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EIF5A eukaryotic translation initiation factor 5A [ Homo sapiens (human) ]

Gene ID: 1984, updated on 26-May-2016
Official Symbol
EIF5Aprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 5Aprovided by HGNC
Primary source
HGNC:HGNC:3300
See related
Ensembl:ENSG00000132507 HPRD:02555; MIM:600187; Vega:OTTHUMG00000102197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF-5A; EIF5A1; eIF5AI
Orthologs
Location:
17p13-p12
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (7306999..7312463)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7210318..7215782)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 4 Neighboring gene Y-box binding protein 2 Neighboring gene uncharacterized LOC105371513 Neighboring gene G protein pathway suppressor 2 Neighboring gene neuralized E3 ubiquitin protein ligase 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef downregulates the expression of eukaryotic translation initiation factor 5A (EIF5A) protein in Nef-transfected SupT1 cells PubMed
Rev rev eIF-5A binds Rev Response Element (RRE) RNA, an interaction likely to be involved in its association with Rev during nuclear export PubMed
rev eIF-5A directly interacts with CRM1 and mediates its binding to Rev, an effect that is required for nuclear export of Rev PubMed
rev eIF-5A is a hypusine-containing protein required for Rev-mediated nuclear export of HIV-1 mRNA PubMed
rev eIF-5A interacts with the ribosomal protein L5 during its Rev nuclear export activity PubMed
rev eIF-5A interacts with nucleoporins CAN/nup214, nup153, nup98, and nup62 as well as nuclear actin during the nuclear export of Rev PubMed
rev eIF-5A interacts with the activation domain of Rev (amino acids 75-83) PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation initiation factor 5A (EIF5A) at amino acid residues 5-6, 96-97, 97-98, and 100-101 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

  • Gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystem (from REACTOME)
    Gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Hypusine synthesis from eIF5A-lysine, organism-specific biosystem (from REACTOME)
    Hypusine synthesis from eIF5A-lysine, organism-specific biosystemCytosolic eIF5A undergoes a unique two-step post-translational modification at Lys 50 via deoxyhypusine (Dhp) to hypusine (Hyp). In the first step deoxyhypusine synthase transfers the aminobutyl grou...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Translation Factors, organism-specific biosystem (from WikiPathways)
    Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC99547, MGC104255

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
U6 snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IEA
Inferred from Electronic Annotation
more info
 
translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-lysine modification to peptidyl-hypusine TAS
Traceable Author Statement
more info
 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of translational termination IEA
Inferred from Electronic Annotation
more info
 
protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
translational frameshifting IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
annulate lamellae IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
eukaryotic translation initiation factor 5A-1
Names
eIF-4D
eIF-5A-1
eIF-5A1
eukaryotic initiation factor 5A
rev-binding factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143760.1NP_001137232.1  eukaryotic translation initiation factor 5A-1 isoform A

    See identical proteins and their annotated locations for NP_001137232.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) encodes the longer isoform (A).
    Source sequence(s)
    AC026954, AY129319
    Consensus CDS
    CCDS45601.1
    UniProtKB/Swiss-Prot
    P63241
    Related
    ENSP00000336702, OTTHUMP00000258505, ENST00000336452, OTTHUMT00000440513
    Conserved Domains (2) summary
    PLN03107
    Location:31180
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:114182
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
  2. NM_001143761.1NP_001137233.1  eukaryotic translation initiation factor 5A-1 isoform B

    See identical proteins and their annotated locations for NP_001137233.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.
    Source sequence(s)
    AC026954, AY129321
    Consensus CDS
    CCDS11099.1
    UniProtKB/Swiss-Prot
    P63241
    Related
    ENSP00000390677, OTTHUMP00000258515, ENST00000419711, OTTHUMT00000440537
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
  3. NM_001143762.1NP_001137234.1  eukaryotic translation initiation factor 5A-1 isoform B

    See identical proteins and their annotated locations for NP_001137234.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (D) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.
    Source sequence(s)
    AC026954, AY129322, BG479628
    Consensus CDS
    CCDS11099.1
    UniProtKB/Swiss-Prot
    P63241
    Related
    ENSP00000396073, OTTHUMP00000258517, ENST00000416016, OTTHUMT00000440539
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
  4. NM_001970.4NP_001961.1  eukaryotic translation initiation factor 5A-1 isoform B

    See identical proteins and their annotated locations for NP_001961.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.
    Source sequence(s)
    AC026954, AY129320, CB111036
    Consensus CDS
    CCDS11099.1
    UniProtKB/Swiss-Prot
    P63241
    Related
    ENSP00000336776, OTTHUMP00000128384, ENST00000336458, OTTHUMT00000220047
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    7306999..7312463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523709.1XP_011522011.1  

    See identical proteins and their annotated locations for XP_011522011.1

  2. XM_011523708.1XP_011522010.1  

  3. XM_011523712.1XP_011522014.1  

    See identical proteins and their annotated locations for XP_011522014.1

  4. XM_011523710.1XP_011522012.1  

    See identical proteins and their annotated locations for XP_011522012.1

  5. XM_005256509.1XP_005256566.1  

    See identical proteins and their annotated locations for XP_005256566.1

    UniProtKB/Swiss-Prot
    P63241
    Related
    ENSP00000460284, OTTHUMP00000258521, ENST00000573714, OTTHUMT00000440547
    Conserved Domains (2) summary
    PLN03107
    Location:1150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    cd04468
    Location:84152
    S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...
  6. XM_011523711.1XP_011522013.1  

    See identical proteins and their annotated locations for XP_011522013.1

  7. XM_011523713.1XP_011522015.1  

    See identical proteins and their annotated locations for XP_011522015.1

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    7219093..7224550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)