRAF2
NP_001277342.1
NP_033448.2
XP_006497912.1
XP_006497913.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290413.1NP_001277342.1  TNF receptor-associated factor 2 isoform a

    See identical proteins and their annotated locations for NP_001277342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF027570, AK052934, BB841262
    Consensus CDS
    CCDS71002.1
    UniProtKB/TrEMBL
    Q8C6X9, Q8CAQ7
    Related
    ENSMUSP00000109872.2, ENSMUST00000114234.2
    Conserved Domains (4) summary
    cd03778
    Location:341504
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:185242
    zf-TRAF; TRAF-type zinc finger
    cd16639
    Location:3280
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    pfam16673
    Location:276336
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  2. NM_009422.3NP_033448.2  TNF receptor-associated factor 2 isoform b

    See identical proteins and their annotated locations for NP_033448.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK052934, AK152174, BB841262
    Consensus CDS
    CCDS15779.1
    UniProtKB/Swiss-Prot
    A2AJA3, O54896, P39429
    UniProtKB/TrEMBL
    Q3U8L1, Q8C6X9, Q8CAQ7
    Related
    ENSMUSP00000028311.7, ENSMUST00000028311.13
    Conserved Domains (4) summary
    cd03778
    Location:334497
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam00097
    Location:3472
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:178235
    zf-TRAF; TRAF-type zinc finger
    pfam16673
    Location:267329
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25407994..25436952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497850.2XP_006497913.1  TNF receptor-associated factor 2 isoform X2

    Conserved Domains (3) summary
    cd03778
    Location:303466
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:147204
    zf-TRAF; TRAF-type zinc finger
    pfam16673
    Location:236298
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
  2. XM_006497849.2XP_006497912.1  TNF receptor-associated factor 2 isoform X1

    UniProtKB/TrEMBL
    Q8CAQ7
    Conserved Domains (3) summary
    cd03778
    Location:336499
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:180237
    zf-TRAF; TRAF-type zinc finger
    pfam16673
    Location:269331
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain