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    HLA-DRB4 major histocompatibility complex, class II, DR beta 4 [ Homo sapiens ]

    Gene ID: 3126, updated on 19-May-2012
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    Summary

    Official Symbol
    HLA-DRB4provided by HGNC
    Official Full Name
    major histocompatibility complex, class II, DR beta 4provided by HGNC
    Primary source
    HGNC:4952
    Locus tag
    DAMC-146E17.2
    See related
    HPRD:09986
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRB4; HLA-DR4B
    Summary
    HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
    Annotation information
    Annotation category: not annotated on reference assembly
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    Genomic context

    Location :
    6p21.3
    See HLA-DRB4 in MapViewer

    NT_167246.1Genomic Context describing neighboring genes Neighboring gene butyrophilin-like 2 (MHC class II associated) Neighboring gene major histocompatibility complex, class II, DR alpha Neighboring gene protein FAM136A-like Neighboring gene protein kinase, interferon-inducible double stranded RNA dependent activator pseudogene 1

    NT_167247.1Genomic Context describing neighboring genes Neighboring gene butyrophilin-like 2 (MHC class II associated) Neighboring gene major histocompatibility complex, class II, DR alpha Neighboring gene HLA class II histocompatibility antigen, DQ alpha 1 chain-like Neighboring gene major histocompatibility complex, class II, DQ beta 1

    NT_167249.1Genomic Context describing neighboring genes Neighboring gene butyrophilin-like 2 (MHC class II associated) Neighboring gene major histocompatibility complex, class II, DR alpha Neighboring gene major histocompatibility complex, class II, DR beta 8 (pseudogene) Neighboring gene protein kinase, interferon-inducible double stranded RNA dependent activator pseudogene 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Effects of chronic ascariasis and trichuriasis on cytokine production and gene expression in human blood: a cross-sectional study. Reina Ortiz M, et al. PLoS Negl Trop Dis, 2011 Jun. PMID 21666788.
    2. A meta-analysis of HLA-DR polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy. Jin B, et al. Mol Biol Rep, 2012 Jan. PMID 21556773.
    3. A novel HLA-DRB4 allele, DRB4*01:08, identified by sequence-based typing. Lee E, et al. Tissue Antigens, 2011 Aug. PMID 21410658.
    4. Individual genetic variations directly effect polarization of cytokine responses to superantigens associated with streptococcal sepsis: implications for customized patient care. Nooh MM, et al. J Immunol, 2011 Mar 1. PMID 21282506.
    5. Visual hallucinations and HLA class II antigens in cortical dementia. Gómez-Tortosa E, et al. Dement Geriatr Cogn Disord, 2010. PMID 20606439.

    See all (151) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Elevated frequencies of HLA-DR4 and HLA-DR5 alleles were found in patients with idiopathic dilated cardiomyopathy compared with controls.
      Title: A meta-analysis of HLA-DR polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy.
    2. DRB4*01:08 is a novel HLA-DRB4 allele
      Title: A novel HLA-DRB4 allele, DRB4*01:08, identified by sequence-based typing.
    3. HLA-DR14/DR7/DQ5 alleles significantly increase the risk for toxic shock syndrome, regardless of individual variations in T cell receptor variable region repertoires.
      Title: Individual genetic variations directly effect polarization of cytokine responses to superantigens associated with streptococcal sepsis: implications for customized patient care.
    4. IA2 positivity was associated with HLA-DR4/X and HLA-DR3/4 positivity, and hypothyroidism was linked to HLA-DR4/4. More females carried the HLA-DR4/4 genotype or were thyroid antibody positive.
      Title: HLA-DR genotypes influence age at disease onset in children and juveniles with type 1 diabetes mellitus.
    5. Our results revealed HLA-DRB1*04 as predisposing factor in papillary thyroid carcinoma in Iranian population.
      Title: HLA-DR association in papillary thyroid carcinoma.
    6. primary biliary cirrhosis patients had a higher gene frequency of HLA-DR4 and DR1 compared to healthy controls and patients with overlap syndromes
      Title: HLA-DR allele frequencies in Mexican mestizos with autoimmune liver diseases including overlap syndromes.
    7. Significant transmission disequilibrium for HLA-DR4 was seen (odds ratio, 4.67; 95% confidence interval, 1.34-16.24; P = .008) for transmissions from maternal grandparents to mothers of probands.
      Title: HLA-DR4 as a risk allele for autism acting in mothers of probands possibly during pregnancy.
    8. associated with antiphospholipid syndrome
      Title: Clinical and laboratory features of the catastrophic antiphospholipid syndrome.
    9. HLA-DR and INS VNTR alleles mark both type 1 diabetes disease susceptibility and separate Caucasian parental subpopulations
      Title: A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease.
    10. Thirty-eight percent of the B burgdorferi-infected DR4+/+CD28(-/-)MHCII(-/-) mice, but none of the B burgdorferi-infected CD28(-/-)MHCII(-/-) mice, remained arthritic post-antibiotic treatment
      Title: Persistent arthritis in Borrelia burgdorferi-infected HLA-DR4-positive CD28-negative mice post-antibiotic treatment.
    Submit: New GeneRIF Correction See all (34)
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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env CD4+ T cells infected with CCR5-tropic HIV-1 have significantly higher levels of activation-marker expression (e.g. CD25, CD71 and HLA-DR) than CD4+ T lymphocytes infected with CXCR4-tropic HIV-1 PubMed
    env HIV envelope protein gp120 can specifically inhibit CD4-dependent class II MHC-restricted T cell response to Ag PubMed
    env Genetic variability in HIV-1 gp120 affects its interactions with HLA-DR molecules and T cell receptor PubMed
    env Amino acid residues 42-49 in the V1 region of CD4 are involved in the interaction between HIV-1 gp120 and class II major histocompatibility complex molecules PubMed
    Envelope surface glycoprotein gp160, precursor env Processing of HIV-1 gp160 to gp120 and gp41 is necessary for the association of HIV-1 envelope glycoproteins with class II MHC PubMed
    env Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells PubMed
    Envelope transmembrane glycoprotein gp41 env Soluble HIV-1 gp41 enhancement effects on MHC class I and II antigen expression can be inhibited by soluble gp41-binding proteins of 45, 49 and 62 kD from human B cells PubMed
    env Soluble HIV-1 gp41 can selectively enhance MHC class I and II expression on human B cells, but does not increase expression of other cell surface antigens such as CD21 and CD54 (ICAM-1) PubMed
    env A 43-amino-acid sequence between amino acids 708 and 750 in the HIV-1 gp41(TM) cytoplasmic tail is required for efficient incorporation of HLA class II proteins into virions PubMed
    Pr55(Gag) gag Human Leukocyte Antigen DR (HLA-DR), Major Histocompatibility Complex class II molecules (MHC-II) induce a relocation of Gag to late endosomal/multivesicular bodies (LE/MVB) and increase the accumulation of viral particles assembling intracellularly PubMed
    gag HIV-1 Gag expression is able to induce HLA-DR cell-surface localization in H78-C10.0 cells PubMed
    gag In human macrophages, HIV-1 Gag proteins co-localize with MHC II (HLA-DR), CD63, and Lamp1 in MHC II compartments PubMed
    Tat tat HIV-1 Tat downregulates expression of MHC class II genes in antigen-presenting cells (APC) by inhibiting the transactivator of MHC class II genes, CIITA PubMed
    tat HIV-1 Tat upregulates HLA-DR expression in monocyte-derived dendritic cells and T cells, thereby driving T cell-mediated immune responses and activation PubMed
    capsid gag HIV-1 Capsid (p24) inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P13762 P78358 CTAG1B    HPRD  PubMed  
    BioGRID:109371 BioGRID:106808 ANXA11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109371 BioGRID:106971 ATP1B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109371 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109371 BioGRID:109558 HSP90AB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109371 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109371 BioGRID:107369 MS4A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109371 BioGRID:111332 PKM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109371 BioGRID:113363 YWHAE    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Allograft rejection, organism-specific biosystem (from KEGG)
      Allograft rejection, organism-specific biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Allograft rejection, conserved biosystem (from KEGG)
      Allograft rejection, conserved biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • Asthma, organism-specific biosystem (from KEGG)
      Asthma, organism-specific biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
    • Asthma, conserved biosystem (from KEGG)
      Asthma, conserved biosystemAsthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and ...
    • Autoimmune thyroid disease, organism-specific biosystem (from KEGG)
      Autoimmune thyroid disease, organism-specific biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Autoimmune thyroid disease, conserved biosystem (from KEGG)
      Autoimmune thyroid disease, conserved biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Downstream TCR signaling, organism-specific biosystem (from REACTOME)
      Downstream TCR signaling, organism-specific biosystemChanges in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
      Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
    • Graft-versus-host disease, organism-specific biosystem (from KEGG)
      Graft-versus-host disease, organism-specific biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • Graft-versus-host disease, conserved biosystem (from KEGG)
      Graft-versus-host disease, conserved biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
      Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
      Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • PD-1 signaling, organism-specific biosystem (from REACTOME)
      PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
      Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemPrior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulato...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Translocation of ZAP-70 to Immunological synapse, organism-specific biosystem (from REACTOME)
      Translocation of ZAP-70 to Immunological synapse, organism-specific biosystemThe dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via their tandem SH2 domains (step 4). ZAP-70 subsequently undergoes phosphorylation on multiple tyrosine residues for further activation. ZAP-...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    MHC class II receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    major histocompatibility complex, class II, DR beta 4
    Names
    major histocompatibility complex, class II, DR beta 4
    DR4
    DR-4
    leukocyte antigen
    MHC class2 antigen
    MHC HLA DR-beta chain
    MHC class II antigen DRB4
    DRB1 transplantation antigen
    human leucocyte antigen DRB4
    MHC class II antigen HLA-DR-beta
    HLA class II histocompatibility antigen, DR beta 4 chain
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_002433.1 Reference

      Range
      3612..18584, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021983.4 → NP_068818.4  major histocompatibility complex, class II, DR beta 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AI829825, BC005312, BF974249
      UniProtKB/Swiss-Prot
      P13762
      Conserved Domains (2) summary
      cd05766
      Location:126 – 219
      Blast Score: 378
      IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
      cl03042
      Location:43 – 116
      Blast Score: 377
      MHC_II_beta; Class II histocompatibility antigen, beta domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p5 ALT_REF_LOCI_4

      Range
      3846047..3861015, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p5 ALT_REF_LOCI_5

      Range
      3882321..3897292, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p5 ALT_REF_LOCI_7

      Range
      3850430..3865402, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AADB02027554.1 None
    genomic AB049459.1 BAB16298.1
    genomic AB107960.1 BAC75547.1
    genomic AB112911.1 BAD02942.1
    genomic AB207269.1 BAD91204.1
    genomic AF028010.1 AAB94612.1
    genomic AF029284.1 AAF65493.1
    genomic AF029287.1 AAF65496.1
    genomic AF036944.1 AAC05578.1
    genomic AF142448.1 AAD31292.1
    genomic AF144081.1 AAD53054.1
    genomic AF177215.1 AAD53910.1
    genomic AF207709.1 AAG22593.1
    genomic AF214572.2 AAF32284.2
    genomic AF227518.1 AAF61218.1
    genomic AF305212.1 AAG22826.1
    genomic AF324240.1 AAN52494.1
    genomic AF335233.1 AAK20875.1
    genomic AF352295.1 AAK27712.1
    genomic AJ131789.1 CAB65073.1
    genomic AJ223124.1 CAA11127.1
    genomic AJ242833.1 CAC20415.1
    genomic AJ243701.1 CAB65103.1
    genomic AJ252282.1 CAB65735.1
    genomic AJ289123.1 CAC19015.1
    genomic AJ292564.1 CAC00534.1
    genomic AJ293725.1 CAC28260.1
    genomic AJ297503.1 CAC27124.1
    genomic AJ401236.1 CAB96577.1
    genomic AJ812566.1 CAH23708.1
    genomic AJ870921.1 CAI35044.1
    genomic AL929581.5 (86717..100105) None
    genomic AM086025.1 CAJ30431.1
    genomic AM109974.1 CAJ33581.1
    genomic AY033428.1 AAK55114.1
    genomic AY043181.1 AAK81687.1
    genomic AY174091.1 AAO20088.1
    genomic AY174092.1 AAO20089.1
    genomic AY283604.1 AAQ18120.1
    genomic AY339246.1 AAQ18913.1
    genomic AY394720.1 AAQ96922.1
    genomic AY428805.1 AAR07616.1
    genomic AY465114.1 AAR28666.1
    genomic AY663410.1 AAU88021.1
    genomic AY724685.1 AAW59561.1
    genomic AY750899.1 AAV38129.1
    genomic AY772533.1 AAV38108.1
    genomic AY899825.1 AAW82078.1
    genomic BX120007.9 CAM26205.1
    genomic BX296568.4 CAM25996.1
    genomic BX571807.5 CAM25971.1
    genomic BX927235.7 (50196..65164) None
    genomic CR788250.6 CAQ07647.1
    genomic D50865.1 BAA09461.1
    genomic D64042.1 BAA10907.1
    genomic D86502.1 BAA13097.1
    genomic D86503.1 BAA13098.1
    genomic D89879.1 BAA14036.1
    genomic D89918.1 BAA14037.1
    genomic DQ011879.1 AAY40254.1
    genomic DQ136035.1 AAZ67361.1
    genomic DQ179038.1 ABA06596.1
    genomic DQ358688.1 ABC84557.1
    genomic EF536016.1 ABQ08747.1
    genomic K02775.1 AAA59802.1
    genomic L08621.1 AAA59691.1
    genomic L14852.1 AAC37561.1
    genomic M15838.1 AAA52769.1
    genomic M20555.1 AAA59830.1
    genomic M27509.1 AAA59815.1
    genomic M27644.1 AAA72782.1
    genomic M35006.1 AAA52327.1
    genomic M63195.1 AAA52320.1
    genomic M63200.1 AAA52323.1
    genomic M74030.1 AAA62840.1
    genomic M74031.1 AAA62839.1
    genomic M81176.1 AAA91843.1
    genomic M96130.1 AAA03144.1
    genomic U03291.1 AAA99536.1
    genomic U03721.1 AAA03486.1
    genomic U09200.1 AAA17991.1
    genomic U26659.1 AAD09441.1
    genomic U36827.1 AAC51629.1
    genomic U39087.1 AAB18636.1
    genomic U41490.1 AAA86243.1
    genomic U41491.1 AAA86244.1
    genomic U59686.1 AAB52230.1
    genomic U70545.1 AAC51630.1
    genomic X65567.1 CAA46536.1
    genomic X99839.1 CAA68150.1
    genomic Y09313.1 CAA70497.1
    mRNA AF017439.1 AAB70553.1
    mRNA AF048707.1 AAC31951.1
    mRNA AF361548.1 AAM00252.1
    mRNA AF361549.1 AAM00253.1
    mRNA AI829825.1 None
    mRNA AK225683.1 None
    mRNA AK225690.1 None
    mRNA AK291499.1 BAF84188.1
    mRNA AK292151.1 BAF84840.1
    mRNA AK293020.1 BAF85709.1
    mRNA AY961064.1 AAX63452.1
    mRNA AY961067.1 AAX63455.1
    mRNA AY961070.2 AAX63458.2
    mRNA BC005312.1 AAH05312.1
    mRNA BF974249.1 None
    mRNA DQ284431.1 ABC66198.1
    mRNA DQ284433.1 ABC66200.1
    mRNA GQ891550.1 ACX50637.1
    mRNA M14190.1 AAA36288.1
    mRNA M15071.1 AAA59813.1
    mRNA M15178.1 AAA35995.1
    mRNA M16732.1 AAA59825.1
    mRNA M16942.1 AAA36296.1
    mRNA M17385.1 AAA36300.1
    mRNA M17388.1 AAA36299.1
    mRNA M30180.1 AAA59714.1
    mRNA M59803.1 AAA64237.1
    mRNA S48645.1 AAB24005.2
    mRNA U17379.1 AAC50165.1
    mRNA U29342.1 AAB63410.1
    mRNA U35375.1 AAA75373.1
    mRNA U35729.1 AAA79144.1
    mRNA U37433.1 AAB63411.1
    mRNA U47028.1 AAB63412.1
    mRNA U70544.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0AQY1 GenPept UniProtKB/TrEMBL:A0AQY1
    A0AQY4 GenPept UniProtKB/TrEMBL:A0AQY4
    A0AQY5 GenPept UniProtKB/TrEMBL:A0AQY5
    A0AQY6 GenPept UniProtKB/TrEMBL:A0AQY6
    A0AQY7 GenPept UniProtKB/TrEMBL:A0AQY7
    A0AQY8 GenPept UniProtKB/TrEMBL:A0AQY8
    A0AQZ4 GenPept UniProtKB/TrEMBL:A0AQZ4
    O00664 GenPept UniProtKB/TrEMBL:O00664
    O19190 GenPept UniProtKB/TrEMBL:O19190
    O19503 GenPept UniProtKB/TrEMBL:O19503
    O19504 GenPept UniProtKB/TrEMBL:O19504
    O19586 GenPept UniProtKB/TrEMBL:O19586
    O19661 GenPept UniProtKB/TrEMBL:O19661
    O19662 GenPept UniProtKB/TrEMBL:O19662
    O19663 GenPept UniProtKB/TrEMBL:O19663
    O19665 GenPept UniProtKB/TrEMBL:O19665
    O19666 GenPept UniProtKB/TrEMBL:O19666
    O19668 GenPept UniProtKB/TrEMBL:O19668
    O19678 GenPept UniProtKB/TrEMBL:O19678
    O19679 GenPept UniProtKB/TrEMBL:O19679
    O19681 GenPept UniProtKB/TrEMBL:O19681
    O19719 GenPept UniProtKB/TrEMBL:O19719
    O19721 GenPept UniProtKB/TrEMBL:O19721
    O19725 GenPept UniProtKB/TrEMBL:O19725
    O19727 GenPept UniProtKB/TrEMBL:O19727
    O19729 GenPept UniProtKB/TrEMBL:O19729
    O19733 GenPept UniProtKB/TrEMBL:O19733
    O19735 GenPept UniProtKB/TrEMBL:O19735
    O19736 GenPept UniProtKB/TrEMBL:O19736
    O19737 GenPept UniProtKB/TrEMBL:O19737
    O19738 GenPept UniProtKB/TrEMBL:O19738
    O19740 GenPept UniProtKB/TrEMBL:O19740
    O19742 GenPept UniProtKB/TrEMBL:O19742
    O19743 GenPept UniProtKB/TrEMBL:O19743
    O19759 GenPept UniProtKB/TrEMBL:O19759
    O19762 GenPept UniProtKB/TrEMBL:O19762
    O19763 GenPept UniProtKB/TrEMBL:O19763
    O62870 GenPept UniProtKB/TrEMBL:O62870
    O62880 GenPept UniProtKB/TrEMBL:O62880
    O77961 GenPept UniProtKB/TrEMBL:O77961
    O77963 GenPept UniProtKB/TrEMBL:O77963
    O78054 GenPept UniProtKB/TrEMBL:O78054
    O78117 GenPept UniProtKB/TrEMBL:O78117
    P13760.1 GenPept UniProtKB/Swiss-Prot:P13760
    P13762.2 GenPept UniProtKB/Swiss-Prot:P13762
    P79491 GenPept UniProtKB/TrEMBL:P79491
    P79552 GenPept UniProtKB/TrEMBL:P79552
    Q05563 GenPept UniProtKB/TrEMBL:Q05563
    Q0PGS7 GenPept UniProtKB/TrEMBL:Q0PGS7
    Q0VUQ9 GenPept UniProtKB/TrEMBL:Q0VUQ9
    Q1KLJ9 GenPept UniProtKB/TrEMBL:Q1KLJ9
    Q29668 GenPept UniProtKB/TrEMBL:Q29668
    Q29696 GenPept UniProtKB/TrEMBL:Q29696
    Q29726 GenPept UniProtKB/TrEMBL:Q29726
    Q29728 GenPept UniProtKB/TrEMBL:Q29728
    Q29732 GenPept UniProtKB/TrEMBL:Q29732
    Q29745 GenPept UniProtKB/TrEMBL:Q29745
    Q29869 GenPept UniProtKB/TrEMBL:Q29869
    Q29888 GenPept UniProtKB/TrEMBL:Q29888
    Q29890 GenPept UniProtKB/TrEMBL:Q29890
    Q29895 GenPept UniProtKB/TrEMBL:Q29895
    Q2L4U2 GenPept UniProtKB/TrEMBL:Q2L4U2
    Q2LIR3 GenPept UniProtKB/TrEMBL:Q2LIR3
    Q2LIR4 GenPept UniProtKB/TrEMBL:Q2LIR4
    Q2LIR5 GenPept UniProtKB/TrEMBL:Q2LIR5
    Q30103 GenPept UniProtKB/TrEMBL:Q30103
    Q30104 GenPept UniProtKB/TrEMBL:Q30104
    Q30106 GenPept UniProtKB/TrEMBL:Q30106
    Q30123 GenPept UniProtKB/TrEMBL:Q30123
    Q30143 GenPept UniProtKB/TrEMBL:Q30143
    Q30147 GenPept UniProtKB/TrEMBL:Q30147
    Q30152 GenPept UniProtKB/TrEMBL:Q30152
    Q30162 GenPept UniProtKB/TrEMBL:Q30162
    Q31624 GenPept UniProtKB/TrEMBL:Q31624
    Q31635 GenPept UniProtKB/TrEMBL:Q31635
    Q31642 GenPept UniProtKB/TrEMBL:Q31642
    Q31646 GenPept UniProtKB/TrEMBL:Q31646
    Q3LAB7 GenPept UniProtKB/TrEMBL:Q3LAB7
    Q3LAB8 GenPept UniProtKB/TrEMBL:Q3LAB8
    Q3LAB9 GenPept UniProtKB/TrEMBL:Q3LAB9
    Q3LAC0 GenPept UniProtKB/TrEMBL:Q3LAC0
    Q3LAC1 GenPept UniProtKB/TrEMBL:Q3LAC1
    Q3LTJ6 GenPept UniProtKB/TrEMBL:Q3LTJ6
    Q45FY1 GenPept UniProtKB/TrEMBL:Q45FY1
    Q45KF7 GenPept UniProtKB/TrEMBL:Q45KF7
    Q4F6M7 GenPept UniProtKB/TrEMBL:Q4F6M7
    Q4U0U6 GenPept UniProtKB/TrEMBL:Q4U0U6
    Q4U4M6 GenPept UniProtKB/TrEMBL:Q4U4M6
    Q53YS1 GenPept UniProtKB/TrEMBL:Q53YS1
    Q53ZR8 GenPept UniProtKB/TrEMBL:Q53ZR8
    Q56FN5 GenPept UniProtKB/TrEMBL:Q56FN5
    Q56FN7 GenPept UniProtKB/TrEMBL:Q56FN7
    Q56FN8 GenPept UniProtKB/TrEMBL:Q56FN8
    Q56FP5 GenPept UniProtKB/TrEMBL:Q56FP5
    Q58HT8 GenPept UniProtKB/TrEMBL:Q58HT8
    Q5IFG9 GenPept UniProtKB/TrEMBL:Q5IFG9
    Q5IWM0 GenPept UniProtKB/TrEMBL:Q5IWM0
    Q5Y7D1 GenPept UniProtKB/TrEMBL:Q5Y7D1
    Q5Y7D7 GenPept UniProtKB/TrEMBL:Q5Y7D7
    Q5Y7G6 GenPept UniProtKB/TrEMBL:Q5Y7G6
    Q5Y7G9 GenPept UniProtKB/TrEMBL:Q5Y7G9
    Q6QJL9 GenPept UniProtKB/TrEMBL:Q6QJL9
    Q6RCP8 GenPept UniProtKB/TrEMBL:Q6RCP8
    Q6UB42 GenPept UniProtKB/TrEMBL:Q6UB42
    Q6Y1S2 GenPept UniProtKB/TrEMBL:Q6Y1S2
    Q7JFU9 GenPept UniProtKB/TrEMBL:Q7JFU9
    Q7YPZ5 GenPept UniProtKB/TrEMBL:Q7YPZ5
    Q7YQ30 GenPept UniProtKB/TrEMBL:Q7YQ30
    Q860C0 GenPept UniProtKB/TrEMBL:Q860C0
    Q860S8 GenPept UniProtKB/TrEMBL:Q860S8
    Q861F4 GenPept UniProtKB/TrEMBL:Q861F4
    Q861G2 GenPept UniProtKB/TrEMBL:Q861G2
    Q8HWT8 GenPept UniProtKB/TrEMBL:Q8HWT8
    Q8MH61 GenPept UniProtKB/TrEMBL:Q8MH61
    Q8NEI3 GenPept UniProtKB/TrEMBL:Q8NEI3
    Q8SNB5 GenPept UniProtKB/TrEMBL:Q8SNB5
    Q8SNC3 GenPept UniProtKB/TrEMBL:Q8SNC3
    Q8WLQ7 GenPept UniProtKB/TrEMBL:Q8WLQ7
    Q8WLU0 GenPept UniProtKB/TrEMBL:Q8WLU0
    Q95465 GenPept UniProtKB/TrEMBL:Q95465
    Q95HL4 GenPept UniProtKB/TrEMBL:Q95HL4
    Q95IE4 GenPept UniProtKB/TrEMBL:Q95IE4
    Q95IE6 GenPept UniProtKB/TrEMBL:Q95IE6
    Q9BCN9 GenPept UniProtKB/TrEMBL:Q9BCN9
    Q9BCQ0 GenPept UniProtKB/TrEMBL:Q9BCQ0
    Q9BCS5 GenPept UniProtKB/TrEMBL:Q9BCS5
    Q9BD10 GenPept UniProtKB/TrEMBL:Q9BD10
    Q9BD12 GenPept UniProtKB/TrEMBL:Q9BD12
    Q9BD26 GenPept UniProtKB/TrEMBL:Q9BD26
    Q9GIJ6 GenPept UniProtKB/TrEMBL:Q9GIJ6
    Q9GJ28 GenPept UniProtKB/TrEMBL:Q9GJ28
    Q9GJ49 GenPept UniProtKB/TrEMBL:Q9GJ49
    Q9GJG2 GenPept UniProtKB/TrEMBL:Q9GJG2
    Q9MXZ6 GenPept UniProtKB/TrEMBL:Q9MXZ6
    Q9MXZ9 GenPept UniProtKB/TrEMBL:Q9MXZ9
    Q9MY14 GenPept UniProtKB/TrEMBL:Q9MY14
    Q9MYA0 GenPept UniProtKB/TrEMBL:Q9MYA0
    Q9MYA1 GenPept UniProtKB/TrEMBL:Q9MYA1
    Q9MYB9 GenPept UniProtKB/TrEMBL:Q9MYB9
    Q9MYD7 GenPept UniProtKB/TrEMBL:Q9MYD7
    Q9MYE4 GenPept UniProtKB/TrEMBL:Q9MYE4
    Q9NQ54 GenPept UniProtKB/TrEMBL:Q9NQ54
    Q9TPE1 GenPept UniProtKB/TrEMBL:Q9TPE1
    Q9TQ44 GenPept UniProtKB/TrEMBL:Q9TQ44
    Q9TQ47 GenPept UniProtKB/TrEMBL:Q9TQ47
    Q9TQ59 GenPept UniProtKB/TrEMBL:Q9TQ59
    Q9TQD6 GenPept UniProtKB/TrEMBL:Q9TQD6
    Q9TQD9 GenPept UniProtKB/TrEMBL:Q9TQD9
    Q9TQE1 GenPept UniProtKB/TrEMBL:Q9TQE1
    Q9UEX8 GenPept UniProtKB/TrEMBL:Q9UEX8
    Q9UEY1 GenPept UniProtKB/TrEMBL:Q9UEY1
    Q9UEY3 GenPept UniProtKB/TrEMBL:Q9UEY3
    Q9UM28 GenPept UniProtKB/TrEMBL:Q9UM28
    Help top of page

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