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    PVR poliovirus receptor [ Homo sapiens ]

    Gene ID: 5817, updated on 11-May-2012
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    Summary

    Official Symbol
    PVRprovided by HGNC
    Official Full Name
    poliovirus receptorprovided by HGNC
    Primary source
    HGNC:9705
    See related
    Ensembl:ENSG00000073008; HPRD:01434; MIM:173850; Vega:OTTHUMG00000151527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PVS; HVED; CD155; NECL5; TAGE4; Necl-5; FLJ25946
    Summary
    The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
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    Genomic context

    Location :
    19q13.2
    Sequence :
    Chromosome: 19; NC_000019.9 (45147098..45169429)
    See PVR in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 2, pseudogene Neighboring gene immunoglobulin superfamily, member 23 Neighboring gene microRNA 4531 Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 19 Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 16

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection. Oshiumi H, et al. J Immunol, 2011 Nov 15. PMID 21998457.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. CD155 on human vascular endothelial cells attenuates the acquisition of effector functions in CD8 T cells. Escalante NK, et al. Arterioscler Thromb Vasc Biol, 2011 May. PMID 21330602.
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
    5. Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma. Nakai R, et al. Cancer Sci, 2010 May. PMID 20331633.

    See all (56) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The host TICAM-1 pathway, particularly in macrophages, serves as a source of type I interferon induction that protects poliovirus (PV) receptor-bearing transgenic mice from PV infection and paralytic death.
      Title: The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.
    2. CD155 is an IFNgamma-inducible immune regulatory protein on the surface of human endothelial cells that attenuates the acquisition of effector functions in CD8 T cells.
      Title: CD155 on human vascular endothelial cells attenuates the acquisition of effector functions in CD8 T cells.
    3. Necl-5 plays a role in mediating tumor cell invasion and that the overexpression of Necl-5 in cancer cells has clinical significance for prognostic evaluation of patients with primary pulmonary adenocarcinoma.
      Title: Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma.
    4. TIGIT is expressed by all NK cells, it binds PVR and PVRL2 but not PVRL3, and it inhibits NK cytotoxicity
      Title: The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity.
    5. evidence provided for the contribution of DNAM-1/CD155 interactions to the reduction of DNAM-1 expression, suggesting that chronic receptor-ligand interactions in the tumor environment may induce loss of DNAM-1 on tumor-associated NK cells.
      Title: Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells.
    6. The Ala67Thr mutation in the poliovirus receptor is a possible risk factor for the development of vaccine-associated or paralytic poliomyelitis associated with wild-type virus.
      Title: Ala67Thr mutation in the poliovirus receptor CD155 is a potential risk factor for vaccine and wild-type paralytic poliomyelitis.
    7. CD96-driven adhesion to CD155 may be crucial in developmental processes
      Title: CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains.
    8. crystal structure of C155 D1D2 has been determined to 3.5-A resolution and fitted into approximately 8.5-A resolution cryoelectron microscopy reconstructions of the virus-receptor complexes for the 3 PV serotypes
      Title: Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
    10. CD155, at least in part, enhances the proliferation of ras-mutated cells
      Title: The CD155/poliovirus receptor enhances the proliferation of ras-mutated cells.
    Submit: New GeneRIF Correction See all (24)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Polio, susceptibility to

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_006496.2 NP_000629.2 VTN    BIND  PubMed The poliovirus receptor CD 155 interacts with vitronectin. 
    P15151 Q9Y6Q5 AP1M2    HPRD  PubMed  
    P15151 Q15762 CD226    HPRD  PubMed  
    P15151 P40200 CD96    HPRD  PubMed  
    P15151 P51808 DYNLT3    HPRD  PubMed  
    P15151 P15151 PVR    HPRD  PubMed  
    P15151 Q15223 PVRL1    HPRD  PubMed  
    P15151 Q9NQS3 PVRL3    HPRD  PubMed  
    P15151 P04004 VTN    HPRD  PubMed  
    BioGRID:111775 BioGRID:115364 AP1M2    BioGRID  PubMed Two-hybrid 
    BioGRID:111775 BioGRID:115908 CD226    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111775 BioGRID:112853 DYNLT1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111775 BioGRID:117441 PVRL3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:111775 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111775 BioGRID:113287 VTN    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
      Adherens junctions interactions, organism-specific biosystemThe adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystem
      Cell junction organization
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
      Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Nectin adhesion pathway, organism-specific biosystem (from Pathway Interaction Database)
      Nectin adhesion pathway, organism-specific biosystem
      Nectin adhesion pathway
    • Nectin/Necl trans heterodimerization, organism-specific biosystem (from REACTOME)
      Nectin/Necl trans heterodimerization, organism-specific biosystemNectins and Nectin-like molecules (Necls) also undergo trans-heterophilic interactions to interact with other nectin or Necl family members. Besides these trans interactions among nectins and nectin-...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    adherens junction organization TAS
    Traceable Author Statement
    more info
    		  
    cell junction assembly TAS
    Traceable Author Statement
    more info
    		  
    cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-cell junction organization TAS
    Traceable Author Statement
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
    		  
    susceptibility to T cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    susceptibility to natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 
    integral to membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    poliovirus receptor
    Names
    poliovirus receptor
    nectin-like 5
    nectin-like protein 5
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008781.1 RefSeqGene

      Range
      5001..27332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135768.1 → NP_001129240.1  poliovirus receptor isoform beta precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (beta) lacks an internal segment including the putative transmembrane domain, compared to isoform alpha, resulting in its secretion into serum and cerebrospinal fluid.
      Source sequence(s)
      AC068948, AI374885, AK300349, DC400059
      Consensus CDS
      CCDS46105.1
      UniProtKB/Swiss-Prot
      P15151
      Related
      ENSP00000385344, OTTHUMP00000200168, ENST00000403059, OTTHUMT00000323020
      Conserved Domains (4) summary
      cd05718
      Location:43 – 142
      Blast Score: 307
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145 – 240
      Blast Score: 364
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00406
      Location:44 – 125
      Blast Score: 109
      IGv; Immunoglobulin V-Type
      cl11960
      Location:260 – 314
      Blast Score: 77
      Ig; Immunoglobulin domain

    2. NM_001135769.1 → NP_001129241.1  poliovirus receptor isoform gamma precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (gamma) lacks an internal segment including the putative transmembrane domain, compared to isoform alpha, resulting in its secretion into serum and cerebrospinal fluid.
      Source sequence(s)
      AC068948, AI374885, BC015542, DA849917, DC400059
      Consensus CDS
      CCDS46106.1
      UniProtKB/Swiss-Prot
      P15151
      Related
      ENSP00000340870, ENST00000344956
      Conserved Domains (4) summary
      cd05718
      Location:43 – 142
      Blast Score: 307
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145 – 240
      Blast Score: 365
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00406
      Location:44 – 125
      Blast Score: 109
      IGv; Immunoglobulin V-Type
      cl11960
      Location:260 – 314
      Blast Score: 77
      Ig; Immunoglobulin domain

    3. NM_001135770.1 → NP_001129242.1  poliovirus receptor isoform delta precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (delta), also known as H20B, has a shorter and distinct C-terminus, compared to isoform alpha.
      Source sequence(s)
      AC068948, BE838104, CA416069, DC400059, M24406
      Consensus CDS
      CCDS46107.1
      UniProtKB/Swiss-Prot
      P15151
      Related
      ENSP00000383907, OTTHUMP00000200167, ENST00000406449, OTTHUMT00000323019
      Conserved Domains (4) summary
      cd05718
      Location:43 – 142
      Blast Score: 308
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145 – 240
      Blast Score: 373
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00406
      Location:44 – 125
      Blast Score: 108
      IGv; Immunoglobulin V-Type
      cl11960
      Location:260 – 314
      Blast Score: 76
      Ig; Immunoglobulin domain

    4. NM_006505.3 → NP_006496.3  poliovirus receptor isoform alpha precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (alpha), also known as H20A.
      Source sequence(s)
      AC068948, AI374885, BC015542, DC400059, M24407
      Consensus CDS
      CCDS12640.1
      UniProtKB/Swiss-Prot
      P15151
      Related
      ENSP00000402060, OTTHUMP00000200165, ENST00000425690, OTTHUMT00000323017
      Conserved Domains (4) summary
      cd05718
      Location:43 – 142
      Blast Score: 307
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145 – 240
      Blast Score: 368
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00406
      Location:44 – 125
      Blast Score: 107
      IGv; Immunoglobulin V-Type
      cl11960
      Location:260 – 314
      Blast Score: 76
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      45147098..45169429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      41579341..41601754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC068948.1 AAF69803.1
    genomic CH471126.1 EAW57284.1
      EAW57285.1
      EAW57286.1
    genomic HH958003.1 CBX51265.1
    genomic X64116.1 CAA45478.1
      CAA45479.1
      CAA45480.1
    mRNA AI374885.1 None
    mRNA AK025949.1 None
    mRNA AK094177.1 BAG52836.1
    mRNA AK098812.1 None
    mRNA AK290946.1 BAF83635.1
    mRNA AK300349.1 BAG62091.1
    mRNA BC015542.1 AAH15542.1
    mRNA BE838104.1 None
    mRNA CA416069.1 None
    mRNA DA849917.1 None
    mRNA DC400059.1 None
    mRNA M24406.1 AAA36462.1
    mRNA M24407.1 AAA36461.1
    other-genetic DQ890969.2 ABM81895.1
    other-genetic DQ894143.2 ABM85069.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15151.2 GenPept UniProtKB/Swiss-Prot:P15151
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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