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    IARS isoleucyl-tRNA synthetase [ Homo sapiens ]

    Gene ID: 3376, updated on 11-May-2012
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    Summary

    Official Symbol
    IARSprovided by HGNC
    Official Full Name
    isoleucyl-tRNA synthetaseprovided by HGNC
    Primary source
    HGNC:5330
    Locus tag
    RP11-62C3.1
    See related
    Ensembl:ENSG00000196305; HPRD:02832; MIM:600709; Vega:OTTHUMG00000020219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRS; ILRS; IARS1; ILERS; PRO0785; FLJ20736
    Summary
    Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5' UTRs. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    9q21
    Sequence :
    Chromosome: 9; NC_000009.11 (94972625..95056038, complement)
    See IARS in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene BEN domain containing 3 pseudogene Neighboring gene protease, serine, 47 Neighboring gene small nucleolar RNA, H/ACA box 84 Neighboring gene chromosome 16 open reading frame 70 pseudogene Neighboring gene nucleolar protein 8 Neighboring gene centromere protein P

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Greco TM, et al. Mol Cell Proteomics, 2011 Feb. PMID 21081666.
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.

    See all (31) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P41252 P10275 AR    HPRD  PubMed  
    P41252 P07814 EPRS    HPRD  PubMed  
    P41252 P41250 GARS    HPRD  PubMed  
    BioGRID:109605 BioGRID:113684 AIMP2    BioGRID  PubMed Two-hybrid 
    BioGRID:109605 BioGRID:122157 AKTIP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109605 BioGRID:114000 BCAR3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109605 BioGRID:971788 EBNA-LP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109605 BioGRID:108372 EPRS    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109605 BioGRID:108887 GARS    BioGRID  PubMed Two-hybrid 
    BioGRID:109605 BioGRID:131875 GSTK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109605 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109605 BioGRID:114879 MAGED1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109605 BioGRID:110333 MCC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109605 BioGRID:112344 SGK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109605 BioGRID:112506 SNCA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109605 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109605 BioGRID:114374 TSC22D1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109605 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109605 BioGRID:116078 USP19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109605 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the IARS gene: The IARS gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and P.falciparum.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    isoleucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    isoleucine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		  
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    isoleucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    tRNA aminoacylation for protein translation TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    soluble fraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    isoleucine--tRNA ligase, cytoplasmic
    Names
    isoleucine--tRNA ligase, cytoplasmic
    isoleucine tRNA ligase 1, cytoplasmic
    isoleucyl-tRNA synthetase, cytoplasmic
    NP_002152.2
    NP_038203.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002161.4 → NP_002152.2  isoleucine--tRNA ligase, cytoplasmic

      Status: REVIEWED

      Description
      Transcript Variant: This variant represents an alternate 5' UTR.
      Source sequence(s)
      AK293014, BX537429, BX648567, DA335066
      Consensus CDS
      CCDS6694.1
      UniProtKB/Swiss-Prot
      P41252
      Related
      ENSP00000406448, ENST00000443024
      Conserved Domains (3) summary
      cd07961
      Location:640 – 833
      Blast Score: 669
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:406 – 640
      Blast Score: 883
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:6 – 1070
      Blast Score: 4180
      PLN02882; aminoacyl-tRNA ligase

    2. NM_013417.2 → NP_038203.2  isoleucine--tRNA ligase, cytoplasmic

      Status: REVIEWED

      Description
      Transcript Variant: This variant represents an alternate 5' UTR.
      Source sequence(s)
      BX537417, D28473
      Consensus CDS
      CCDS6694.1
      UniProtKB/Swiss-Prot
      P41252
      UniProtKB/TrEMBL
      Q7Z3U5
      Related
      ENSP00000364794, OTTHUMP00000021636, ENST00000375643, OTTHUMT00000053059
      Conserved Domains (3) summary
      cd07961
      Location:640 – 833
      Blast Score: 669
      Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
      cd00818
      Location:406 – 640
      Blast Score: 883
      IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
      PLN02882
      Location:6 – 1070
      Blast Score: 4180
      PLN02882; aminoacyl-tRNA ligase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      94972625..95056038, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      64650488..64733811, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL136097.10 CAI16197.1
      CAI16198.1
      CAI16199.1
      CAI16200.1
      CAI16201.1
      CAI16202.2
      CAI16203.1
    genomic CH471089.1 EAW62809.1
      EAW62810.1
      EAW62811.1
      EAW62812.1
      EAW62813.1
    mRNA AB209234.1 BAD92471.1
    mRNA AF113680.1 AAF29582.1
    mRNA AK057920.1 None
    mRNA AK293014.1 BAF85703.1
    mRNA AK301272.1 BAG62834.1
    mRNA AK308202.1 None
    mRNA BC008318.1 AAH08318.2
    mRNA BC065552.1 AAH65552.1
    mRNA BX537417.1 CAD97659.1
    mRNA BX537429.1 CAD97671.1
    mRNA BX538109.1 CAD98022.1
    mRNA BX647071.1 None
    mRNA BX647236.1 None
    mRNA BX647430.1 None
    mRNA BX648567.1 None
    mRNA D28473.1 BAA05835.1
    mRNA DA335066.1 None
    mRNA U04953.1 AAA80153.1
    other-genetic EU831952.1 ACE87393.1
    other-genetic EU832046.1 ACE86708.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41252.2 GenPept UniProtKB/Swiss-Prot:P41252
    Q59G75 GenPept UniProtKB/TrEMBL:Q59G75
    Q5TCC4 GenPept UniProtKB/TrEMBL:Q5TCC4
    Q5TCC6 GenPept UniProtKB/TrEMBL:Q5TCC6
    Q5TCD1 GenPept UniProtKB/TrEMBL:Q5TCD1
    Q6P0M4 GenPept UniProtKB/TrEMBL:Q6P0M4
    Q7L4K8 GenPept UniProtKB/TrEMBL:Q7L4K8
    Q7Z355 GenPept UniProtKB/TrEMBL:Q7Z355
    Q7Z3U5 GenPept UniProtKB/TrEMBL:Q7Z3U5
    Q9P1N9 GenPept UniProtKB/TrEMBL:Q9P1N9
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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