GATA3 GATA binding protein 3 [Homo sapiens] - Gene

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Summary

Official Symbol: GATA3provided by HGNC
Official Full Name: GATA binding protein 3provided by HGNC
Primary source: HGNC:4172
See related: Ensembl:ENSG00000107485; HPRD:00572; MIM:131320; Vega:OTTHUMG00000017640
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HDR; HDRS; MGC2346; MGC5199; MGC5445
Summary: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]

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Genomic context

Location :: 10p15

Sequence :: Chromosome: 10; NC_000010.10 (8096667..8117164)

See GATA3 in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Compared with transplant recipients not exhibiting operational tolerance operationally tolerant individuals had a predominant regulatory gene expression profile with higher expression of GATA3, TGFB1, TGFBR1, and FOXP3 which was stable over time.
Title: GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation.
c-Myb critically regulates IL-13 expression via direct binding to the conserved GATA-3 response element
Title: c-Myb and GATA-3 cooperatively regulate IL-13 expression via conserved GATA-3 response element and recruit mixed lineage leukemia (MLL) for histone modification of the IL-13 locus.
CDKN2A, GATA3, CREBBP, ITGA2, NBL1 and TGM4 were down-regulated in the prostate carcinoma glands compared to the corresponding normal glands
Title: Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers.
All the enhanceosome components comprising estrogen receptor alpha (ERalpha), FOXA1, and GATA3 are necessary for the full repertoire of cancer-associated effects of the ERalpha.
Title: Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state.
A strong association was evident between GATA-3 and caspase-14 expression in preinvasive ductal carcinoma in situ samples, where GATA-3 also displayed prognostic significance
Title: Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.
These results demonstrate a direct positive role of estrogen in regulating Aurora-A expression through activation of the ERalpha-GATA-3 signaling cascade
Title: Estrogen-induced aurora kinase-A (AURKA) gene expression is activated by GATA-3 in estrogen receptor-positive breast cancer cells.
Compared with the normal controls, T-bet mRNA expression decreased whereas GATA-3 mRNA expression increased significantly in patients with systemic lupus erythematosus.
Title: [Expression of transcription factors T-bet and GATA-3 in peripheral blood mononuclear cells from patients with systemic lupus erythematosus].
Allergic inflammatory responses are orchestrated by several transcription factors, particularly NF-kappaB and GATA3. (Review)
Title: Pathophysiology of allergic inflammation.
The ratio of T-bet/GATA-3 can be used as an objective indicator of immune imbalance in patients with allergic asthma.
Title: Correlation between the ratio of T-bet/GATA-3 and the levels of IL-4 and IFN-γ in patients with allergic asthma.
The prototypic Th2 cytokine IL-4 was the only cytokine capable of inducing GATA3 in skin explants from healthy donors.
Title: GATA3 expression is decreased in psoriasis and during epidermal regeneration; induction by narrow-band UVB and IL-4.

Submit: New GeneRIF Correction See all (120)

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Phenotypes

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).

Hypoparathyroidism, sensorineural deafness, and renal dysplasia

MIM: 146255

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	Amino acids 19-26 of HIV-1 Nef mediate the binding of Nef to murine GATA-1 and GATA-3 in vitro, suggesting Nef may act as a nuclear regulatory factor through binding to human GATA-1 and GATA-3	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
P23771	P14921	ETS1	HPRD	PubMed
P23771	P15036	ETS2	HPRD	PubMed
P23771	P25800	LMO1	HPRD	PubMed
P23771	P25791	LMO2	HPRD	PubMed
P23771	Q15648	MED1	HPRD	PubMed
P23771	Q01826	SATB1	HPRD	PubMed
P23771	P17542	TAL1	HPRD	PubMed
P23771	Q8WW38	ZFPM2	HPRD	PubMed
BioGRID:108895	BioGRID:107116	BMI1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108895	BioGRID:114368	HDAC3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108895	BioGRID:115106	HDAC4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108895	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108895	BioGRID:110190	LMO1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108895	BioGRID:110191	LMO2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108895	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108895	BioGRID:110687	MYB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108895	BioGRID:111850	RARB	BioGRID	PubMed	Two-hybrid
BioGRID:108895	BioGRID:118927	REPIN1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108895	BioGRID:112550	SP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108895	BioGRID:112749	TAL1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108895	BioGRID:119027	TBX21	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108895	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
DNA binding	TAS Traceable Author Statement more info	PubMed
E-box binding	IDA Inferred from Direct Assay more info
HMG box domain binding	IPI Inferred from Physical Interaction more info	PubMed
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	IMP Inferred from Mutant Phenotype more info	PubMed
core promoter proximal region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleic acid binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
nucleic acid binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info
sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
transcription coactivator activity	IDA Inferred from Direct Assay more info
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
TOR signaling cascade	ISS Inferred from Sequence or Structural Similarity more info
anatomical structure formation involved in morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
anatomical structure morphogenesis	TAS Traceable Author Statement more info	PubMed
aortic valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
blood coagulation	TAS Traceable Author Statement more info
canonical Wnt receptor signaling pathway involved in metanephric kidney development	ISS Inferred from Sequence or Structural Similarity more info
cardiac right ventricle morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
cell fate determination	ISS Inferred from Sequence or Structural Similarity more info
cellular response to interferon-alpha	IEP Inferred from Expression Pattern more info
cellular response to interleukin-4	IEP Inferred from Expression Pattern more info
cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
defense response	TAS Traceable Author Statement more info	PubMed
ear development	IMP Inferred from Mutant Phenotype more info	PubMed
kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
lymphocyte migration	IDA Inferred from Direct Assay more info	PubMed
male gonad development	ISS Inferred from Sequence or Structural Similarity more info
mesenchymal to epithelial transition	IDA Inferred from Direct Assay more info
mesonephros development	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info
negative regulation of cell motility	IMP Inferred from Mutant Phenotype more info
negative regulation of cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell proliferation involved in mesonephros development	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of endothelial cell apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info
negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of mammary gland epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
nephric duct formation	ISS Inferred from Sequence or Structural Similarity more info
nephric duct morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
norepinephrine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
pharyngeal system development	ISS Inferred from Sequence or Structural Similarity more info
phosphatidylinositol 3-kinase cascade	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of interleukin-13 secretion	IDA Inferred from Direct Assay more info
positive regulation of interleukin-13 secretion	IMP Inferred from Mutant Phenotype more info
positive regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-5 secretion	IDA Inferred from Direct Assay more info
positive regulation of protein kinase B signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of thyroid hormone generation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info
positive regulation of transcription from RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription regulatory region DNA binding	IMP Inferred from Mutant Phenotype more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-dependent	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
regulation of cellular response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cytokine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
regulation of nephron tubule epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed
response to estrogen stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to virus	IEP Inferred from Expression Pattern more info
signal transduction	ISS Inferred from Sequence or Structural Similarity more info
sympathetic nervous system development	ISS Inferred from Sequence or Structural Similarity more info
transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
ureteric bud formation	ISS Inferred from Sequence or Structural Similarity more info
uterus development	ISS Inferred from Sequence or Structural Similarity more info
ventricular septum development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
nuclear chromatin	IDA Inferred from Direct Assay more info
nucleolus	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: trans-acting T-cell-specific transcription factor GATA-3

Names: trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015859.1 RefSeqGene

Range

5001..25498

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001002295.1 → NP_001002295.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AI024501, AI686327, BC003070, BC006793, BC006839, BG287052, BM152193

Consensus CDS

CCDS31143.1

UniProtKB/Swiss-Prot

P23771

Related

ENSP00000368632, OTTHUMP00000019070, ENST00000379328, OTTHUMT00000046718

Conserved Domains (1) summary

cd00202
Location:263 – 313
Blast Score: 162

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_002051.2 → NP_002042.1 trans-acting T-cell-specific transcription factor GATA-3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid-coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.

Source sequence(s)

AI024501, AI686327, BC006793, BC006839, BG287052, BM152193

Consensus CDS

CCDS7083.1

UniProtKB/Swiss-Prot

P23771

Related

ENSP00000341619, OTTHUMP00000019071, ENST00000346208, OTTHUMT00000046719

Conserved Domains (1) summary

cd00202
Location:262 – 312
Blast Score: 162

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p5 Primary Assembly

Range

8096667..8117164

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

8015002..8035471

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL390294.19	CAH73143.1
		CAH73144.1
genomic	AY497006.1	AAR32096.1
genomic	CH471072.2	EAW86367.1
		EAW86368.1
genomic	FB571433.1	CAR95134.1
genomic	FB571435.1	CAR95135.1
genomic	HI179114.1	CBX53865.1
genomic	HI179116.1	CBX53866.1
mRNA	AI024501.1	None
mRNA	AI686327.1	None
mRNA	AK298213.1	BAG60483.1
mRNA	BC003070.2	AAH03070.1
mRNA	BC006793.1	AAH06793.1
mRNA	BC006839.1	None
mRNA	BG287052.1	None
mRNA	BM152193.1	None
mRNA	M69106.1	AAA35870.1
mRNA	X55037.1	CAA38877.1
mRNA	X55122.1	CAA38916.1
mRNA	X58072.1	CAA41102.1
other-genetic	AM392571.1	CAL37449.1
other-genetic	AM392688.1	CAL37566.1