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    CD5 CD5 molecule [ Homo sapiens ]

    Gene ID: 921, updated on 11-May-2012
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    Summary

    Official Symbol
    CD5provided by HGNC
    Official Full Name
    CD5 moleculeprovided by HGNC
    Primary source
    HGNC:1685
    See related
    Ensembl:ENSG00000110448; HPRD:01078; MIM:153340; Vega:OTTHUMG00000167825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T1; LEU1
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    Genomic context

    Location :
    11q13
    Sequence :
    Chromosome: 11; NC_000011.9 (60869930..60895324)
    See CD5 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene transmembrane protein 132A Neighboring gene solute carrier family 15, member 3 Neighboring gene CD6 molecule Neighboring gene transfer RNA alanine 45 (anticodon UGC) pseudogene Neighboring gene vacuolar protein sorting 37 homolog C (S. cerevisiae) Neighboring gene pepsinogen 3, group I (pepsinogen A)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation. de Wit J, et al. Blood, 2011 Dec 1. PMID 21926348.
    2. Immunohistochemical comparison of CD5, lambda, and kappa expression in primary and recurrent buccal mucosa-associated lymphoid tissue (MALT) lymphomas. Tanaka T, et al. Diagn Pathol, 2011 Sep 6. PMID 21892966.
    3. Absence of gene mutations in KIT-positive carcinoma showing thymus-like elements of the thyroid. Pan Y, et al. Hum Pathol, 2012 Mar. PMID 21835435.
    4. IL-10 is predominantly produced by CD19(low)CD5(+) regulatory B cell subpopulation: characterisation of CD19 (high) and CD19(low) subpopulations of CD5(+) B cells. Lee JH, et al. Yonsei Med J, 2011 Sep. PMID 21786452.
    5. A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase. Bamberger M, et al. J Biol Chem, 2011 Sep 2. PMID 21757751.

    See all (64) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The primary carcinoma showing thymus-like elements of the thyroid frequently expresses KIT and CD5 proteins.
      Title: Absence of gene mutations in KIT-positive carcinoma showing thymus-like elements of the thyroid.
    2. Alternative costimulation via CD5, rather than classic costimulation via CD28, primes naive T cells for stable Th17 development through promoting the expression of IL-23R.
      Title: CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation.
    3. Post-thymic regulation of CD5 levels in human memory T cells is inversely associated with the strength of responsiveness to interleukin-15.
      Title: Post-thymic regulation of CD5 levels in human memory T cells is inversely associated with the strength of responsiveness to interleukin-15.
    4. immunological significance of CD19 for the IL-10 production by CD5(+) B cells
      Title: IL-10 is predominantly produced by CD19(low)CD5(+) regulatory B cell subpopulation: characterisation of CD19 (high) and CD19(low) subpopulations of CD5(+) B cells.
    5. Case Report: describe the recurrence of CD5 positive MALT lymphoma in the oral cavity and compared the immunohistochemical expressions of CD5, lambda, and kappa between the primary and recurrent tumors.
      Title: Immunohistochemical comparison of CD5, lambda, and kappa expression in primary and recurrent buccal mucosa-associated lymphoid tissue (MALT) lymphomas.
    6. CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase
      Title: A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase.
    7. Conclude that high percentages of CD5+B cells independently associate with increased risk of early conversion to multiple sclerosis in clinically isolated syndrome patients.
      Title: Increased peripheral blood CD5+ B cells predict earlier conversion to MS in high-risk clinically isolated syndromes.
    8. Data show that CD5 expression is associated with NFAT2 activity and mildly STAT3 activity, indicating that CD5 controls IL-10 secretion.
      Title: CD5 promotes IL-10 production in chronic lymphocytic leukemia B cells through STAT3 and NFAT2 activation.
    9. full-length protein variant, encoded by E1A-cd5, translocates the phosphatase SHP-1 to the vicinity of the B-cell receptor, raises its threshold, and thereby limits the response of autoreactive B cells [review]
      Title: CD5 expression in B cells from patients with systemic lupus erythematosus.
    10. CD5-positive splenic marginal zone lymphoma may be related to memory B-cell neoplasm or plasma cell differentiation
      Title: Characteristics of CD5-positive splenic marginal zone lymphoma with leukemic manifestation ; clinical, flow cytometry, and histopathological findings of 11 cases.
    Submit: New GeneRIF Correction See all (36)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P06127 Q13557 CAMK2D    HPRD  PubMed  
    P06127 P22681 CBL    HPRD  PubMed  
    P06127 P06729 CD2    HPRD  PubMed  
    P06127 P20963 CD247    HPRD  PubMed  
    P06127 P01730 CD4    HPRD  PubMed  
    P06127 P30203 CD6    HPRD  PubMed  
    P06127 P21854 CD72    HPRD  PubMed  
    P06127 P11912 CD79A    HPRD  PubMed  
    P06127 P40259 CD79B    HPRD  PubMed  
    P06127 P68400 CSNK2A1    HPRD  PubMed  
    P06127 P51808 DYNLT3    HPRD  PubMed  
    P06127 P06241 FYN    HPRD  PubMed  
    P06127 Q00839 HNRNPU    HPRD  PubMed  
    P06127 P06239 LCK    HPRD  PubMed  
    P06127 P27986 PIK3R1    HPRD  PubMed  
    P06127 P17252 PRKCA    HPRD  PubMed  
    P06127 P05771 PRKCB    HPRD  PubMed  
    P06127 P05129 PRKCG    HPRD  PubMed  
    P06127 P29350 PTPN6    HPRD  PubMed  
    P06127 P20936 RASA1    HPRD  PubMed  
    P06127 P43403 ZAP70    HPRD  PubMed  
    BioGRID:107359 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107359 BioGRID:107352 CD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107359 BioGRID:107377 CD27    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107359 BioGRID:107361 CD6    BioGRID  PubMed FRET 
    BioGRID:107359 BioGRID:111742 PTPN6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107359 BioGRID:111856 RASA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107359 BioGRID:113367 ZAP70    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glycoprotein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    T cell costimulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell recognition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    induction of apoptosis by extracellular signals IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    fully spanning plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    T-cell surface glycoprotein CD5
    Names
    T-cell surface glycoprotein CD5
    CD5 antigen (p56-62)
    lymphocyte antigen T1/Leu-1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014207.3 → NP_055022.2  T-cell surface glycoprotein CD5 precursor

      Status: VALIDATED

      Source sequence(s)
      AK292698, AP000437, BC027901, DB143341, X04391
      Consensus CDS
      CCDS8000.1
      UniProtKB/Swiss-Prot
      P06127
      Related
      ENSP00000342681, OTTHUMP00000236973, ENST00000347785, OTTHUMT00000396465
      Conserved Domains (1) summary
      cl02509
      Location:36 – 133
      Blast Score: 174
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      60869930..60895324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      57229625..57239225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP000437.5 (25546..50903) None
    genomic CH471076.1 EAW73924.1
    genomic EF064752.1 ABK41935.1
    genomic X89405.1 CAA61584.2
    mRNA AK292698.1 BAF85387.1
    mRNA AY541703.1 AAS55053.1
    mRNA BC027901.1 AAH27901.1
    mRNA DB143341.1 None
    mRNA X04391.1 CAA27979.1
    other-genetic DQ892077.2 ABM83003.1
    other-genetic DQ895270.2 ABM86196.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06127.2 GenPept UniProtKB/Swiss-Prot:P06127
    Q6QHB8 GenPept UniProtKB/TrEMBL:Q6QHB8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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      Supplemental Content

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