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    GATA3 GATA binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 2625, updated on 14-May-2013
    Official Symbol
    GATA3provided by HGNC
    Official Full Name
    GATA binding protein 3provided by HGNC
    Primary source
    HGNC:4172
    See related
    Ensembl:ENSG00000107485; HPRD:00572; MIM:131320; Vega:OTTHUMG00000017640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HDR; HDRS
    Summary
    This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
    Location :
    10p15
    Sequence :
    Chromosome: 10; NC_000010.10 (8096667..8117164)
    See GATA3 in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa Neighboring gene GATA3 antisense RNA 1 Neighboring gene PRP38 domain containing A pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 708

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Nef, p27 nef Amino acids 19-26 of HIV-1 Nef mediate the binding of Nef to murine GATA-1 and GATA-3 in vitro, suggesting Nef may act as a nuclear regulatory factor through binding to human GATA-1 and GATA-3 PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    P23771 P14921 ETS1    HPRD  PubMed  
    P23771 P15036 ETS2    HPRD  PubMed  
    P23771 P25800 LMO1    HPRD  PubMed  
    P23771 P25791 LMO2    HPRD  PubMed  
    P23771 Q15648 MED1    HPRD  PubMed  
    P23771 Q01826 SATB1    HPRD  PubMed  
    P23771 P17542 TAL1    HPRD  PubMed  
    P23771 Q8WW38 ZFPM2    HPRD  PubMed  
    BioGRID:108895 BioGRID:107116 BMI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108895 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108895 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108895 BioGRID:115106 HDAC4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108895 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108895 BioGRID:110190 LMO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108895 BioGRID:110191 LMO2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108895 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108895 BioGRID:110687 MYB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108895 BioGRID:111850 RARB    BioGRID  PubMed Two-hybrid 
    BioGRID:108895 BioGRID:118927 REPIN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108895 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108895 BioGRID:112566 SPI1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108895 BioGRID:112749 TAL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108895 BioGRID:119027 TBX21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108895 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Homology

    Clone Names

    • MGC2346, MGC5199, MGC5445

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    E-box binding IDA
    Inferred from Direct Assay
    more info
     
    HMG box domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II core promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    core promoter proximal region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enhancer sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-2 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleic acid binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T-helper 2 cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    TOR signaling cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    anatomical structure formation involved in morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    aortic valve morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    canonical Wnt receptor signaling pathway involved in metanephric kidney development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cardiac right ventricle morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell fate determination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell maturation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to BMP stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interferon-alpha IEP
    Inferred from Expression Pattern
    more info
     
    cellular response to interleukin-4 IEP
    Inferred from Expression Pattern
    more info
     
    cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    developmental growth IEA
    Inferred from Electronic Annotation
    more info
     
    ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    humoral immune response IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    inner ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    interferon-gamma secretion IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-4 secretion IEA
    Inferred from Electronic Annotation
    more info
     
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lens development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    lymphocyte migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    male gonad development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mast cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mesenchymal to epithelial transition IDA
    Inferred from Direct Assay
    more info
     
    mesonephros development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
     
    negative regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
     
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell proliferation involved in mesonephros development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of endothelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
     
    negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-2 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mammary gland epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nephric duct formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nephric duct morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    norepinephrine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    otic vesicle development IEA
    Inferred from Electronic Annotation
    more info
     
    parathyroid gland development IEA
    Inferred from Electronic Annotation
    more info
     
    parathyroid hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    pharyngeal system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol 3-kinase cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-13 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-13 secretion IDA
    Inferred from Direct Assay
    more info
     
    positive regulation of interleukin-13 secretion IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of interleukin-4 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-5 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-5 secretion IDA
    Inferred from Direct Assay
    more info
     
    positive regulation of protein kinase B signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of thyroid hormone generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription regulatory region DNA binding IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ureteric bud formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    pro-T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of CD4-positive, alpha-beta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cellular response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cytokine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of histone H3-K27 methylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of histone H3-K4 methylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of nephron tubule epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to estrogen stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    response to virus IEP
    Inferred from Expression Pattern
    more info
     
    signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sympathetic nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
     
    thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    type IV hypersensitivity IEA
    Inferred from Electronic Annotation
    more info
     
    ureter maturation IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    uterus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ventricular septum development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    trans-acting T-cell-specific transcription factor GATA-3
    Names
    trans-acting T-cell-specific transcription factor GATA-3
    GATA-binding factor 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015859.1 RefSeqGene

      Range
      5001..25498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001002295.1NP_001002295.1  trans-acting T-cell-specific transcription factor GATA-3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI024501, AI686327, BC003070, BC006793, BC006839, BG287052, BM152193
      Consensus CDS
      CCDS31143.1
      UniProtKB/Swiss-Prot
      P23771
      Related
      ENSP00000368632, OTTHUMP00000019070, ENST00000379328, OTTHUMT00000046718
      Conserved Domains (1) summary
      cd00202
      Location:263313
      Blast Score: 162
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    2. NM_002051.2NP_002042.1  trans-acting T-cell-specific transcription factor GATA-3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid-coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AI024501, AI686327, BC006793, BC006839, BG287052, BM152193
      Consensus CDS
      CCDS7083.1
      UniProtKB/Swiss-Prot
      P23771
      Related
      ENSP00000341619, OTTHUMP00000019071, ENST00000346208, OTTHUMT00000046719
      Conserved Domains (1) summary
      cd00202
      Location:262312
      Blast Score: 162
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p10 Primary Assembly

      Range
      8096667..8117164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      8015002..8035471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018921.1 Alternate CHM1_1.0

      Range
      8007807..8028302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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