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TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b [ Homo sapiens (human) ]

Gene ID: 10673, updated on 4-May-2015
Official Symbol
TNFSF13Bprovided by HGNC
Official Full Name
tumor necrosis factor (ligand) superfamily, member 13bprovided by HGNC
Primary source
HGNC:HGNC:11929
See related
Ensembl:ENSG00000102524; HPRD:04914; MIM:603969; Vega:OTTHUMG00000017329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20
Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Orthologs
See TNFSF13B in MapViewer
Location:
13q32-q34
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (108269420..108308484)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (108921875..108960832)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 13 Neighboring gene uncharacterized LOC105370354 Neighboring gene uncharacterized LOC102724347 Neighboring gene RNA, 5S ribosomal pseudogene 39 Neighboring gene uncharacterized LOC105370355 Neighboring gene host cell factor C2 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 cooperates with BAFF and cytokines IL-4 and IL-10 to activate mannose C-type lectin receptors-expressing B cells PubMed
Nef nef HIV-1 Nef upregulates levels of B lymphocyte stimulator (BLyS) expression in monocyte-derived DCs PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of tumor necrosis factor superfamily, member 13b (TNFSF13B) in primary human brain microvascular endothelial cells PubMed
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that TNFSF13B gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with TNFSF13B PubMed

Go to the HIV-1, Human Interaction Database

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
    Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
    Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
    Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Rheumatoid arthritis, conserved biosystem (from KEGG)
    Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding TAS
Traceable Author Statement
more info
PubMed 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell costimulation IEA
Inferred from Electronic Annotation
more info
 
B cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
T cell costimulation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
immunoglobulin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of germinal center formation IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tumor necrosis factor ligand superfamily member 13B
Names
tumor necrosis factor ligand superfamily member 13B
ApoL related ligand TALL-1
B-cell-activating factor
B-lymphocyte stimulator
Delta4 BAFF
TNF and ApoL-related leukocyte expressed ligand 1
TNF homolog that activates apoptosis
delta BAFF
dendritic cell-derived TNF-like molecule
tumor necrosis factor (ligand) superfamily, member 20
tumor necrosis factor-like protein ZTNF4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029524.1 RefSeqGene

    Range
    5001..43856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145645.2NP_001139117.1  tumor necrosis factor ligand superfamily member 13B isoform 2

    See identical proteins and their annotated locations for NP_001139117.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) omits an in-frame coding exon, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AL157762, AY302751, BI818459, BQ778438
    Consensus CDS
    CCDS45067.1
    UniProtKB/Swiss-Prot
    Q9Y275
    Related
    ENSP00000389540, ENST00000430559
    Conserved Domains (1) summary
    cd00184
    Location:135263
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
  2. NM_006573.4NP_006564.1  tumor necrosis factor ligand superfamily member 13B isoform 1

    See identical proteins and their annotated locations for NP_006564.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents a longer transcript and encodes the longer protein isoform (1).
    Source sequence(s)
    AL157762, BC020674, BI818459, BQ778438
    Consensus CDS
    CCDS9509.1
    UniProtKB/Swiss-Prot
    Q9Y275
    Related
    ENSP00000365048, OTTHUMP00000018691, ENST00000375887, OTTHUMT00000045739
    Conserved Domains (1) summary
    cd00184
    Location:146282
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

    Range
    108269420..108308484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254029.3XP_005254086.1  

    See identical proteins and their annotated locations for XP_005254086.1

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 Alternate CHM1_1.1

    Range
    108891226..108925602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)