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    ILF3 interleukin enhancer binding factor 3, 90kDa [ Homo sapiens ]

    Gene ID: 3609, updated on 11-May-2012

    Summary

    Official Symbol
    ILF3provided by HGNC
    Official Full Name
    interleukin enhancer binding factor 3, 90kDaprovided by HGNC
    Primary source
    HGNC:6038
    See related
    Ensembl:ENSG00000129351; HPRD:04420; MIM:603182
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CBTF; DRBF; MMP4; MPP4; NF90; NFAR; NF110; NF90a; NF90b; NFAR2; TCP80; DRBP76; NF110b; NFAR-1; TCP110; MPHOSPH4; NF-AT-90
    Summary
    This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]

    Genomic context

    Location :
    19p13.2
    Sequence :
    Chromosome: 19; NC_000019.9 (10764937..10803095)
    See ILF3 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene solute carrier family 44, member 2 Neighboring gene uncharacterized LOC147727 Neighboring gene queuine tRNA-ribosyltransferase 1 Neighboring gene microRNA 638 Neighboring gene dynamin 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Rev rev The C-terminal 67 amino acids (604-671) of NF90 interact with HIV-1 Rev PubMed
    rev NF90 inhibits HIV-1 Rev-dependent activity by interfering with the RNA export function of Rev PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q12906 Q08211 DHX9    HPRD  PubMed  
    Q12906 P19525 EIF2AK2    HPRD  PubMed  
    Q12906 P35637 FUS    HPRD  PubMed  
    Q12906 O60383 GDF9    HPRD  PubMed  
    Q12906 Q9BQ66 KRTAP4-12    HPRD  PubMed  
    Q12906 P43364 MAGEA11    HPRD  PubMed  
    Q12906 Q99750 MDFI    HPRD  PubMed  
    Q12906 Q92597 NDRG1    HPRD  PubMed  
    Q12906 O15162 PLSCR1    HPRD  PubMed  
    Q12906 Q99873 PRMT1    HPRD  PubMed  
    Q12906 Q16637 SMN2    HPRD  PubMed  
    Q12906 Q15654 TRIP6    HPRD  PubMed  
    Q12906 Q9HAV4 XPO5    HPRD  PubMed  
    Q12906 Q9UL40 ZNF346    HPRD  PubMed  
    BioGRID:109822 BioGRID:119986 DGCR8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109822 BioGRID:971788 EBNA-LP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:111596 EIF2AK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:109822 BioGRID:108797 FUS    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109822 BioGRID:108930 GDF9    BioGRID  PubMed Two-hybrid 
    BioGRID:109822 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:109420 HNRNPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:109821 ILF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109822 BioGRID:128436 KHDRBS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:123756 KRTAP4-12    BioGRID  PubMed Two-hybrid 
    BioGRID:109822 BioGRID:110284 MAGEA11    BioGRID  PubMed Two-hybrid 
    BioGRID:109822 BioGRID:110353 MDFI    BioGRID  PubMed Two-hybrid 
    BioGRID:109822 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:115669 NDRG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:115783 NOP56    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:108772 NR5A2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109822 BioGRID:111373 PLSCR1    BioGRID  PubMed Two-hybrid 
    BioGRID:109822 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:109822 BioGRID:109512 PRMT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:109822 BioGRID:117487 RPAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:116708 RRP1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:215383 Rrp1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:112657 STAU1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:113056 TRIP6    BioGRID  PubMed Two-hybrid 
    BioGRID:109822 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:121574 XPO5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109822 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109822 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109822 BioGRID:204613 Ybx1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109822 BioGRID:117109 ZNF346    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109822 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    M phase NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin enhancer-binding factor 3
    Names
    interleukin enhancer-binding factor 3
    M-phase phosphoprotein 4
    translational control protein 80
    dsRNA binding protein NFAR-2/MPP4
    nuclear factor associated with dsRNA
    double-stranded RNA-binding protein, 76 kD
    nuclear factor of activated T-cells 90 kDa
    nuclear factor of activated T-cells, 90 kD

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029220.1 RefSeqGene

      Range
      5001..43159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001137673.1NP_001131145.1  interleukin enhancer-binding factor 3 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and coding region compared to variant 4. The resulting isoform (e) has a distinct C-terminus compared to isoform d.
      Source sequence(s)
      AC011475, AW576353, BC064836, DC320902
      Consensus CDS
      CCDS45967.1
      UniProtKB/Swiss-Prot
      Q12906
      Related
      ENSP00000384660, ENST00000407004
      Conserved Domains (2) summary
      cd00048
      Location:402465
      Blast Score: 140
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cl02675
      Location:88342
      Blast Score: 947
      DZF; DZF domain
    2. NM_004516.3NP_004507.2  interleukin enhancer-binding factor 3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 4. The resulting isoform (b) has a distinct C-terminus compared to isoform d. This isoform is also called NFAR-1 or DRBP76.
      Source sequence(s)
      AJ271745, AJ271747, AW576353, DC320902, X98264
      Consensus CDS
      CCDS12247.1
      UniProtKB/Swiss-Prot
      Q12906
      Related
      ENSP00000250241, ENST00000250241
      Conserved Domains (2) summary
      cd00048
      Location:402465
      Blast Score: 140
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cl02675
      Location:88342
      Blast Score: 946
      DZF; DZF domain
    3. NM_012218.3NP_036350.2  interleukin enhancer-binding factor 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region compared to variant 4. The resulting isoform (a) has a shorter C-terminus compared to isoform d. This isoform is also called NFAR-2, ILF3-E and NF110.
      Source sequence(s)
      AF167570, AJ271747, BC018633, DC320902, X98264
      Consensus CDS
      CCDS12246.1
      UniProtKB/Swiss-Prot
      Q12906
      Related
      ENSP00000315205, ENST00000318511
      Conserved Domains (2) summary
      cd00048
      Location:402465
      Blast Score: 138
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cl02675
      Location:88342
      Blast Score: 952
      DZF; DZF domain
    4. NM_017620.2NP_060090.2  interleukin enhancer-binding factor 3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
      Source sequence(s)
      AF167570, AJ271744, AJ271747, BC018633, BC064836, DC320902
      Consensus CDS
      CCDS45965.1
      UniProtKB/TrEMBL
      G5E9M5
      UniProtKB/Swiss-Prot
      Q12906
      Related
      ENSP00000404121, ENST00000449870
      Conserved Domains (2) summary
      cd00048
      Location:402465
      Blast Score: 138
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cl02675
      Location:88342
      Blast Score: 953
      DZF; DZF domain
    5. NM_153464.2NP_703194.1  interleukin enhancer-binding factor 3 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding region compared to variant 4. The resulting isoform (c) has a distinct C-terminus compared to isoform d. This isoform is also called DRBP76 delta and ILF3-C.
      Source sequence(s)
      AJ271745, AJ271746, AJ271747, AW576353, DC320902, X98264
      Consensus CDS
      CCDS45966.1
      UniProtKB/Swiss-Prot
      Q12906
      Related
      ENSP00000405436, ENST00000420083
      Conserved Domains (2) summary
      cd00048
      Location:402465
      Blast Score: 140
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cl02675
      Location:88342
      Blast Score: 942
      DZF; DZF domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      10764937..10803095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      10342365..10380213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

      Supplemental Content

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